Pathophysiology and Rational Pharmacotherapy of Myocardial Ischemia

Front Matter....Pages I-VIII
A Brief History of Angina Pectoris: Change of Concepts and Ideas....Pages 1-9
Myocardial Ultrastructure in Ischemia....Pages 11-36
Myocardial Metabolism in Ischemia....Pages 37-57
Metabolic Imaging of Ischemic Heart Disease by Positron Emission Tomography....Pages 59-81
Coagulation, Thrombosis and Fibrinolysis in Myocardial Ischemia....Pages 83-110
Regional Myocardial Flow-Function Relationship in Ischemia....Pages 111-135
Electrophysiologic and Biochemical Mechanisms Underlying Malignant Ventricular Arrhythmias during Early Myocardial Ischemia....Pages 137-173
Reperfused Myocardium: Stunning, Preconditioning, and Reperfusion Injury....Pages 175-197
Coronary Vasomotor Tone in Myocardial Ischemia....Pages 199-216
Clinical Significance of Coronary Vasomotor Tone in Myocardial Ischemia....Pages 217-229
The Challenge of Silent Myocardial Ischemia....Pages 231-246
Exercise-Induced Myocardial Ischemia: The Role of Heart Rate Reduction in Therapeutic Approach....Pages 247-260
Treatment of Myocardial Ischemia with Beta-Blockers....Pages 261-274
Treatment of Myocardial Ischemia with Nitrates....Pages 275-293
Treatment of Myocardial Ischemia with Calcium Antagonists....Pages 295-313
Combination Anti-Anginal Therapy: Rationale and Results....Pages 315-329
Combined Treatment of Stable Effort-Induced Angina and Mixed Angina....Pages 331-347
Back Matter....Pages 349-354