Pathogenesis and Treatment of Acne and Rosacea

Front Matter....Pages i-xxviii
Front Matter....Pages 1-1
The Sebaceous Gland Through the Centuries: A Difficult Path to Independence....Pages 3-8
Embryology of the Pilosebaceous Unit....Pages 9-17
Molecular Aspects of Sebaceous Differentiation....Pages 19-26
Anatomy of the Sebaceous Gland....Pages 27-31
Sebum and Sebaceous Lipids....Pages 33-41
Experimental Models of the Sebaceous Gland....Pages 43-49
Front Matter....Pages 51-51
Acne Epidemiology and Socioeconomic Aspects....Pages 53-57
Front Matter....Pages 59-59
Acne Pathogenesis: What We Have Learned Over the Years....Pages 61-70
The Role of Hyperkeratinization....Pages 71-76
The Role of the Sebaceous Gland....Pages 77-90
The Role of Bacteria....Pages 91-96
Inflammation in Acne....Pages 97-101
Front Matter....Pages 103-103
A New Concept of Acne Pathogenesis....Pages 105-107
Acne and Genetics....Pages 109-130
Acne and Androgens....Pages 131-134
Acne and Inflammation....Pages 135-141
Acne and Neuropeptides....Pages 143-150
Acne and Bacteria....Pages 151-153
The Acne Biofilm....Pages 155-159
The Evidence Supporting a Link Between Acne and Nutrition....Pages 161-166
Front Matter....Pages 103-103
Acne and Smoking....Pages 167-169
Antimicrobial Peptides in Acne....Pages 171-178
Acne and Antimicrobial Lipids....Pages 179-183
Natural and Artificial Suntanning....Pages 185-188
Acne and Environmental Pollution (Chloracne)....Pages 189-194
Myths and Beliefs of Acne Pathogenesis: Diet, Smoking, Hygiene....Pages 195-205
Front Matter....Pages 207-207
Understanding Acne as a Chronic Disease....Pages 209-211
Clinical Aspects of Acne Vulgaris....Pages 213-221
Clinical Aspects of Acne Fulminans....Pages 223-226
Childhood Acne....Pages 227-234
Congenital Adrenal Hyperplasia and Acne in the Male Patients....Pages 235-241
Adult Acne....Pages 243-249
Drug-Induced Acne....Pages 251-257
Body-Builder Acne....Pages 259-263
Acne Cosmetica....Pages 265-270
Acne in Persons with Dark Skin....Pages 271-275
Front Matter....Pages 277-277
Acne and Heredity....Pages 279-282
Acne Neonatorum....Pages 283-289
Serum Androgens....Pages 291-294
Body Mass Index....Pages 295-297
Front Matter....Pages 277-277
Sebum Secretion, Skin Type, and pH....Pages 299-303
Lipids in Serum and Sebum....Pages 305-313
Front Matter....Pages 315-315
The Leeds Acne Grading Technique....Pages 317-324
Evaluation of Clinical Severity by Acne Grading and Lesion Counting....Pages 325-330
Modern Technology for Imaging and Evaluation of Acne Lesions....Pages 331-340
Front Matter....Pages 341-341
Acne and Congenital Adrenal Hyperplasia....Pages 343-348
The Acne Genes....Pages 349-354
Vitamins and the Skin....Pages 355-361
Urinary Hormone Analysis in Acne....Pages 363-368
Laboratory Evaluations in Acne....Pages 369-375
Front Matter....Pages 377-377
Evidenced-Based Treatment of Acne....Pages 379-382
The Difficult Acne Patient....Pages 383-388
Improving Compliance with Acne Therapy....Pages 389-395
Keratolytic Treatment....Pages 397-414
Topical Antibiotics....Pages 415-418
Benzoyl Peroxide....Pages 419-423
Topical Retinoids....Pages 425-433
Azelaic Acid....Pages 435-440
Emerging Acne Treatments....Pages 441-447
Oral Antibiotics....Pages 449-458
Front Matter....Pages 377-377
The Antibiotic Resistance in Acne....Pages 459-464
Prescribing Oral Isotretinoin: The European Approach....Pages 465-469
Oral Isotretinoin: The US Approach....Pages 471-475
Hormonal Therapy for Acne....Pages 477-482
Less Common Treatments....Pages 483-489
Risk Factors of Acne Relapse....Pages 491-495
Acne Maintenance Therapy....Pages 497-502
Cosmetics and Cleansers in Acne....Pages 503-509
Chemical Peeling in Acne....Pages 511-517
Lasers and Phototherapy in Acne....Pages 519-526
Treatment of Acne Scarring....Pages 527-536
Concepts of Future Acne Treatment....Pages 537-542
Front Matter....Pages 543-543
Acne and Quality of Life....Pages 545-549
Instruments of Measurement of Quality of Life in Acne....Pages 551-560
Front Matter....Pages 561-561
The SAHA Syndrome....Pages 563-567
The Polycystic Ovary Syndrome and Acne....Pages 569-577
The SAPHO Syndrome....Pages 579-584
The PAPA Syndrome....Pages 585-590
Acne in Transplantation Patients....Pages 591-602
Front Matter....Pages 603-603
Rosacea: The State of the Art....Pages 605-609
Front Matter....Pages 603-603
The Vascular Concept....Pages 611-619
Rosacea and Neuropeptides....Pages 621-626
Rosacea and Demodex folliculorum ....Pages 627-639
The Role of Adenosine Triphosphate in the Pathogenesis of Rosacea: An Explanation for the Mode of Action of Tetracyclines for the Treatment of Rosacea....Pages 641-643
Front Matter....Pages 645-645
Standard Grading System for Rosacea....Pages 647-651
Classical Clinical Presentations of Rosacea....Pages 653-659
Rhinophyma: A Variation of Rosacea?....Pages 661-664
Ocular Rosacea....Pages 665-667
Childhood Rosacea....Pages 669-672
Differential Diagnosis of Rosacea....Pages 673-679
Front Matter....Pages 681-681
A Treatment Strategy for Rosacea....Pages 683-692
Topical Treatment of Rosacea....Pages 693-698
Systemic Treatment of Rosacea....Pages 699-705
Laser and Light Therapy of Rosacea....Pages 707-711
Nonclassical Treatments....Pages 713-717
Cosmetics in Rosacea....Pages 719-727
Treatment of Rhinophyma....Pages 729-731
The Future of Rosacea Treatment....Pages 733-739
Front Matter....Pages 741-741
Impact of Rosacea on Quality of Life....Pages 743-747
Erratum....Pages E1-E1
Back Matter....Pages 749-768