Paroxysmal Nocturnal Hemoglobinuria: From Bench to Bedside

Front Matter....Pages i-viii
A History of Research of PNH: Defining a Disease....Pages 1-8
Front Matter....Pages 9-9
Synthesis, Genetics, and Congenital Diseases of GPI-Anchored Proteins....Pages 11-54
Animal Models of Paroxysmal Nocturnal Hemoglobinuria....Pages 55-65
Complement and PNH....Pages 67-95
Front Matter....Pages 97-97
Epidemiology in PNH: The PNH Global Registry....Pages 99-107
Epidemiology in PNH: Clinical Epidemiological Studies in Korea....Pages 109-120
Haemolysis in PNH: Depletion of Nitric Oxide....Pages 121-135
Bone Marrow Failure in PNH....Pages 137-151
Thrombophilia in PNH....Pages 153-172
Diagnosis and Classification of PNH....Pages 173-183
Clinical Significance of a Small Population of Glycosylphosphatidylinositol-Anchored Membrane Proteins (GPI-APs)-Deficient Cells in the Management of Bone Marrow Failure....Pages 185-195
Clonal Origin and Clonal Selection in PNH....Pages 197-213
Pathogenesis of Clonal Dominance in PNH: Selection Mechanisms in PNH....Pages 215-227
Pathogenesis of Clonal Dominance in PNH: Growth Advantage in PNH....Pages 229-251
Clinical Management in PNH....Pages 253-269
Clinical Effects of Eculizumab in PNH....Pages 271-282
Clinical Effects of Eculizumab in PNH: Extravascular Hemolysis After Eculizumab Treatment....Pages 283-295
Clinical Effects of Eculizumab in PNH: Poor Responders to Eculizumab....Pages 297-306
Hematopoietic Stem Cell Transplantation in PNH....Pages 307-317
Future Strategies of Complement Inhibition in Paroxysmal Nocturnal Hemoglobinuria....Pages 319-346
Front Matter....Pages 97-97
Pregnancy in Paroxysmal Nocturnal Hemoglobinuria....Pages 347-358