Paraoxonases in Inflammation, Infection, and Toxicology

Front Matter....Pages i-xv
ApoE Mimetic Peptide Reduces Plasma Lipid Hydroperoxide Content with a Concomitant Increase in HDL Paraoxonase Activity....Pages 1-4
Interrelationships Between Paraoxonase-1 and Monocyte Chemoattractant Protein-1 in the Regulation of Hepatic Inflammation....Pages 5-18
Biomarkers of Sensitivity and Exposure in Washington State Pesticide Handlers....Pages 19-27
Paraoxonase 1 Status as a Risk Factor for Disease or Exposure....Pages 29-35
Engineering Human PON1 in an E. coli Expression System....Pages 37-45
The Toxicity of Mixtures of Specific Organophosphate Compounds is Modulated by Paraoxonase 1 Status....Pages 47-60
Identification and Characterization of Biomarkers of Organophosphorus Exposures in Humans....Pages 61-71
Temporal and Tissue-Specific Patterns of Pon3 Expression in Mouse: In situ Hybridization Analysis....Pages 73-87
PON1 and Oxidative Stress in Human Sepsis and an Animal Model of Sepsis....Pages 89-97
Paraoxonase 1 Attenuates Human Plaque Atherogenicity: Relevance to the Enzyme Lactonase Activity....Pages 99-111
The Role of Paraoxonase 1 in the Detoxification of Homocysteine Thiolactone....Pages 113-127
Alteration of PON1 Activity in Adult and Childhood Obesity and Its Relation to Adipokine Levels....Pages 129-142
Anti-Inflammatory Properties of Paraoxonase-1 in Atherosclerosis....Pages 143-151
Paraoxonase 1 Interactions with HDL, Antioxidants and Macrophages Regulate Atherogenesis – A Protective Role for HDL Phospholipids....Pages 153-166
The Effect of HDL Mimetic Peptide 4F on PON1....Pages 167-172
The Contribution of High Density Lipoprotein Apolipoproteins and Derivatives to Serum Paraoxonase-1 Activity and Function....Pages 173-181
Paraoxonase 1, Quorum Sensing, and P. aeruginosa Infection: A Novel Model....Pages 183-193
Back Matter....Pages 195-211