Paller and Mancini - Hurwitz Clinical Pediatric Dermatology: A Textbook of Skin Disorders of Childhood & Adolescence

cover
Inside front cover
	Inside front cover
Front matter
	Front matter
		Paller and Mancini - Hurwitz Clinical Pediatric Dermatology
Copyright
	Copyright
Dedication
	Dedication
Preface
	Preface
Contents
	Contents
1 - An overview of dermatologic diagnosis and procedures
	1 An overview of dermatologic diagnosis and procedures
		Configuration of lesions
		Distribution and morphologic patterns of common skin disorders
		Changes in skin color
		Racial variations in the skin and hair
		Procedures to aid in diagnosis
			Better visualization
		Therapeutic procedures
		Key references
2 - Cutaneous disorders of the newborn
	2 Cutaneous disorders of the newborn
		Neonatal skin
			Skin care of the newborn
		Physiologic phenomena of the newborn
			Cutis marmorata
			Harlequin color change
			Infantile transient smooth muscle contraction of the skin
			Bronze baby syndrome
		Cephalohematoma
		Caput succedaneum
		Complications from fetal and neonatal diagnostic procedures
		Abnormalities of subcutaneous tissue
			Sclerema neonatorum
			Subcutaneous fat necrosis
		Miscellaneous cutaneous disorders
			Miliaria
			Milia
			Bohn nodules and Epstein pearls
			Sebaceous gland hyperplasia
			Acne neonatorum
			Erythema toxicum neonatorum
			Eosinophilic pustular folliculitis
			Impetigo neonatorum
			Sucking blisters
			Transient neonatal pustular melanosis
			Acropustulosis of infancy
			Congenital erosive and vesicular dermatosis
			Seborrheic dermatitis
			Leiner disease
			Diaper dermatitis
				Chafing dermatitis
				Irritant contact dermatitis
				Allergic contact dermatitis
				Diaper candidiasis
				Seborrheic dermatitis
				Psoriasis
				Intertrigo
				Jacquet dermatitis
				Perianal pseudoverrucous papules and nodules
				Acrodermatitis enteropathica
				Langerhans cell histiocytosis
				Treatment of diaper dermatitis
			Granuloma gluteale infantum
		Developmental abnormalities of the newborn
			Skin signs of occult spinal dysraphism
			Drug-induced fetal skin malformations
			Congenital hemihypertrophy
			Aplasia cutis congenita
				Setleis syndrome
			Other developmental defects
		Congenital infections of the newborn
			Congenital rubella
			Congenital varicella syndrome
			Neonatal herpes
			Congenital parvovirus B19 infection
			Congenital syphilis
				Early congenital syphilis
				Late congenital syphilis
				Diagnosis and treatment of congenital syphilis
			Cytomegalic inclusion disease
			Congenital Epstein–Barr virus syndrome
			Congenital toxoplasmosis
			Congenital Zika virus infection
		Key references
3 - Eczematous eruptions in childhood
	3 Eczematous eruptions in childhood
		Atopic dermatitis
			Pathogenesis of atopic dermatitis
			Clinical features
			Other clinical signs
			Effect on quality of life
			Comorbidities of atopic dermatitis
				Allergic disorders
			Infectious complications
				Other comorbidities
			Differential diagnosis
			Management
				Preventing the development of atopic dermatitis
				Avoidance of irritant triggers
				Avoidance of triggering allergens
				Use of bathing and emollients
				Topical antiinflammatory medications
				Role of antihistamines
				Treatment of secondary cutaneous infections
				Other considerations for atopic dermatitis that fails to respond: Adherence and alternative diagnoses
				Management of children with severe atopic dermatitis requiring systemic immunosuppressive therapy
				Systemic immunosuppressant therapy
				Targeted immunomodulatory agents
				Use of complementary treatment approaches
		Pityriasis alba
		Hyperimmunoglobulinemia E syndrome
		Wiskott–Aldrich syndrome
		Lichen simplex chronicus
		Seborrheic dermatitis
		Intertrigo
		Dyshidrotic eczema
		Juvenile plantar dermatosis
		Frictional lichenoid dermatitis
		Nummular dermatitis
		Winter eczema
		Lichen striatus
		Contact dermatitis
			Primary irritant dermatitis
			Allergic contact dermatitis
				Autosensitization dermatitis or id reaction
				Patch testing
				Poison ivy (Rhus) dermatitis
				Metal and metal salt dermatitis
				Shoe dermatitis
				Dermatitis to cosmetics and topical medications
				Adhesive tape dermatitis
				Clothing dermatitis
				Compositae dermatitis
		Key references
4 - Papulosquamous and related disorders
	4 Papulosquamous and related disorders
		Childhood psoriasis
			Clinical manifestations
				Facial psoriasis
				Guttate psoriasis
				Scalp psoriasis
				Diaper-area psoriasis
				Nail involvement
				Other forms of psoriasis
				Comorbidities
			Diagnosis of psoriasis
			Course
			Differential diagnosis
			Therapy of pediatric psoriasis
				Topical therapy
				Treatment of scalp lesions
				Treatment of nail psoriasis
				Compresses for pustular psoriasis
				Ultraviolet light
				Systemic therapy130–132
				Development of psoriasis and psoriasiform dermatitis during administration of tumor necrosis factor inhibitors
			Therapy for psoriatic arthritis
			Psychosocial and educational support
		Reactive arthritis
		Pityriasis rubra pilaris192
		Pityriasis lichenoides225,226
		Pityriasis rosea
		Lichen planus
		Lichen nitidus
		Keratosis lichenoides chronica
		Key references
5 - Hereditary disorders of cornification (the ichthyoses and palmoplantar keratodermas)
	5 Hereditary disorders of cornification (the ichthyoses and palmoplantar keratodermas)
		Nonsyndromic forms of ichthyosis
			Ichthyosis vulgaris
			Recessive X-linked ichthyosis
			Keratinopathic ichthyoses
			Collodion baby
			Autosomal recessive congenital ichthyosis
			Other forms of nonsyndromic ichthyosis
				Loricrin keratoderma
				Erythrokeratodermias
				Peeling skin syndrome
				Keratosis linearis–ichthyosis congenital–keratoderma
		Syndromic forms of ichthyosis
			Neutral lipid storage disease with ichthyosis
			Chime syndrome
			KID syndrome
			Netherton syndrome
			Refsum disease
			Sjögren–Larsson syndrome
			Neu–Laxova syndrome
			Gaucher syndrome type 2
			CEDNIK syndrome
			MEDNIK syndrome
			Deafness–dystonia syndrome
			ARC syndrome
			Conradi–Hünermann–Happle syndrome
			CHILD syndrome
		Treatment of nonsyndromic and syndromic ichthyoses
		Other disorders of differentiation
			Darier disease
			Hailey–Hailey disease (familial benign pemphigus)
		Porokeratoses
		Palmoplantar keratodermas
			Striate PPK
			Focal keratodermas
			Diffuse keratodermas
			Punctate PPK
			Aquagenic PPK
		Key references
6 - Hereditary disorders of the dermis
	6 Hereditary disorders of the dermis
		Ehlers–danlos syndrome
			Management of ehlers–danlos syndrome
		Marfan syndrome
		Osteogenesis imperfecta
		Cutis laxa
		Pseudoxanthoma elasticum
		Elastosis perforans serpiginosa
		Focal dermal hypoplasia
		Laminopathies
		Restrictive dermopathy
		Werner syndrome
		Stiff skin syndrome
		Winchester syndrome
		Buschke–ollendorff syndrome
		Lipoid proteinosis
		Infantile systemic hyalinosis and juvenile hyaline fibromatosis
		Key references
7 - Disorders of hair and nails
	7 Disorders of hair and nails
		Hair
		Neonatal hair
		Tools for diagnosis of hair loss disorders
		Alopecias
			Nonscarring alopecias with hair shaft abnormalities
				Hair shaft abnormalities with increased fragility
					Trichorrhexis nodosa.
					Monilethrix.
					Pseudomonilethrix.
					Trichorrhexis invaginata.
					Pili torti.
					Pili bifurcati.
					Trichothiodystrophy.
					Marie unna hypotrichosis.
				Hair shaft abnormalities without increased fragility
					Pili annulati.
				Woolly hair
					Acquired progressive kinking of the hair.
					Uncombable hair syndrome.
				Loose anagen syndrome
			Nonscarring alopecias without hair shaft abnormalities146
				Congenital/genetic disorders
					Congenital triangular alopecia.
				Atrichia with papular lesions
				Hypotrichosis simplex
				Ectodermal dysplasias
					EDA and Wnt signaling pathways.
						Hypohidrotic ectodermal dysplasia.
						Features of ectodermal dysplasia in HED.
						Features of immunodeficiency in HED-ID.
						p63-related forms of ectodermal dysplasia.
					Ectodermal dysplasia related to abnormalities in structural proteins.
						Clouston syndrome (hidrotic ectodermal dysplasia).
			Disorders of follicular plugging
				Keratosis pilaris
				Keratosis pilaris atrophicans
			Central centrifugal cicatricial alopecia
			Other scarring alopecias
				Follicular mucinosis
				Folliculitis decalvans
				Dissecting cellulitis of the scalp
				Acne keloidalis
				Pseudofolliculitis barbae
				Pseudopelade
				Trichodysplasia spinulosa
				Telogen effluvium
				Anagen effluvium
				Alopecia areata
				Androgenetic alopecia
				Traumatic alopecias: Traction alopecia and trichotillomania
		Eruptive vellus hair cysts
		Hypertrichosis and hirsutism
			Acquired generalized hypertrichosis
			Congenital hypertrichosis
			Localized forms of hypertrichosis
				Nevoid hypertrichosis
				Idiopathic hirsutism
				Treatment of hypertrichosis and hirsutism
		Pigmentary changes of hair
			Premature graying
			Green discoloration
		Nails
			Median nail dystrophy and habit-tic dystrophy
			Onychoschizia
			Nail pitting
			Nail matrix arrest (beau lines and onychomadesis)
			Spoon nail
			Racket nail
			Trachyonychia
			Onychogryphosis
			Congenital malalignment of the great toenails
			Ingrown nails
			Nail atrophy
			Nail–patella syndrome
			Congenital onychodysplasia of the index fingers
			Pachyonychia congenita
			Dyskeratosis congenita
			Disorders of the nail bed
			Paronychia
			Disorders of nail coloration
		Key references
8 - Acne vulgaris and other disorders of the sebaceous and sweat glands
	8 Acne vulgaris and other disorders of the sebaceous and sweat glands
		Disorders of the sebaceous glands
			Acne vulgaris
				Acne therapy
			Neonatal acne
			Infantile acne
			Mid-childhood acne
			Androgen excess and acne
			Acne rosacea
			Pomade acne
			Acne cosmetica
			Acne excoriée
			Acne conglobata
			Acne with facial edema/solid facial edema
			Periorificial dermatitis
			Idiopathic facial aseptic granuloma
			Fordyce spots
		Disorders of the apocrine glands
			Fox–fordyce disease
			Chromhidrosis
			Hidradenitis suppurativa
		Disorders of the eccrine glands
			Hyperhidrosis
			Dyshidrosis
			Anhidrosis
			Bromhidrosis
			Miliaria
		Key references
9 - Cutaneous tumors and tumor syndromes
	9 Cutaneous tumors and tumor syndromes
		Pigmented lesions
		Melanocytic nevi
			Melanonychia striata
			Congenital melanocytic nevi
			Atypical nevi/familial atypical multiple mole–melanoma syndrome
			Malignant melanoma
			Spitz nevus
			Halo nevus
			Nevus spilus
			Becker melanosis
		Tumors of the epidermis
			Epidermal nevi
			Epidermal nevus syndrome
			Inflammatory linear verrucous epidermal nevi
			Basal cell carcinoma
			Basal cell nevus syndrome
			Squamous cell carcinoma
			Keratoacanthoma
		Tumors of the oral mucosa
			White sponge nevus
			Leukoplakia
		Tumors of the epidermal appendages
			Nevus sebaceus
			Nevus comedonicus
			Trichoepithelioma
			Trichilemmoma
			Trichofolliculoma
			Pilomatricoma
			Syringoma
			Eccrine poroma
			Cylindroma
		Dermal tumors
			Angiofibroma
			Connective tissue nevus
			Mastocytosis
			Granuloma annulare
			Neurofibroma
			Dermatofibroma
			Dermatofibrosarcoma protuberans
		Fibromatoses
			Recurring digital fibroma of childhood
			Infantile myofibromatosis
			Fibrous hamartoma of infancy
		Tumors of fat, muscles, and bone
			Lipomas
				Bannayan–Riley–Ruvalcaba syndrome
				Encephalocraniocutaneous lipomatosis
				Michelin tire baby syndrome
			Congenital smooth muscle hamartoma
			Leiomyomas
			Granular cell tumor
			Calcinosis cutis
			Osteoma cutis
			Subungual exostosis
		Miscellaneous
			Epidermal cyst
			Mucocele (mucous cyst)
			Congenital lingual melanotic macule
			Digital mucous cyst
			Steatocystoma multiplex
			Clear cell papulosis
			Keloid
		Key references
10 - Histiocytoses and malignant skin diseases
	10 Histiocytoses and malignant skin diseases
		Langerhans cell histiocytosis
		Juvenile Xanthogranuloma
		Xanthoma Disseminatum
		Benign Cephalic Histiocytosis
		Necrobiotic Xanthogranuloma
		Generalized Eruptive Histiocytoma
		Progressive nodular histiocytoma
		Multicentric reticulohistiocytosis
		Hemophagocytic lymphohistiocytosis
		Sinus histiocytosis with massive lymphadenopathy (Rosai–Dorfman disease)
		Cutaneous pseudolymphoma
		Leukemia cutis
			Congenital leukemia cutis
		Lymphomatoid papulosis
		Lymphoma cutis
		Cutaneous T-cell lymphoma
		Neuroblastoma
		Rhabdomyosarcoma
		Key references
11 - Disorders of pigmentation
	11 Disorders of pigmentation
		Disorders of abnormal pigmentation
			Vitiligo
			Vogt–Koyanagi–Harada syndrome
			Alezzandrini syndrome
			Oculocutaneous Albinism
				Nonsyndromic Oculocutaneous Albinism
			Hermansky–Pudlak syndrome
				Phenylketonuria
			Silvery hair syndromes
				Chédiak–Higashi syndrome
				Griscelli syndrome
			Piebaldism
			Waardenburg syndrome
			Tuberous sclerosis complex
			Chemically induced depigmentation
				Hypo- and depigmentation from medications
			Idiopathic guttate hypomelanosis
			Postinflammatory hypopigmentation
			Genetic reticulate pigmentary disorders
			Dyschromatoses
			Poikiloderma
			Incontinentia pigmenti
			Pigmentary mosaicism
		Disorders of hyperpigmentation
			Epidermal melanocyte lesions
				Freckles
				Becker nevus
				Lentigines
				Peutz–Jeghers syndrome
				Carney complex
				Multiple lentigines/LEOPARD syndrome
				Café-au-lait spots
				Neurofibromatosis
					Cutaneous manifestations of neurofibromatosis type 1.
					Systemic manifestations of neurofibromatosis.
					Therapy of neurofibromatosis type 1.
			Erythema dyschromicum perstans
			Postinflammatory hyperpigmentation
				Retention hyperkeratosis
			Melasma
			Metabolic causes of hyperpigmentation
				Hemochromatosis
				Ochronosis
			Hyperpigmentation caused by heavy metals
			Drug-induced hyperpigmentation
				Carotenemia
			Dermal melanocytoses
				Congenital dermal melanocytosis (formerly called mongolian spots)
				Nevus of Ota and nevus of Ito
				Dermal melanocytosis with vascular or pigmented lesions
			Blue nevi
		Key references
12 - Infantile hemangiomas, vascular malformations, and other vascular disorders of infancy and childhood
	12 Infantile hemangiomas, vascular malformations, and other vascular disorders of infancy and childhood
		Classification of vascular lesions
		Vascular tumors and tumor syndromes
			Infantile hemangioma
			Clinical variants and associated syndromes
				Diffuse neonatal hemangiomatosis
			Kasabach-Merritt phenomenon
				Kaposiform Hemangioendothelioma
				Tufted angioma
			Pyogenic granuloma
			Bacillary angiomatosis
			Glomus tumor
			Hemangiopericytoma
			Angiolymphoid hyperplasia with eosinophilia
		Vascular malformations and malformation syndromes
			Salmon patch
			Nevus flammeus/port wine stain
				Sturge–weber syndrome
				Phakomatosis pigmentovascularis
				Klippel–Trénaunay and Parkes Weber syndromes
				Proteus syndrome
				CLOVES syndrome and PIK3CA-related overgrowth spectrum
				Macrocephaly–Capillary Malformation syndrome
				Diffuse Capillary Malformation with overgrowth
				Capillary Malformation–Arteriovenous Malformation syndrome
				Bannayan–Riley–Ruvalcaba syndrome
				Cobb syndrome
				Beckwith–Wiedemann syndrome
			Venous malformation
				Maffucci syndrome
				Blue rubber bleb nevus syndrome
				Fibroadipose vascular anomaly
			Arteriovenous malformation
		Disorders of lymphatic vessels
			Lymphedema
			Gorham syndrome
			Multifocal lymphangioendotheliomatosis with thrombocytopenia
			Angiokeratomas
				Solitary or multiple angiokeratomas
				Angiokeratoma circumscriptum
				Angiokeratoma of mibelli
				Angiokeratoma of fordyce
				Angiokeratoma corporis diffusum
		Disorders associated with vascular dilation or constriction
			Livedo reticularis
			Flushing and the auriculotemporal nerve syndrome
			Erythromelalgia
			Angiospastic macules (bier spots)
			Cutis marmorata telangiectatica congenita
			Telangiectases
				Spider angioma
				Angioma serpiginosum
				Hereditary hemorrhagic telangiectasia
				Unilateral nevoid telangiectasia
				Ataxia-telangiectasia
				Generalized essential telangiectasia
		Pigmented purpuric eruptions
		Purpura fulminans
		Gardner–diamond syndrome
		Scurvy
		Key references
13 - Bullous disorders of childhood
	13 Bullous disorders of childhood
		Hereditary blistering disorders
			Epidermolysis bullosa
			Epidermolysis bullosa simplex
				Classical epidermolysis bullosa simplex
				Erosive, peeling, and hyperkeratotic disorders with skin fragility
			Junctional epidermolysis bullosa
				Dystrophic epidermolysis bullosa
				Dominant dystrophic epidermolysis bullosa
				Recessive dystrophic epidermolysis bullosa
			Kindler syndrome
				Treatment of epidermolysis bullosa
					Practical measures to reduce blistering.
				Experimental approaches for treating EB164
					Gene therapy.
					Cell therapy.
					Bone marrow transplantation.
					Pharmacologic approaches
						Readthrough.
						Protein replacement therapy.
						Inhibitors of inflammation.
						Reduction of fibrosis.
						Experimental approaches to promote wound healing thymosin β4 peptide.
				Immune-mediated blistering disorders
			Pemphigus
				Pemphigus vulgaris
				Pemphigus foliaceus
				Drug-induced pemphigus
				Immunoglobulin a pemphigus
				Paraneoplastic pemphigus
				Treatment of pemphigus
			Bullous pemphigoid
				Pemphigoid gestationis
			Dermatitis herpetiformis
			Linear immunoglobulin a bullous dermatosis
			Epidermolysis bullosa acquisita
			Bullous systemic lupus erythematosus
		Key references
14 - Bacterial, mycobacterial, and protozoal infections of the skin
	14 Bacterial, mycobacterial, and protozoal infections of the skin
		Bacterial infections
			Impetigo
			Methicillin-resistant staphylococcus aureus infections
			Ecthyma
			Folliculitis
				Folliculitis barbae
				Pseudofolliculitis barbae
				Pseudomonal folliculitis (hot tub folliculitis)
				Eosinophilic pustular folliculitis/eosinophilic folliculitis of infancy
			Furuncles and carbuncles
			Cellulitis
			Erysipelas
			Perianal streptococcal dermatitis
			Blistering dactylitis
			Necrotizing fasciitis
			Noma
			Meningococcemia
			Gonococcemia
			Staphylococcal scalded skin syndrome
			Toxic shock syndrome
			Corynebacterial infections
			Erysipeloid
		Nontuberculous (“atypical”) mycobacterial infections
		Tuberculosis of the skin
		The tuberculid disorders
		Leprosy
		Anthrax
		Cat-scratch disease
		Disorders resulting from fungus-like bacteria
			Actinomycosis
			Nocardiosis
		Treponemal infections
			Syphilis
			Pinta
			Yaws
			Lyme disease
				Early localized lyme disease (stage I)
				Early disseminated lyme disease (stage II)
				Late lyme disease (stage III)
		Protozoal disorders
			Leishmaniasis
		Key references
15 - Viral diseases of the skin
	15 Viral diseases of the skin
		Herpes simplex virus infection
			Herpetic gingivostomatitis
			Ocular herpes infection
			Herpes labialis
			Genital herpes
			Cutaneous herpes and eczema herpeticum
			Herpetic whitlow
			Herpes gladiatorum
			Herpes in the immunocompromised host
		Herpes zoster
		Viral-like disorders of the oral mucosa
			Aphthous stomatitis
			Acute necrotizing gingivitis
		Warts
			Verrucae vulgaris
			Verrucae plana
			Verrucae plantaris
			Condylomata acuminata
				Treatment of common warts and condylomata acuminata
			Epidermodysplasia verruciformis
			Recurrent respiratory papillomatosis
		Molluscum contagiosum
		Cowpox and pseudocowpox
		Orf
		Smallpox
		Acquired immunodeficiency syndrome in children
		Key references
16 - Exanthematous diseases of childhood
	16 Exanthematous diseases of childhood
		Varicella (chickenpox)
		Rubeola (measles)
		Scarlet fever
		Rubella (German measles)
		Filatow–Dukes disease
		Erythema infectiosum
			Papular-purpuric gloves-and-socks syndrome
		Roseola infantum
		Other viral exanthems
			Nonspecific viral exanthems
			Gianotti–Crosti syndrome
			Unilateral laterothoracic exanthem
			Enteroviral exanthems
			Infectious mononucleosis
		Exanthems associated with mycoplasma pneumoniae infection
		Rickettsial diseases
			Endemic typhus
			Rickettsialpox
			Rocky mountain spotted fever
			Q fever
			Ehrlichiosis
		Key references
17 - Skin disorders caused by fungi
	17 Skin disorders caused by fungi
		Superficial fungal infections
			Diagnosis of fungal infections
				Wood light examination
				Potassium hydroxide wet-mount preparations
				Fungal culture
			The dermatophytoses
				Tinea capitis
				Tinea faciei
				Tinea barbae
				Tinea corporis
				Tinea imbricata
				Tinea cruris
				Tinea pedis
				Tinea manuum
				Tinea unguium (onychomycosis)
			Tinea versicolor
			Tinea nigra
			Piedra
		Candidiasis
			Oral candidiasis (thrush)
			Intertrigo
			Candidal vulvovaginitis
			Perlèche
			Chronic paronychia
			Erosio interdigitalis blastomycetica
			Black hairy tongue
			Neonatal and systemic candidiasis
			Chronic mucocutaneous candidiasis
		Deep fungal disorders
			Subcutaneous mycoses
				Sporotrichosis
				Chromoblastomycosis
				Mycetoma
				Rhinosporidiosis
			Systemic mycoses
				Blastomycosis
				Coccidioidomycosis
				Paracoccidioidomycosis
				Histoplasmosis
			Opportunistic mycoses
				Aspergillosis
				Cryptococcosis
				Fusarium infection
				Mucormycosis
		Key references
18 - Infestations, bites, and stings
	18 Infestations, bites, and stings
		Arthropods
			Arachnids
				Scabies
				Other mites
				Ticks
				Spiders
				Scorpions
			Insects
				Lice (pediculosis)
				Mosquitoes and flies
				Fleas
				Bed bugs
				Bees, wasps, and ants
				Blister beetles
				Papular urticaria
				Insect repellents
				Caterpillars and moths
		Other cutaneous parasites
			Cutaneous larva migrans (creeping eruption)
			Cercarial dermatitis (swimmer’s itch)
		Seabather’s eruption
		Jellyfish stings
		Key references
19 - Photosensitivity and photoreactions
	19 Photosensitivity and photoreactions
		Tanning and sunburn reactions
		Photodermatoses
			Immunologically mediated photodermatoses
				Solar urticaria
				Polymorphous light eruption
				Actinic prurigo
				Hydroa vacciniforme
		Photosensitivity induced by exogenous sources
			Phototoxicity
			Photoallergy
		Genetic disorders associated with photosensitivity
			Xeroderma pigmentosum
			Cockayne syndrome
			Rothmund–thomson syndrome
			Bloom syndrome
			Smith–lemli–opitz syndrome
			Hartnup disease
		Pellagra
		The porphyrias
			Congenital erythropoietic porphyria
			Erythropoietic protoporphyria
			Porphyria cutanea tarda
			Hepatoerythropoietic porphyria
			Hereditary coproporphyria
			Variegate porphyria
			Acute intermittent porphyria and δ-aminolevulinic acid dehydratase porphyria
		Key references
20 - Urticarias and other hypersensitivity disorders
	20 Urticarias and other hypersensitivity disorders
		Allergic reactions
		Urticaria
		Contact urticaria
		Physical urticarias
		Anaphylaxis
			Latex allergy
			Nut allergy
		Angioedema
		C1 inhibitor–hereditary angioneurotic edema
		Scombroid and ciguatera fish poisoning
		Serum sickness and serum sickness–like reactions
		Exanthematous eruptions
		Drug reaction with eosinophilia and systemic symptoms
		Stevens–Johnson syndrome and toxic epidermal necrolysis
		Reactive infectious mucocutaneous or mucosal-predominant eruption
		Fixed drug eruption
		Acute generalized exanthematous pustulosis
		Erythema multiforme
		Annular erythemas
			Erythema marginatum and rheumatic fever
			Erythema annulare centrifugum
				Annular erythema of infancy
				Eosinophilic annular erythema
			Erythema migrans
		Panniculitis
		Erythema nodosum
		Eccrine hidradenitis
		Cutaneous reactions to cold
			Frostbite
			Trench foot (immersion foot)
			Perniosis
			Cold-sensitive dysproteinemias
		Cutaneous reactions to heat
			Erythema ab igne
		Sweet syndrome (acute febrile neutrophilic dermatosis)
		Bowel-associated dermatosis-arthritis syndrome
		Hypereosinophilic syndrome
		Wells syndrome
		Pregnancy and pregnancy-related dermatoses
		Autoimmune progesterone dermatitis
		Key references
21 - Vasculitic disorders
	21 Vasculitic disorders
		Henoch–Schönlein (anaphylactoid) purpura
		Acute hemorrhagic edema of infancy
		Hypersensitivity vasculitis
		Urticarial vasculitis
			Hypocomplementemic urticarial vasculitis syndrome
		Cryoglobulinemic vasculitis
		Necrotizing vasculitis with granulomas
			Granulomatosis with polyangiitis
			Eosinophilic granulomatosis with polyangiitis
		Erythema elevatum diutinum
		Polyarteritis nodosa
		Kawasaki disease
		Key references
22 - Collagen vascular disorders
	22 Collagen vascular disorders
		Juvenile idiopathic arthritis
			Macrophage activation syndrome
		Systemic lupus erythematosus
		Cutaneous lupus erythematosus
		Nonspecific clinical manifestations of SLE
		Laboratory features in the diagnosis of SLE
		Drug-induced lupus erythematosus
		Prognosis and therapy for SLE
		Neonatal lupus erythematosus
		Antiphospholipid antibody syndrome
		Degos disease
		Juvenile dermatomyositis
		Systemic sclerosis (scleroderma)
		Eosinophilic fasciitis
		Nephrogenic systemic fibrosis
		Scleredema
		Morphea
		Lichen sclerosus et atrophicus
		Anetoderma
		Relapsing polychondritis
		Sjögren syndrome
		Mixed connective tissue disease
		Key references
23 - Endocrine disorders and the skin
	23 Endocrine disorders and the skin
		Thyroid disorders
			Hyperthyroidism
				Pretibial myxedema
				Thyroid acropachy
			Hypothyroidism
		Parathyroid disorders
			Hyperparathyroidism
			Hypoparathyroidism/DiGeorge syndrome
			Pseudohypoparathyroidism/Albright hereditary osteodystrophy
		Disorders of the adrenal glands
			Addison disease
			Cushing syndrome
		Disorders of androgen excess
			Congenital adrenal hyperplasia
			Polycystic Ovary syndrome
		Gonadal dysgenesis/Turner syndrome
		Pituitary disorders
			Hyperpituitarism
			Hypopituitarism
		Multiple Endocrine Neoplasia Syndromes
		Autoimmune Polyglandular syndromes
		Mccune–Albright syndrome
		Disorders associated with diabetes mellitus
			Necrobiosis lipoidica diabeticorum
			Diabetic dermopathy
			Diabetic bullae
			Acanthosis nigricans
				Confluent and reticulated papillomatosis
		Scleredema diabeticorum
		Glucagonoma syndrome
		Key references
24 - Inborn errors of metabolism
	24 Inborn errors of metabolism
		Phenylketonuria
		Disorders of tyrosine metabolism
		Cobalamin deficiency
		Homocystinuria
		Trimethylaminuria
		Wilson disease (Hepatolenticular degeneration)
		Lesch–Nyhan syndrome
		Dermatitis from nutritional abnormalities
			Acrodermatitis enteropathica
		Disorders that resemble acrodermatitis enteropathica
			Biotin deficiency/organic acid disorders
			Kwashiorkor
			Essential fatty acid deficiency
		The hyperlipidemias
			Plane (planar) xanthomas
			Eruptive (papuloeruptive) xanthomas
			Tendinous xanthomas
			Tuberous (tuberoeruptive) xanthomas
			Other xanthomas
			Alagille disease
			Sitosterolemia
			Cerebrotendinous xanthomatosis
			Deficiencies in high-density lipoprotein
			Tangier disease
		The mucopolysaccharidoses
			Hurler syndrome
			Hunter syndrome
			Therapy for mucopolysaccharidoses
		Other storage disorders
		Key references
25 - Skin signs of other systemic diseases
	25 Skin signs of other systemic diseases
		Primary immunodeficiency disorders
			Immunoglobulin deficiencies
			Chronic granulomatous disease
			Leukocyte adhesion deficiencies
			Severe combined immunodeficiency
		Graft-Versus-Host Disease
		Anorexia nervosa and bulimia
		Autoinflammatory disorders
		Polygenic forms of autoinflammatory disorders
			Pyoderma gangrenosum
		Amicrobial pustulosis of the folds
		Behçet disease
		Sarcoidosis
			Sarcoidosis in older children and adolescents
			Sarcoidosis in preschool children (see Blau Syndrome in the other monogenic forms of autoinflammatory disorders section)
			The inflammasomopathies
			Familial mediterranean fever
				TNF Receptor–Associated Periodic Syndrome
				Periodic fever associated with mevalonate kinase deficiency (Hyperimmunoglobulin D Syndrome)
			The cryopyrinopathies or caps: Familial cold autoinflammatory, muckle–wells, and CINCA/NOMID Syndromes
		Other inflammasomopathies
			Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome
		Inflammasomopathies with pyoderma gangrenosum
			Pyogenic sterile arthritis, pyoderma gangrenosum, acne (PAPA) syndrome
			Interferonopathies
				STING-associated vasculopathy with onset in infancy (SAVI) syndrome
		CANDLE syndrome
		The ubiquitinopathies (relopathies)
		LUBAC component deficiency
			Otulin-related autoinflammatory syndrome
			A20 Haploinsufficiency
			Other monogenic forms of autoinflammatory disorders
				Blau syndrome
				Deficiency of the interleukin-1 receptor antagonist
				Deficiency of the interleukin-36 receptor antagonist
			PLAID and APLAID Syndromes
			Deficiency of adenosine deaminase 2
		Key references
26 - Abuse and factitial disorders
	26 Abuse and factitial disorders
		Child abuse
			Physical abuse
			Sexual abuse
			Neglect
		Factitial skin disorders
			Factitious dermatitis/dermatitis artefacta
			Delusional infestation
			Obsessive-compulsive disorders
			Psychogenic purpura/Gardner–Diamond syndrome
			Caregiver-fabricated illness
		Cutaneous mimickers of abuse and factitial disorders
		Key references
Inside back cover
	Inside back cover