Oxygen Homeostasis and Its Dynamics

Front Matter....Pages I-XX
Front Matter....Pages 1-1
Structure and Possible Mechanism of Action of Cytochrome c Oxidase from the Soil Bacterium Paracoccus denitrificans ....Pages 3-12
Crystal Structure and Reaction Mechanism of Bovine Heart Cytochrome c Oxidase....Pages 13-23
Cooperation of Two Quinone-Binding Sites in the Oxidation of Substrates by Cytochrome bo ....Pages 24-32
Rapid Formation of a Semiquinone Species on Oxidation of Quinol by the Cytochrome bo 3 Oxidase from Escherichia coli ....Pages 33-39
Coupling of Ion and Charge Movements: From Peroxidases to Protonmotive Oxidases....Pages 40-46
Ligand Dynamics in the Binuclear Site in Cytochrome Oxidase....Pages 47-56
Time-Resolved Resonance Raman Study of Dioxygen Reduction by Cytochrome c Oxidase....Pages 57-71
Human Cytochrome c Oxidase Analyzed with Cytoplasts....Pages 72-83
Redox Behavior of Copper A in Cytochrome Oxidase in the Brain In Vivo: Its Clinical Significance....Pages 84-97
Crystallization of Bovine Heart Mitochondrial Cytochrome c Oxidase for X-Ray Diffraction at Atomic Resolution (2.8 Å)....Pages 98-101
Mechanism of Dioxygen Reduction by Cytochrome c Oxidase as Studied by Time-Resolved Resonance Raman Spectroscopy....Pages 102-105
Coupling of Proton Transfer to Oxygen Chemistry in Cytochrome Oxidase: the Roles of Residues I67 and E243....Pages 106-111
Respiration of Helicobacter pylori, cb -Type Cytochrome c Oxidase, and Inhibition of NADH Oxidation by O 2 ....Pages 112-119
The Regulation by ATP of the Catalytic Activity and Molecular State of Thiobacillus novellus Cytochrome c Oxidase....Pages 120-124
Front Matter....Pages 125-125
Structure-Function Studies of P-450BM-3....Pages 127-138
Oxygen Binding to P-450 cam Induces Conformational Changes of Putidaredoxin in the Ferrous P-450 cam -Reduced Putidaredoxin Complex....Pages 139-146
Crystal Structure of Nitric Oxide Reductase Cytochrome P-450 nor from Fusarium oxysporum ....Pages 147-155
Analysis of NAD(P)H Binding Site of Cytochrome P-450 nor ....Pages 156-160
Substitutions of Artificial Amino Acids O -Methyl-Thr, O -Methyl-Asp, S -Methyl-Cys, and 3-Amino-Ala for Thr-252 of Cytochrome P-450 cam : Probing the Importance of the Hydroxyl Group of Thr-252 for Oxygen Activation....Pages 161-165
From a Monooxygenase to an Oxidase: The P-450 BM3 Mutant T268A....Pages 166-171
Front Matter....Pages 125-125
Thiolate Adducts of the Myoglobin Cavity Mutant H93G as Models for Cytochrome P-450....Pages 172-180
Pronounced Effects of Axial Thiolate Ligand on Oxygen Activation by Iron Porphyrin....Pages 181-188
Superoxide via Peroxynitrite Blocks Prostacyclin Synthesis....Pages 189-198
The N=N Bond Cleavage of Angeli’s Salt Is Markedly Enhanced by Cytochrome P-450 1A2: Effects of Distal Amino Acid Mutations on the Formation of Nitric Oxide Complexes....Pages 199-203
Langmuir-Blodgett Films of Cytochrome P-450 scc : Molecular Organization and Thermostability....Pages 204-213
Kinetic Analysis of Successive Reactions Catalyzed by Cytochromes P-450 17α,lyase and P-450 11β ....Pages 214-220
Changing Substrate Specificity and Product Pattern in Adrenal Cytochrome P-450-Dependent Steroid Hydroxylases....Pages 221-230
Inhibition Studies of Steroid Conversions Mediated by Human CYP11B1 and CYP11B2 Expressed in Cell Cultures....Pages 231-236
Effects of ACTH and Angiotensin II on the Novel Cell Layer Without Corticosteroid-Synthesizing Activity in Rat Adrenal Cortex....Pages 237-243
Cell-Specific and Hormonally Regulated Gene Expression Directed by the CYP11B1 Gene Promoter in Rat Adrenal Cortex....Pages 244-247
Gene Organization and Genetic Defects of Bilirubin UDP-Glucuronosyltransferase....Pages 248-251
Imaging of Calcium Oscillations and Activity of Cytochrome P-450 scc in Adrenocortical Cells....Pages 252-259
Front Matter....Pages 261-261
Fundamentally Divergent Strategies for Oxygen Activation by Fe 2+ and Fe 3+ Catecholic Dioxygenases....Pages 263-275
Three-Dimensional Structure of an Extradiol-Type Catechol Ring Cleavage Dioxygenase BphC derived from Pseudomonas sp. strain KKS102: Structural Features Pertinent to Substrate Specificity and Reaction Mechanisms....Pages 276-281
Probing the Reaction Mechanism of Protocatechuate 3,4-Dioxygenase with X-Ray Crystallography....Pages 282-288
Nitric Oxide Synthases: Structure, Function, and Control....Pages 289-297
Electron Paramagnetic Resonance Studies on Substrate Binding to the NO Complex of Neuronal Nitric Oxide Synthase....Pages 298-303
Heme Oxygenase: A Central Enzyme of Oxygen-Dependent Heme Catabolism and Carbon Monoxide Synthesis....Pages 304-314
Heme Degradation Mechanism by Heme Oxygenase: Conversion of α - meso -Hydroxyheme to Verdoheme IX α ....Pages 315-321
A Spectroscopic Study on the Intermediates of Heme Degradation by Heme Oxygenase....Pages 322-327
Front Matter....Pages 261-261
Expression of Heme Oxygenase and Inducible Nitric Oxide Synthase mRNA in a Human Glioblastoma Cell Line....Pages 328-332
The Mechanism of Conversion of Xanthine Dehydrogenase to Xanthine Oxidase....Pages 333-339
Mechanism-Based Molecular Design of Peroxygenases....Pages 340-353
Catalytic Roles of the Distal Site Hydrogen Bond Network of Peroxidases....Pages 354-358
Catalytic Intermediates of Polyethylene-Glycolated Horseradish Peroxidase in Benzene....Pages 359-362
Formation of a Hydroperoxy Complex of Heme During the Reaction of Ferric Myoglobin with H 2 0 2 ....Pages 363-366
Photooxidation in Ternary System Human Serum Albumin-Chlorin e 6 -Tryptophan....Pages 367-373
Front Matter....Pages 375-375
Tissue Oxygen Pressure and Oxygen Sensing by the Carotid Body....Pages 377-387
Molecular Mechanisms of Hypoxia-Induced Angiogenesis....Pages 388-399
Mechanisms of Pulmonary Vasodilatation and Ductus Arteriosus Constriction by Normoxia....Pages 400-409
Biological Impediment to Oxygen Sensing in Injured Pulmonary Microcirculation Exposed to a High-Oxygen Environment....Pages 410-420
Transcriptional Responses Mediated by Hypoxia-Inducible Factor 1....Pages 421-427
Differences in Particle Size and Oxygen-Binding Affinity Between Cross-Linked Hemoglobin and Hemoglobin Vesicle....Pages 428-433
Activation of Gene Expression of Collagenase and ICAM-1 by UVA Radiation and by Exposure to Singlet Oxygen....Pages 434-437
Redox Regulation of the Nuclear Factor Kappa B (NF-κB) Signaling Pathway and Disease Control....Pages 438-449
Thioredoxin and Its Involvement in the Redox Regulation of Transcription Factors, NF-κB and AP-1....Pages 450-456
Inhibition of Cytokines and ICAM-1 Induction in Rheumatoid Fibroblasts by anti-NF-κB Reagents....Pages 457-463
Detection of a Nuclear 60-kDa Protein Coimmunoprecipitated with Human Thioredoxin....Pages 464-468
Ito Cells: A Putative Cellular Component Responsible for Carbon Monoxide-Mediated Microvascular Relaxation in the Rat Liver....Pages 469-472
K + Channels and the Normoxic Constriction of the Rabbit Ductus Arteriosus....Pages 473-478
Front Matter....Pages 375-375
Modulation of Adhesion Molecule Expression in Pulmonary Vascular Endothelium by Oxygen....Pages 479-483
Cross Talk Between Nitric Oxide and Cyclooxygenase Pathways in Glomerular Mesangial Cells....Pages 484-489
Front Matter....Pages 491-491
Pathophysiological Reactivities of Nitric Oxide....Pages 493-504
Defenses Against Peroxynitrite....Pages 505-509
Bioactive 6-Nitronorepinephrine Formation Requiring Nitric Oxide Synthase in Mammalian Brain....Pages 510-517
Role of Nitric Oxide in the Regulation of Cerebral Blood Flow in Conscious Rats....Pages 518-536
Physiological Implication of Induction of Heme Oxygenase-1 Gene Expression....Pages 537-543
Carbon Monoxide: Toxic Waste or Endogenous Modulator of Hepatobiliary Function?....Pages 544-549
Microspectrophotometry of Nitric Oxide-Dependent Changes in Hemoglobin in Single Red Blood Cells Incubated with Stimulated Macrophages....Pages 550-556
An Antioxidant Role of Nitric Oxide in Modulation of Oxidative Stress in Human Placental Trophoblastic Cells....Pages 557-561
Liberation of Nitric Oxide from S -Nitrosothiols....Pages 562-568
Change of Nitric Oxide Concentration in Exhaled Gas After Lung Resection....Pages 569-575
Induction of NADPH Cytochrome P-450 Reductase in Kupffer Cells After Chronic Ethanol Consumption Associated with Increase of Superoxide Anion Formation....Pages 576-579
In Vivo Measurement of Superoxide in the Cerebral Cortex Utilizing Cypridina luciferin analog (MCLA) Chemiluminescence....Pages 580-584
Effects of Zinc Protoporphyrin IX, a Heme Oxygenase Inhibitor, on Mitochondrial Membrane Potential in Rat Cultured Hepatocytes....Pages 585-590
Structure and Function of NO Reductase with Oxygen-Reducing Activity....Pages 591-596
Oxidative Modification of Apolipoprotein E3 and Its Biological Significance....Pages 597-602
Sequential Multistep Mechanisms for Leukocyte Adhesion: Applicable to Lung Microcirculation?....Pages 603-608
Role of Nitric Oxide in Autoregulation of Cerebral Blood Flow in the Rat....Pages 609-615
Back Matter....Pages 617-620