Oxidative stress and redox signalling in Parkinson’s disease

Content: Cover
 Oxidative Stress and Redox Signalling in Parkinson\'s Disease
 Preface
 Contents
 Chapter 1 --
Etiology and Pathogenesis of Parkinson\'s Disease
 1.1 Introduction
 1.2 Clinical Manifestations of Parkinson\'s Disease
 1.3 Neuropathology
 1.3.1 Selective Vulnerability of the Nigrostriatal Dopamine Neuron
 1.3.2 Mitochondrial Dysfunction in PD
 1.3.2.1 Mitochondrial DNA Damage
 1.3.2.2 Complex I Inhibition
 1.3.3 Oxidative Stress
 1.3.4 Dopamine Metabolism
 1.3.5 Neuroinflammation
 1.4 Genetics of Parkinson\'s Disease
 1.5 Environmental Exposures and the Risk of Parkinson\'s Disease 1.5.1 Pesticides1.5.2 Metals
 1.5.3 Pathogens
 1.6 Gene-Environment Interaction
 1.7 Conclusions
 Acknowledgements
 References
 Chapter 2 --
Oxidative Stress and Redox Signalling in the Parkinson\'s Disease Brain
 2.1 Introduction
 2.2 Oxidative Stress and Antioxidant Systems
 2.2.1 Reactive Oxygen and Nitrogen Species: Sources
 2.2.2 Antioxidant Systems
 2.2.3 Oxidative Damage to Biomolecules
 2.2.3.1 Oxidative DNA Damage
 2.2.3.2 Oxidative Damage to Lipids
 2.2.3.3 Oxidative Protein Modifications: Redox Sensors and Transducers
 2.3 What Makes the Dopaminergic Neurons in the SNpc Vulnerable 3.1 Reactive Oxygen Species (ROS)3.1.1 Mitochondria and ROS Production
 3.2 Parkinson\'s Disease
 3.3 Mitochondrial Dysfunction in PD
 3.3.1 ETC Complex Deficiency in PD
 3.3.2 Altered Mitochondrial Morphology
 3.3.3 Mitochondrial Ca2+ Buffering in PD
 3.3.4 PD-Related Genes and Mitochondrial Dysfunction
 3.4 Mitochondrial Dysfunction in Toxicant-Induced PD
 3.4.1 6-OHDA and MPTP: Classic Toxicant Models
 3.4.1.1 6-OHDA: An Experimental Catecholaminergic Neurotoxicant
 3.4.1.2 MPTP: Evidence for CI and the Toxic Exposure Hypothesis of PD
 3.4.2 Rotenone: A Case for Complex I Inhibition 3.4.3 Paraquat: Redox Cycling Agent3.4.3.1 Characteristics and Risk of Exposure
 3.4.3.2 Mechanism of Toxicity: Redox Cycling and ROS Generation
 3.4.3.3 Role of Mitochondria in PQ Toxicity
 3.4.3.4 PQ and Excitotoxicity
 3.4.3.5 Using PQ for Developing Animal Models of PD
 3.4.3.6 Diquat Use with PQ: Example of Another Redox Cycling Agent
 3.4.4 Maneb: A Role of Complex III in PD Pathogenesis
 3.4.5 Other Environmental Toxins
 3.5 Concluding Remarks
 References
 Chapter 4 --
Dopamine Metabolism and the Generation of a Reactive Aldehyde