Ovarian Follicular and Corpus Luteum Function

Front Matter....Pages i-xv
Front Matter....Pages 1-1
Introductory Remarks: Ruminations on Ovarian Function....Pages 3-8
Front Matter....Pages 9-9
Follicular Growth in the Rat: A Reevaluation of the Roles of FSH and LH....Pages 11-26
LH-Induced Desensitization of the Adenylyl Cyclase System in Ovarian Follicles....Pages 27-44
Gonadal LH Receptors: Resolution from Adenylate Cyclase and Transfer to Heterologous Cells....Pages 45-51
Prolactin Control of Receptor for Estradiol in Corpora Lutea of Pregnant Rats....Pages 53-58
Discussion — Chairperson....Pages 59-68
Lateral Mobility and Internalization of Hormone Receptors to Human Chorionic Gonadotropin in Cultured Rat Granulosa Cells....Pages 69-75
FSH Stimulation of Mucopolysaccharide Synthesis in Rat and Porcine Ovary....Pages 77-82
Immunologic Impairment of Δ 5 -3B Hydroxysteroid Dehydrogenase and Its Effect on Ovarian Function: The Use of a Purified Enzyme....Pages 83-88
Receptors for Gonadotrophins in the Ovine Follicle During Growth and Atresia....Pages 89-94
Effect of Oestradiol-17β and Gonadotrophins on Prostaglandin production by Pre-Ovulatory Pig Follicles Superfused In Vitro ....Pages 95-103
LH-Stimulated cAMP Formation in Rat Granulosa Cells During Follicular Maturation — A Non-Refractory Response....Pages 105-112
Effect of the Administration of an Ovulatory Dose of HCG on the Subcellular Distribution of Follicular Protein Kinase....Pages 113-121
Structural Analysis of Granulosa Cells from Human Ovaries in Correlation with Function....Pages 123-128
Regulation of LH(hCG)-Receptor and Adenylate Cyclase in Luteinizing Granulosa Cells....Pages 129-135
Changes in Responsiveness of Porcine Granulosa Cells to Prostaglandins and Luteinizing Hormone in Terms of Cyclic-AMP Accumulation During Follicular Maturation....Pages 137-143
Some Morphological and Functional Characteristics of Cells of the Porcine Theca Interna in Tissue Culture....Pages 145-148
The Control of Ovulation in the Cow by Prostaglandin Inhibitor....Pages 149-152
Front Matter....Pages 153-153
Steroidal Modulation of Steroid Secretion in vitro : An Experimental Approach to Intra-Follicular Regulatory Mechanisms....Pages 155-168
On the Mechanism of Prolactin Stimulation of Steroidogenesis....Pages 169-178
Front Matter....Pages 153-153
Steroid Secretion by Perifused Ovarian Follicles of Immature, Pmsg-Treated Immature, and Mature Rabbits....Pages 179-185
Effects of Follicular Development on the Ability of Cultured Porcine Granulosa Cells to Convert Androgens to Estrogens....Pages 187-195
Testosterone Synthesis by Chicken Follicular Cells....Pages 197-202
Modulation of Thecal Progesterone Secretion by Estradiol-17β....Pages 203-208
General Discussion — Steroidogenesis....Pages 209-218
Steroid Secretion by Ovarian Follicles of Rabbits in Different Reproductive States....Pages 219-224
Hormone Requirements for Long-Term Maintenance of Rat Granulosa Cell Cultures....Pages 225-233
Long Term Perifusion of Rabbit Ovarian Follicles....Pages 235-239
Estrogen Inhibits Porcine Thecal Androgen Production in vitro ....Pages 241-243
Antral Follicular and Interstitial Contributions to Progesterone Secretion in the Proestrous Hamster....Pages 245-247
Front Matter....Pages 249-249
Meiotic Maturation of Mouse Oocytes in Vitro ....Pages 251-268
Mammalian Oocyte Maturation: Model Systems and Their Physiological Relevance....Pages 269-282
Action of Porcine Follicular Fluid Oocyte Maturation Inhibitor in Vitro: Possible Role of the Cumulus Cells....Pages 283-291
Relationship Between Steroidogenesis and Oocyte Maturation in Rat Graafian Follicles Cultured in vitro ....Pages 293-300
Discussion....Pages 301-306
The Somatic-Germ Cell Complex: Interactions and Transformations in Relation to Oocyte Maturation....Pages 307-314
Rapid Oocyte Death Prior to and at Puberty in Neonatally Thymectomized Mice....Pages 315-320
Maturation and Atresia of Human Oocytes in Vivo ....Pages 321-324
Front Matter....Pages 325-325
Follicular Non-Steroidal Regulators....Pages 327-345
The Influence of Follicular Fluid on Progesterone Secretion by Porcine Granulosa Cells in Vitro....Pages 347-359
Front Matter....Pages 325-325
Inhibition of in Vivo and in Vitro FSH Secretion by Steroid-Free Hamster Ovarian Extracts....Pages 361-373
The Differential Ability of Porcine Follicular Fluid to Suppress Serum FSH in Female Rats from 6 Days of Age to Adulthood....Pages 375-381
Evidence for the Presence of a Low Molecular Weight Follitropin Binding Inhibitor in Bovine Follicular Fluid....Pages 383-388
Chairperson’s Remarks....Pages 389-400
Inhibition by Follicular Fluid of Luteinizing Hormone-Sensitive Adenylate Cyclase in Ovarian Plasma Membranes....Pages 401-406
Inhibitory Effect of Charcoal-Treated Porcine Follicular Fluid upon Serum FSH Levels and Follicular Development in the Rhesus Monkey....Pages 407-415
Follicular Fluid Inhibition of Ovulation....Pages 417-421
Modulation of Pituitary Responsiveness to LHRH by Porcine Follicular Fluid: Time and dose- Dependent Effects....Pages 423-428
Isolation and Preliminary Characterization of Inhibin-f....Pages 429-435
Evidence That the Pituitary Gland is the Site of Inhibitory Action of Porcine Follicular Fluid upon FSH Secretion in the Rat....Pages 437-443
Front Matter....Pages 445-445
Estrogen Action in the Corpus Luteum....Pages 447-463
Follicular Determinants of Corpus Luteum Function in the Human Ovary....Pages 465-481
LH Receptors in the Ovine Corpus Luteum During the Estrous Cycle and Early Pregnancy....Pages 483-488
Gonadotropin Action in Isolated Ovarian Luteal Cells: The Intermediate Role of Adenosine 3′, 5′ Cyclic Monophosphate in Hormonal Stimulation of Progesterone Synthesis....Pages 489-495
Chairperson’s Remarks....Pages 497-503
Changes in Ovarian Mitochondria: Early Indicators of Follicular Luteinization....Pages 505-510
Prostaglandin F 2 α and Progesterone Synthesis in Vitro by Bovine Corpora Lutea of Early Pregnancy....Pages 511-517
Luteal Phase Deficiencies in Peripubertal Rhesus Monkeys: Mechanistic Considerations....Pages 519-525
Cellular Mechanisms Involved in Luteolysis....Pages 527-533
Role of Pituitary LH and Placenta in Luteal Progesterone Production and Maintenance of Pregnancy in the Rat....Pages 535-540
Front Matter....Pages 445-445
Relationships between Cholesterol Supply and Luteal Mitochondrial Steroid Synthesis....Pages 541-543
A Comparison of the LH Control of Progesterone Synthesis in Small and Large Cells from Pregnant Cow Corpus Luteum....Pages 545-548
Cytochalasin B Inhibition of Luteinizing Hormone Action on Bovine Luteal Cells....Pages 549-554
Front Matter....Pages 555-555
Mechanisms of PGF 2α Action in Functional Luteolysis....Pages 557-575
Prostaglandin F 2α and Its 13-Dehydro Analogs: Comparative Luteolytic Effects in Vivo ....Pages 577-601
Effects of Cholera Toxin, LH and PGF 2α on Steroidogenesis in Luteal Cells....Pages 603-611
Effects of Prostaglandin F 2 α, Estradiol and Luteinizing Hormone in Dispersed Cell Preparations of Bovine Corpora Lutea....Pages 613-620
General Discussion of Luteolysis....Pages 621-625
 In Vitro Release of Progesterone and Prostaglandins F and E by Porcine Luteal and Endometrial Tissue during Induced Luteolysis....Pages 627-632
Demonstration of Luteal Cell Membrane Receptors for Prostaglandin F 2α by Ultrastructural and Binding Analysis....Pages 633-638
Prostaglandin F 2α and Progesterone Release in Vitro by Ovine Luteal Tissue during Induced Luteolysis....Pages 639-644
Front Matter....Pages 645-645
Luteal Desensitization: Hormonal Regulation of LH Receptors, Adenylate Cyclase and Steroidogenic Responses in the Luteal Cell....Pages 647-662
Interactions among Estrogen, Prolactin and Luteinizing Hormone at the Level of Adenylyl Cyclase in the Corpus Luteum: Findings and Physiological Correlates....Pages 663-677
Desensitization and Recovery of PGE 2 -Responsive Ovarian Adenylate Cyclase Modulated by Agents Affecting Cytoskeletal Function....Pages 679-686
Inhibitory Effects of Treatment with LHRH or Its Agonists on Ovarian Receptor Levels and Function....Pages 687-693
Discussion....Pages 695-701
Mechanism and Significance of Luteal Desensitization: Chairman’s Concluding Remarks....Pages 703-710
Lutropin Induced Desensitization of Rat Ovarian Adenylate Cyclase: A GTP-Dependent Process....Pages 711-715
hCG-Induced Loss of LH-hCG Receptor and Desensitization of Adenylate Cyclase....Pages 717-722
Evidence of a Greater Activity of LH/HCH Binding Inhibitor Present in Aqueous Extracts from Old Compared to Young Porcine Corpus Luteum....Pages 723-728
Front Matter....Pages 645-645
Suppression of Ovarian Function by LHRH and Its Analogues in Pregnant Rats....Pages 729-734
Front Matter....Pages 735-735
Clinical Applications in the Area of Contraceptive Development....Pages 737-742
Serum Immunoreactive Relaxin Concentrations in Human Pregnancy, Labor and the Puerperium....Pages 743-748
Effect of Removal of Carbohydrate Residues upon the Half Life and in Vivo Biological Activity of Human Chorionic Gondadotropin....Pages 749-756
A Procedure for Evaluating Luteolytic Agents in Primates....Pages 757-766
Summing Up....Pages 767-789
Back Matter....Pages 791-808