Organ Preservation: Basic and Applied Aspects A Symposium of the Transplantation Society

Front Matter....Pages i-xxi
Front Matter....Pages 1-1
Energetics and mitochondria....Pages 3-15
Membrane functions....Pages 17-25
Biological significance and therapeutic potential of prostacyclin....Pages 27-32
A free radical approach to tissue injury....Pages 33-42
Endothelial cell function and organ preservation ex vivo ....Pages 43-54
The principles of organ storage procedures....Pages 55-66
Front Matter....Pages 67-67
Recovery of renal function in the rat after warm ischaemia: functional and morphological changes....Pages 69-76
The dynamics of regional blood flow after ischaemic trauma of the rat kidney....Pages 77-81
Renal function impairment in swelling with and without anoxia....Pages 83-89
Prostacyclin and the ischaemic kidney....Pages 91-95
Kidney blood flow and microcirculatory changes after autologous kidney transplantation....Pages 97-100
Front Matter....Pages 101-101
Future prospects in organ preservation....Pages 103-108
Tissue pH changes in renal preservation....Pages 109-112
Study of human kidneys prior to transplantation by phosphorus nuclear magnetic resonance....Pages 113-119
Effects of hypothermia on anabolic and catabolic processes and on oxygen consumption in perfused rat livers....Pages 121-126
Mechanism of loss of mitochondrial functions during hypothermic storage of kidneys....Pages 127-131
Depletion of CoA in dog kidneys during hypothermic perfusion....Pages 133-137
Renal viability testing during preservation by metabolic parameters....Pages 139-145
Hibernatory animals as a model for hypothermic organ preservation....Pages 147-150
Pharmacological factors in organ preservation....Pages 151-159
Front Matter....Pages 101-101
Effect of chlorpromazine on the contractile function and metabolic status of continuously perfused and ischaemic hearts....Pages 161-164
Front Matter....Pages 165-165
Flush preservation....Pages 167-177
The effect of cooling rate in flush preservation of rabbit kidneys....Pages 179-182
Washout of red blood cells from kidneys damaged by warm ischaemia....Pages 183-186
Comparative evaluation of a new low ionic strength, hyperkalaemic flush solution....Pages 187-189
Hypothermic preservation of the rat pancreas....Pages 191-198
Deuterium oxide (D 2 O) for organ preservation....Pages 199-203
Retrograde oxygen persufflation — a technique for preservation of ischaemically damaged organs....Pages 205-211
Front Matter....Pages 213-213
Kidney preservation by continuous perfusion....Pages 215-223
Continuous perfusion and transplantation of rat kidneys....Pages 225-230
Cold storage and machine preservation of kidney: studies with the isolated rat kidney....Pages 231-237
Light microscopy findings in intermediate term kidney preservation....Pages 239-243
Five days preservation of canine kidneys using a preservation machine....Pages 245-248
Lysosomal enzyme release during successful 5-, 7- and 8-day canine kidney storage....Pages 249-251
Aerobic and anaerobic perfusion of canine kidneys with a new perfusate....Pages 253-259
The use of oncotic support agents in perfusion preservation....Pages 261-265
Intermediate ex-vivo and in-vitro perfusion to prolong hypothermic kidney preservation up to 6 days....Pages 267-272
Is normothermic preservation an alternative to hypothermic preservation?....Pages 273-277
Measurement of tissue P O 2 during kidney perfusion with Fluosol®-43....Pages 279-281
Liver preservation in the rat....Pages 283-286
Front Matter....Pages 213-213
The effect of donor pretreatment on tubular function of the preserved canine allograft....Pages 287-289
Xenobanking....Pages 291-301
Front Matter....Pages 303-303
Factors influencing primary function in kidney transplants from brain-dead donors....Pages 305-306
Can immediate function of a cadaver renal transplant be predicted?....Pages 307-308
Factors of consequence for graft survival: a statistical analysis....Pages 309-311
Early and long-term function of cadaveric kidneys preserved by ice storage after flushing with Collins’ solution....Pages 313-314
The effect of dopamine administered to kidney graft recipients....Pages 315-319
Front Matter....Pages 321-321
Pretreatment....Pages 323-324
Initial perfusion....Pages 325-328
Hypothermic preservation....Pages 329-350
Experimental models....Pages 351-360
Front Matter....Pages 361-361
Perfusion of canine kidneys with dimethyl sulphoxide: techniques and toxicity....Pages 363-365
Prevention of toxicity from high concentrations of cryoprotective agents....Pages 367-369
Kidney preservation with Me 2 SO- and sucrose-containing solutions....Pages 371-375
Investigation into subzero non-freezing storage of rabbit kidney....Pages 377-380
Survival of hepatocytes upon thawing from −196 °C: functional assessment after transplantation....Pages 381-383
The effect of cryoprotectant concentration on freezing damage in kidney slices....Pages 385-388
The mechanism of cryoinjury in glycerol-treated rabbit kidneys....Pages 389-393
Rabbit kidney function in vitro following cooling to −20°C with glycerol or dimethyl sulphoxide....Pages 395-397
Prospects for organ preservation by vitrification....Pages 399-404
Front Matter....Pages 361-361
General discussion of cryopreservation....Pages 405-421
Back Matter....Pages 423-433