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دانلود کتاب Ophthalmology

دانلود کتاب چشم پزشکی

Ophthalmology

مشخصات کتاب

Ophthalmology

دسته بندی: چشم پزشکی
ویرایش: 5 
نویسندگان: ,   
سری: Eğitim Tanrısı 
ISBN (شابک) : 0323528198, 9780323528191 
ناشر: Elsevier 
سال نشر: 2018 
تعداد صفحات: 1671 
زبان: English 
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) 
حجم فایل: 800 مگابایت 

قیمت کتاب (تومان) : 33,000



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توضیحاتی در مورد کتاب چشم پزشکی

این عنوان برنده جایزه توسط Drs. مایرون یانوف و جی اس. دوکر تقریباً برای هر موضوعی در این زمینه به سرعت در حال تغییر مرجع اصلی شما هستند. در یک جلد راحت، راهنمای دقیق و فوق العاده مصور تقریباً در مورد هر بیماری و روش چشم پزشکی که ممکن است با آن روبرو شوید ارائه می دهد، و بدون توجه به سطح تجربه شما، آن را به منبعی ضروری تبدیل می کند. به روز رسانی های گسترده در سراسرشما را در جریان همه چیزهای جدید در هر زمینه فوق تخصصی در این زمینه قرار می دهد.


توضیحاتی درمورد کتاب به خارجی

Long consideredone of ophthalmology's premier texts, this award-winning title by Drs. Myron Yanoff and Jay S. Duker remains your go-to reference for virtually any topic in this fast-changing field. In a single, convenient volume, it offersdetailed, superbly illustrated guidanceon nearly every ophthalmic condition and procedure you may encounter, making it a must-have resource no matter what your level of experience.Extensive updates throughoutkeep you current with all that's new in every subspecialty area of the field.



فهرست مطالب

Ophthalmology
Copyright Page
User Guide
	Color Coding
	ExpertConsult Website
Video Contents
Preface
Preface to First Edition
List of Contributors
Acknowledgments
Dedication
1.1 Fundamentals of Human Genetics
	Key Features
	DNA and the Central Dogma of Human Genetics
	Human Genome
		Mitosis and Meiosis
	Basic Mendelian Principles
	Mutations
	Genes and Phenotypes
	Patterns of Human Inheritance
		Autosomal Dominant
		Autosomal Recessive
		X-Linked Recessive
		Mitochondrial Inheritance
		Pseudodominance
		X-Linked Dominant Inheritance
		Digenic Inheritance and Polygenic Inheritance
		Imprinting
	Molecular Mechanisms of Disease
		Autosomal Dominant
			Haploinsufficiency
			Gain-of-Function Dominant Negative Effect
		Autosomal and X-Linked Recessive
	Gene Therapy
	Key References
	References
1.2 Molecular Genetics of Selected Ocular Disorders
	Key Features
	Introduction
	Dominant Corneal Dystrophies
	Aniridia, Peter’s Anomaly, Autosomal Dominant Keratitis
	Rieger’s Syndrome
	Juvenile Glaucoma
	Congenital Glaucoma
	Nonsyndromic Congenital Cataract
	Retinitis Pigmentosa
	Stargardt Disease
	X-Linked Juvenile Retinoschisis
	Norrie’s Disease
	Sorsby’s Macular Dystrophy
	Gyrate Atrophy
	Color Vision
	Retinoblastoma
	Albinism
	Leber’s Optic Neuropathy
	Congenital Fibrosis Syndromes and Disorders of Axon Guidance
	Autosomal Dominant Optic Atrophy
	Complex Traits
	Key References
	References
1.3 Genetic Testing and Genetic Counseling
	Key Features
	Genetic Testing
		Role of Genetic Testing in the Clinic
		Methods for DNA-Based Genetic Testing
		Current Recommendations for Genetic Testing for Ophthalmic Diseases
		CLIA Laboratories
		Genetic Reports
	Genetic Counseling
		Clinical Evaluation and Family History
		Risk Prediction Based on Inheritance
		Indications to Refer for Genetic Counseling
			Known Inherited Condition
			Ocular and Systemic Congenital Anomalies
			Specific Eye Diseases
			Ocular Defects Associated With Genetic Diseases
		Confidentiality
	Key References
	References
2.1 Light
	Key Features
	Introduction
	Geometrical Optics
	Basic Stigmatic Optics
	Astigmatic Optics
	Wave Properties of Light
		Interference
		Diffraction
		Polarization
		Dispersion
		Quantum Effects
			Fluorescence and Phosphorescence
			Lasers
	Key References
	References
2.2 Optics of the Human Eye
	Key Features
	Introduction
	Cornea
	Pupil
	Lens
	Accommodation
		Range and Amplitude
	Scattering
	Aberrations
		Monochromatic Aberrations
		Chromatic Aberrations
	Retina
	Resolution and Focal Length
	Refractive Errors
		Change in Size or Position or Absence of Optical Elements
		Change in the Shape of Optical Elements
		Change in Refractive Indexes
		Myopia
		Hypermetropia
		Astigmatism
		Presbyopia
	Key References
	References
2.3 Clinical Refraction
	Key Features
	Introduction
	History
	Visual Acuity
		Testing Distance
		Other Considerations
		Contrast Sensitivity
			Contrast
			Targets
			Sine Waves
			Recording Contrast Sensitivity
	Spherical Equivalent
	Detecting Astigmatism
		Utility of the Test
		Procedure
		Instrumentation
		Determination of the Cylinder Axis
		Determination of Cylinder Power
		Rechecking the Sphere
		Final Checks
			Accommodation
			Binocular Balance
	Refracting at Near
	Additional Subjective Techniques
	Retinoscopy
		Retinoscope
			Optics of Retinoscopy
			Neutrality
			With and Against Motion
			Other Clues
			Myopia Estimation
			Astigmatism
	Key References
	References
2.4 Correction of Refractive Errors
	Key Features
	Introduction
	Spectacle Correction
		Spectacle Material
		Monofocal Spectacles
		Bifocals
		Progressive Spectacles
		Occupational Bifocals
		Pantoscopic Tilt and Wrap Angle
		Base Curve and Center Thickness
	Contact Lenses
		Vertex Correction
		Rigid Contact Lenses
		Special Purpose Contact Lenses
		Contact Lens Complications
		Soft Contacts
		Contact Lens Correction of Presbyopia
		Orthokeratology
	Intraocular Lenses
		Monofocal Intraocular Lenses
		Toric IOLs
		Presbyopia Correcting Intraocular Lenses
	Keratorefractive Surgery
	Corneal Inlays
	Key References
	References
2.5 Ophthalmic Instruments
	Key Features
	Introduction
	Direct Ophthalmoscope
	Binocular Indirect Ophthalmoscope
		Illumination System
		Observation System
			Contrast
			Inverted Image
			Field of View
			Magnification
			Stereopsis
	Fundus Camera
		Lighting
		Reducing Reflections From the Cornea and Instrument
		The Observation System
		Field of View
	Optical Coherence Tomography
	Slit-Lamp Biomicroscope
		Illumination
		Improving Tissue Contrast
		Observation System
	Slit-Lamp Fundus Lenses
	Goldmann Applanation Tonometer
		Specular Microscope
	Operating Microscope
	Keratometer and Corneal Topographer
	Lensmeter
	Automated Refractor
	Magnifying Devices
		Angular Magnification
		Magnifying Glass
		Galilean Telescope
		Simple Microscope (Operating Loupe)
	Key References
	References
2.6 Wavefront Optics and Aberrations of the Eye
	Key Features
	Introduction
	Ray Aberrations
	The Wavefront Approach to Aberrations
	Spherical Aberration
	Coma
	Distortion
	Field Curvature (FC)
	Oblique Astigmatism (OA)
	Higher-Order Aberrations (HOA)
	Chromatic Aberration
	Measurement of Ocular Aberrations
		Mathematical Considerations
	An Overall Perspective on Aberration Theory
	Key References
	References
3.1 Current Concepts, Classification, and History of Refractive Surgery
	Key Features
	Associated Features
	Introduction
	Excimer Laser and Ablation Profiles
		Laser Ablation Profiles
		Munnerlyn’s Formula
		Wavefront-Guided Ablation
		Topography-Guided Ablation
		Wavefront-Optimized/Aspherical/ Q-Factor-Adjusted Laser Profiles
		Presbyopia Correction
	Concepts in Development
	Classification of Refractive Procedures
		Cornea
			Central Cornea
				Corneal Surface: Addition
					Epikeratophakia.
				Corneal Surface: Subtraction
					Photorefractive Keratectomy.
					Laser Subepithelial Keratomileusis.
					EpiLASIK.
					Epi-Bowman Keratectomy (EBK).
				Corneal Stroma: Subtraction
					Keratomileusis.
					Laser-Assisted in situ Keratomileusis.
					Femto-LASIK.
					Intrastromal Laser Ablation.
					Intrastromal Lenticule Extraction.
				Corneal Stroma: Addition
					Keratophakia.
					Intracorneal Inlays.
				Corneal Stroma: Relaxation
					Lamellar Keratotomy (Hyperopic Automated Lamellar Keratoplasty).
			Peripheral Cornea
				Peripheral Cornea: Addition
					Intracorneal Rings.
					Intracorneal Ring Segments.
				Peripheral Cornea: Subtraction
					Wedge Resection.
				Peripheral Cornea: Relaxation
					Radial Keratotomy.
					Hexagonal Keratotomy.
					Astigmatic Keratotomy.
				Peripheral Cornea: Coagulation–Compression
					Thermokeratoplasty.
					Microwave-Induced Thermokeratoplasty: Keraflex Procedure.
					Circular Keratorrhaphy.
				Peripheral Cornea: Oppression
					Orthokeratology.
		Intraocular Lenses and Refractive Lensectomy
			Refractive Lens Exchange
			Toric Intraocular Lenses
			Multifocal Intraocular Lenses
			Potentially Accommodative Intraocular Lenses
			Light-Adjustable Intraocular Lenses
			Phakic Intraocular Lenses
			Add-on Intraocular Lenses in Pseudophakic Eyes
		New or Alternative Approaches
			Photorefractive Intrastromal Cross-Linking (PiXL)
				LASIK Extra
				Prophylactic
			IntraCor
			Ciliary Muscle–Zonular Complex
			Axial Length
			Refractive Indexes
	Summary
	Key References
	References
3.2 Preoperative Evaluation for Refractive Surgery
	Key Features
	Introduction
		General Considerations
			Age
			Degree of Correction
			Patient Expectations
		Systemic Contraindications to Keratorefractive Surgery
			Diabetes Mellitus
			Pregnancy and Lactation
			Autoimmune Diseases
			Dermatological Keloid
			Human Immunodeficiency Virus
			Medications
		Ophthalmic Diseases
			Corneal Dystrophy
			Corneal Curvature
			Ocular Surface Disease
			Herpes Reactivation
			Glaucoma
			Other Considerations
	Ophthalmic Examination
	Ancillary Testing
		Wavefront Measurement (Aberrometry)
		Computerized Videokeratography
		Pachymetry
			Counseling
	Key References
	References
3.3 Excimer Laser Surface Ablation
	Key Features
	Introduction
	Ablation Profiles
	Indications
	Preoperative Evaluation
	PRK Surgical Technique
		Patient Preparation and Epithelial Removal
		Stromal Ablation
		LASEK Surgical Technique (see Fig. 3.3.3)
		Epi-LASIK Surgical Technique (Fig. 3.3.4)
		Surface Ablation With Mitomycin-C
		Wavefront-Guided Surface Ablation
	Results
		Photorefractive Keratectomy for Myopia and Astigmatism
		Photorefractive Keratectomy for Hyperopia
		Wavefront-Guided PRK
	Complications
		General Complications for All Surface Ablation Procedures
			Undercorrection or Overcorrection
			Epithelial Problems
			Corneal Haze/Scar Formation
			Dry Eyes
			Infectious Keratitis
		Specific Intraoperative Complications Related to LASEK
			Alcohol Leakage During Surgery
			Incomplete Epithelial Detachment
		Specific Intraoperative Complications Related to Epi-LASIK
	Conclusions
	Key References
	References
3.4 LASIK
	Key Features
	Associated Features
	Historical Review
	LASIK
		Excimer Lasers
		Patient Selection
			Preoperative Evaluation and Diagnostic Approach
			Limitations and Contraindications
		Microkeratomes and Femtosecond Lasers
		Operative Technique
			Microkeratome Surgical Technique
			Femtosecond Laser Flap Creation
			Excimer Laser Ablation
		Postoperative Care
		Complications
			Intraoperative Complications
			Ablation Complications
			Postoperative Complications
			Keratectasia
		Results
	LASIK Enhancements
	LASIK in Complex Cases
		LASIK After Radial Keratotomy
		LASIK After Photorefractive Keratectomy
		LASIK After Penetrating Keratoplasty
		LASIK After Intraocular Lens Implantation and Bioptics
		Intraocular Lens Calculations After LASIK
	Summary
	Key References
	References
3.5 Small Incision Lenticule Extraction (SMILE)
	Key Features
	Introduction
	Femtosecond Laser System
	Treatment Range for SMILE
	Patient Evaluation
	Surgical Procedure
		Femtosecond Laser Application
		Lenticule Removal
		Postoperative Management
	Complications
		Perioperative Complications
		Postoperative Complications
	Higher-Order Aberrations
	Biomechanical Stability
	Refractive and Visual Outcome
	Retreatments
	Conclusions
	Key References
	References
3.6 Wavefront-Based Excimer Laser Refractive Surgery
	Key Features
	Introduction
	Wavefront Optics
	Higher-Order Aberrations
	Ideal Corneal Shape
	Measurements of Wavefront Aberrations
	Quality of Vision and Measures of Optical Quality
	Wavefront-Measuring Devices
	Wavefront-Based Surgery
	Results
	Wavefront Platforms (Table 3.6.1)
	Conclusions
	Key References
	References
3.7 Phakic Intraocular Lenses
	Key Features
	Associated Features
	Introduction
	History of Phakic Lenses
	Indications of Phakic Lenses
		Moderate and High Myopia
		High Hyperopia
		High Astigmatism
	Advantages and Disadvantages of Phakic Iols
	Intraocular Lens Power Calculation
		Sizing the Phakic IOLs
	Visual Outcomes
	Anterior Chamber Angle-Supported Phakic Intraocular Lenses
		Complications
			Pupillary Ovalization
			Endothelial Damage
		Elevation of Intraocular Pressure
			Uveitis
			Cataract
	Iris-Fixated Phakic Intraocular Lenses
		Surgical Procedure
		Complications
			Glare and Halos
			Anterior Chamber Inflammation/Pigment Dispersion
			Endothelial Cell Loss
			Glaucoma
			Iris Atrophy or Dislocation
			Cataract
			Other Complications
	Posterior Chamber Phakic Intraocular Lenses
		Surgical Technique
		Complications
			Cataract
			ICL Replacement
			Pigmentary Dispersion and Elevated Intraocular Pressure
			Endothelial Cell Damage
	Bioptics
	Conclusion
	Key References
	References
3.8 Astigmatic Keratotomy
	Key Features
	Historical Review
		Incisional Keratotomy
	Surgical Techniques for Astigmatic and Radial Keratotomy
		Preoperative Considerations
			Patient Selection
			Visual Axis Determination and Marking
			Intraoperative Corneal Pachymetry
		Incision Technique
			Diamond Blade–Assisted AK
			Full Penetrating Femtosecond AK
			Femtosecond Intrastromal Astigmatic Keratotomy (ISAK)
			Wedge Resection Using Laser Arcuate Resection (LAR)
		Surgical Protocol
			Axis of Astigmatism
		Postoperative Protocol
	Outcome Comparison for Various Astigmatism Correction Methods
	Complications and Management of Astigmatism Correction Methods
		Complications Related to Corneal Incisions
			Incision Beyond Clear Cornea
			Optical Zone Invasion
		Complications Related to Corneal Perforations
		Postoperative Complications
			Progressive Hyperopia
			Induced Astigmatism
			Contact Lens Intolerance
			Stromal Melting
			Infectious Keratitis
	Conclusions
	Key References
	References
3.9 Intrastromal Corneal Ring Segments and Corneal Cross-Linking
	Key Features
	Introduction
	Intracorneal Ring Segments
		Corneal Cross-Linking (CXL)
			CXL Plus
	Surgical Procedure: ICRS
		Patient Selection
		Preoperative Considerations
		ICRS Selection
		Single Versus Paired ICRS
		ICRS Surgical Technique
		Clinical Outcomes
		Postoperative Complications
	Surgical Procedure: CXL
	CXL Clinical Outcomes
		Postoperative Complications
	Combining ICRS With CXL
	Conclusions
	Key References
	References
3.10 Surgical Correction of Presbyopia
	Key Features
	Introduction
	Presbyopia Correction at the Corneal Level
		Monovision
		Presby-LASIK
			Central Presby-LASIK
		Laser Blended Vision
			Intracorneal Inlays
				Historical Background
			Corneal Reshaping Inlay
				Raindrop
			Refractive Inlays
				Presbia Flexivue Microlens
				Icolens (Neoptics AG)
			Small Aperture Inlays
				KAMRA
		Presbyopic IOLs
			Multifocal IOLs
				Rotationally Symmetrical
					Diffractive IOLs.
					Refractive IOLs.
				Rotationally Asymmetrical IOLs (Varifocal)
				Patient Selection Criteria
					AcrySof Restor SN6AD3 (Alcon Laboratories, Inc.)
					Lentis Mplus LS-313 (Oculentis GmbH)
					Symfony (Abbott Medical Optics, Inc.)
					AT LISA tri 839 MP (Carl Zeiss Meditec AG)
				Fine Vision Micro F (Physiol)
					Panoptix (Alcon)
				Clinical Outcomes and Quality of Life
				Complications
			Accommodating IOLs
				1) IOLs With Change in Axial Position, Single Optic
					Crystalens HD (Bauch & Lomb)
					1CU (Human Optics AG)
					Tetraflex (Lenstec Inc)
				2) IOLs With Change in Axial Position, Dual Optic
					Synchrony (Visiogen Inc.)
				3) IOLs With Change in Shape or Curvature
					FluidVision (Powervision, Inc).
					Nulens (DynaCurve).
				4) IOL With Change in Refractive Index or Power
					Lumina (Akkolens).
					Comments.
			Other Treatments
				Scleral Expansion Bands
				Topical Treatment
				FOV Tears
				Liquid Vision
				EV06 (Encore Vision)
	Key References
	References
4.1 Corneal Anatomy, Physiology, and Wound Healing
	Key Features
	Introduction
		Embryology, Anatomy, and Physiology of the Cornea
			Epithelium
			Stroma
			Endothelium
		Endothelial Responses to Stress
	Corneal Wound Healing
		Epithelial Injury
		Stromal Injury
		Endothelial Injury
	Key References
	References
4.2 Anterior Segment Imaging Modalities
	Key Features
	Introduction
	Anterior Segment Optical Coherence Tomography
		Clinical Applications
			Tear Film Evaluation
			Refractive Surgery and Ectasia-Related Disorders
			Penetrating and Endothelial Keratoplasty–Related Procedures
			Ocular Surface Tumors
			Cataract Surgery and Intraocular Lens Implantation
			Keratitis
			Miscellaneous Uses
		Limitations
	Specular Microscopy
		Clinical Applications
		Corneal Dystrophies
			Intraocular Surgery Evaluation
			Donor Cornea Evaluation
		Limitations
	Ultrasound Biomicroscopy
		Clinical Applications
			Ocular Masses
			Glaucoma
			Ocular Trauma
		Limitations
	Meibography
		Clinical Applications
			Meibomian Gland Dysfunction
		Limitations
	In vivo Confocal Microscopy
		Clinical Applications
			Dry Eye Disease and Neuropathic Corneal Pain
			Infectious Keratitis and Demodex
			Corneal Deposits and Corneal Dystrophies
		Limitations
	Topography and Tomography
		Clinical Applications
			Refractive Surgery
			Ectasia-Related Disorders
			Astigmatism
	Wavefront Analysis
		Clinical Applications
			Refractive Surgery
		Limitations
	Summary
	Key References
	References
4.3 Congenital Corneal Anomalies
	Key Features
	Introduction
	Size and Shape Anomalies
		Microcornea
			Epidemiology, Pathogenesis, and Ocular Manifestations
			Treatment
		Megalocornea
			Epidemiology, Pathogenesis, and Ocular Manifestations
			Treatment
		Corneal Absence
		Congenital Anterior Staphyloma
	Anomalies of Corneal Clarity
		Anterior Embryotoxon
		Posterior Embryotoxon
		Corneal Keloids
		Dermoids
		Axenfeld’s Anomaly and Rieger’s Syndrome
		Peters’ Anomaly
			Ocular Manifestations
			Systemic Associations
			Pathology
			Treatment and Outcome
		Sclerocornea
		Congenital Hereditary Endothelial Dystrophy and Congenital Stromal Corneal Dystrophy
	Key References
	References
4.4 Blepharitis
	Key Features
	Associated Features
	Introduction
	Epidemiology
	Pathogenesis
	Ocular Manifestations
	Diagnosis and Ancillary Testing
	Treatment
	Key References
	References
4.5 Herpes Zoster Ophthalmicus
	Key Features
	Associated Features
	Epidemiology and Pathogenesis
		Ophthalmic Herpes Zoster
	Clinical Manifestations
		Postherpetic Neuralgia
	Herpes Zoster Ophthalmicus in Acquired Immune Deficiency Syndrome
	Diagnosis
	Management
		Management of Ocular Manifestation
		Postherpetic Neuralgia
	Prevention
	Key References
	References
4.6 Conjunctivitis
	Key Features
	Infectious Conjunctivitis
		Bacterial Infections
			Acute Bacterial Conjunctivitis
			Hyperacute Bacterial Conjunctivitis
			Chronic Bacterial Conjunctivitis
		Adenoviral Conjunctivitis
			Follicular Conjunctivitis
			Pharyngoconjunctival Fever
			Epidemic Keratoconjunctivitis
			Acute Hemorrhagic Conjunctivitis
		Herpes Simplex Conjunctivitis
		Other Causes of Viral Conjunctivitis
		Chronic Follicular Conjunctivitis
			Trachoma
			Adult Inclusion Conjunctivitis
		Neonatal Conjunctivitis (Ophthalmia Neonatorum)
			Chlamydial Infections
			Neisserial Infections
			Other Bacterial Infections
			Viral Infections
		Fungal and Parasitic Conjunctivitis
		Microsporidial Keratoconjunctivitis
		Loiasis
		Parinaud’s Oculoglandular Syndrome
	Noninfectious Conjunctivitis
		Toxic Follicular Conjunctivitis
		Erythema Multiforme Major (Stevens–Johnson Syndrome) and Toxic Epidermal Necrolysis
		Epidermolysis Bullosa
		Graft-versus-Host Disease
		Xeroderma Pigmentosa
		Kawasaki Disease
		Ligneous Conjunctivitis
	Key References
	References
4.7 Allergic Conjunctivitis
	Key Features
	Acute Allergic Conjunctivitis: Seasonal/Perennial
	Chronic Atopic Keratoconjunctivitis
	Vernal Conjunctivitis
	Treatment of Allergic/Atopic Keratoconjunctivitis
	Allergic Dermatoconjunctivitis
	Microbial Allergic Conjunctivitis
	Giant Papillary Conjunctivitis
	Key References
	References
4.8 Tumors of the Conjunctiva
	Key Features
	Conjunctival Malignant Neoplasms
		Ocular Surface Squamous Neoplasia
		Conjunctival Melanoma
		Conjunctival Lymphoma
	Benign Conjunctival Neoplasms and Neoplasias
		Conjunctival Nevus
		Benign Acquired Melanosis of Conjunctiva
			Conjunctival Hemangioma
			Conjunctival Squamous Papilloma
			Conjunctival Lymphangioma
			Conjunctival Choristomas
			Limbal Dermoid
			Conjunctival Solid Dermoid
			Conjunctival Dermolipoma
			Conjunctival Osteoma
	Nonneoplastic Lesions and Disorders Simulating Malignant Conjunctival Neoplasms and Neoplasias
		Lesions Simulating Ocular Surface Squamous Neoplasms and Neoplasias
			Conjunctival Hyperplasia
			Conjunctival Keratosis/Hyperkeratosis/Dyskeratosis
			Inflamed Pinguecula/Hypertrophic Pterygium
			Inflammatory Granuloma of Conjunctiva
			Viral Papilloma of Conjunctiva
		Lesions Simulating Conjunctival Melanoma and Malignant Primary Acquired Melanosis
			Posterior Uveal Melanoma With Anterior Transcleral Extension
			Occult Eyewall Laceration With Incarceration of Uveal Tissue
			Nodular Anterior Scleritis
			Ciliary Body Staphyloma
			Conjunctival Argyrosis
		Lesions Simulating Conjunctival Lymphoma
			Benign Reactive Lymphoid Hyperplasia of the Conjunctiva
			Inflammatory Granulomas of Conjunctiva
	Management of Conjunctival Tumors Suspected of Being Malignant Neoplasms or Neoplasias
	Key References
	References
4.9 Pterygium and Conjunctival Degenerations
	Key Features
	Associated Features
	Introduction
	Pinguecula
	Pterygium
	Senile Scleral Plaques
	Conjunctival Amyloid
	Conjunctival Melanosis
	Key References
	References
4.10 Ocular Cicatricial Pemphigoid/Mucous Membrane Pemphigoid
	Key Features
	Associated Features
	Introduction
	Pathogenesis
	Clinical Findings
	Diagnosis
	Treatment
	Conclusions
	Key References
	References
4.11 Episcleritis and Scleritis
	Key Features
	Associated Feature
	Key Features
	Associated Features
	Introduction
	Inflammatory Diseases
		Episcleritis
			Epidemiology and Pathogenesis
			Diagnosis and Ocular Manifestations
			Differential Diagnosis
			Systemic Associations
			Treatment
		Scleritis
			Epidemiology and Pathogenesis
			Ocular Manifestations
			Differential Diagnosis
			Diagnosis and Ancillary Testing
			Systemic Associations
			Pathology
			Treatment
				Medical Treatment
				Surgical Treatment
			Course and Outcome
	Key References
	References
4.12 Bacterial Keratitis
	Key Feature
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Clinical Features
		Gram-Positive Cocci
			Staphylococcus
			Streptococcus
		Gram-Positive Bacilli
			Bacillus
			Corynebacterium
			Listeria
			Clostridium
			Propionibacterium acnes
		Filamentous Bacteria
			Actinomyces and Nocardia
		Gram-Negative Rods
			Pseudomonas
			Serratia
			Escherichia, Klebsiella, and Proteus
			Moraxella
			Haemophilus
		Gram-Negative Cocci
			Neisseria
			Moraxella (Branhamella) catarrhalis
		Mycobacteria
			Nontuberculous Mycobacteria
	Diagnosis
	Differential Diagnosis
	Systemic Associations
	Pathology
	Treatment
	Outcome
	Key References
	References
4.13 Fungal Keratitis
	Key Feature
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Clinical Features
	Diagnosis
	Differential Diagnosis
	Systemic Associations
	Pathology
	Treatment
	Outcome
	Key References
	References
4.14 Parasitic Keratitis
	Key Feature
	Associated Features
	Introduction
	Acanthamoeba Keratitis
		Epidemiology and Pathogenesis
		Clinical Features
		Diagnosis
		Differential Diagnosis
		Pathology
		Treatment
		Outcome
	Microsporidiosis
		Epidemiology and Pathogenesis
		Clinical Features
		Diagnosis
		Differential Diagnosis
		Systemic Associations
		Treatment
		Outcome
	Onchocerciasis
		Epidemiology and Pathogenesis
		Clinical Features
		Diagnosis
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Outcome
	Key References
	References
4.15 Herpes Simplex Keratitis
	Key Features
	Associated Features
	Epidemiology
	Herpes Simplex Virus
		Life Cycle of HSV
	Primary HSV Infection
	Recurrent HSV Infections
		Epithelial Keratitis
			Dendritic Ulcer
			Geographical Ulcer
			Marginal Keratitis
			Metaherpetic (Trophic) Ulcer
		Stromal/Endothelial Keratitis
			Endotheliitis
				Localized Endotheliitis
				Diffuse and Linear Endotheliitis
			Necrotizing Keratitis
			Immune Stromal Keratitis
			Lipid Keratopathy
			Keratouveitis
			Miscellaneous Syndromes
	Diagnosis
		Culture
		DNA Testing
		Fluorescent Antibody Testing
		Tzanck’s Smear
		Serum Antibody Testing
	Herpetic Eye Disease Study
	Treatment
		Infectious Epithelial Keratitis
		Stromal Keratouveitis
		Metaherpetic Keratitis
		Medications
			Antivirals
			Corticosteroids
		Surgery
			Penetrating Keratoplasty
			Conjunctival Flap
			Amniotic Membrane Transplantation
	Future Directions
	Key References
	References
4.16 Peripheral Ulcerative Keratitis
	Key Features
	Associated Features
	Introduction
	Anatomy and Pathogenesis
	Ocular Manifestations
	Systemic Associations
	Differential Diagnosis
	Diagnostic and Ancillary Testing
	Treatment
		Medical Treatment
		Surgical Treatment
	Course and Outcome
	Key References
	References
4.17 Noninfectious Keratitis
	Key Feature
	Associated Feature
	Introduction
	Thygeson’s Superficial Punctate Keratitis
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Pathology
		Treatment
		Course and Outcome
	Superior Limbic Keratoconjunctivitis of Theodore
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcome
	Mooren’s Ulcer
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Pathology
		Treatment
		Course and Outcome
	Neurotrophic Keratitis
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcome
	Terrien’s Marginal Degeneration
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Pathology
		Treatment
		Course and Outcome
	Lax Eyelid Condition, Lax Eyelid Syndrome, and Floppy Eyelid Syndrome
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Systemic Associations
		Pathology
	Treatment
	Key References
	References
4.18 Keratoconus and Other Ectasias
	Key Features
	Associated Features
	Keratoconus
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcome
	Pellucid Corneal Degeneration
	Keratoglobus
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Pathology
		Treatment
	Posterior Keratoconus
	Post–Refractive Surgery Corneal Ectasia
	Key References
	References
4.19 Anterior Corneal Dystrophies
	Key Features
	Associated Features
	Introduction
	Anterior Basement Membrane Dystrophy
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Pathology
		Treatment
	Meesmann’s Epithelial Dystrophy
	Reis–Bückler Dystrophy
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Pathology
		Treatment
	Thiel–Behnke Dystrophy
	Key References
	References
4.20 Stromal Corneal Dystrophies
	Key Features
	Associated Features
	Introduction
	Gelatinous Drop-Like Dystrophy
	Lattice Dystrophy Type I
		Genetics
		Ocular Manifestations
		Clinical Presentation
		Pathology
		Treatment
	Systemic Amyloidosis With Corneal Lattice
		Genetics
		Ocular Manifestations
		Patient Presentation
		Pathology
		Treatment
		Other Lattice Dystrophies
	Granular Corneal Dystrophy Type I
		Genetics
		Ocular Manifestation
		Patient Presentation
		Pathology
		Treatment
	Granular Corneal Dystrophy Type 2
		Genetics
		Ocular Manifestations
		Patient Presentation
		Pathology
		Treatment
	Macular Corneal Dystrophy
		Genetics
		Ocular Manifestations
		Patient Presentation
	Pathology
		Treatment
	Schnyder’s Corneal Dystrophy
		Genetics
		Ocular Manifestations
		Patient Presentations
		Pathology
		Treatment
	Central Cloudy Dystrophy
		Genetics
		Ocular Manifestations
		Patient Presentations
		Pathology
		Treatment
	Fleck Dystrophy
		Genetics
		Ocular Manifestations
		Patient Presentation
		Pathology
		Treatment
	Posterior Amorphous Corneal Dystrophy
		Genetics
		Ocular Manifestations
		Patient Presentation
		Pathology
		Treatment
	Congenital Stromal Corneal Dystrophy
		Genetics
		Ocular Manifestations
		Differential Diagnosis
		Pathology
		Treatment
	Key References
	References
4.21 Diseases of the Corneal Endothelium
	Key Features
	Associated Features
	Introduction
	Fuchs’ Dystrophy
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Differential Diagnosis
		Pathology
		Treatment
		Course and Outcome
	Congenital Hereditary Endothelial Dystrophy
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Pathology
		Treatment
		Course and Outcome
	Posterior Polymorphous Corneal Dystrophy
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Pathology
		Treatment
		Course and Outcome
	Key References
	References
4.22 Corneal Degenerations
	Key Features
	Associated Features
	Introduction
	Corneal Arcus (Arcus Senilis)
	Lipid Keratopathy
	Vogt’s White Limbal Girdle
	Senile Corneal Furrow Degeneration
	Terrien’s Marginal Corneal Degeneration
	Peripheral Corneal Guttae
	Calcific Band Keratopathy
	Spheroidal Degeneration
	Iron Deposition
	Crocodile Shagreen
	Cornea Farinata
	Salzmann’s Corneal Degeneration
	Corneal Keloids
	Corneal Amyloid Degeneration
	Key References
	References
4.23 Dry Eye Disease
	Key Features
	Associated Features
	Introduction
	Epidemiology
	Pathogenesis
		Normal Physiology
		Pathophysiology
		Diagnosis and Classification
		Aqueous Tear-Deficient Dry Eye
			Non-Sjögren’s Tear Deficiency
			Sjögren’s Syndrome Tear Deficiency
		Evaporative Dry Eye Disease
		Meibomian Gland Disease and Blepharitis
		Exposure
		Mucin Deficiency
		Extrinsic Causes
	Ocular Manifestations
	Diagnosis and Ancillary Testing
		Diagnostic Dye Evaluation
		Tear Film Stability
		Measurement of Tear Production
		Other Tests
	Treatment
		Aqueous Tear Deficiency
		Evaporative Dry Eye Disease
		Ocular Surface Inflammation
	Key References
	References
4.24 Complications of Contact Lens Wear
	Key Features
	Introduction
	Toxic, Allergic and Mechanical Reactions
		Solutions
		Giant Papillary Conjunctivitis
		Superior Limbic Keratoconjunctivitis
	Conditions Reflecting Metabolic Challenge
		Corneal Hypoxia and Edema
		Neovascularization
		Limbal Stem Cell Deficiency
		Abrasions
	Corneal Inflammatory Events and Microbial Keratitis
		The Role of Lens Care Systems
		Corneal Inflammatory Events
		Microbial Keratitis
		Fungal Keratitis
		Acanthamoeba Keratitis
	Unsupervised Lens Wear
	FDA and CDC Recommendations
	Conclusions
	Key References
	References
4.25 Corneal and External Eye Manifestations of Systemic Disease
	Key Feature
	Associated Feature
	Introduction
	Congenital Disorders
	Chromosomal Disorders
	Inherited Connective Tissue Disorders
	Metabolic Disorders
		Protein and Amino Acid Metabolic Disorders
		Mucopolysaccharidoses
		Sphingolipidoses
		Dyslipoproteinemias
		Mucolipidoses
	Other Oculosystemic Disorders
	Conclusions
	Key References
	References
4.26 Acid and Alkali Burns
	Key Features
	Associated Feature
	Introduction
	Alkali Injuries
	Acid Injuries
	Pathophysiology
	Clinical Course
	Therapy
		Immediate Phase
		Acute and Reparative Phases
		Surgical Therapy
	Key References
	References
4.27 Corneal Surgery
	Key Features
	Associated Feature
	Keratoplasty
		Introduction
		Historical Review
		Anesthesia
		Specific Techniques
			Penetrating Keratoplasty
				Preoperative Evaluation and Diagnostic Approach
				Donor Selection
				Surgical Techniques
				Complications and Postoperative Management
					Wound Leak.
					Flat Anterior Chamber With Increased Intraocular Pressure.
					Endophthalmitis.
					Persistent Epithelial Defect.
					Primary Graft Failure.
					Suture-Related Problems.
					Graft Rejection.
					Treatment for Astigmatism.
					Corneal Ulcers.
					Recurrence of Diseases.
			Anterior Lamellar Keratoplasty
				Preoperative Evaluation and Diagnostic Approach
				Donor Selection
					Donor Preparation.
				Surgical Techniques
					Anterior Lamellar Dissection of the Host Tissue.
				Complications and Postoperative Management
					Perforation of Descemet’s Membrane.
					Pseudo-Anterior Chamber.
			Triple Procedure (Combined Procedure)
				Preoperative Evaluation and Diagnostic Approach
				Surgical Techniques
					Open Sky Cataract Extraction.
			Artificial Cornea (Keratoprosthesis)
				Boston K-Pro
				AlphaCor
				Modified Osteo-Odonto-Keratoprosthesis
		Outcome
	Superficial Corneal Procedures
		Historical Review
		Anesthesia
		Specific Techniques
			Superficial Keratectomy
				Preoperative Evaluation and Diagnostic Approach
				Surgical Techniques
				Complications and Postoperative Management
			Corneal Biopsy
				Preoperative Evaluation and Diagnostic Approach
				Surgical Techniques
				Complications and Postoperative Management
		Outcome
	Phototherapeutic Keratectomy
		Preoperative Evaluation and Diagnostic Approach
		Surgical Techniques
			Corneal Dystrophies, Scars, and Elevated Opacities
		Postoperative Care
		Complications
			Hyperopia
			Myopia/Myopic Astigmatism
			Irregular Astigmatism and Decentration
			Pain
			Delayed Epithelization
			Bacterial Keratitis
			Viral Keratitis
			Recurrence and Haze
			Graft Rejection
		Outcome
	Key References
	References
4.28 Conjunctival Surgery
	Key Features
	Associated Feature
	Historical Review
	Anesthesia
	Specific Techniques
		Conjunctival Flap
			Preoperative Evaluation and Diagnostic Approach
			Surgical Techniques
			Complications and Postoperative Management
		Pterygium Surgery
			Preoperative Evaluation and Diagnostic Approach
			Surgical Techniques
				Bare Sclera Technique/Simple Closure
				Autograft
				Amniotic Membrane
					Other Techniques.
					Recurrent Pterygium Excision.
				Antimetabolites and Radiation
				Fibrin Glue
			Complications and Postoperative Management
		Conjunctivochalasis Management
			Surgical Techniques
			Complications
	Key References
	References
4.29 Endothelial Keratoplasty
	Key Feature
	Associated Features
	Introduction
	Evolution of EKP Techniques
	Indications
	Surgical Technique
		Anesthesia and Recipient Preparation
		Donor Tissue Preparation and Insertion
			Descemet’s Stripping With Endothelial Keratoplasty
			Descemet’s Membrane Endothelial Keratoplasty
	Combined Procedures
	Outcomes
		Visual Acuity
		Refractive Changes
		Graft Survival
		Complications
			Graft Detachment
			Immunological Rejection
			Postkeratoplasty Intraocular Pressure Elevation
			Infrequent Complications
	Outlook
	Key References
	References
4.30 Surgical Ocular Surface Reconstruction
	Key Features
	Associated Features
	Introduction
	Historical Perspectives
		General Concepts
	Preoperative Considerations
	Operative Procedures
		Unilateral Disease
		Partial Stem Cell Deficiency
			Mechanical Debridement
			Amniotic Membrane Grafting
			Autologous Limbal Stem Cell Transplantation
		Total Stem Cell Deficiency
			Autologous Limbal Stem Cell Transplantation
		Bilateral Disease
			Keratolimbal Allograft and Allogeneic SLET
			Ex Vivo Expanded Limbal Stem Cells and Nonocular Tissue
	Special Considerations in Ocular Surface Reconstruction
		Ocular Surface Optimization
		Corneal Transplantation
	Conclusions
	Key References
	References
4.31 Management of Corneal Thinning, Melting, and Perforation
	Key Features
	Associated Features
	Introduction
	Corneal Thinning From Noninflammatory Disorders
	Corneal Thinning and Melting From Inflammatory Disorders
	Surgical Treatment of Corneal Perforations
		Tissue Adhesives
		Penetrating Keratoplasty
		Patch Graft
		Miscellaneous Treatments
	Conclusions
	Key References
	References
5.1 Basic Science of the Lens
	Key Features
	Associated Features
	Key References
	References
5.1 Basic Science of the Lens
	Key Features
	Introduction
	Anatomy of the Lens
		Capsule
		Epithelial Cells
		Lens Substance
		Sutures
		Growth
		Mass
		Dimensions
	Physiology of the Lens
		Permeability, Diffusion, and Transport
			Transport of Ions
			Amino Acid and Sugar Transport
	Biophysics
		Light Transmission
		Transparency
		Refractive Indices
		Chromatic Aberration
		Spherical Aberration
		Accommodation
	Biochemistry
		Sugar Metabolism
		Protein Metabolism
		Glutathione
			Amino Acid Transport
		Antioxidant Mechanisms
	Lens Crystallins
		Crystallin Structure
		Crystallin Gene Expression During Lens Growth
		Crystallin Function
	Age Changes
		Morphology
		Physiological Changes
		Biophysical Changes
		Accommodation Changes
		Biochemical Changes
		Crystallins
	Secondary Cataract
		Fibrosis-Type Posterior Capsule Opacification
		Pearl-Type Posterior Capsule Opacification
		Soemmerring’s Ring
		Prevention and Treatment of Posterior Capsule Opacification
	Key References
	References
5.2 Evolution of Intraocular Lens Implantation
	Key Features
	Introduction
	Lens Design and Fixation
		Generation I (Original Ridley Posterior Chamber Lens)
		Generation II (Early Anterior Chamber Lenses)
		Generation III (Iris-Supported Lenses)
		Generation IV (Intermediate Anterior Chamber Lenses)
		Generation V (Improved Posterior Chamber Lenses)
		Generation VI (Modern Capsular Lenses – Rigid PMMA, Soft Foldable, and Modern Anterior Chamber)
	Recent Advances
	Key References
	References
5.2 Evolution of Intraocular Lens Implantation
	Key features
	Introduction
	Lens Design and Fixation
		Generation I (Original Ridley Posterior Chamber Lens)
		Generation II (Early Anterior Chamber Lenses)
		Generation III (Iris-Supported Lenses)
		Generation IV (Intermediate Anterior Chamber Lenses)
		Generation V (Improved Posterior Chamber Lenses)
		Generation VI (Modern Capsular Lenses—Rigid PMMA, Soft Foldable, and Modern Anterior Chamber)
	Recent Advances
	Key References
	References
5.3 Epidemiology, Pathophysiology, Causes, Morphology, and Visual Effects of Cataract
	Key Features
	Epidemiology of Cataracts
	Pathophysiology of Cataracts
		Genetics
		Cell Proliferation and Differentiation
		Metabolic Disturbance and Osmotic Regulation Failure
		Calpains
		Protein Modification
		Oxidation
		Defensive Mechanisms
		Other Factors
	Cataract Causes, Associations, and Prevention
		Age
		Sunlight and Irradiation
		Smoking and Alcohol
		Body Mass Index
		Myopia
		Trauma
		Systemic Disorders
		Dermatological Disorders
		Central Nervous System Disorders
		Ocular Disease and Cataracts
		Toxic Causes
		Congenital and Juvenile Cataracts
	Prevention of Cataracts
	Morphology and Visual Effects of Cataract
		Morphology
		Assessment and Grading of Cataracts
		Visual Effects of Cataracts
			Visual Acuity
			Contrast Sensitivity, Glare, and Wavefront Aberrometry
			Other Effects
		Anomalies of Lens Growth
			Aphakia
			Microspherophakia
			Lenticonus and Lentiglobus
			Lens Coloboma
			Ectopia Lentis
	Key References
	References
5.4 Patient Workup for Cataract Surgery
	Key Features
	Introduction
	Medical History and Current Therapeutic Regimen
	General Ophthalmic History and Examination
	Assessment of Lens Opacities
		Introduction
		Diagnosis of Lens Opacities
		Classification of Lens Opacities
			Nuclear Opacities
			Cortical Opacities
			Posterior Subcapsular Opacities
			Advanced Cataracts
		Grading of Lens Opacities
			Lens Opacities Classification System III (Fig. 5.4.2)
		Effects of Opacities on Vision
			Visual Acuity Reduction
			Contrast Sensitivity Reduction
			Myopic Shift
			Monocular Diplopia
			Glare
			Color Shift
			Visual Field Loss
	Investigations for Further Surgical Refinement
		Corneal Topography
		Preoperative Topography
		Determination of IOL Type and Power
		Planning the Incision
	Good Clinical Practice (Social and Legal Aspects)
	Key References
	References
5.5 Intraocular Lens Power Calculations
	Key Features
	Introduction
	Ocular Biometry
		Ultrasound Biometry
		Optical Biometry
	IOL Power Formulas
		Vergence Formulas
		Ray Tracing Formulas
		Artificial Intelligence Formulas
		Combination Formulas
	IOL Calculations in Special Eyes
		IOL Power Calculation in Short Eyes
		IOL Power Calculation in Long Eyes
		IOL Power Calculation in Eyes With Previous Corneal Refractive Surgery
			Factors Contributing to Challenges in IOL Power Calculation
			Methods to Improve the Accuracy of IOL Power Calculations in Postrefractive Eyes
				Methods Relying on Prior Clinical Data
				Methods Using a Combination of the Surgically Induced Refractive Change (ΔMR) and Current Corneal Power Values
				Methods Requiring No Historical Data
				Web-Based Post-Refractive IOL Calculator
				Radial Keratotomy
		IOL Power Calculation in Keratoconic Eyes
		IOL Power Calculation in Eyes Following Keratoplasty
	Toric IOL Calculation
		Impact of Posterior Corneal Astigmatism
		Selection of Toric IOL Toricity
		Imaging and Guidance Systems for Toric IOL Alignment
	Intraoperative Wavefront Aberrometry
	Postoperative IOL Adjustment
	Conclusion
	Key References
	References
5.6 Indications for Lens Surgery/Indications for Application of Different Lens Surgery Techniques
	Key Features
	Introduction
	Medical Indications for Lens Surgery
		Lenticular Opacification (Cataract)
			Cataract in the Presence of Other Ocular Disorders
		Lenticular Malposition
		Lenticular Malformation
		Lens-Induced Ocular Inflammation
		Lens-Induced Glaucoma
			Inflammatory Glaucoma (Phacolytic Glaucoma)
			Pupil Block and Angle Closure (Phacomorphic Glaucoma)
	Refractive Indications for Lens Surgery
	Indications for Different Lens Surgery Techniques
		Intracapsular Cataract Extraction
		Extracapsular Extraction (Large-Incision Nuclear Expression Cataract Surgery)
		Small-Incision Nuclear Expression Cataract Surgery (“Mini-nuc” and Other Techniques)
		Phacoemulsification
		Surgery of the Lens Capsule
		Zonular Surgery
		Surgery for Presbyopia
		Monovision
		Astigmatism
	Key References
	References
5.7 The Pharmacotherapy of Cataract Surgery
	Key Features
	Introduction
	Preoperative Medications
		Pupil Dilatation
		Anti-infective Prophylaxis
	Anesthetics
	Intraoperative Medications
		Additives to Irrigating Solutions, Intracameral Antibiotics, and Other Intraocular Drugs Used During the Surgical Procedure
		Irrigating Solutions
	Ophthalmic Viscosurgical Devices
		Intracameral Medications to Replace Postoperative Drops
	Postoperative Medications
		Antibiotics
		Corticosteroids and Nonsteroidal Anti-inflammatory Drugs
	Late Postoperative Medications
		Treatment of Endophthalmitis
		Treatment of Cystoid Macular Edema
	Key References
	References
5.8 Anesthesia for Cataract Surgery
	Key Features
	Introduction
	Medical Aspects of Anesthesia for Cataract Surgery
		Cataract Type and Associated Medical Conditions
		Specific Conditions
			Ischemic Heart Disease
			Anticoagulants
			Diabetes Mellitus
	Local Anesthesia
		General Considerations
		Topical Anesthesia (see Box 5.8.1)
		Retrobulbar Block (see Box 5.8.2)
		Peribulbar Block (see also Table 5.8.1)
			Technique
			Local Anesthetic Agent
			Complications
		Sub-Tenon’s Block (see also Table 5.8.1)
			Anatomy
			Technique
	Sedative Agents
	General Anesthesia
		Technique
			Spontaneous Respiration
			Ventilation
			Conclusions
	Postoperative Care
	Key References
	References
5.9 Phacoemulsification
	Key Features
	Introduction
	Handpieces and Tips
	Power Modulation
	Pumps and Fluidics
		Flow-Based (Peristaltic)
		Vacuum-Based
		Anterior Chamber Hydrodynamics
		Fluidics of Microincisional Phaco
	Postocclusion Surge
	Key References
	References
5.10 Refractive Aspects of Cataract Surgery
	Key Features
	Introduction
	Value of Corneal Topography
	Intraoperative Management of Preoperative Corneal Astigmatism to Prevent Induction of Corneal Astigmatism
		Corneal Incisions
	To Treat Preoperative Corneal Astigmatism
		Astigmatic Incisions
		Limbal Relaxing Incisions
		Opposite Clear Corneal Incisions
	Toric Intraocular Lens Implantation
	Postoperative Management of Residual or Induced Corneal Astigmatism
		Corneal Laser Ablative Techniques
	Post–Cataract Surgery Piggyback IOLs
	Light-Adjustable Intraocular Lens Implant
	Key References
	References
5.11 Small Incision and Femtosecond Laser-Assisted Cataract Surgery
	Key Features
	Associated Feature
	Introduction
	Incision Construction and Architecture
	Continuous Curvilinear Capsulorrhexis
	Hydrodissection and Hydrodelineation
	Nucleofractis Techniques
		Divide and Conquer
		Phaco Chop
	Power Modulations
	Biaxial Microincision Cataract Surgery
	B-MICS Vertical Chop Technique
	Femtosecond Laser-Assisted Cataract Surgery
		Anterior Capsulectomy
		Lens Fragmentation
		Corneal Incisions
	Conclusions
	Key References
	References
5.12 Manual Cataract Extraction
	Key Features
	Introduction
		Historical Issues
	Manual (Large-Incision) Cataract Surgery
		Incision
		Wound Closure
	Intracapsular Cataract Extraction
		General Comments
		Specific Techniques
			Iris Management
			Vitreous Presentation or Prolapse
			Intraocular Lenses
	Extracapsular Cataract Extraction
		Anterior Capsulectomy
			“Can Opener” Capsulectomy
			Linear Capsulectomy and Intercapsular Techniques
			Capsulorrhexis
			Size, Type, and Position of Capsulectomy
			Nucleus Expression
			Cortical Washout
			Intraocular Lens Insertion
		Mininuc Technique
			Anterior Chamber Maintainer
			Capsulorrhexis
			Sclerocorneal Pocket Tunnel
			Nucleus Manipulation
			Nucleus Expression
			Cortex Removal and Intraocular Lens Implantation
	Complications
	Discussion
	Key References
	References
5.13 Combined Procedures
	Key Features
	Introduction
	Combined Glaucoma Surgery
		Overview
		Trabeculectomy and Cataract Surgery
		Nonpenetrating Glaucoma Surgery and Cataract
		Minimally Invasive Glaucoma Surgery
		Aqueous Shunts
		Outcomes
	Lens Surgery Combined With Keratoplasty
		Historical Review
		Surgical Options
		Specific Techniques
		Complications
		Outcomes
	Combined Phacovitrectomy
		Introduction
		Indications and Advantages Over Sequential Noncombined Surgery
		Disadvantages
		Specific Techniques
		Conclusion
	Key References
	References
5.14 Cataract Surgery in Complex Eyes
	Key Features
	Associated Features
	Introduction
	Zonular Instability
	Uveitis
	Compromised Endothelium
	Key References
	References
5.15 Pediatric Cataract Surgery
	Key Features
	Introduction
	Historical Review
	Preoperative Evaluation and Diagnostic Approach
	Alternatives to Surgery
	Anesthesia
	General Techniques
	Specific Techniques
		Pars Plana Approach
		Corneolimbal Approach
	Choices for Correction of Aphakia in Children
		Spectacles
		Contact Lenses
		Intraocular Lenses
			Selection of Intraocular Lenses
			Implantation in Children Under 2 Years of Age
			Implantation in Children Above 2 Years of Age
			Postoperative Treatment
	Complications
		Postoperative Complications
		Amblyopia Management
		Options to Correct Myopic Shift
	Outcome
	Key References
	References
5.16 Complications of Cataract Surgery
	Key Features
	Associated Feature
	Introduction
	Intraoperative Complications
		Cataract Incision
		Tunnel Perforation
		Descemet’s Detachment
		Thermal Burns
		Anterior Capsulectomy
			Preventing Radial Tears in the Anterior Capsule
			Excessively Small Capsulorrhexis
			Minimizing Complications When Radial Tears Are Present
		Nucleus Expression Cataract Extraction
		Complications During Phaco
			Hydrodissection
			Iris Prolapse or Damage
			Floppy Iris Syndrome
			Trapped Nucleus
			Subluxated Lens
		Ruptured Posterior Capsule
			Before Nucleus Removal
			During Cortical Irrigation–Aspiration
			Intraocular Lens Insertion
				Capsular Bag
				Iris Fixated (Retropupillary or Prepupillary)
				Ciliary Sulcus
				Sutured Posterior Chamber
				Anterior Chamber
		Dropped Nucleus
		Anterior Segment Hemorrhage
	Postoperative Complications
		Wound Dehiscence
		Wound Leakage
		Inadvertent Filtering Bleb
		Epithelial Ingrowth
		Postoperative Astigmatism
		Corneal Edema and Bullous Keratopathy
		Hyphema
		Endocapsular Hematoma
		Intraocular Pressure Elevation
		Capsular Block Syndrome
		Intraocular Lens Miscalculation
		Intraocular Lens Decentration and Dislocation
			Asymmetrical Haptic Placement
			Sunset Syndrome
			Lens-Bag Decentration
			Pupillary Capture
		Sulcus-Fixated Intraocular Lens Dislocation
		Posterior and Anterior Dislocation
		Intraocular Lens Exchange
		Cystoid Macular Edema
		Endophthalmitis
		Posterior Capsular Opacification
		Retinal Detachment
	Key References
	References
5.17 Secondary Cataract
	Key Features
	Introduction
	Pathogenesis
		Treatment and Prevention
			Hydrodissection-Enhanced Cortical Cleanup
			In-the-Bag IOL Fixation
			Capsulorrhexis Size
			Biocompatible Intraocular Lens
			Contact Between the IOL Optic and the Posterior Capsule
			Intraocular Lens Optic Geometry
	Intraocular Lenses Maintaining the Capsular Bag Open or Expanded
	Key References
	References
5.18 Outcomes of Cataract Surgery
	Key Features
	Introduction
	Evaluation of Outcomes
	Five Parameters That Describe Visual Function
		Visual Acuity Testing
			Standardized Visual Acuity Testing
			Potential Retinal Acuity Testing
		Contrast Sensitivity Testing
		Glare Testing
		Visual Fields
		Color Vision
	Objective Findings of Cataract Surgery Outcomes
		Best-Corrected Visual Acuity
		Uncorrected Visual Acuity
		Target Refraction Prediction Error
		Contrast Sensitivity
		Glare
		Visual Fields
		Color Vision
	Subjective Findings of Cataract Surgery Outcomes
		Patients’ Self-Assessment of the Visual Outcome
	Cataract Surgery of One or Both Eyes
	Cataract Surgery in Eyes With Ocular Comorbidity
	Summary
	Key References
	References
6.1 Structure of the Neural Retina
	Key Feature
	Introduction
	Center of the Macula: Umbo
	Foveola
	Fovea
	Parafovea
	Perifovea
	Macula, or Central Area
	Extra-Areal Periphery
	Layers of the Neural Retina
	Key References
	References
6.2 Retinal Pigment Epithelium
	Key Features
	Introduction
	Structure and Metabolism
		Cellular Architecture and Blood–Retinal Barrier
		Pigments
		Metabolism and Growth Factors
	Membrane Properties and Fluid Transport
		Ion Channels and Transport Systems
		Electrical Activity
	Photoreceptor–Retinal Pigment Epithelium Interactions
		Visual Pigment Regeneration
		Photoreceptor Renewal and Phagocytosis
		Retinal Adhesion and Interphotoreceptor Matrix
	Repair, Regeneration, and Therapy
	References
6.3 Retinal and Choroidal Circulation
	Key Features
	Introduction
	Posterior Segment Vascular Anatomy
		Retinal Vascular Anatomy
		Choroidal Vascular Anatomy
	Blood–Retinal Barrier
	Retinal and Choroidal Blood Flow
	Retina and Choroidal Circulation Evaluated by OCTA
	Regulation of Retinal and Choroidal Blood Flows
	Key References
	References
6.4 Vitreous Anatomy and Pathology
	Key Features
	Associated Features
	Introduction
	Molecular Morphology
		Supramolecular Organization
	Vitreous Anatomy
		Macroscopic Morphology
		Microscopic Morphology
	Age-Related Changes
		Embryology and Postnatal Development
		Developmental Anomalies
		Aging of the Vitreous Body
		Posterior Vitreous Detachment
		Anomalous Posterior Vitreous Detachment
			Premacular (Epiretinal) Membrane/Macular Pucker
			Macular Holes
		Diabetic Vitreopathy
		Asteroid Hyalosis
	Key References
	References
6.5 Contact B-Scan Ultrasonography
	Key Features
	Associated Features
	Introduction
	Devices
	Technique of Examination
	Concepts of B-Scan Interpretation
		Real Time
		Gray Scale
		Three-Dimensional Analysis
	Display Presentation and Documentation
		Normal Vitreous Cavity
		Vitreous Hemorrhage
		Retinal Detachment
		Choroidal Detachment
		Tumors
	Digital Contact Ultrasonography
	What’s New?
		Anterior Segment High-Frequency Ultrasonography
	Summary
	Key References
	References
6.6 Camera-Based Ancillary Retinal Testing
	Key Features
	Key Features
	Key Features
	Fluorescein Angiography
		Introduction
		Purpose of the Test
		Properties of Sodium Fluorescein Dye
		Procedure
		Complications
		Interpretation of Results
			Normal Fluorescein Angiogram
			Abnormal Fluorescein Angiography
	Indocyanine Green Angiography
		Introduction
		Properties of Indocyanine Green
		Procedure
		Complications
		Interpretation of Results
	Fundus Autofluorescence
	Acknowledgments
	Key References
	References
6.7 Optical Coherence Tomography in Retinal Imaging
	Key Features
	Associated Features
	Introduction
	OCT Technology Platforms
		Time-Domain OCT
		Spectral-Domain OCT
		Multifunctional OCT
		Time-Encoded Frequency-Domain OCT (Swept-Source OCT)
		High-Speed, Ultra-High-Resolution OCT
		Adaptive Optics OCT
	Anatomical Results
	Image Optimization
	OCT Image Interpretation
		Preretinal
			Posterior Vitreous Detachment
			Vitreomacular Traction
			Epiretinal Membrane
			Macular Holes
			Lamellar Holes
			Pseudo-Hole
		Intraretinal
			Macular Edema
			Irvine–Gass Syndrome: Cystoid Macular Edema After Cataract Surgery
			Retinal Exudates
		Subretinal
			Subretinal Fluid
			Pigment Epithelial Detachment
			RPE Tear
		Choroidal Pathology
			Choroidal Neovascularization
		OCT Artifacts
			Time-Domain OCT
			Spectral-Domain OCT
	Key References
	References
6.8 Optical Coherence Tomography Angiography
	Key Features
	Introduction
	Biological Basis of OCTA
	OCTA Versus Dye-Based Angiography Methods
	Key Applications of SD-OCTA
		Detection of Impaired Perfusion (or “Nonperfusion”)
		Detection of Choroidal Neovascularization
		Quantification of Vascular Changes
	Conclusions
	Key References
	References
6.9 Retinal Electrophysiology
	Key Features
	Introduction
	Full-Field ERG
	Multifocal ERG
	Electro-oculography
	Key References
	References
6.10 Light and Laser Injury
	Key Features
	Associated Features
	Introduction
	Light Interaction With the Retina
	Photic Retinopathy
		Solar Retinopathy
		Welding Arc Exposure
		Lightning Maculopathy
		Retinal Phototoxicity From Ophthalmic Instruments
	Light Exposure and Age-Related Macular Degeneration
	Laser Injury
	Laser Pointers
	Complications of Therapeutic Retinal Laser Photocogulation
	Key References
	References
6.11 Scleral Buckling Surgery
	Key Features
	Associated Features
	Introduction
	Historical Review
	Preoperative Evaluation and Diagnostic Approach
	Differential Diagnosis
	Alternatives to Scleral Buckling
	Anesthesia
	General Techniques
		Treatment of Retinal Breaks
		Explant Scleral Buckling Techniques
		Drainage of Subretinal Fluid
		Chandelier-Assisted Scleral Buckling
		Closure
	Complications
		Intraoperative Complications
			Scleral Perforation
			Drainage Complications
		Postoperative Complications
			Glaucoma
			Infection and Extrusion
			Choroidal Effusion
			Cystoid Macular Edema and Residual Subretinal Fluid
			Macular Pucker
			Diplopia
			Changes in Refractive Error
	Outcome
	Key References
	References
6.12 Vitrectomy
	Key Features
	Introduction
	Historical Review
	Preoperative Evaluation and Diagnostic Approach
	Indications and Alternatives to Surgery
	Anesthesia
	General Techniques
	Specific Techniques
		Lensectomy
		Vitreous Cutters
		Epiretinal Membrane Dissection
		Intraoperative Tissue Staining
		Perfluorocarbon Liquids
		Endophotocoagulation
		Gas and Silicone Oil Tamponade
	Complications
	Outcomes
	Key References
	References
6.13 Intravitreal Injections and Medication Implants
	Key Features
	Associated Features
	Introduction
	Preinjection Preparation
		Pupillary Dilation
		Anesthesia
		Antisepsis
	Injection
	Postinjection
	Complications
		Endophthalmitis
		Hemorrhage
		Intraocular Pressure Changes
		Retinal Pigment Epithelium Tears
		Retinal Tears and Detachments
		Other Complications
	Other Considerations
	Implants
	Conclusions
	Key References
	References
6.14 Progressive and “Stationary” Inherited Retinal Degenerations
	Key Features
	Associated Features
	Key Features
	Associated Features
	Progressive Diffuse/Panretinal Degenerations
		Introduction
		Epidemiology and Pathogenesis
			Rod-Cone Dystrophy
			Cone-Rod Dystrophy
		Diagnosis and Ancillary Testing
			Electroretinography
			Monitoring Disease Progression
			Visual Field Testing
			Dark Adaptation Testing
			Color Vision Tests
			Fluorescein Angiography
			Fundus Autofluorescence
			Optical Coherence Tomography
			Electro-oculography
			Multifocal Electroretinography
			Visual Evoked Cortical Potential
			Genetic Testing
		Ocular Findings/Manifestations
			Typical Retinitis Pigmentosa
			X-Linked Retinitis Pigmentosa
			Leber’s Congenital Amaurosis
			Cone Dystrophy
		Genetics and Pathology
		Systemic Associations and Differential Diagnosis of Pigmentary Retinopathy
		Course and Outcomes
	“Stationary” Retinal Disorders
		Congenital Stationary Night Blindness
		Congenital Stationary Night Blindness With Normal Fundus
		Oguchi’s Disease
		Fundus Albipunctatus
		Congenital Red–Green Color Deficiency
		Blue Cone Monochromatism
		Achromatopsia
		Ocular Albinism
	Female Carriers of X-Linked Retinal Degenerations
	Treatment of Retinal Degenerations
		Vitamin A
		Docosahexaenoic Acid
		Carbonic Anhydrase Inhibitors for Cystoid Macular Edema
		Gene Therapy
		Neurotrophic Factors
		Stem Cell–Based Therapies
		Retinal Prostheses/Implants
	References
	Key References
6.15 Macular Dystrophies
	Key Features
	Associated Features
	Introduction
	Stargardt Disease and Fundus Flavimaculatus
		Epidemiology and Pathogenesis
		Ocular Manifestations and Diagnosis
		Pathology
		Treatment, Course, and Outcome
	Vitelliform Macular Dystrophy (Best Disease)
		Epidemiology and Pathogenesis
		Ocular Manifestations and Diagnosis
		Pathology
		Treatment, Course, and Outcome
	Adult Vitelliform Macular Dystrophy/ Adult-Onset Foveomacular Dystrophy (Pattern Dystrophy)
		Epidemiology and Pathogenesis
		Ocular Manifestations and Diagnosis
		Pathology
		Treatment, Course, and Outcome
	Dominant Drusen (Doyne’s Drusen, Malattia Leventinese)
		Epidemiology and Pathogenesis
		Ocular Manifestations and Diagnosis
		Pathology
		Treatment, Course, and Outcome
	Pattern Dystrophy
		Epidemiology and Pathogenesis
		Ocular Manifestations and Diagnosis
		Pathology
		Treatment, Course, and Outcome
	Dominant Cystoid Macular Edema
		Epidemiology and Pathogenesis
		Ocular Manifestations and Diagnosis
		Pathology
		Treatment, Course, and Outcome
	Sorsby’s Macular Dystrophy
		Epidemiology and Pathogenesis
		Ocular Manifestations and Diagnosis
		Pathology
		Treatment, Course, and Outcome
	North Carolina Macular Dystrophy
		Epidemiology and Pathogenesis
		Ocular Manifestations and Diagnosis
		Pathology
		Treatment, Course, and Outcome
	Atrophia Areata
		Epidemiology and Pathogenesis
		Ocular Manifestations and Diagnosis
		Treatment, Course, and Outcome
	Cone Dystrophy
		Epidemiology and Pathogenesis
		Ocular Manifestations and Diagnosis
		Treatment, Course, and Outcome
	Central Areolar Choroidal Dystrophy
		Epidemiology and Pathogenesis
		Ocular Manifestations and Diagnosis
		Pathology
		Treatment, Course, and Outcome
	Key References
	References
6.16 Choroidal Dystrophies
	Key Features
		Choroideremia
		Gyrate Atrophy
	Associated Features
	Introduction
	Choroideremia
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment, Course, and Outcome
	Gyrate Atrophy
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment, Course, and Outcome
	Key References
	References
6.17 Hereditary Vitreoretinopathies
	Key Features
	Associated Features
	Introduction
	Stickler’s Syndrome
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Systemic Associations
		Treatment, Course, and Outcome
	X-Linked Juvenile Retinoschisis
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Treatment, Course, and Outcome
	Autosomal Dominant Vitreoretinochoroidopathy
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Treatment, Course, and Outcome
	Familial Exudative Vitreoretinopathy
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Systemic Associations
		Treatment, Course, and Outcome
	Norrie’s Disease
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Systemic Associations
		Treatment, Course, and Outcome
	Key References
	References
6.18 Hypertensive Retinopathy
	Chronic Hypertensive Retinopathy
		Key Features
		Associated Retinal Findings
	Malignant Acute Hypertensive Retinopathy
		Key Features
		Associated Feature
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
			Hypertensive Retinopathy
			Hypertensive Choroidopathy
			Hypertensive Optic Disc Edema
		Diagnosis and Ancillary Testing
		Treatment and Future Directions
	Key References
	References
6.19 Retinal Arterial Obstruction
	Central Retinal Artery Obstruction
		Key Features
		Associated Features
	Branch Retinal Artery Obstruction
		Key Features
		Associated Features
	Central Retinal Artery Obstruction
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcome
	Branch Retinal Artery Obstruction
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcome
	Ophthalmic Artery Obstruction
	Cilioretinal Artery Obstruction
	Combined Artery and Vein Obstructions
	Key References
	References
6.20 Venous Occlusive Disease of the Retina
	Central Retinal Vein Occlusion
		Key Features
		Associated Features
	Branch Retinal Vein Occlusion
		Key Features
		Associated Features
		Introduction
		Epidemiology
	Central Retinal Vein Occlusion
		Pathogenesis
		Ocular Manifestations
		Ancillary Testing
		Differential Diagnosis
		Systemic Associations and Laboratory Evaluation
		Pathology
		Treatment
			Neovascular Glaucoma
			Macular Edema
		Course and Outcome
	Branch Retinal Vein Occlusion
		Pathogenesis
		Ocular Manifestations
		Ancillary Testing
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcome
	Key References
	References
6.21 Retinopathy of Prematurity
	Key Features
		Avascular Retina
	Associated Features
	Introduction
	Pathogenesis
	Clinical Features and Classification
	Diagnosis and Screening
	Role of Telemedicine in ROP Screening
	Differential Diagnosis
	Pathology
	Treatment
	Ablation of Peripheral Avascular Retina
	Role of Anti-VEGF Therapy in ROP Treatment
	Surgery in ROP Treatment
	Late Complications of ROP
	Key References
	References
6.22 Diabetic Retinopathy
	Key Features
	Associated Features
	Introduction
	Epidemiology
	Pathogenesis
		Aldose Reductase
		Vasoproliferative Factors
		Platelets and Blood Viscosity
	Ocular Manifestations
		Early Nonproliferative Diabetic Retinopathy
		Advanced Nonproliferative Diabetic Retinopathy
		Proliferative Diabetic Retinopathy
		Other Ocular Complications of Diabetes Mellitus
			Cornea
			Glaucoma
			Lens
		Optic Neuropathy
		Cranial Neuropathy
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Pathology
	Treatment
		Medical Therapy
			Antiplatelet Therapy
			Antihypertensive Agents
			Antiangiogenesis Agents
			Bevacizumab
			Pegaptanib
			Aflibercept
			Additional Medical Therapies
		Pharmacotherapy for Proliferative Diabetic Retinopathy
			Corticosteroids
		Surgical Therapy
			Panretinal Photocoagulation
			Peripheral Retinal Cryotherapy
			Focal Laser for Macular Edema
			Vitrectomy in Diabetic Retinopathy
	Conclusions
	Key References
	References
6.23 Ocular Ischemic Syndrome
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
		Symptoms
		Anterior Segment
		Posterior Segment
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Systemic Associations
	Pathology
	Treatment, Course, and Outcome
	Key References
	References
6.24 Hemoglobinopathies
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Systemic Associations
	Treatment
	Course and Outcome
	Key References
	References
6.25 Coats’ Disease and Retinal Telangiectasia
	Key Features
	Associated Features
	Introduction
	Epidemiology
	Ocular Manifestations
	Diagnosis
	Ancillary Testing
	Differential Diagnosis
		Idiopathic Juxtafoveal Retinal Telangiectasia
			Group 1A
			Group 1B
			Group 2
			Group 3
		The MacTel Project
		Potential Treatments for Idiopathic Juxtafoveal Retinal Telangiectasia
	Systemic Associations
	Treatment
	Complications of Treatment
	Course and Outcome
	Key References
	References
6.26 Radiation Retinopathy and Papillopathy
	Key Features
	Associated Features
	Radiation Retinopathy
		Pathology and Pathogenesis
		Clinical Features
		Diagnostic Studies
		Risk Factors
			Brachytherapy
			Teletherapy
		Differential Diagnosis
		Treatment
			Reducing the Dose of Radiation
			Laser Photocoagulation
			Intravitreal Anti–Vascular Endothelial Growth Factor Agents
			Corticosteroids
			Other Treatments
		Prognosis
	Radiation Papillopathy
		Pathology and Pathogenesis
		Clinical Features
		Diagnostic Studies
		Differential Diagnosis
		Treatment
		Prognosis
	Summary
	Key References
	References
6.27 Proliferative Retinopathies
	Key Features
	Associated Features
	Introduction
	Retinal Angiogenesis
	Overview of Diagnosing Neovascularization
	Overview of Treating Neovascularization
	Entities Associated With Retinal Neovascularization
		Systemic Diseases
			Diabetes Mellitus
			Hyperviscosity Syndromes
			Aortic Arch Syndromes and Ocular Ischemic Syndromes
			Carotid–Cavernous Fistula
			Multiple Sclerosis
			Retinal Vasculitis
			Sarcoidosis
		Systemic Diseases That Have a Strong Hereditary Component
			Hemoglobinopathies
			Incontinentia Pigmenti
		Retinal Vascular and Ocular Inflammatory Diseases
			Eales’ Disease
			Retinal Vein Occlusion
			Retinal Embolization
			Retinopathy of Prematurity
			Uveitis
			Acute Retinal Necrosis
			Birdshot Chorioretinopathy
			Long-Standing Retinal Detachment
			Choroidal Melanoma and Hemangioma
		Hereditary Retinal Diseases
			Familial Exudative Vitreoretinopathy
			Inherited Retinal Venous Beading
			Retinoschisis
			Retinitis Pigmentosa
			Autosomal Dominant Vitreoretinochoroidopathy
	Key References
	References
6.28 Retinal Arterial Macroaneurysms
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Systemic Associations
	Pathology
	Treatment, Course, and Outcome
	Key References
	References
6.29 Age-Related Macular Degeneration
	Key Features
	Associated Features
	Introduction
	Epidemiology
	Pathogenesis
	Ocular Manifestations
		Dry AMD
			Drusen and Focal Hyperpigmentation of the RPE
			Geographic Atrophy
		Neovascular AMD
			Detachment of the RPE
	Diagnosis and Ancillary Testing
		Fundus Autofluorescence
		Optical Coherence Tomography
		Fluorescein Angiography
		Indocyanine Green Angiography
		Optical Coherence Tomography Angiography
	Differential Diagnosis
	Pathology
	Natural History and Prognosis
	Treatment and Prevention
		Dry AMD
		Neovascular AMD
		Verteporfin Photodynamic Therapy
		Anti-VEGF Therapies
			Pegaptanib Sodium
			Ranibizumab
			Bevacizumab
			Ranibizumab Versus Bevacizumab
		Aflibercept
		Anti-VEGF Treatment Regimens
		Combination Therapies
			Anti-VEGF Therapy Plus PDT
			Anti-VEGF Therapy Plus PDGF Inhibitors
			Long-Term Outcomes With Anti-VEGF Therapy
	Conclusions
	Key References
	References
6.30 Secondary Causes of Choroidal Neovascularization
	Key Features
	Associated Feature
	Traumatic Ruptures of Bruch’s Membrane
		Treatment
	Angioid Streaks
		Treatment
	Pathological Myopia
		Treatment
	Inflammatory Disorders
	Key References
	References
6.31 Central Serous Chorioretinopathy
	Key Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Systemic Associations
	Pathology
	Treatment
	Course and Outcome
	Key References
	References
6.32 Macular Hole
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
		Gass Stage 1 Macular Hole
		Gass Stage 2 Macular Hole
		Gass Stage 3 Macular Hole
		Gass Stage 4 Macular Hole
			Vitreomacular Adhesion
			Vitreomacular Traction
		Full-Thickness Macular Hole
		Lamellar Macular Hole
		Pseudo-Macular Hole
		“Stage 0” Macular Hole
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Pathology
	Treatment
	Course and Outcome
	Key References
	References
6.33 Epiretinal Membrane
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Pathology
	Treatment
	Course and Outcomes
	Key References
	References
6.34 Vitreomacular Traction
	Key Features
	Associated Features
	Introduction
	Natural History of Vitreomacular Traction
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Pathology
	Treatment
		Vitrectomy
		Pharmacological Vitreolysis
		Pneumatic Vitreolysis
	Conclusions
	Key References
	References
6.35 Cystoid Macular Edema
	Key Features
	Associated Features
	Introduction
	Pathogenesis and Etiology
		Vascular
		Postoperative
		Uveitis-Related
		Medication-Related
		Retinal Dystrophies
		Tractional Causes
		Anatomical
		Intraocular Neoplasms
	Diagnosis and Ancillary Testing
		Fundoscopy
		Optical Coherence Tomography
		Autofluorescence
		Fluorescein Angiography
	Treatment
		Vascular
			Diabetic Macular Edema (See Chapter 6.22, Diabetic Retinopathy)
			Retinal Venous Occlusive Disease (See Chapter 6.20, Venous Occlusive Disease of the Retina)
				Branch Retinal Vein Occlusion
				Central Retinal Vein Occlusion
			Macroaneurysms (See Chapter 6.28, Retinal Arterial Macroaneurysms)
			Juxtafoveal Retinal Telangiectasias (See Chapter 6.25, Coats’ Disease and Retinal Telangiectasia)
			Radiation Retinopathy (See Chapter 6.26, Radiation Retinopathy and Papillopathy)
			Age-Related Macular Degeneration (See Chapter 6.29, Age-Related Macular Degeneration)
		Postoperative
		Inflammatory (See Part 7: Uveitis and Other Intraocular Inflammations)
		Medication Induced (See Chapter 6.45, Retinal Toxicity of Systemically Administered Drugs)
		Retinal Dystrophy (See Chapter 6.14, Progressive and ‘Stationary’ Inherited Retinal Degenerations)
		Tractional (See Chapter 6.32, Macular Hole, Chapter 6.33, Epiretinal Membrane, Chapter 6.34, Vitreomacular Traction Syndrome)
		Anatomical Abnormalities (See Chapter 6.36, Coexistent Optic Nerve and Macular Abnormalities)
		Neoplastic (See Part 8: Intraocular Tumors)
	Conclusions
	Key References
	References
6.36 Coexistent Optic Nerve and Macular Abnormalities
	Key Features
	Associated Features
	Introduction
	Congenital Anomalies of the Optic Disc
		Congenital Optic Disc Pit
		Morning Glory Optic Disc Anomaly
		Optic Nerve Coloboma
		Treatment of Retinal Detachments Secondary to Congenital Anomalies of the Optic Disc
	Other Optic Nerve Abnormalities Associated With Macular Pathology
		Optic Nerve Abnormalities Associated With Choroidal Neovascularization
		Abnormalities Associated With Exudation
	Key References
	References
6.37 Peripheral Retinal Lesions
	Key Features
	Associated Features
	Introduction and Anatomy
		Ora Serrata
		Vitreous Base
	Ocular Manifestations and Diagnosis of Peripheral Retinal Lesions
		Meridional Folds or Radial Folds
		Pars Plana Cysts
		Ora Serrata Pearls
		Degenerative Adult Retinoschisis
		Congenital X-Linked Retinoschisis
		Paving Stone Degeneration
		Lattice Degeneration and Retinal Breaks
	Key References
	References
6.38 Retinal Breaks
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
		Retinal Tears
		Round Holes With Opercula
		Round Holes Without Opercula (Atrophic Holes)
		Traumatic Retinal Breaks
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Systemic Associations
	Treatment of Retinal Breaks
		Cryopexy
		Photocoagulation
		Anesthesia
	Course and Outcome
	Key References
	References
6.39 Rhegmatogenous Retinal Detachment
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
		Factors Causing Retinal Detachment
			Retinal Breaks
			Vitreous Liquefaction and Detachment
			Traction on the Retina
			Liquid Currents
		Conditions Predisposing an Eye to Retinal Detachment
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Pathology
	Treatment
	Course and Outcome
	Key References
	References
6.40 Serous Detachments of the Neural Retina
	Key Features
	Associated Features
	Introduction
	Pathophysiology
	Alterations in Choroidal Flow
		Idiopathic Central Serous Chorioretinopathy
		Tumors of the Choroid and Retina
		Systemic Disease With Disrupted Choroidal Blood Flow
		Vasculitis and Autoimmune Disease
	Poor Scleral Outflow
		Nanophthalmos and Uveal Effusion Syndrome
		Posterior Scleritis
	Breakdown of the RPE and Retina
		Vogt–Koyanagi–Harada Disease, Sympathetic Ophthalmia, and Sarcoidosis
		Infectious Diseases
		Retinal Vascular Diseases
	Miscellaneous
	Diagnostic and Ancillary Testing
		Diagnostic Ultrasonography
		Optical Coherence Tomography
		Fluorescein Angiography and Indocyanine Green Angiography
		Optical Coherence Tomography Angiography
		Computed Tomography and Magnetic Resonance Imaging
	Differential Diagnosis
	Treatment
	Course and Outcome
	Key References
	References
6.41 Choroidal Hemorrhage
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Treatment
		Primary Management
		Secondary Management
		Choroidal Hemorrhage in Trauma
		Choroidal Hemorrhage in Other Conditions
	Course and Outcome
	Key References
	References
6.42 Proliferative Vitreoretinopathy
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Systemic Associations
	Pathology
	Treatment
	Course and Outcome
	Key References
	References
6.43 Posterior Segment Ocular Trauma
	Key Features
	Associated Features
	Introduction
	Ocular Manifestations and Clinical Examination
		History
		Clinical Examination
		Ancillary Testing
	Nonpenetrating Trauma
		Commotio Retinae
		Choroidal Rupture
		Traumatic Macular Hole
		Chorioretinitis Sclopetaria
		Retinal Tear
		Retinal Detachment
		Retinal Dialysis
		Retinal Pigment Epithelium Contusion/Traumatic Choroidopathy
		Macular Hemorrhage
		Optic Nerve Avulsion
	Penetrating Trauma
		Initial Closure
	Intraocular Foreign Bodies
		Metallosis
		Secondary Infection
		Rehabilitation: Secondary Surgical Timing
		Rehabilitation: Surgical Technique
		Traumatic Endophthalmitis
	Course and Outcome
		Prognosis
		Sympathetic Ophthalmia
		Additional Considerations
	Key References
	References
6.44 Distant Trauma With Posterior Segment Effects
	Terson Syndrome
		Key Features
		Associated Features
	Purtscher Retinopathy
		Key Features
		Associated Features
	Shaken Baby Syndrome
		Key Features
		Associated Features
	Terson Syndrome
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Differential Diagnosis
		Treatment and Outcome
	Purtscher Retinopathy
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Systemic Associations
		Pathology
		Treatment and Course
	Shaken Baby Syndrome
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Differential Diagnosis
		Pathology
		Treatment, Course, and Outcome
	Miscellaneous Conditions
		Whiplash Injury
		Fat Embolism Syndrome
		Valsalva Retinopathy
	Key References
	References
6.45 Retinal Toxicity of Systemically Administered Drugs
	Key Features
	Associated Features
	Introduction
	Chloroquine and Hydroxychloroquine
	Sildenafil
	Thioridazine
	Niacin
	Canthaxanthine
	Tamoxifen
	Fingolimod
	Paclitaxel
	Deferoxamine
	Didanosine
	Clofazimine
	Thiazolidinediones
	Imatinib
	Mitogen-Activated Protein Kinase Inhibitors and Immune Checkpoint Inhibitors
	Key References
	References
7.1 Anatomy of the Uvea
	Key Feature
	Associated Features
	Introduction
	Iris
	Ciliary Body
	Choroid
	Key References
	References
7.2 Mechanisms of Uveitis
	Key Feature
	Associated Features
	Introduction
	Innate and Adaptive Immunities
	Cells of the Immune System
		Nonlymphocytic Leukocytes
		B Cells
		T Cells
		Mast Cells
		NK and NK T Cells
		Antigen-Presenting Cells
	Molecules of the Immune System Involved in Uveitis
		Antibodies
		Cytokines
		Chemokines and Chemokine Receptors
		Adhesion Molecules
		Other Molecules
	Tolerance and Autoimmunity
		Central Tolerance
		Peripheral Tolerance
		Ignorance
	Mechanisms That Trigger and Promote Uveitogenic Processes
		Genetic Background
		Trauma
		Microbial Infection
	Mechanisms of Inflammation
		Types of Immunopathogenic Processes
	Immunopathogenic Processes of Uveitis in Humans
	Mechanisms That Inhibit Inflammation in the Eye
	Key References
	References
7.3 General Approach to the Uveitis Patient and Treatment Strategies
	Key Feature
	Associated Features
	Introduction
	Classification
	Epidemiology
	Ocular Manifestations
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Treatment
		Mydriatic and Cycloplegic Agents
		Nonsteroidal Anti-inflammatory Drugs
		Corticosteroids
			Topical
			Periocular
			Intravitreal
			Systemic
		Immunosuppressive Therapy
	Course and Outcome
	Key References
	References
7.4 Herpetic Viral Uveitis
	Herpes Simplex and Varicella Zoster
		Herpetic Anterior Uveitis
	Key Features
	Associated Features
	Varicella-Zoster and Herpes Simplex Virus–Induced Acute Retinal Necrosis
	Key Features
	Associated Features
	Progressive Outer Retinal Necrosis
	Key Features
	Associated Features
	Herpes Simples Virus and Varicella-Zoster Virus
		Introduction
		Epidemiology and Pathogenesis
		Ocular Presentation
		Differential Diagnosis
		Pathology
		Treatment
		Course and Outcome
	Cytomegalovirus
		Cytomegalovirus Retinitis
		Key Features
		Associated Features
		Cytomegalovirus-Associated Anterior Uveitis
		Key Features
		Associated Features
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Pathology
		Treatment
		Course and Outcome
	Epstein–Barr Virus
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Differential Diagnosis
		Treatment and Outcome
	Key References
	References
7.5 Nonherpetic Viral Infections
	Key Features
	West Nile Virus
		Introduction
		Epidemiology
		Ocular Manifestations
		Diagnosis
		Treatment
	Chikungunya
		Introduction
		Epidemiology
		Ocular Manifestations
		Diagnosis
		Treatment
	Zika
		Introduction
		Epidemiology
		Ocular Manifestations
		Diagnosis
		Treatment
	Ebola
		Introduction
		Epidemiology
		Ocular Manifestations
		Diagnosis
		Treatment
	Human T-Cell Lymphotropic Virus Type I
		Introduction
		Epidemiology/Pathogenesis
		Ocular Manifestations
		Diagnosis
		Treatment
	Measles Virus
		Introduction
		Epidemiology/Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Pathology
		Treatment
	Rubella Virus
		Summary
	Key References
	References
7.6 Syphilitic and Other Spirochetal Uveitis
	Syphilitic Uveitis
		Key Features
		Associated Features
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcome
	Lyme Disease
		Key Features
		Associated Features
		Introduction
		Epidemiology and Pathogenesis
		Systemic Associations
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Pathology
		Treatment
		Course and Outcome
	Leptospirosis
		Key Features
		Associated Feature
		Introduction
		Epidemiology and Pathogenesis
		Systemic Manifestations
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Treatment
		Course and Outcome
	Key References
	References
7.7 Tuberculosis, Leprosy, and Brucellosis
	Key Ocular Features
		Tuberculous Uveitis
		Leprosy Uveitis
		Brucellosis Uveitis
	Associated Systemic Features
	Tuberculosis
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
			Anterior Uveitis
			Intermediate Uveitis
			Posterior and Pan-Uveitis
		Diagnosis
		Pathology
		Treatment
	Leprosy
		Introduction
		Epidemiology
		Systemic Manifestations and Pathogenesis of Ocular Disease
		Clinical Presentation
		Diagnosis
		Treatment
	Brucellosis
		Introduction
		Systemic Manifestations
		Ocular Manifestations
		Diagnosis
		Treatment
	Acknowledgements
	Key References
	References
7.8 Bartonella-Related Infectious Uveitis (Cat Scratch Disease) and Whipple’s Disease
	Key Features
		Cat Scratch Disease
		Whipple’s Disease
	Introduction
	Cat Scratch Disease: Bartonella Henselae–Associated Uveitis
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Imaging
		Differential Diagnosis
		Pathology
		Treatment
	Whipple’s Disease: Tropheryma Whipplei–Associated Uveitis
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Pathology
		Treatment
	Key References
	References
7.9 Infectious Endophthalmitis
	Key Features
	Associated Features
	Introduction
	Epidemiology and Risk Factors
		Exogenous Endophthalmitis
			Trauma
			Cataract Surgery
			Penetrating Corneal Surgery
			Glaucoma Filtration Procedures
			Vitrectomy
			Intravitreal Injections
			Endogenous Endophthalmitis
	Pathology and Pathogenesis
	Clinical Presentation and Evaluation
	Microbiological Testing
	Differential Diagnosis
	Treatment
		Medications
		Surgical Intervention
	Outcomes
	Conclusions
	Key References
	References
7.10 Histoplasmosis
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Pathology
	Treatment
	Course and Outcome
	Key References
	References
7.11 Fungal Endophthalmitis
	Key Features
	Associated Features
		Candidal Intraocular Infection
		Aspergillus Endogenous Endophthalmitis
		Coccidioidal Intraocular Inflammation
	Candida
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Histopathology
	Aspergillus
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Histopathology
	Fusarium
		Epidemiology and Pathogenesis
		Ocular Manifestations
	Coccidioides Immitis—Ocular Coccidioidomycosis
	Cryptococcal Endophthalmitis
	Histoplasma Endophthalmitis
		Diagnosis of Fungal Endophthalmitis
		Differential Diagnosis
		Treatment of Fungal Endophthalmitis
		Course and Outcome
	Key References
	References
7.12 Ocular Toxoplasmosis
	Key Features
	Associated Features
	Introduction
	Organism and Life Cycle
	Epidemiology
	Pathology and Pathogenesis
	Clinical Manifestations
		Systemic Disease
		Ocular Disease
	Diagnosis
	Differential Diagnosis
	Therapy
	Course and Prognosis
	Key References
	References
7.13 Posterior Parasitic Uveitis
	Key Features
	Introduction
	Ocular Cysticercosis
		Clinical Presentation
		Treatment
	Ocular Toxocariasis
		Chronic Endophthalmitis
		Posterior Pole Granuloma
		Peripheral Granuloma
		Atypical Presentations
		Differential Diagnosis
		Ancillary Testing
		Treatment
	Onchocerciasis
	Gnathostomiasis
	Diffuse Unilateral Subacute Neuroretinitis
	Amebiasis
	Giardiasis
	Malaria
	Leishmaniasis
		Ocular Manifestation
	Pediatric Presumed Trematode Infection
	Ophthalmomyiasis
	Acknowledgement
	Key References
	References
7.14 Uveitis Related to HLA-B27 and Juvenile Idiopathic Arthritis–Associated Uveitis
	Uveitis Related to HLA-B27
		Key Features
		Associated Features
	Juvenile Idiopathic Arthritis-Associated UveiTIS
		Key Features
		Associated Features
	Uveitis Related to HLA-B27
		Introduction
		Pathogenetic Mechanisms
		Clinical Features and Laboratory Investigations
		Associated Systemic Disease
		Treatment and Prevention
	Juvenile Idiopathic Arthritis
		Introduction
		Pathogenetic Mechanisms
		Clinical Picture
		Uveitis in JIA
		Risk Factors
		Clinical Picture
		Complications and Prognosis
		Management
		Management of Complications
		Outcomes
		Screening
	Key References
	References
7.15 Sarcoidosis
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Systemic Associations
	Pathology
	Treatment
	Course and Outcome
	Key References
	References
7.16 Behçet’s Disease
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Systemic Associations
	Pathology
	Treatment
		Corticosteroids
		Immunophilin Ligands
		Cytotoxic Agents
		Biological Agents
	Course and Outcome
	Key References
	References
7.17 Vogt–Koyanagi–Harada Disease
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
		Prodromal Phase
		Uveitic Phase
		Chronic and Recurrent Phases
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Systemic Associations
		Auditory Signs
		Neurological Signs
		Dermal Signs
		Other Signs
	Pathology
		Uveitic Phase
		Chronic and Recurrent Phases
	Treatment
	Course and Outcome
	Key References
	References
7.18 Phacogenic Uveitis
	Key Feature
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Pathology
	Treatment
	Course and Outcome
	Key References
	References
7.19 Sympathetic Uveitis
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Systemic Associations
	Pathology
	Prevention
	Treatment
	Course and Outcome
	Key References
	References
7.20 Idiopathic and Other Anterior Uveitis Syndromes
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Pathology
	Treatment
	Fuchs’ Heterochromic Iridocyclitis
	Posner–Schlossman Syndrome
	Drug-Induced Anterior Uveitis
	Schwartz–Matsuo Syndrome
	Ellingson Syndrome
	Key References
	References
7.21 Pars Planitis and Other Intermediate Uveitis
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Findings and Complications
	Diagnosis
	Management
		Medical Management
		Surgical Management
	Prognosis
	Key References
	References
7.22 Posterior Uveitis of Unknown Cause—White Spot Syndromes
	Key Feature
	Associated Features
	Introduction
	Birdshot Chorioretinopathy
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Treatment
		Course and Outcome
	Acute Posterior Multifocal Placoid Pigment Epitheliopathy
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcomes
	Serpiginous Choroiditis
		Epidemiology
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Pathology
		Treatment
		Course and Outcomes
	Relentless Placoid Chorioretinitis
		Epidemiology
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Treatment
		Course and Prognosis
	Persistent Placoid Maculopathy
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Differential Diagnosis
		Treatment
		Course and Outcome
	Multifocal Choroiditis/Punctate Inner Choroidopathy
		Epidemiology
		Ocular Manifestations
		Diagnosis
		Systemic Associations
		Course and Outcomes
		Differential Diagnosis
		Treatment
	Multiple Evanescent White Dot Syndrome
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Course and Outcomes
	Acute Zonal Occult Outer Retinopathy
		Epidemiology
		Ocular Manifestations and Diagnosis
		Differential Diagnosis
		Course and Outcome
	Acute Macular Neuoretinopathy
		Epidemiology and Pathogenesis
		Diagnosis
		Differential Diagnosis
		Course and Outcomes
	Acknowledgment
	Key References
	References
7.23 Masquerade Syndromes
	Key Features
	Associated Features
	Introduction
	Primary Neoplasms
		Primary Intraocular (Vitreoretinal) Lymphoma
			Diagnosis
			Treatment
		Primary Choroidal Lymphomas and Lymphoid Hyperplasia
		Melanoma
		Other Primary Neoplasms
	Secondary Neoplasms and Metastases
		Lymphoma and Leukemia
		Metastatic Carcinoma
		Metastatic Melanoma
		Paraneoplastic Syndromes
	Conclusions
	Key References
	References
8.1 Malignant Intraocular Neoplasms
	Key Features
	Introduction
	Primary Malignant Intraocular Neoplasms
		Retinoblastoma
		Primary Uveal Melanoma
			Primary Anterior Uveal Melanoma
			Primary Posterior Uveal Melanoma
			Primary Intraocular Lymphoma
			Primary Vitreoretinal Lymphoma
			Primary Uveal Lymphoma
		Medulloepithelioma
		Adenocarcinomas of Intraocular Neuroectodermal Epithelial Layers
	Primary Nonophthalmic Malignant Neoplasms Metastatic to the Eye
	Secondary Malignant Intraocular Neoplasms
	Hematological Neoplasias Involving the Eyes
	Key References
	References
8.2 Benign Intraocular Neoplasms, Hamartomas, and Choristomas
	Key Features
	Introduction
	Benign Intraocular Neoplasms
		Uveal Nevus
			Anterior Uveal Nevus
			Posterior Uveal Nevus
	Retinal Astrocytoma
	Retinal Capillary Hemangioma
		Uveal Leiomyoma
		Uveal Neurilemoma
	Adenomas of Intraocular Neuroectodermal Epithelial Tissues
	Intraocular Hamartomas
		Circumscribed Choroidal Hemangioma
		Combined Hamartoma of the Retina
	Intraocular Choristomas
	Benign Cellular Tumors of Uncertain Category
		Choroidal Osteoma
	Key References
	References
8.3 Non-Neoplastic Intraocular Lesions and Disorders Simulating Malignant Intraocular Neoplasms
	Key Features
	Introduction
	Non-Neoplastic Lesions and Disorders Simulating Malignant Intraocular Neoplasms of the Anterior Ocular Segment
		Neuroepithelial Cysts of Iris and Ciliary Body
		Epithelial Inclusion Cyst of Iris
		Anterior Scleral Staphyloma
		Iridocorneal Endothelial Syndrome
		Inflammatory Tumor of Iris or Ciliary Body
		Iris Foreign Body
		Advanced Cataract Simulating Ciliary Body Melanoma on B-Scan Ultrasonography
	Non-Neoplastic Lesions and Disorders Simulating Malignant Intraocular Neoplasms of the Posterior Ocular Segment Other Than Retinoblastoma
		Congenital Hypertrophy of Retinal Pigment Epithelium
		Focal Retinal Pigment Epithelial Hyperplasia
		Spontaneous Subretinal Hematomas
		Localized Suprachoroidal Hematoma
		Acquired Nonfamilial Retinal Hemangiomatous Lesion
		Nodular Posterior Scleritis
		Bilateral Diffuse Uveal Melanocytic Proliferation Associated With Systemic Carcinoma
		Vortex Vein Varicosity
		Orbital Tumor Indenting Eye Wall
		Sclerochoroidal Calcification
		Endogenous Microbial Subretinal Abscess
		Atypical Retinal Pigment Epithelial Detachment
		Bullous Central Serous Chorioretinopathy
		Ciliochoroidal Effusion and Idiopathic Uveal Effusion Syndrome
		Multifocal Best Vitelliform Retinal Dystrophy and Vitelliform Paraneoplastic Retinopathy
		Massive Gliosis of Retina
		Inflammatory Chorioretinal Granuloma
		Harada’s Disease
		Idiopathic Uveitis in the Elderly
		Vitiliginous (Birdshot) Choroiditis
		Endogenous Endophthalmitis
	Non-Neoplastic Intraocular Lesions and Disorders Simulating Intraocular Retinoblastoma
	Non-Neoplastic Lesions and Disorders Simulating Intraretinal Retinoblastoma
		Vitreoretinal Toxocara Granuloma
		Extensive Myelination of Retinal Nerve Fiber Layer
		Chorioretinal Coloboma
		Toxoplasmic Retinitis
		Focal Retinal Gliosis
	Lesions and Disorders Simulating Exophytic Retinoblastoma
		Advanced Coats’ Disease
		Persistent Hyperplastic Primary Vitreous (Persistent Fetal Vasculature)
		Congenital Retinal Dysplasia
		Advanced Retinopathy of Prematurity (Retrolental Fibroplasia)
		Advanced Familial Exudative Vitreoretinopathy (Fev)
		Advanced Incontinentia Pigmenti Retinopathy
	Lesions and Disorders Simulating Endophytic Retinoblastoma
		Pars Planitis (Intermediate Uveitis)
	Endogenous Endophthalmitis Simulating Endophytic Retinoblastoma
	Key References
	References
8.4 Phakomatoses
	Key Features
	Introduction
	Neurofibromatosis
		Epidemiology and Pathogenesis
		Extraophthalmic Manifestations
		Ocular Manifestations
		Systemic Manifestations
		Treatment
		Course and Outcomes
	Tuberous Sclerosis
		Epidemiology and Pathogenesis
		Extraophthalmic Manifestations
		Ocular Manifestations
		Systemic Evaluation
		Treatment
		Course and Outcome
	Von Hippel–Lindau Syndrome
		Epidemiology and Pathogenesis
		Extraophthalmic Manifestations
		Ocular Manifestations
		Systemic Evaluation
		Treatment
		Course and Outcomes
	Sturge–Weber Syndrome
		Epidemiology and Pathogenesis
		Extraophthalmic Manifestations
		Ocular Manifestations
		Systemic Evaluation
		Treatment
		Course and Outcome
	Wyburn–Mason Syndrome
		Epidemiology and Pathogenesis
		Extraophthalmic Manifestations
		Ocular Manifestations
		Systemic Evaluation
		Treatment
		Course and Outcomes
	Key References
	References
9.1 Principles of Imaging in Neuro-Ophthalmology
	Key Features
	Introduction
		Ophthalmologist’s Role in Neuroimaging
	Computed Tomography
		Principles
		Clinical Applications
		Safety
	Magnetic Resonance Imaging
		Principles
		Imaging Parameters
			T1 and T2
			TR and TE
		Special Sequences and Techniques in the Production of an Image
			Spin Echo, Gradient-Echo, Fluid-Attenuated Inversion Recovery, and Fat Suppression
			Diffusion-Weighted Imaging
			Contrast Enhancement
			Surface and Head Coils
			Magnetization Transfer Imaging
		Safety
	Angiography
		Magnetic Resonance Angiography
			Principles
			Clinical Applications of MRA
		Computed Tomographic Angiography
			Principles
			Clinical Applications
		CTA Versus MRA
		Conventional Angiography
			Principles
		Ultrasonography
			Principles
	Functional Imaging
		Positron Emission Technology and Single-Photon Emission Computed Tomography
			Principles
			Clinical Applications
		Magnetic Resonance Spectroscopy
			Principles
		Functional Magnetic Resonance Imaging
			Principles
	Imaging Strategies in Neuro-Ophthalmology
	Key References
	References
9.2 Optical Coherence Tomography in Neuro-Ophthalmology
	Key Features
	Introduction
	OCT Interpretation
		Peripapillar Retinal Nerve Fiber Layer
		Macular Ganglion Cells Layer
		Microcystic Inner Nuclear Layer Abnormalities
	Papilledema
		Nonarteritic Ischemic Optic Neuropathy
	Compressive Optic Neuropathy
		Transsynaptic Retrograde Degeneration in Homonymous Hemianopia
	Multiple Sclerosis
		OCT and Brain Atrophy
		Neuromyelitis Optica
	Neurodegenerative Diseases
		Parkinson’s Disease
		Alzheimer’s Disease
		Friedreich’s Ataxia and Other Rare Neurological Syndromes
	Hereditary Optic Neuropathies
		Leber’s Hereditary Optic Neuropathy
		Dominant Optic Atrophy
			Nutritional and Toxic Optic Neuropathies
				Optical Coherence Tomography Angiography
	Key References
	References
9.3 Anatomy and Physiology
	Key Features
	Historical Review
	General Anatomy
	Constituent Elements
		Axons
		Glia
	Four Portions of the Optic Nerve
		Optic Disc
		Intraorbital Optic Nerve
		Intracanalicular Optic Nerve
		Intracranial Optic Nerve
	Circulation of the Optic Nerve
	Key References
	References
9.4 Differentiation of Optic Nerve From Macular Retinal Disease
	Key Features
	Diagnostic Features
	Introduction
	Ocular Features
	Diagnosis and Ancillary Testing
		History
		Physical Examination
		Ancillary Testing
	Key References
	References
9.5 Congenital Optic Disc Anomalies
	Key Feature
	Associated Feature
	Introduction
		Age Association
		Central Nervous System Malformations
	Optic Nerve Hypoplasia
	Morning Glory Disc Anomaly
	Optic Disc Coloboma
	Optic Pit
	Megalopapilla
	Congenital Tilted Disc Syndrome
	Congenital Optic Disc Pigmentation
	Aicardi Syndrome
	Key References
	References
9.6 Papilledema and Raised Intracranial Pressure
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis and Testing
	Differential Diagnosis
		Compressive Optic Neuropathies
		Papillitis
		Anterior Ischemic Optic Neuropathy
		Central Retinal Vein Occlusion
		Diabetic Papillopathy
		Optic Disc Vasculitis
		Other Causes
	Systemic Associations
	Pathology
	Treatment
	Course and Outcome
	Key References
	Reference
9.7 Inflammatory Optic Neuropathies and Neuroretinitis
	Key Features
	Associated Feature
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis and Ancillary Testing
	Differential Diagnosis
		Viral and Postviral Syndromes
		Sarcoidosis
		Syphilis
		Lyme Disease
		Cat Scratch Disease
		Toxoplasmosis
		Optic Neuropathy in HIV Disease
		Systemic Lupus Erythematosus and Other Vasculitides
		Neuromyelitis Optica
		Association With Multiple Sclerosis
	Pathology
	Treatment
		Other Treatments
		Management Recommendations
	Course and Outcome
	Key References
	References
9.8 Ischemic Optic Neuropathy
	Key Features
	Associated Features
	Ischemic Optic Neuropathy
		Introduction
		Anterior Ischemic Optic Neuropathy
			Epidemiology and Pathogenesis
				Arteritic Anterior Ischemic Optic Neuropathy
				Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
			Ocular Manifestations
				Arteritic Anterior Ischemic Optic Neuropathy
				Nonarteritic Anterior Ischemic Optic Neuropathy
			Diagnosis and Ancillary Testing
			Differential Diagnosis
			Systemic Associations
			Treatment
				Arteritic Anterior Ischemic Optic Neuropathy
				Nonarteritic Anterior Ischemic Optic Neuropathy
			Course and Outcome
				Arteritic Anterior Ischemic Optic Neuropathy
				Nonarteritic Anterior Ischemic Optic Neuropathy
		Posterior Ischemic Optic Neuropathy
	Diabetic Papillopathy
		Pathogenesis and Features
		Course and Outcome
	Key References
	References
9.9 Hereditary, Nutritional, and Toxic Optic Atrophies
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Systemic Associations
	Pathology
	Treatment
	Course and Outcome
	Key References
	References
9.10 Prechiasmal Pathways—Compression by Optic Nerve and Sheath Tumors
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis and Ancillary Testing
	Treatment
	Optic Nerve Compression by Optic Nerve and Sheath Tumors
		Introduction
		Gliomas and Malignant Gliomas
			Epidemiology and Pathogenesis
			Ocular Manifestations
			Diagnosis
			Differential Diagnosis
			Systemic Associations
			Pathology
			Treatment
			Course and Outcome
	Optic Nerve Sheath Meningiomas
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Pathology
		Treatment
		Course and Outcome
		Other Intracanalicular and Intracranial Compressive Lesions
	Key References
	References
9.11 Traumatic Optic Neuropathies
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Pathology
	Treatment
	Key References
	References
9.12 Lesions of the Optic Chiasm, Parasellar Region, and Pituitary Fossa
	Key Feature
	Associated Features
	Introduction
		Anatomy
	Epidemiology and Pathogenesis
		Pituitary Adenomas
		Meningiomas
		Craniopharyngiomas
		Optic Gliomas
		Other Causes of Chiasmal Syndrome
	Ocular Manifestations
		Signs and Symptoms of Chiasmal Lesions
		Signs and Symptoms of Parasellar Lesions
	Diagnosis
		Visual Field Testing
		Neuroimaging
		Other Diagnostic Testing
	Differential Diagnosis
	Systemic Associations
	Pathology
		Pituitary Adenomas
		Meningiomas
		Craniopharyngiomas
		Optic Pathway Gliomas
	Treatment, Course, and Outcome
		Pituitary Adenomas
		Surgical Treatment
		Radiation Therapy
		Meningiomas
		Craniopharyngiomas
	Optic Gliomas
	Key References
	References
9.13 Lesions of Retrochiasmal Pathways, Higher Cortical Function, and Nonorganic Visual Loss
	Key Features
	Retrochiasmal Pathways and Higher Cortical Function
		Optic Tracts
		Lateral Geniculate Bodies
		Optic Radiations
		Higher Cortical Function
		Topographical Diagnosis of Retrochiasmal Disease
	Cortical Representation of Vision
		Introduction
		Object Identification and Memory
		Reading and Dyslexia
		Color Perception
		Integration of Visual–Auditory Space
		Motion Detection
		Nonorganic Visual Loss
	Key References
	References
9.14 Disorders of Supranuclear Control of Ocular Motility
	Key Features
	Associated Features
	Introduction
	Anatomy of Eye Movement
		Anatomy of Supranuclear Eye Movement Control
		Horizontal Eye Movements
		Vertical Eye Movements
		Slow Eye Movements
		Pursuit Eye Movements
		Vestibular System
		Optokinetic System
		Vergence System
	Diagnostic Testing
		Saccades
		Fixation
		Pursuit
		Vergence Eye Movements
		Ocular Alignment
		Differentiating Supranuclear From Nuclear and Infranuclear Lesions
			Oculocephalic (Doll’s Eyes) Reflex
			Vestibulo–Ocular Reflex Testing
	Disorders of Supranuclear Ocular Motility
		Congenital Gaze Palsies
		Acquired Gaze Palsies
		Disorders of Pursuit
		Internuclear Ophthalmoplegia
		Disorders of Vertical Gaze
	Ocular Motility Disorders and the Cerebellum
	Ocular Motility Disorders and the Vestibular System
	Vergence Disorders
	Development of the Ocular Motor System
		Transient Ocular Motility Abnormalities in Infancy
	Key References
	References
9.15 Nuclear and Fascicular Disorders of Eye Movement
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
		Palsies of the Third Cranial Nerve
		Third Cranial Nerve Nuclear Lesions
		Third Cranial Nerve Fascicular Palsies
		Congenital Third Cranial Nerve Palsies
		Palsies of the Fourth Cranial Nerve
		Fourth Cranial Nerve Nuclear and Fascicular Lesions
		Palsies of the Sixth Cranial Nerve
		Sixth Cranial Nerve Nuclear Palsies
		Sixth Cranial Nerve Fascicular Palsies
	Diagnosis
		Palsies of the Third Cranial Nerve
		Palsies of the Fourth Cranial Nerve
		Palsies of the Sixth Cranial Nerve
	Treatment, Course, and Outcome
		Palsies of the Third Cranial Nerve
		Palsies of the Fourth Cranial Nerve
		Palsies of the Sixth Cranial Nerve
	Key References
	References
9.16 Paresis of Isolated and Multiple Cranial Nerves and Painful Ophthalmoplegia
	Key Features
	Associated Features
	Introduction
	Anatomy
	Ocular Manifestations
		General Symptoms
		Isolated Cranial Neuropathies
			Isolated Sixth Cranial Nerve Palsy
			Isolated Fourth Cranial Nerve Palsy
			Isolated Third Cranial Nerve Palsy
			Divisional Third Cranial Nerve Palsy
		Nonisolated Cranial Neuropathies
			Multiple Cranial Neuropathies
				Bilateral Ophthalmoplegia
				Subarachnoid Involvement
			Nonisolated Third Cranial Nerve Palsies
	Diagnosis
		Isolated Cranial Neuropathies
			Isolated Sixth Cranial Nerve Palsy
			Isolated Fourth Cranial Nerve Palsy
			Isolated Third Cranial Nerve Palsy
		Nonisolated Cranial Neuropathies
			Multiple Cranial Neuropathies
				Bilateral Ophthalmoplegia
	Differential Diagnosis
		Isolated Cranial Neuropathies
			Isolated Sixth Cranial Nerve Palsy
			Isolated Fourth Cranial Nerve Palsy
			Isolated Third Cranial Nerve Palsy
		Nonisolated Cranial Neuropathies
	Treatment
		Nonisolated Cranial Neuropathies
	Key References
	References
9.17 Disorders of the Neuromuscular Junction
	Key Feature
	Associated Features
	Myasthenia Gravis
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Systemic Associations
		Treatment
		Course and Outcome
	Botulism
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Systemic Associations
		Treatment
	Lambert–Eaton Myasthenic Syndrome
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Systemic Associations
		Treatment
		Course and Outcome
	Key References
	References
9.18 Ocular Myopathies
	Key Features
	Associated Features
	Introduction
	Mitochondrial Myopathies
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcome
	Dystrophic Myopathies
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcome
	Inflammatory and Infiltrative Myopathies
		Epidemiology and Pathogenesis
			Orbital Myositis
		Ocular Manifestations
		Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcome
	Key References
	References
9.19 Nystagmus, Saccadic Intrusions, and Oscillations
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
		Congenital Nystagmus
		Latent and Manifest Latent Nystagmus
			Spasmus Nutans
		Vestibular Nystagmus
		Peripheral Vestibular Nystagmus
		Central Vestibular Nystagmus
		Positional Vestibular Nystagmus
		Benign Paroxysmal Positional Nystagmus
		Gaze-Evoked Nystagmus
		Rebound Nystagmus
		Alternating Nystagmus
		Upbeat Nystagmus
		Downbeat Nystagmus
		Dissociated Nystagmus
			Acquired Pendular Nystagmus in Adults
			Monocular Visual Loss and Bilateral Visual Loss
			See-Saw Nystagmus
			Abducting Nystagmus in Internuclear Ophthalmoplegia
		Ocular Bobbing
		Saccadic Intrusions
			Superior Oblique Myokymia
		Convergence–Retraction Nystagmus and Convergence Nystagmus
			Square-Wave Jerks
			Macrosquare-Wave Jerks
			Macrosaccadic Oscillations
			Voluntary “Nystagmus”
			Saccadic Pulses
			Ocular Flutter
			Opsoclonus
	Treatment
		Drug Treatment
		Optical Treatment
		Surgical Treatment
		Other Treatments
	Key References
	References
9.20 Pupillary Signs of Neuro-Ophthalmic Disease
	Key Features
	Associated Features
	Introduction
	Relative Afferent Pupillary Defects
	Efferent Pupillary Defects
		Anisocoria
		Pupillary Inequality That Increases in the Dark
			Physiological Anisocoria
			Horner’s Syndrome
			Diagnosis of Horner’s Syndrome—Cocaine and Apraclonidine Pharmacological Testing
			Location of Damage to the Sympathetic Pathway
			Horner’s Syndrome in Children and Infants
		Pupillary Inequality That Increases With Light
			Slit-Lamp Examination of the Iris
			No or Little Residual Light Reaction
			Segmental Paralysis of the Iris Sphincter
			Pupillary Supersensitivity to Cholinergic Drugs
			Pupillary Undersensitivity to a Miotic Dose of Pilocarpine
		Tonic Pupil of Adie’s Syndrome
		Third Nerve Palsy
		Aberrant Regeneration of the Third Cranial Nerve
	Poor Pupil Dilation
	Retinal Origin of the Pupil Light Reflex—The Melanopsin-Containing Retinal Ganglion Cell
	Key References
	References
9.21 Presbyopia and Loss of Accommodation
	Key Feature
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Treatment
	Key References
	References
9.22 Headache and Facial Pain
	Key Features
	Associated Feature
	Introduction
		The Art and Science of Taking a Headache History
		Basic Outline of the Headache History
			Date of Onset, Age at Onset, and Frequency of Symptoms
			Location
			Duration
			Predisposing Factors
			Preceding Symptoms
			Quality and Severity of Pain
			Accompanying Symptoms
	Differential Diagnosis of Headache Syndromes
		Migraine
			Epidemiology of Migraine
			Clinical Features of Various Migraine Syndromes
				Migraine Without Aura (Previously Termed Common Migraine)
				Migraine With Aura (Previously Termed Classic Migraine)
				Structural Lesions That Mimic Migraine With Aura
				Recurrent Painful Ophthalmoplegic Neuropathy (Previously Termed Ophthalmoplegic Migraine)
				Retinal Migraine
			Pathogenesis of Migraine
				Treatment of Migraine With Aura and Migraine Without Aura
		Tension-Type Headache
		Cluster Headache
		Paroxysmal Hemicrania
		Temporal Arteritis
		Headache as a Result of Intracranial Processes
	Differential Diagnosis of Facial Pain
		Headache Attributed to Disorders of the Nose or Paranasal Sinuses (Previously Termed Sinus Headache)
		Orbital Inflammation and Neoplasia
		Classic Trigeminal Neuralgia (Previously Termed Tic Douloureux)
		Paratrigeminal Oculosympathetic (Raeder’s) Syndrome
		Primary Stabbing Headache (Ice-Pick Headaches, Jabs and Jolts Syndrome)
	Key References
	References
9.23 Tumors, Infections, Inflammations, and Neurodegenerations
	Key Features
	Associated Features
	Tumors
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Pathology
		Treatment
		Course and Outcome
	Infections
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Testing
		Pathology
		Treatment
		Course and Outcome
	Inflammations
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Systemic Necrotizing Vasculitides
		Diagnosis and Testing
		Pathology
		Treatment
		Course and Outcome
	Neurodegenerations
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
			Cerebellar Neurodegenerative Diseases
			Parkinsonism
			Progressive Supranuclear Palsy
			Chorea
			Dementias With Eye Findings
				Alzheimer’s Disease
				Charles Bonnet’s Syndrome
			Cerebrovascular Diseases
			Dementia Complex Associated With HIV
			Prion Diseases
		Diagnosis and Testing
		Pathology
		Treatment
		Course and Outcome
	Key References
	References
9.24 Urgent Neuro-Ophthalmic Disorders
	Key Features
	Introduction
	Epidemiology and Pathogenesis
		Giant Cell Arteritis
		Aneurysm
		Cavernous Sinus Thrombosis
		Orbital Apex Syndrome
		Pituitary Apoplexy
	Ocular Manifestations
		Giant Cell Arteritis
		Aneurysm
		Cavernous Sinus Thrombosis
		Orbital Apex Syndrome
		Pituitary Apoplexy
	Diagnosis and Ancillary Testing
		Giant Cell Arteritis
		Aneurysm
		Cavernous Sinus Thrombosis and Orbital Apex Syndrome
		Pituitary Apoplexy
	Differential Diagnosis
		Giant Cell Arteritis
		Aneurysm
		Cavernous Sinus Thrombosis and Orbital Apex Syndrome
		Pituitary Apoplexy
	Pathology
		Giant Cell Arteritis
		Aneurysm
		Cavernous Sinus Thrombosis and Orbital Apex Syndrome
		Pituitary Apoplexy
	Treatment
		Giant Cell Arteritis
		Aneurysm
		Cavernous Sinus Thrombosis and Orbital Apex Syndrome
		Pituitary Apoplexy
	Course and Outcomes
		Giant Cell Arteritis
		Aneurysm
		Cavernous Sinus Thrombosis
		Orbital Apex Syndrome
		Pituitary Apoplexy
	Key References
	References
9.25 Trauma, Drugs, and Toxins
	Key Features
	Associated Features
	Trauma and the Brain
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcome
	Drugs, Toxins, and the Brain
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment, Course, and Outcome
	Key References
	References
9.26 Vascular Disorders
	Key Feature
	Associated Features
	Introduction
	Aneurysms
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
			Head Pain
			Ophthalmoplegia
			Pupillary Involvement
		Differential Diagnosis
		Treatment, Course, and Outcome
	Carotid–Cavernous Sinus Fistulas and Dural Shunts
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Differential Diagnosis
		Treatment, Course, and Outcome
		Arteriovenous Malformations
	Transient Visual Loss
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
			Nature of the Episodes
			Type of Visual Loss
			Length of Episodes
			Frequency of Episodes
			Associated Symptoms
			Underlying Risk Factors
		Treatment, Course, and Outcome
	Transient Isolated Bilateral Loss of Vision
		Aura Without Headache
	Strokes
		Epidemiology and Pathogenesis
			Transient Ischemic Attacks and Stroke
			Carotid–Ophthalmic Ischemic Attacks and Stroke
		Ocular Manifestations
	Key References
	References
9.27 Electrophysiology
	Key Features
	Introduction
	NonOrganic Vision Loss
	Optic Nerve Disease
	Key References
	References
10.1 Epidemiology of Glaucoma
	Key Features
	Introduction
	Prevalence and Rates of Associated Blindness
	Primary Open-Angle Glaucoma
		Demographic Risk Factors for Primary Open-Angle Glaucoma
			Race
			Age
			Gender
			Family History
		Ocular Risk Factors for Primary Open-Angle Glaucoma
			Intraocular Pressure
			Optic Nerve Parameters
			Nerve Fiber Layer Imaging
			Myopia
			Peripapillary Atrophy
			Corneal Thickness and Hysteresis
		Systemic Risk Factors for Primary Open-Angle Glaucoma
			Diabetes
			Hypertension
			Cigarette Smoking, Alcohol Use, and Caffeine Consumption
	Primary Angle-Closure Glaucoma
		Demographic Risk Factors for Primary Angle-Closure Glaucoma
			Race
			Gender
			Family History
		Ocular Risk Factors for Primary Angle-Closure Glaucoma
			Anterior Chamber Depth
			Anterior Segment Optical Coherence Tomography
			Limbal Anterior Chamber Depth
			Axial Length/Refractive Error
			Lens Thickness
			Radius of Corneal Curvature
		Systemic Risk Factors for Primary Angle-Closure Glaucoma
	Secondary Glaucomas
	Ocular Hypertension
	Glaucoma Suspects
	Key References
	References
10.2 Screening for Glaucoma
	Key Features
	Introduction
	Historical Review
		Screening Programs
		Prior Glaucoma Screening Efforts
		Current Definition of Open-Angle Glaucoma
	Purpose of the Test
	Utility of the Test and Interpretation of Results
	Procedure
	Complications
	Alternative Tests
		Analysis of Tests
		Telemedicine and Glaucoma Screening
		Marker Testing for Glaucoma
	Future Direction of Glaucoma Screening
	Key References
	References
10.3 Mechanisms of Glaucoma
	Key Features
	Introduction
	Physiology of Aqueous Production
		Structural and Functional Overview of Aqueous Humor Formation
		Three Steps in Aqueous Secretion
			Ion and Fluid Uptake From the Stroma
		Fluid Transfer Through Gap Junctions
		Fluid Transfer Into the Aqueous Humor
			Regulation of Net Aqueous Humor Formation
		Conclusions and Future Directions
	The Aqueous Humor Outflow Pathway
		Pathology of the Glaucomatous Outflow Pathway
		Conclusions and Future Directions
	Pathophysiology of Glaucomatous Optic Neuropathy
		Glaucomatous Neuropathy Occurs in Response to Increased Cell Stress Conditions
		Disrupted Axon Transport
		Vascular Hypothesis
		Excitotoxicity Due to Excessive Glutamate
		Oxidative Stress and Free Radical Damage
		Inflammatory Cytokines
		Aberrant Immunity
		Cellular Mechanisms of Apoptosis in Glaucoma
		Neurotrophic Factors for Survival and Growth
		Central Visual Pathway Degeneration in Glaucoma
	Conclusions and Future Directions
	Key References
	References
10.4 Clinical Examination of Glaucoma
	Key Features
	Introduction
	Obtaining Clinically Relevant Information
		Assessing the Patient’s Functional Status
		Obtaining the Patient’s History
			Medical History
			Ocular History
			Family History
			Ethnicity
	Examination Techniques
		Visual Acuity Testing
		Pupillary Response Testing
		Tonometry
			The Role of Intraocular Pressure in Glaucoma
			Applanation Tonometry
		Pachymetry
		External Examination
		Slit-lamp Examination
			Conjunctiva, Sclera, and Episclera
			Cornea
			Anterior Chamber
			Iris
			Lens
		Gonioscopy
			Estimation of the Peripheral Anterior Chamber Angle
			Principles of Gonioscopy
			Direct Gonioscopy
			Indirect Gonioscopy
			Gonioscopic Grading Systems
				Gonioscopic Anatomy of the Angle
				Shaffer System
				Spaeth System
				Occludable Angles
			Specific Findings of the Anterior Chamber Angle
		Optic Nerve Examination
	Testing for Glaucoma
	Key References
	References
10.5 Visual Field Testing in Glaucoma
	Key Features
	Associated Features
	Introduction
	Standard Automated Perimetry
		Testing Algorithms in Standard Automated Perimetry
		Visual Field Testing and Glaucoma Diagnosis
		Visual Field and Assessing the Severity of Glaucoma
		Visual Field and Assessing Progression in Glaucoma
	Key References
	References
10.6 Advanced Psychophysical Tests for Glaucoma
	Key Features
	Introduction
	Test Strategies
	Test Procedures
	Analysis Methods
	Conclusion
	Key References
	References
10.7 Optic Nerve Analysis
	Key Features
	Associated Features
	Diagnostic Technologies
	Introduction
	Normal Anatomy
	Clinical Examination: Glaucomatous Features
		Disc Cup
		Blood Vessels
		Peripapillary Atrophy
	Imaging
	Optic Disc Photography
	Confocal Scanning Laser Ophthalmoscopy
	Optical Coherence Tomography
	Conclusions
	Key References
	References
10.8 Optic Nerve Blood Flow Measurement
	Key Features
	Associated Features
	Introduction
	Applied Anatomy
	Physiology
	Experimental Investigations
	Clinical Studies
	Optical Coherence Tomography Angiography
	Retinal Oximetry
		Ocular Blood Flow and Visual Field Loss
		Systemic Vascular Disease and Glaucoma
	Pharmacology
	Statement of Disclosure
	Key References
	References
10.9 Ocular Hypertension
	Key Features
	Introduction
	Epidemiology and Pathogenesis
		Predictive Factors for Conversion of OHT to POAG
		Central Corneal Thickness
		Intraocular Pressure
		Age
		Pattern Standard Deviation
		Optic Nerve
		Optic Disc Hemorrhage
		Other Predictive Factors
	Diagnosis
	Differential Diagnosis
	Treatment
	Course and Outcome
	Key References
	References
10.10 Primary Open-Angle Glaucoma
	Key Features
	Associated Features
	Definition and Classification
	Intraocular Pressure, Risk Factors, and Aspects of Molecular Pathogenesis
	Diagnosis
	Nature of Progressive Visual Loss
		Preperimetric Glaucoma
		Threshold and Conversion
		Critical Phase
		Blindness
	Treatment and Monitoring
	Key References
	References
10.11 Normal-Tension Glaucoma
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Systemic Associations
	Treatment
		Lower Intraocular Pressure
	Course and Outcome
	Key References
	References
10.12 Angle-Closure Glaucoma
	Key Features
	Introduction
	Epidemiology and Pathogenesis
		Prevalence
		Incidence
		Risk Factors
		Pupillary Block
		Nonpupillary Block Mechanisms
		Plateau Iris Configuration
		Aqueous Misdirection
	Diagnosis
		External Examination
		Penlight Examination
		Slit-Lamp Examination
		Gonioscopy
		Other Imaging Techniques
			Ultrasound Biomicroscopy
			Anterior-Segment Optical Coherence Tomography
			Provocative Tests
	Differential Diagnosis
	Management of Acute Angle Closure
		After 1 to 2 Hours
		Later
		Even Later
	Management of Chronic Angle-Closure Glaucoma
	Management of Angle-Closure Glaucoma
		Medical Treatment
		Laser Treatment
		Surgical Treatment
			Surgical Iridectomy
			Lens Extraction
			Goniosynechialysis
			Trabeculectomy
			Glaucoma Drainage Implant
			Cyclodestructive Procedures
			Micropulse Laser
	Prognosis
	Acknowledgments
	Key References
	References
10.13 Glaucoma Associated With (Pseudo)-Exfoliation Syndrome
	Key Features
	Associated Features
	Introduction
	Epidemiology and Genetics
	Clinical Presentation and Ocular Manifestations
	Glaucoma in Exfoliation Syndrome
	Systemic Manifestations
	Differential Diagnosis
	Key References
	References
10.14 Pigmentary Glaucoma
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Differential Diagnosis
	Treatment
	Course and Outcome
	Key References
	References
10.15 Neovascular Glaucoma
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Treatment
	Course and Outcome
	Emerging Treatments
	Key References
	References
10.16 Inflammatory and Corticosteroid-Induced Glaucoma
	Key Features
	Associated Features
	Introduction
	Pathophysiology
	Mechanisms of Elevated IOP
		Secondary Open-Angle Glaucoma
		Pre-Existing Open-Angle Glaucoma
		Secondary Angle-Closure Glaucoma
		Pre-Existing Disposition to Primary Angle Closure
		Combined-Mechanism Glaucoma
	Principles of Management
	Uveitis
		Diagnosis
		Management
		Mydriasis and Cycloplegia
	Glaucoma
		Medical Management
		Surgical Management
	Specific Entities
		Glaucomatocyclitic Crisis (Posner–Schlossman Syndrome)
		Fuchs’ Uveitis Syndrome (Fuchs’ Heterochromic Iridocyclitis)
	Key References
	References
10.17 Glaucoma Associated With Ocular Trauma
	Key Features
	Associated Features
	Introduction
	Immediate or Early-Onset Glaucoma After Ocular Trauma
		Contusion
		Trabecular Disruption
		Hyphema
		Massive Choroidal Hemorrhage
		Chemical Trauma
	Late-Onset Glaucoma After Ocular Trauma
		Angle Recession
		Peripheral Anterior Synechiae
		Ghost Cell (Hemolytic) Glaucoma
		Lens-Induced Glaucoma
			Lens Dislocation
			Phacomorphic Glaucoma
			Phacolytic Glaucoma
			Phacoantigenic Glaucoma
			Lens Particle Glaucoma
		Delayed Closure of a Cyclodialysis Cleft
		Epithelial Downgrowth
		Retained Intraocular Foreign Body
		Rhegmatogenous Retinal Detachment
	Key References
	References
10.18 Glaucoma With Raised Episcleral Venous Pressure
	Key Feature
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Systemic Associations
	Treatment
	Course and Outcome
	Key References
	References
10.19 Malignant Glaucoma
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
	Ocular Manifestations
	Diagnosis
	Differential Diagnosis
	Treatment
		Medical
		Laser
		Surgery
		Fellow Eye
	Key References
	References
10.20 Glaucomas Secondary to Abnormalities of the Cornea, Iris, Retina, and Intraocular Tumors
	Key Features
	Ghost Cell Hemolytic Glaucoma
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Pathology
		Treatment
	Schwartz’s Syndrome
	Iridocorneal Endothelial Syndrome
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
			Progressive (Essential) Iris Atrophy
			Chandler’s Syndrome
			Iris–Nevus Syndrome (Cogan–Reese Syndrome)
		Pathology
		Treatment
	Axenfeld–Rieger Syndrome
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Systemic Associations
		Pathology
		Treatment
	Epithelial Downgrowth and Fibrous Ingrowth (Proliferation)
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Pathology
		Treatment
	Aniridia
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Systemic Associations
		Pathology
		Treatment
	Tumors and Glaucoma
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Pathology
		Treatment
	Penetrating Keratoplasty
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Treatment
	Alkali Chemical Trauma
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Pathology
		Treatment
	Key References
	References
10.21 Congenital Glaucoma
	Key Features
	Associated Features
	Introduction
	Epidemiology and Pathogenesis
		Primary Congenital Glaucoma (PCG)
		Glaucoma Following Cataract Surgery
		Secondary Glaucomas Associated With Ocular Anomalies or Systemic Syndromes
	Ocular Manifestations
	Diagnosis and Ancillary Testing
	Differential Diagnosis
	Classification Schemes
	Pathology
	Treatment
	Course and Outcome
	Key References
	References
10.22 When to Treat Glaucoma
	Key Features
	Introduction
	Analysis of Risk Factors
	Risk Factors
		Intraocular Pressure
			Optic Disc Characteristics
			Central Corneal Thickness and Corneal Hysteresis
		Age
		Race and Ethnicity
		Family History
	Principles of Initiation of Therapy
	Initiation of Therapy in the Glaucoma Patient
	Initiation of Therapy in the Glaucoma Suspect
	Conclusions
	Key References
	References
10.23 Which Therapy to Use in Glaucoma
	Key Feature
	Introduction
	Historical Review
	Treatment Modalities
		Medical Treatment
		Laser Trabeculoplasty
		Surgery
		Cyclodestructive Procedures
	Treatment Algorithms
	Conclusions
	Key References
	References
10.24 Current Medical Management of Glaucoma
	Key Features
	Introduction
	Drugs That Decrease Aqueous Production
		Beta-Blockers
			Mechanism
			Efficacy
			Side Effects
		Alpha-Adrenergic Agonists
			Mechanism
			Efficacy
			Side Effects
		Carbonic Anhydrase Inhibitors
			Mechanism
			Efficacy
			Side Effects
				Oral
				Topical
	Drugs That Increase Aqueous Outflow
		Miotics
			Mechanism
			Efficacy
			Side Effects
		Prostaglandin Analogues
			Mechanism
			Efficacy
			Side Effects
			Systemic Safety
	Fixed Combination Medications
	Drug Development Pipeline
	The Medical Armamentarium for Glaucoma Treatment
	Key References
	References
10.25 Laser Trabeculoplasty and Laser Peripheral Iridectomy
	Key Features
	Associated Features: Laser Trabeculoplasty
	Associated Features: Laser Peripheral Iridectomy
	Laser Trabeculoplasty
		Introduction and Historical Review
		Preoperative Evaluation and Diagnostic Approach
		General Techniques
			Patient Preparation
			Lens Choice
			Equipment Preparation
			Treatment Guidelines
			Follow-Up
			Re-treatment
		Complications
		Outcome
	Laser Peripheral Iridectomy
		Introduction and Historical Review
		Preoperative Evaluation and Diagnostic Approach
			Indications
			Contraindications
		General Techniques
			Argon versus Nd:YAG Laser
			Patient Preparation
			Lens Choice
		Specific Techniques
			Argon Laser
			Nd:YAG Laser
			Combined Argon–Nd:YAG Technique
			Second Iridectomy
		Complications
			Intraocular Pressure Spikes
			Laser-Induced Inflammation
			Iridectomy Failure
			Diplopia
			Bleeding
			Lens Opacities
			Corneal Injury
			Other Complications
		Outcome
	Laser Iridoplasty
	Micropulse Laser Trabeculoplasty
	Key References
	References
10.26 Cyclodestructive Procedures in Glaucoma
	Key Features
	Associated Features
	Introduction
	Historical Review
	Preoperative Evaluation and Diagnostic Approach
	Mechanism of Action
	Alternatives to a Cyclodestructive Procedure
	Anesthesia
	Specific Techniques
		Cyclocryotherapy
		Transscleral Cyclophotocoagulation
			Noncontact and Contact Nd:YAG Laser Cyclophotocoagulation
			Semiconductor Diode Laser Transscleral Cyclophotocoagulation
			Micropulse Diode Cyclophotocoagulation
	Endoscopic Laser Cyclophotocoagulation
	Complications
	Outcome
	Key References
	References
10.27 Goniotomy and Trabeculotomy
	Key Features
	Associated Feature
	Introduction
	Indications
	Instruments
	Preoperative Care
	Examination Under Anesthesia
	Procedures
		Goniotomy
		Trabeculotomy
	Postoperative Care
	Results
	Complications
	Key References
	References
10.28 Minimally Invasive and Microincisional Glaucoma Surgeries
	Key Features
	Introduction
	Considerations for Patient Selection
	Angle Surgeries
		Trabecular Microbypass Stents
			Concept
			iStent G2 Inject (GTS-400)
				Technique
				Results
			iStent G1
				Technique
				Results
		Hydrus: Ab Interno Schlemm’s Canal Scaffold
			Concept
			Technique
			Results
		Laser-Assisted Endoscopic Trabeculotomy
			Concept
			Endoscopic Excimer Laser Trabeculotomy
				Technique
				Results
		Trabeculectomy Ab Interno: Trabectome
			Concept
			Technique
			Results
				Phaco Combined With Trabectome
				Trabectome Alone in Pseudo-Phakic and Phakic Eyes
				Trabectome and Goniosynechialysis in Narrow Angles and Angle Closure
				Trabectome After Failed Trabeculectomy or Tube Shunt Surgery
				Adjuvant Trabectome Surgery at the Time of Tube Shunt Surgery
				Trabectome Surgery in Severe Glaucoma
		Other Ab Interno Trabeculectomy and Trabeculotomy Techniques
	Subconjunctival Microshunts
		Concept
		Technique
		Results
	Suprachoroidal Drainage Devices
		Concept
		Ab Externo Suprachoroidal Shunts
			SOLX Gold Micro-Shunt
				Technique
				Results
		Ab Interno Suprachoroidal Shunts
			CyPass Micro-Stent
				Technique
				Results
			iStent G3 Supra
	Conclusions
	Key References
	References
10.29 Trabeculectomy
	Key Features
	Associated Features
	Introduction
	Indications
	Surgical Planning
	Preoperative Factors to Consider
	Patient Counseling
	Surgical Techniques
		Intraoperative Technique: Limbal-Based Conjunctival Flap
		Surgical Technique: Fornix-Based Conjunctival Flap
			Avoiding Intraoperative Complications
	Postoperative Care
	Conclusions
	Key References
	References
10.30 Antifibrotic Agents in Glaucoma Surgery
	Key Features
	Associated Features
	Introduction
	Types of Antifibrotic Agents
	Indications for Antimetabolite Use
		Patient Groups With a High Risk of Scarring
		Patient Groups With an Intermediate or Low Risk of Scarring
	Application Techniques
		Type and Concentration of Intraoperative Agent and Time of Exposure
		Type of Sponge
		Larger Areas of Antimetabolite Treatment
	Position of Drainage Area Under Eyelid
	Closure of Scleral Flap and Associated Surgical Techniques
	Postoperative Injections
	Complications
	Future Strategies to Prevent Fibrosis
	Key References
	References
10.31 Drainage Implants
	Key Feature
	Associated Features
	Historical Perspective
	Basic Concept
	Indications
	Preoperative Considerations
	Implant Selection
	Surgical Technique
		Anesthesia
		Quadrant Selection
		Conjunctival Flap and Dissection
		Endplate Attachment
		Implant Preparation
		Tube Insertion
		Patch Graft Placement
		Conjunctival Closure
	Postoperative Management
	Complications
		Intraoperative
		Postoperative
	Evidence From Randomized Clinical Trials
		Drainage Implants Versus Trabeculectomy
		Valved Versus Nonvalved Drainage Implants
		Drainage Implants of Different Endplate Sizes
	Conclusions
	Key References
	References
10.32 Complications of Glaucoma Surgery and Their Management
	Key Features
	Associated Features
	Introduction
	Trabeculectomy
		Intraoperative Complications
			Conjunctival Buttonhole
			Trabeculectomy Scleral Flap Tear/Disinsertion
			Intraoperative Bleeding
		Early Postoperative Complications
			Shallow Anterior Chamber
			Low Filtration
			Choroidal Effusion
		Late Postoperative Complications
			Late Hypotony
			Late Bleb Failure
			Cataract Formation
			Late Bleb Leaks
			Blebitis and Endophthalmitis
	Glaucoma Drainage Implants
	Key References
	References
10.33 Genes Associated With Human Glaucoma
	Key Features
	Associated Feature
	Introduction
	Congenital Glaucoma
	Developmental Glaucoma
	Primary Open-Angle Glaucoma: Juvenile Onset
	Pigment Dispersion Syndrome and Glaucoma
	Adult-Onset Primary Open-Angle Glaucoma
	Normal-Tension Glaucoma
	Exfoliation Syndrome and Glaucoma
	Angle-Closure Glaucoma
	Key References
	References
10.34 Evidence-Based Medicine in Glaucoma
	Key Features
	Introduction
	Tools of Evidence-Based Medicine
		Randomized Clinical Trials
		Meta-Analyses and Systematic Reviews
		Other Study Designs
			Case Reports
			Cross-Sectional Studies
			Case-Control Studies
			Cohort Study
		Other Limitations
			Selection Bias
			Information Bias
	Evaluation of Diagnostic Testing in Glaucoma
	Examples of Evidence-Based Medicine in Glaucoma Therapy
	Barriers to the Practice of Evidence-Based Medicine
	Future Directions
	Conclusions
	Key References
	References
11.1 Anatomy and Physiology of the Extraocular Muscles and Surrounding Tissues
	Key Features
	Embryology
	General Structure of Extraocular Muscles
	Gross Anatomy of the Extraocular Muscles
		Origins of the Extraocular Muscles
		Compartments of the Extraocular Muscles
		Insertions of the Extraocular Muscles
		Paths and Actions of the Extraocular Muscles
		Innervation
		Blood Supply
	The Orbital Infrastructure and Anatomy
	Clinical Correlates
	Extraocular Muscle Physiology
		Hering’s and Sherrington’s Laws
	Key References
	References
11.2 Evaluating Vision in Preverbal and Preliterate Infants and Children
	Key Features
	Introduction
	Historical and Observational Techniques
	Fixation Targets
	Optokinetic Nystagmus
	Visual Evoked Potentials
	Forced-Choice Preferential Looking
	Graded Optotypes
		Digital Photoscreening
	Maturation of Visual Acuity
	Key References
	References
11.3 Examination of Ocular Alignment and Eye Movements
	Key Features
	Evaluation of Ocular Alignment
		Introduction
		Laboratory Methods
		Clinical Methods
		Objective Clinical Methods
			Corneal Light Reflex Tests
			Cover Tests
			Subjective Clinical Methods
	Eye Movement Examinations
		Introduction
		Mechanical Tests of Eye Movement Limitation
			Forced Duction Test
			Active Force Generation Test
	Key References
	References
11.4 Sensory Adaptations in Strabismus
	Key Features
	Visual Confusion and Diplopia
		Introduction
		Ocular Manifestations
		Treatment, Course, and Outcome
	Suppression and Anomalous Retinal Correspondence
		Introduction
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Treatment, Course, and Outcome
	Monofixation Syndrome
		Introduction
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Course and Outcome
	Key References
	References
11.5 Sensory Status in Strabismus
	Key Features
	Introduction
	Sensory Fusion
	Depth Perception and Stereopsis
	Clinical Testing
		Testing for Binocularity (Simultaneous Perception)
		Tests of Retinal Correspondence
		Stereopsis Tests
		Test for Monofixation Syndrome
	Key References
	References
11.6 Esotropia
	Key Features of Infantile Esotropia
	Associated Features (Often Appear After the First Year of Life)
	Key Features of Accommodative Esotropia
	Associated Feature
	Key Features of Duane’s Syndrome
	Associated Features of Duane’s Syndrome
	Introduction
	Infantile Esotropia
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Treatment
		Course and Outcome
	Accommodative Esotropia
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis and Ancillary Testing
		Differential Diagnosis
		Treatment, Course, and Outcome
	Cyclic Esotropia
	Moebius’ Sequence
	Duane’s Syndrome
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Treatment
		Systematic Associations
	Strabismus Fixus
	Esotropia in the Neurologically Impaired
	Esotropia Associated With Visual Deficit (Sensory Esotropia)
	The “Heavy Eye Syndrome” and the “Sagging Eye Syndrome”
	Key References
	References
11.7 Exotropia
	Key Feature
	Associated Features
	Introduction
	Epidemiology and Pathogenesis of Intermittent Exotropia
	Ocular Manifestations of Intermittent Exotropia
		Classification of Intermittent Exotropia According to Distance/Near Angle
		Control of Intermittent Exotropia
		Complications of Exotropia
	Diagnosis and Ancillary Testing for Exotropia
	Differential Diagnosis
	Treatment
		Correction of Refractive Errors
		Orthoptic Treatment
		Therapeutic Occlusion
		Overcorrecting Minus Lenses
		Optical Treatment
		Pharmacological Treatment
		Surgical Treatment
	Course and Outcome
	Key References
	References
11.8 Torsional Strabismus
	Key Features
	Introduction
		Definitions of Inferior Oblique Overaction, Superior Oblique Overaction, A-Pattern, and V-Pattern
		The Three Axes of Strabismus
		Example: Child With Accommodative Esotropia Who Develops a V-Pattern
		Summary of Upcoming Sections
	Clinical Observations
		Epidemiology
		Age of Observation
		How to Observe or Measure Torsion
			Directly With Fundoscopy or Photography
			Correlation of the Appearance of Oblique Overaction, Pattern Strabismus, and Fundus Torsion
			Blind Spot Mapping
		Location of Rectus Muscle Insertions at Surgery
			Forced Ductions
			Double Maddox Rod
			Lancaster Red-Green Test
			Magnetic Resonance Imaging of the Orbits
			Parks’ Three-Step Test
		Torsion Is Sufficient to Cause the Appearance of Oblique Dysfunction
			A- and V-Patterns From Excyclotorsion of the Globe Absent Primary Oblique Dysfunction
			The Observation of Normal Version Testing After Denervation and Extirpation (D&E) of the IOs
	Etiology
		Sensory Torsion
			Well-Known Examples of Sensory Esotropia or Sensory Exotropia
			Muscle Length Adaptation
			Bias
			Sensory Deprivation or the Lack of Fusion Leads to Tropia
		Pulley Arrays
		Other Causes of Oblique Dysfunctions and Pattern Strabismus
			Superior Oblique Muscle Palsy
			Brown’s Syndrome
			Duane’s Syndrome
			Dissociated Vertical Deviation
			Craniosynostosis
			Pseudo-Oblique Overaction Occurs in Patients With a Large Quantity of Exotropia
	Management
		Observation
		Oblique Muscle Surgery
		Surgical Variations
		Rectus Transpositions
	Summary
	Key References
	References
11.9 Paralytic Strabismus
	Key Features
	Associated Features
	Introduction
	Third Nerve Palsy (Oculomotor)
		Introduction
		Ocular Manifestations
			Congenital Third Nerve Palsies
			Acquired Third Cranial Nerve Palsies
		Nonsurgical Treatment
			Surgical Treatment
	Fourth Nerve Palsy (Trochlear)
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Nonsurgical Treatment
			Surgical Treatment
	Sixth Nerve Palsy
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
			Nonsurgical Treatment
			Surgical Treatment
	Summary
	Key References
	References
11.10 Other Vertical Strabismus Forms
	Key Features
	Introduction
	Dissociated Vertical Divergence
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Treatment
	Primary Inferior Oblique Muscle Overaction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Differential Diagnosis
		Treatment
	Monocular Elevation Deficiency (Previously Termed “Double Elevator Palsy”)
		Introduction
		Epidemiology and Pathogenesis
		Differential Diagnosis
		Treatment, Course, and Outcome
	Brown’s Syndrome
		Introduction
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Treatment
	Congenital Fibrosis
	Fractures of the Orbital Floor
		Ocular Manifestations
		Diagnosis
		Treatment
	Graves’ Ophthalmopathy (Dysthyroid Orbitopathy)
		Introduction
		Ocular Manifestations
		Diagnosis
		Treatment
	Heavy Eye Syndrome
	Key References
	References
11.11 Amblyopia
	Key Features
	Associated Features
	Experimental Findings
	Introduction
	Classification of Amblyopia (the Three Ds)
		Strabismic Amblyopia (Deviated Image)
		Anisometropic Amblyopia (Defocused Image)
		Stimulus-Deprivation Amblyopia (Deprived Image)
	Pathophysiology
	Diagnosis
	Treatment
		Occlusion
		Atropine Penalization
		Optical Penalization
		Systemic Pharmacological Treatment
	Course and Outcome
	Considerations
	Key References
	References
11.12 Forms of Nonsurgical Strabismus Management
	Key Feature
	Orthoptics
	Prisms
	Botulinum Toxin
	Bupivicaine
	Occlusion
	Key References
	References
11.13 Techniques of Strabismus Surgery
	Key Feature
	Introduction
	Historical Review
	Preoperative Evaluation and Diagnostic Approach
	Anesthesia
	General Techniques
	Specific Techniques
		Recession of a Rectus Muscle
			Lateral Rectus
			Medial Rectus and Vertical Recti
		Resection of a Rectus Muscle
			Lateral Rectus
			Medial Rectus and Vertical Recti
		Other Surgical Techniques
	Complications
		Violation of the Posterior Tenon’s Capsule/Fat Adherence
		Anterior Segment Ischemia
		Epithelial Cysts/Suture Granulomas
		Corneal Dellen
		Globe Perforation
		Underresponse or Overresponse
		Lost or Slipped Muscles/Stretch Scar
	Muscle Rupture or Pulled in Two Syndrome (Pits)
	Outcomes
	Key References
	References
12.1 Clinical Anatomy of the Eyelids
	Key Features
	Introduction
	Anatomy of the Eyelids
		Orbicularis Muscle
		Orbital Septum
		Preaponeurotic Fat Pockets
		Major Eyelid Retractors
		Sympathetic Accessory Retractors
		Tarsal Plates
		Canthal Tendons
		Conjunctiva
		Nerves to the Eyelids
		Vascular Supply of the Eyelids
	Key References
	References
12.2 Clinical Anatomy of the Orbit
	Key Features
	Introduction
	General Organization
	Osteology of the Orbit
		Orbital Roof
		Lateral Orbital Wall
		Orbital Floor
		Medial Orbital Wall
	Connective Tissue System
		Periorbita
		Orbital Septal System
		Tenon’s Capsule
	Muscles of Ocular Motility
	Motor Nerves of the Orbit
	Sensory Nerves of the Orbit
	Arterial Supply to the Orbit
	Venous Drainage From the Orbit
	Key References
	References
12.3 Orbital Imaging
	Key Features
	Introduction
	Normal Orbital Anatomy in the Axial Plane
		Axial Section Through the Lowermost Orbit
		Axial Section Through the Inferior Orbit
		Axial Section Through the Midorbit
		Axial Section Through the Superior Orbit
		Axial Section Through the Orbital Roof
	Normal Orbital Anatomy in the Coronal Plane
		Coronal Section Through the Anteriormost Orbit
		Coronal Section Through the Anterior Orbit
		Coronal Section Through the Central Orbit
		Coronal Section Through the Anterior Orbital Apex
		Coronal Section Through the Posterior Orbital Apex
		Computed Tomographic Imaging Features of Some Orbital Pathologies
			Cavernous Hemangioma
			Dermoid Cyst
			Thyroid Eye Disease
			Optic Nerve Sheath Meningioma
			Myositis
			Optic Nerve Glioma
			Adenoid Cystic Carcinoma
			Orbital Mucocele
	Key References
	References
12.4 Blepharoptosis
	Key Features
	Introduction
	Foundation: A Simplified Classification of Ptosis
		Anatomy and Function
		Classification Based on Levator Function
		Common Ptosis
			Acquired Involutional Ptosis
			Simple Congenital Ptosis
	Differential Diagnosis
		Common Ptosis
		Unusual Congenital Ptosis
			Marcus Gunn Jaw-Winking Syndrome
			Blepharophimosis Syndrome
		Unusual Acquired Ptosis
		Neurogenic Ptosis
			Myasthenia Gravis
			Third Cranial Nerve Palsy
			Horner’s Syndrome
		Myogenic Ptosis
			Chronic Progressive External Ophthalmoplegias
			Oculopharyngeal Dystrophy
			Myotonic Dystrophy
			Posttraumatic Ptosis
	Clinical Evaluation and Preoperative Considerations
		History and Examination
			Adults
			Children
		Formulating a Treatment Plan
			General Considerations
	Surgical Correction of Ptosis
		Anesthesia
		Levator Aponeurosis Advancement
		Frontalis Suspension
		Complications
			Undercorrection
			Overcorrection
			Changes in Astigmatism
	Outcome
	Key References
	References
12.5 Entropion
	Key Features
	Introduction
	Preoperative Evaluation and Diagnostic Approach
		The Capsulopalpebral Fascia
		The Tarsus and Canthal Ligament
		Enophthalmos
		Orbicularis Muscle
		The Posterior Lamella
		Other Factors
	Differential Diagnosis
		Epiblepharon
		Trichiasis
		Congenital Entropion
	Alternatives to Surgery
		Quickert–Rathbun Sutures
		Botulinum Toxin
	Anesthesia
	General Technique
	Specific Techniques
		Retractor Reattachment
		Lateral Tarsal Strip Procedure
		Transverse Tarsotomy
		Hard Palate Mucosal Graft
	Complications
		Overcorrection
		Hematoma
		Eyelid Retraction
		Exposure Keratopathy
		Ptosis
	Outcome
	Key References
	References
12.6 Ectropion
	Key Features
	Associated Features
	Introduction
	Preoperative Evaluation and Diagnostic Approach
		Eyelid Laxity Evaluation
		Medial Canthal Tendon Laxity
		Lateral Canthal Tendon Laxity
		Lacrimal Puncta Evaluation
		Anterior Lamellae Inspection
		Orbicularis Oculi Muscle Tone
		Eyelid Masses
		Lower Eyelid Retractor Dehiscence
	Differential Diagnosis
		Involutional Ectropion
		Cicatricial Ectropion
		Paralytic Ectropion
		Mechanical Ectropion
		Congenital Ectropion
	Alternatives to Surgery
	Anesthesia
	General Techniques
	Specific Techniques
		Involutional Ectropion
			Lateral Tarsal Strip Procedure
			Medial Spindle Procedure With Rotational Suture
			Lower Eyelid Retractor Advancement
			Full-Thickness Pentagonal Block Resection
		Cicatricial Ectropion
			Local Skin Flaps (Z-Plasty)
			Full-Thickness Skin Graft
		Paralytic Ectropion
			Medial Canthoplasty
			Lateral Tarsorrhaphy
	Complications
	Outcome
	Key References
	References
12.7 Benign Eyelid Lesions
	Key Features
	Associated Features
	Introduction
	Epithelial Tumors
		Squamous Papilloma
		Cutaneous Horn
		Seborrheic Keratosis
		Inverted Follicular Keratosis
		Keratoacanthoma
		Actinic Keratosis
		Epidermal Inclusion Cyst
		Pilar Cyst
		Epidermoid and Dermoid Cysts
	Adnexal Tumors
		Benign Lesions of Sebaceous Origin
			Milia
			Sebaceous Adenoma
		Benign Lesions of Eccrine Origin
			Eccrine Hidrocystoma
			Syringoma
			Chondroid Syringoma
		Benign Lesions of Apocrine Origin
			Apocrine Hidrocystoma
			Cylindroma
		Benign Lesions of Hair Follicle Origin
			Trichoepithelioma
			Trichofolliculoma
			Trichilemmoma
			Pilomatrixoma
	Vascular Tumors
		Capillary Hemangioma
		Lymphangioma
		Nevus Flammeus
		Pyogenic Granuloma
	Tumors of Neural Origin
		Neurofibroma
	Xanthomatous Lesions
		Xanthelasma
		Juvenile Xanthogranuloma
	Pigmented Lesions of Melanocytic Origin
		Freckles
		Lentigo Simplex
		Solar Lentigo
		Melanocytic Nevi
		Congenital Melanocytic Nevus
		Nevus of Ota
		Blue Nevus
	Inflammatory Lesions
		Chalazion
		Hordeolum
	Infectious Lesions
		Molluscum Contagiosum
		Verruca Vulgaris
	Conclusion
	Outcomes
	Key References
	References
12.8 Eyelid Malignancies
	Key Features
	Associated Features
	Introduction
	Basal Cell Carcinoma
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Differential Diagnosis
		Systemic Associations
		Pathology
		Treatment
			Surgery
			Radiation Therapy
			Cryotherapy
			Chemotherapy and Photodynamic Therapy
		Course and Outcome
	Squamous Cell Carcinoma
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Pathology
		Treatment
		Course and Outcome
	Sebaceous Gland Carcinoma
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Pathology
		Treatment
		Course and Outcome
	Malignant Melanoma
		Epidemiology and Pathogenesis
		Ocular Manifestations
		Diagnosis
		Systemic Associations
		Pathology
		Treatment
		Course and Outcome
	Key References
	References
12.9 Evaluation and Management of Periorbital Soft Tissue Trauma
	Key Features
	Introduction
	Preoperative Evaluation and Diagnostic Approach
		Systemic Stabilization
		Medical History
		Examination
		Ancillary Testing
		Documentation
		Infection Prophylaxis
		Timing of Repair
	Anesthesia
	Treatment
		General Concepts
	Common Patterns of Eyelid Injury
		Partial-Thickness Eyelid Injuries and Abrasions
		Deep Partial-Thickness and Full-Thickness Eyelid Lacerations
		Eyelid Margin Lacerations
		Eyelid Injuries With Tissue Loss
			Tissue Loss of 0% to 25%
			Tissue Loss of 25% to 60%
		Full-Thickness Eyelid Injuries With Greater Than 60% Tissue Loss
			Lower Eyelid
			Upper Eyelid
		Postoperative Care
		Late Repair of Eyelid Injuries
		Dog Bites
		Lacrimal Injury
		Eyelid Burns
	Conclusions
	Key References
	References
12.10 Orbital Diseases
	Key Features
	Introduction
	Clinical Evaluation
	Metastatic Tumors
		Introduction
		Metastatic Carcinoma
			Key Points
			Orbital Imaging
			Treatment and Prognosis
	Lacrimal Gland Lesions
		Introduction
		Pleomorphic Adenoma (Benign Mixed Cell Tumor)
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
		Adenoid Cystic Carcinoma
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
	Mesenchymal Tumors
		Introduction
		Fibrous Histiocytoma
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
		Rhabdomyosarcoma
			Key Points
			Orbital Imaging
			Pathology
			Staging
			Treatment and Prognosis
	Neurogenic Tumors
		Introduction
		Plexiform Neurofibroma
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
		Schwannoma (Neurilemmoma)
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
		Malignant Peripheral Nerve Sheath Tumor (Malignant Schwannoma)
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
		Neuroblastoma
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
		Optic Nerve Glioma (Pilocytic Astrocytoma of Childhood)
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
		Optic Nerve Sheath Meningioma
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
	Lymphoproliferative Diseases
		Introduction
		Benign Reactive Lymphoid Hyperplasia
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
		Atypical Lymphoid Hyperplasia
			Key Points
			Orbital Imaging and Echography
			Pathology
			Treatment and Prognosis
		Malignant Orbital Lymphoma (Lymphosarcoma)
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
	Histiocytic Tumors
		Introduction
		Eosinophilic Granuloma (Histiocytosis X)
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
	Inflammations and Infections
	Thyroid Eye Disease
	Cystic Lesions
		Introduction
		Dermoid Cyst
			Key Points
			Superficial Lesions
				Orbital Imaging
				Pathology
				Treatment and Prognosis
			Deep Lesions
				Orbital Imaging
				Pathology
				Treatment and Prognosis
		Mucocele
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
		Microphthalmos With Cyst
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
	Vascular Neoplastic and Structural Lesions
		Introduction
		Capillary Hemangioma (Hemangioendothelioma)
			Key Points
			Superficial Lesions
				Treatment and Prognosis
			Deep Lesions
				Orbital Imaging
				Pathology
				Treatment and Prognosis
		Cavernous Hemangioma
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
		Lymphangioma
			Key Points
			Superficial Lesions
			Deep Lesions
			Orbital Imaging
			Pathology
			Treatment and Prognosis
		Arteriovenous Fistula
			Key Points
			Low-Flow Type
			High-Flow Type
			Primary Shunts
			Secondary Shunts
			Orbital Imaging
			Treatment and Prognosis
		Varices
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
	Secondary Tumors
		Introduction
		Basal Cell Carcinoma
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
		Malignant Melanoma
			Key Points
			Orbital Imaging
			Pathology
			Treatment and Prognosis
	Key References
	References
12.11 Enucleation, Evisceration, and Exenteration
	Key Features
	Introduction
	Preoperative Evaluation and Diagnostic Approach
		Indications for Surgery
		Preoperative Counseling
	Anesthesia
	Specific Techniques
		Enucleation
			Enucleation With Simple Sphere Implant
			Enucleation With Porous Implant
		Evisceration
			Overview
			Surgical Technique
		Exenteration
			Overview
			Surgical Technique
			Postoperative Management
	Complications
		Evisceration
		Enucleation
		Exenteration
	Key References
	References
12.12 The Lacrimal Drainage System
	Key Features
	Associated Features
	Introduction
	Anatomy and Physiology
	Evaluation of Epiphora
		Clinical History
		Physical Examination
			Eyelids
			Lacrimal Passages
			Nose
		Clinical Diagnostic Tests
			Tear Tests
				Dye Tests
			Excretory Tests
				Lacrimal Syringing
				Jones Fluorescein Dye Test
			Endoscopy
		Diagnostic Imaging
			Nuclear Lacrimal Scan
			Dacryocystography
			Computed Tomography
	Obstructions of the Lacrimal Sac and Duct
		Congenital Obstruction
		Acquired Obstruction
			Nonspecific Acquired Obstruction
			Specific Acquired Obstruction
		Dacryocystitis
	Treatment of Lacrimal Sac and Duct Obstruction
		Congenital Nasolacrimal Obstruction
		Acquired Nasolacrimal Obstruction
		Dacryocystorhinostomy
		Endonasal Dacryocystorhinostomy
	Tumors of the Lacrimal Sac
	Diseases of the Canaliculi
	Punctal Stenosis
	Useful Lacrimal Tips
	Key References
	References
12.13 Thyroid Eye Disease
	Key Features
	Introduction
	Epidemiology, Risk Factors, and Associated Conditions
	Pathogenesis
	Clinical Presentation: Disease Severity and Activity
	Diagnosis
	Evaluation of Disease Severity and Activity
	Quality of Life
	Basic Management
	Medical Therapy
	Orbital Radiotherapy
	Surgical Therapy
	Management Plan Using the VISA Classification
	Key References
	References
12.14 Orbital Infection and Inflammation
	Key Features
	Introduction
	General Assessment
		Orbital Infection
			Orbital Cellulitis
			Bacterial Dacryoadenitis
			Orbital Tuberculosis
			Orbital Viral Infection
			Orbital Fungal Infection
				Rhino-Orbital-Cerebral Mucormycosis
				Orbital Aspergillus Infection
			Orbital Parasitical Infection
		Noninfectious Orbital Inflammation
			Granulomatous Orbital Inflammation
				Sarcoidosis
				Xanthogranulomatous Disease
				IgG4-Related Disease
		Orbital Vasculitic Disease
			Granulomatosis With Polyangiitis
			Sjögren’s Syndrome
		Idiopathic Orbital Inflammation
			Idiopathic Orbital Myositis
			Idiopathic Dacryoadenitis
			Tolosa–Hunt Syndrome (Orbital Apex IOI)
	Key References
	References
12.15 Cosmetic Blepharoplasty and Browplasty
	Key Features
	Introduction
	Anatomical Considerations
		Eyelids
			Upper Eyelid
			Lower Eyelid
		Brows
	Blepharoplasty
		Preoperative Evaluation and Diagnostic Approach
			History and Psychological Evaluation
			Physical Examination
		Anesthesia
		General Techniques
		Specific Techniques
			Upper Lid Blepharoplasty
			Lower Lid Blepharoplasty
				Skin Approach
				Transconjunctival Approach
		Other Surgical Techniques
		Postoperative Care
		Complications
			Orbital Hemorrhage and Blindness
			Infections
		Ptosis
			Lagophthalmos, Lower Lid Retraction, Ectropion, and Lateral Canthal Deformities
			Other Complications
		Outcome
	Brow Malposition
		Preoperative Evaluation and Diagnostic Approach
		Anesthesia
		General Techniques
		Specific Techniques
			The Bicoronal Forehead Lift
			The Midfrontal Brow Lift
			The Direct Brow Lift
			Endoscopic Brow Lift
			Transblepharoplasty Brow Fixation
		Complications
			Excessive Cutaneous Scar and Alopecia
			Paresthesia and Hematoma
			Overcorrection and Undercorrection
		Outcome
	Key References
	References
12.16 Aesthetic Fillers and Botulinum Toxin for Wrinkle Reduction
	Key Features
	Introduction
	Approach to Periorbital Rejuvenation
		Botulinum Toxin
		Fillers
	Anatomical Considerations
	The Brow and Temple
		Rhytides in the Upper Face
		Shaping the Brow
		Temple and Forehead Contouring
	The Eye
		Widening the Palpebral Aperture
		Lid Ptosis, Malposition, and Asymmetry
		Orbital Augmentation
		Infraorbital Hollow
	Adjunctive Therapies
	Precautions
		Chlorhexidine
		Vascular Compromise
	Conclusion
	Key References
	References




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