One Hundred Years of Chromosome Research and What Remains to be Learned

Front Matter....Pages i-vii
Introduction....Pages 1-2
Front Matter....Pages 3-3
The precursors....Pages 5-7
The pioneers....Pages 9-12
The era of abstract genetics....Pages 13-15
The impact of physics and chemistry on genetics....Pages 17-20
Radioisotopes and electron microscopy became a most fruitful combination....Pages 21-25
The mechanisms of cancer and of development were sought at the DNA level....Pages 27-30
Neurobiology reached the molecular level....Pages 31-34
The genome of humans and of other organisms was sequenced....Pages 35-37
The post-genome era....Pages 39-43
Front Matter....Pages 45-45
From staining methods to DNA sequencing....Pages 47-56
Front Matter....Pages 57-57
Main stages in the discovery of the cell’s structure and function....Pages 59-62
The nucleus versus the cytoplasm. Which was most important?....Pages 63-64
The description of cell division....Pages 65-66
Meiosis was another unexpected property....Pages 67-70
The maintenance of identity of the chromosome during interphase was accompanied by constancy and variability of pattern in different tissues....Pages 71-72
Front Matter....Pages 73-73
The centromere....Pages 75-79
The telomere....Pages 81-84
The nucleolus organizer....Pages 85-88
Front Matter....Pages 89-89
Cytoskeleton....Pages 91-92
Front Matter....Pages 89-89
Nuclear envelope....Pages 93-94
Centriole....Pages 95-96
Endoplasmic reticulum and Golgi apparatus....Pages 97-98
Cell membrane and cell wall....Pages 99-101
Front Matter....Pages 103-103
Chromosomes of viruses....Pages 105-107
Chromosomes of bacteria....Pages 109-111
Chromosomes of mitochondria....Pages 113-115
Chromosomes of chloroplasts....Pages 117-119
Front Matter....Pages 121-121
Physico-chemical processes are antithetical....Pages 123-123
Maintenance of organization....Pages 127-131
Maintenance of the chromosome phenotype....Pages 133-136
Maintenance of gene order....Pages 137-140
Maintenance of function....Pages 141-143
The periodicity of chromosome transformations....Pages 145-148
Structural change....Pages 151-153
Change of pattern....Pages 155-156
Change in size....Pages 157-158
Change in number....Pages 159-160
Change in function....Pages 161-165
Front Matter....Pages 167-167
The models....Pages 169-173
Front Matter....Pages 167-167
What the models do not tell us....Pages 175-176
Front Matter....Pages 177-177
Where did the chromosome come from?....Pages 179-181
Where is the chromosome going?....Pages 183-184
Back Matter....Pages 185-219