Oncogenes and Growth Control

Front Matter....Pages I-XXIII
Introduction....Pages 1-5
Front Matter....Pages 7-8
The Expression of Growth Factors and Growth Factor Receptors During Mouse Embryogenesis....Pages 9-17
A Role for Proto-Oncogenes in Differentiation?....Pages 18-26
Tissue-Specific Expression and Possible Functions of pp60 c-src ....Pages 27-31
Front Matter....Pages 33-34
The Granulocyte-Macrophage Colony-Stimulating Factors....Pages 35-42
Role of PDGF-Like Growth Factors in Autocrine Stimulation of Growth of Normal and Transformed Cells....Pages 43-50
Transforming Growth Factor- β ....Pages 51-57
Transforming Growth Factor- α ....Pages 58-64
The Physiology of Epidermal Growth Factor....Pages 65-69
Structural Relationships Between Growth Factor Precursors and Cell Surface Receptors....Pages 70-76
Regulation of Cell Growth by the EGF Receptor....Pages 77-84
Mutational Analysis of v- erbB Oncogene Function....Pages 85-92
The c- fms Proto-Oncogene and the CSF-1 Receptor....Pages 93-99
Activation of the c- src Gene....Pages 100-105
Normal and Transforming N-Terminal Variants of c- abl ....Pages 106-114
Transformation by the v- abl Oncogene....Pages 115-120
mos....Pages 121-127
Structure and Function of the Human Interleukin-2 Receptor....Pages 128-134
Front Matter....Pages 135-137
Phosphorylation in Signal Transmission and Transformation....Pages 138-146
Inositol Lipids and Cell Proliferation....Pages 147-153
Front Matter....Pages 135-137
Protein Kinase C....Pages 154-162
The Relevance of Protein Kinase C Activation, Glucose Transport and ATP Generation in the Response of Haemopoietic Cells to Growth Factors....Pages 163-169
Cytoplasmic pH and Free Ca 2+ in the Action of Growth Factors....Pages 170-176
Epidermal Growth-Factor Mediation of S6 Phosphorylation During the Mitogenic Response: A Novel S6 Kinase....Pages 177-183
Role of G Proteins in Transmembrane Signaling: Possible Functional Homology with the ras Proteins....Pages 184-191
The ras Gene Family....Pages 192-199
 RAS Genes and Growth Control in the Yeast Saccharomyces cerevisiae ....Pages 200-208
Front Matter....Pages 209-210
Regulation of Human Globin Gene Expression....Pages 211-218
Regulation of Gene Expression by Steroid Hormones....Pages 219-226
Enhancers as Control Elements for Tissue-Specific Transcription....Pages 226-234
The Effect of DNA Methylation on DNA-Protein Interactions and on the Regulation of Gene Expression....Pages 235-240
 Trans -Acting Elements Encoded in Immediate Early Genes of DNA Tumor Viruses....Pages 241-246
Transactivator Genes of HTLV-I, II, and III....Pages 247-252
Involvement of Proto-Oncogenes in Growth Control: The Induction of c- fos and c- myc by Growth Factors....Pages 253-258
Oncogenes and Interferons: Genetic Targets for Animal Cell Growth Factors....Pages 259-263
Regulation of c- myc Expression in Normal and Transformed Mammalian Cells....Pages 264-270
Properties of the myc and myb Gene Products....Pages 271-277
The fos Oncogene and Transformation....Pages 278-283
p53: Molecular Properties and Biological Activities....Pages 284-289
Front Matter....Pages 291-293
Oncogene Cooperativity in Stepwise Transformation of Rodent Embryo Fibroblasts by Polyoma Virus....Pages 294-297
Front Matter....Pages 291-293
Role of the Middle T: pp60 c-src Complex in Cellular Transformation by Polyoma Virus....Pages 298-303
Oncogenes Cooperate, but How?....Pages 304-311
Individual and Combined Effects of Viral Oncogenes in Hematopoietic Cells....Pages 312-319
Multiple Factors Involved in B-Cell Tumorigenesis....Pages 320-325
Molecular Events Associated with Tumor Initiation, Promotion, and Progression in Mouse Skin....Pages 326-331
Amplification of Proto-Oncogenes and Tumor Progression....Pages 332-339
Suppression of the Neoplastic Phenotype....Pages 340-345
Front Matter....Pages 347-348
Oncogenesis in Transgenic Mice....Pages 349-363
Back Matter....Pages 365-369