Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression

Front Matter....Pages i-xii
Introduction: Strategies and Realities....Pages 1-6
Synthesis of Oligonucleotides and Oligonucleotide Analogues....Pages 7-24
Oligodeoxynucleotides Covalently Linked to Intercalating and Reactive Substances: Synthesis, Characterization and Physicochemical Studies....Pages 25-51
Inhibition of Gene Expression by Oligonucleotides....Pages 53-77
Non-ionic Antisense Oligonucleotides....Pages 79-95
Phosphorothioate Oligodeoxynucleotide Analogues....Pages 97-117
α-Oligodeoxynucleotide Analogues....Pages 119-136
Control of Gene Expression by Oligodeoxynucleotides Covalently Linked to Intercalating Agents and Nucleic Acid-cleaving Reagents....Pages 137-172
Oligonucleotides Linked to Reactive Groups....Pages 173-196
Oligonucleotide Recognition of Double-helical DNA by Triple-helix Formation....Pages 197-210
Antisense Oligodeoxynucleotides as a Tool for Studying Cell Regulation: Mechanism of Uptake and Application to the Study of Oncogene Function....Pages 211-231
Pharmaceutical Considerations....Pages 233-247
Back Matter....Pages 249-255