Nutritional Toxicology Volume 2

Front Cover......Page 1
Nutritional Toxicology......Page 4
Copyright Page......Page 5
Table of Contents......Page 6
Contributors......Page 10
Preface......Page 12
Contents of Volume I......Page 14
I. Introduction......Page 18
II. Macronutrients in Detoxification......Page 20
III. Micronutrients in Detoxification......Page 31
IV. Conclusion......Page 42
References......Page 43
I. Introduction......Page 58
II. Regulation of Mixed-Function Oxidation in the Intact Liver......Page 59
III. Regulation of Glucuronidation and Sulfation in the Intact Liver......Page 64
IV. Compartmentation of Monooxygenation and Conjugation in Periportal and Pericentral Regions of the Liver Lobule......Page 65
V. Future Directions......Page 74
References......Page 75
I. Introduction......Page 80
II. Metabolic Effects of Ethanol......Page 82
III. Nutritional Effects of Ethanol......Page 103
References......Page 106
I. Introduction......Page 122
II. Human Malnutrition......Page 123
III. Dietary Effects on Drug Absorption......Page 125
IV. Drug–
Protein Binding and Drug Distribution......Page 126
V. Renal Elimination of Drugs......Page 127
VI. Biotransformation of Drugs......Page 128
VII. Drug Receptors and Pharmacodynamic Responses......Page 132
VIII. Drug-Induced Nutritional Disorders......Page 134
IX. Drug-Induced Deficiencies of Water-Soluble Vitamins......Page 135
X. Drug-Induced Deficiencies of Fat-Soluble Vitamins......Page 137
XI. Antinutrient Effects of Contraceptive Steroids......Page 138
XII. Conclusions......Page 139
References......Page 140
I. Introduction......Page 146
II. Affinity of Toxigens toward Nuclear Chromatin......Page 148
III. Nutritional Effects on Expression of Genes Involved in Toxigen Metabolism......Page 159
IV. Role of the Nucleus in Detoxification......Page 162
References......Page 164
I. Introduction......Page 174
II. Occurrence and Exposure......Page 176
III. Quantitation......Page 177
IV. Formation......Page 178
V. Genotoxic and Carcinogenic Effects......Page 179
VI. Metabolic Activation and Detoxification......Page 180
VIII. Conclusions......Page 183
References......Page 184
I. Introduction and Classification......Page 190
II. Primary Food Sensitivities......Page 191
References......Page 210
I. Introduction......Page 216
II. Acute Toxicity......Page 218
IV. Anatomical Effects......Page 220
V. Cardiovascular Effects......Page 223
VI. Behavioral Effects......Page 226
VII. Conclusion......Page 233
References......Page 234
I. Tin......Page 240
II. Aluminum......Page 245
III. Selenium......Page 250
References......Page 257
I. Introduction......Page 266
II. Mechanisms of Toxicity......Page 267
III. Factors Affecting the Toxicology of Pesticides in Food......Page 282
IV. Occurrence of Pesticide Residues in Food......Page 285
References......Page 287
I. Introduction......Page 298
II. Pesticide Effects on Nutrients in Foods......Page 299
III. General Remarks and Conclusions......Page 302
References......Page 303
Index......Page 306