Nutritional pathology: pathobiochemistry of dietary imbalances

Cover......Page 1
Half Title......Page 2
Series Page......Page 3
Title Page......Page 4
Copyright Page......Page 5
Dedication......Page 6
Preface......Page 8
Contributors......Page 10
Contents......Page 12
 II. Historical Data and Findings in Deficiencies......Page 18
 III. Occurrence in Nature and in Mammals......Page 20
 IV. Chemical Pathways......Page 21
 V. Effect on the Central Nervous System......Page 23
 VI. Effect on the Liver......Page 26
 VII. Effect on the Livers of Rats Treated with Hepatotoxic Agents......Page 44
 VIII. Effect on Other Organs......Page 46
 IX . Tryptophan and Hormones......Page 47
 X. Tryptophan and Cancer......Page 48
 XI. Tryptophan and Pregnancy......Page 51
 XIII. Tryptophan and Hepatic Coma......Page 53
 XIV. Other Essential Amino Acids and Their Possible Unique Actions......Page 56
 XV. Potential Importance of Tryptophan and Its Unique Actions......Page 57
 References......Page 58
 I. Introduction......Page 80
 II. Mechanisms that Control Hepatic Protein Synthesis......Page 81
 III. Influence of Nutritional Components on Hepatic Protein Synthesis......Page 85
 References......Page 116
 I. Introduction......Page 132
 II. Exocrine Pancreas......Page 133
 IV. Conclusion......Page 140
 References......Page 141
 I. Introduction......Page 144
 II. Cholesterol and Lipoproteins......Page 145
 III. The Diet......Page 149
 IV. Fat......Page 151
 V. Protein......Page 153
 VI. Carbohydrate......Page 157
 VII. Fiber......Page 159
 VIII. Trace Minerals......Page 161
 IX. Conclusion......Page 162
 References......Page 163
 I. Introduction......Page 178
 II. Cellular Growth......Page 179
 III. Brain Lipids......Page 182
 IV. Brain Metabolism......Page 185
 V. Effects of Malnutrition on Brain Growth and Development......Page 188
 VI. Brain Size......Page 189
 VII. Brain Composition......Page 192
 VIII. Malnutrition and Synaptic Development......Page 197
 IX. Malnutrition and Energy Metabolism......Page 204
 XI. Malnutrition and Brain Protein......Page 205
 XIII. Iron Deficiency......Page 206
 XV. Brain Function—Behavior and Intelligence......Page 207
 XVI. Conclusions......Page 211
 References......Page 213
 I. Introduction......Page 224
 II. Dietary Fibers and Their Components......Page 225
 III. Physiological and Pharmacological Responses......Page 234
 IV. Therapeutic Applications......Page 250
 V. Undesirable Effects and Pathological Responses......Page 258
 VI. Fiber, Bile Acids, and Colon Cancer......Page 263
 VII. Conclusions......Page 270
 VIII. Glossary of Terms......Page 271
 References......Page 272
 I. Introduction......Page 296
 II. Biochemistry of Choline......Page 297
 III. Pathological Lesions Induced by Choline Deficiency......Page 300
 IV. Pathogenetic Mechanisms......Page 303
 V. Conclusions......Page 320
 References......Page 322
 I. Introduction......Page 338
 II. Measurement of Drug-Metabolizing Activity......Page 340
 III. Consequences of Dietary Manipulation......Page 341
 IV. Protein......Page 342
 V. Undernutrition......Page 349
 VI. Carbohydrate......Page 353
 VII. Lipids......Page 355
 VIII. Vitamins......Page 358
 IX. Minerals......Page 360
 X. Phase-2 Metabolism......Page 361
 XI. Conclusion......Page 363
 References......Page 364
 II. Classifications of Drug-Induced Malnutrition......Page 374
 III. The Pathophysiology of Malabsorption in Drug-Induced Enteropathies......Page 377
 IV. Spindle Poisons......Page 381
 V. The Neurotoxicity of Vitamin Antagonists......Page 384
 VI. Hepatotoxicity of Vitamin Antagonists......Page 388
 VII. Nutrient Depletion Secondary to Drug-Induced Tissue Injury......Page 389
 References......Page 390
Index......Page 398