Nutrient Modulation of the Immune Response

Cover......Page 1
Half Title......Page 2
Title Page......Page 4
Copyright Page......Page 5
Preface......Page 6
Table of Contents......Page 8
Contributors......Page 12
Part I: Expression of Nutrient Interaction in Immune Function......Page 20
 1. Immunoregulatory and Prodifferentiating Effects of 1,25-Dihydroxyvitamin D3 in Human Mononuclear Cells......Page 22
 2. Nutritional Deficiencies and Immunoregulatory Cytokines......Page 50
 3. The Role of Arginine as an Immune Modulator......Page 66
 4. Retinoids, Carotenoids, and Macrophage Activation......Page 82
 5. Vitamin C and Phagocytes......Page 94
 6. Interaction of Vitamin C in Lymphocyte Activation: Current Status and Possible Mechanisms of Action......Page 110
 7. The Immunoregulatory Properties of Iron......Page 124
 8. The Role of Metals in the Production of Toxic Oxygen Metabolites by Mononuclear Phagocytes......Page 146
 9. Zinc Deficiency, Chromatin Structure, and Gene Expression......Page 160
Part II: Effect of Nutritional Conditioning on Immune Response......Page 170
 10. The Influence of Nutrition on Experimental Autoimmune Disease......Page 172
 11. Cholesterol, Apolipoprotein E, and Immune Cell Function......Page 188
 12. Oxygenated Derivatives of Cholesterol: Their Possible Role in Lymphocyte Activation and Differentiation......Page 202
 13. Prostaglandins, Fatty Acids, and Arthritis......Page 220
 14. Vitamin E and the Immune Response......Page 242
 15. Copper and Immunity......Page 258
 16. Modulation of Differentiation Antigen Expression and Function of Immune Cells Following Short and Prolonged Alcohol Intake During Murine Retroviral Infection......Page 274
 17. The Effect of Experimental Zinc Deficiency on Development of the Immune System......Page 282
Part III: Nutrient Modulation of Immune Response in Human Development and Disease......Page 300
 18. Malnutrition and the Thymus Gland......Page 302
 19. Maturation of the Immune System in Breast-Fed and Bottle-Fed Infants......Page 320
 20. Gliadin, Intestinal Hypersensitivity, and Food Protein-Sensitive Enteropathy......Page 338
 21. Macromolecular Antigen Absorption from the Gastrointestinal Tract in Humoral Immunodeficiency......Page 358
 22. Natural Killer Activity in Protein-Calorie Malnutrition......Page 378
 23. Modification of Lymphocyte Function by Fatty Acids—Biological and Clinical Implications......Page 388
 24. Acquired Zinc Deficiency and Immune Dysfunction in Sickle Cell Anemia......Page 412
 25. Effect of Therapeutic Chelation on Immune Response in Transfusion Dependent Thalassemia......Page 430
 26. Stimulation of Breast Cancer-Specific Cellular Immunity by High-Dose Vitamin E and Vitamin A: Adjuvant Therapeutic Implications......Page 442
 27. Malnutrition and Lymphocyte Subpopulation Responses in Humans......Page 460
 28. Influence of Nutrition on Immunocompetence in the Elderly......Page 474
Part IV: Issues and Implications in Nutrient Immune Interactions......Page 486
 29. Issues in Retinoid and Carotenoid Research......Page 488
 30. Impact of Infectious Disease on the Interaction Between Nutrition and Immunity......Page 494
 31. Nutritional Indications for Cancer Prevention— Calorie Restriction......Page 500
 32. Circulation and Distribution of Iron: A Key to Immune Interaction......Page 510
 33. Rationale for the Mechanism of Zinc Interaction in the Immune System......Page 520
 34. Interactions Between Cytokine Production and Inflammation: Implications for Therapies Aimed at Modulating the Host Defense to Infection......Page 530
 35. Human Milk Antibodies and Their Importance for the Infant......Page 544
 36. Dietary Antigens and Regulation of the Mucosal Immune Response......Page 552
Index......Page 560