Nuclear Medicine and Molecular Imaging: The Requisites

Title page......Page 2
Table of Contents......Page 4
Copyright......Page 12
Contributor......Page 15
Foreword......Page 16
Preface to the 5th edition of the Requisites, Nuclear Medicine......Page 19
Part 1. Basic Principles......Page 22
Atomic Structure of Matter......Page 23
Electromagnetic Radiation......Page 30
Radioactivity and Radioactive Decay......Page 37
Interactions Between Radiation and Matter......Page 56
Radiation detection......Page 65
Scintillation detectors......Page 72
Ancillary Nuclear Medicine Equipment......Page 76
The Patient as a Radioactive Source......Page 80
Gamma cameras......Page 84
Collimators......Page 89
Quality Control......Page 100
Data Acquisition of Emission Tomographyn......Page 114
Production of Radionuclides......Page 158
Radiopharmaceuticals......Page 178
Radiopharmaceutical Preparation......Page 181
New Radioactive Drug Development......Page 192
Quality Assurance in Radionuclides and Radiopharmaceuticals......Page 193
Dispensing Radiopharmaceuticals......Page 205
Radiation Accidents (Spills)......Page 217
Quality Control in the Nuclear Pharmacy......Page 218
Receiving Radioactive Packages......Page 221
Radiation Dosimetry......Page 222
Imaging Techniques......Page 228
Biomarkers......Page 233
Cell Metabolism and Proliferation......Page 234
Reporter Gene Imaging and Gene Therapy......Page 252
Imaging Biomarkers and New-Drug Development......Page 254
Part 2. Clinical Studies......Page 259
6. The Skeletal System......Page 261
Radionuclide Imaging of the Skeleton: Radiopharmaceuticals......Page 262
Clinical Uses of Skeletal Scintigraphy......Page 288
Targeted Radionuclide Therapy of Metastatic Disease in Bone......Page 363
Bone Mineral Density Assessment......Page 385
Introduction: The Ventilation–Perfusion Lung Scan......Page 395
Pulmonary Embolism......Page 398
VQ Background......Page 404
Radiopharmaceuticals......Page 406
Technique......Page 415
Image Interpretation......Page 421
PIOPED......Page 428
Quantitative Lung Scan......Page 450
Thyroid Disease—Radionuclide Diagnosis and Therapy......Page 460
Parathyroid Scintigraphy......Page 527
Cholescintigraphy......Page 545
Tc-99m Macroaggregated Albumin (MAA) Hepatic Arterial Perfusion Scintigraphy......Page 605
Hepatic Arterial Radiolabeled Microspheres for Tumor Therapy......Page 608
Tc-99m Red Blood Cell Liver Scintigraphy......Page 621
Tc-99m Sulfur Colloid Liver and Spleen Imaging......Page 628
Splenic Scintigraphy......Page 639
Gastrointestinal Transit Scintigraphy......Page 645
Esophageal Transit Scintigraphy......Page 671
Gastroesophageal Reflux Disease......Page 679
Gastrointestinal Bleeding......Page 692
Meckel Scan......Page 720
Protein-Losing Enteropathy......Page 731
Peritoneal Scintigraphy......Page 732
Helicobacter pylori Infection......Page 736
Renal Anatomy and Physiology......Page 741
Dynamic Renal Imaging......Page 743
Dynamic Renography Imaging Protocols......Page 749
Clinical Applications of Renal Scintigraphy......Page 760
Renovascular Hypertension......Page 771
Renal Transplant Evaluation......Page 777
Measuring Renal Function: Glomerular Filtration Rate......Page 790
Renal Cortical Imaging......Page 792
Radionuclide Cystography......Page 801
Background......Page 816
F-18 FDG Oncology Protocol......Page 821
Dedicated PET/MR......Page 829
Image Interpretation......Page 835
Clinical F-18 FDG PET Use in Oncology......Page 860
13. Oncology—Beyond Fluorodeoxyglucose......Page 943
Neuroendocrine Tumor Imaging and Peptide Receptor Radiotherapy......Page 944
I-123 and I-131 mIBG Adrenergic Tumor Imaging and Therapy......Page 963
Prostate Cancer Diagnostic Imaging and Therapy......Page 979
Sentinel Node Mapping With Lymphoscintigraphy......Page 986
Molecular Breast Imaging—Scintimammography......Page 1001
Radionuclide Monoclonal Antibody Therapy—B-Cell Lymphoma......Page 1005
Tc-99m Sestamibi Renal Imaging—Oncocytoma Versus Renal Cell Carcinoma......Page 1012
Gallium-67 Tumor Imaging......Page 1013
14. Central Nervous System......Page 1021
Radiopharmaceuticals......Page 1025
PET......Page 1104
Pathophysiology of Inflammation and Infection......Page 1133
Radiopharmaceuticals......Page 1135
Clinical Applications for Infection Scintigraphy......Page 1158
Common Clinical Indications......Page 1176
Myocardial Perfusion Scintigraphy......Page 1218
Single-Photon Radiopharmaceuticals for Myocardial Scintigraphy......Page 1219
Myocardial Infarction Imaging......Page 1278
Cardiac Amyloidosis......Page 1279
Cardiac Sympathetic Hyperactivity—I-123 Metaiodo-Benzyl-Guanidine......Page 1282
Cardiac Positron Emission Tomography......Page 1283
Radionuclide Ventriculography......Page 1295
Radiopharmaceuticals......Page 1315
Nuclear Medicine Physics......Page 1318
Radiation Detection and Instrumentation......Page 1322
Single-Photon Emission Computed Tomography and Positron Emission Tomography......Page 1325
Endocrine......Page 1328
Bone......Page 1333
Hepatobiliary......Page 1337
Genitourinary......Page 1343
Oncology: Positron Emission Tomography......Page 1346
Oncology: Beyond Fluorodeoxyglucose......Page 1349
Gastrointestinal......Page 1352
Infection and Inflammation......Page 1356
Central Nervous System......Page 1359
Cardiac......Page 1361
Pulmonary......Page 1365
Appendix 1. Dosimetry......Page 1371
Appendix 2. The Periodic Table of the Elements......Page 1375
Index......Page 1376