Novel Pharmacological Interventions for Alcoholism

Front Matter....Pages i-xv
Front Matter....Pages 1-1
Animal Models for Testing Drug Effects on Alcohol Consumption....Pages 3-16
Animal Models for Screening Drugs to Decrease Alcohol Consumption....Pages 17-32
Medications for Alcohol Abuse and Dependence: Methodology for Clinical Studies....Pages 33-39
Some Issues in the Evaluation of a Pharmacotherapy of Alcoholism....Pages 40-55
Front Matter....Pages 57-57
Serotonin and Alcohol Consumption....Pages 59-67
Serotonergic and Dopaminergic Involvement in Ethanol Intake....Pages 68-82
Serotonin and Alcohol Consumption....Pages 83-91
Basic and Clinical Studies on Serotonin, Alcohol, and Alcoholism....Pages 92-104
Evaluation of the Effects of Serotonin Uptake Inhibitors in Alcoholics: A Review....Pages 105-117
Front Matter....Pages 119-119
Opioids Modulate Rats’ Propensities to Take Alcoholic Beverages....Pages 121-134
The Enkephalinergic System and Maintenance of Ethanol Drinking....Pages 135-136
The Relationship of Alcohol Drinking and Endogenous Opioids: The Opioid Compensation Hypothesis....Pages 137-147
Naltrexone in the Treatment of Alcohol Dependence: Preliminary Findings....Pages 148-157
Front Matter....Pages 159-159
Neurotransmitter Systems Regulating Alcohol Intake....Pages 161-183
Agents Which Modify Channels as Potential Treatments in Alcohol Withdrawal....Pages 184-200
Management of Alcohol Consumption with Angiotensin Converting Enzyme Inhibitors: A Review of the Animal Findings....Pages 201-214
Enalapril Does not Decrease Alcohol Intake in Normotensive Alcoholics....Pages 215-225
Front Matter....Pages 227-227
Rational vs. reflexive alcohol drinking....Pages 229-231
Rats’ Intakes of Different Alcoholic Beverages....Pages 232-236
Drug-Induced Specific and Nonspecific Changes in Voluntary Ethanol Intake by Rats....Pages 237-246
Front Matter....Pages 227-227
Rationale for Alcoholism Treatment Based on Inhibition of Aldehyde Dehydrogenase....Pages 247-250
The Effect of Low Alcohol Beverages on Alcoholism Levels in Canada in 1986....Pages 251-253
Alcoholism, Antisocial Behavior, and Family History: A Synopsis....Pages 254-261
Perception of Whether Drug or Placebo has been Administered is a Determinant of Drinking Reduction....Pages 262-264
Disulfiram Treatment of Alcoholism....Pages 265-266
Controlled Release Disulfiram (DS) Implant....Pages 267-272
Depot Disulfiram: Pharmacokinetics and Clinical Effects during 28 Days Following a Single Subcutaneous Dose....Pages 273-276
Mildly Intoxicating Levels of Alcohol Produces Direct Myocardial Depression on Left Ventricular Performance....Pages 277-287
A Human Model for Testing Drug-Induced Concomitant Variations in Alcohol Consumption and Desire to Drink....Pages 288-295
Mianserin, a Serotonergic Antagonist, and Intake of an Alcoholic Beverage....Pages 299-300
Effects of the 5-HT Uptake Inhibitor, Sertraline, on Ethanol, Water and Food Consumption....Pages 301-303
Fluvoxamine is Poorly Tolerated by Alcoholics....Pages 304-306
Effects of Differential Handling on Rats’ Intake of Alcohol....Pages 309-311
Stereoselectivity of Opioids’ Effects on Intake of an Alcoholic Beverage....Pages 312-314
Metabolites of Morphine and Intake of an Alcoholic Beverage....Pages 315-317
Peripheral Administration of Tiqs and Intake of an Alcoholic Beverage....Pages 318-320
Morphine Enhances Intake of an Alcoholic Beverage Regardless of Type of Flavoring....Pages 321-322
LY78335, An Inhibitor of Phenylethanolamine N-Methyltransferase, and Rats’ Intake of an Alcoholic Beverage....Pages 323-325
LY255582, An Opioid Antagonist, and Intake of an Alcoholic Beverage....Pages 326-328
Effects of Naltrexone on the Cognitive Functioning of Recently Abstinent Alcohol Dependent Patients....Pages 329-334
Front Matter....Pages 227-227
Calcium-Diacetyl-Homotaurinate which Pre-Vents Relapse in Weaned Alcoholics Decreases the Action of Excitatory Amino Acids in Neo-Cortical Neurons of the Rat in Vitro....Pages 337-341
THC, An Active Ingredient in Marijuana, and Rats’ Intake of a Sweetened Alcoholic Beverage....Pages 342-343
Cocaine and Rats’ Intake of an Alcoholic Beverage....Pages 344-347
Calcium-Acetylhomotaurinate for Maintaining Abstinence in Weaned Alcoholic Patients: A Placebo-Controlled Double-Blind Multicenter Study....Pages 348-352
Effects of Angiotensin Converting Enzyme Inhibitors on Free Choice Ethanol Consumption by Rats....Pages 353-355
Calcium Channel Antagonists Attenuate the Alcohol Dependence Syndrome....Pages 356-365
Pharmacological Antagonism of Ethanol by dl -α-Tocopherol....Pages 366-368
Characterization of Dsm-IIIr Criteria for Uncomplicated Alcohol Withdrawal: Proposal for a Diagnostic Inventory and Revised Withdrawal Scale....Pages 369-371
Ethanol Effects on CNS Dopamine Receptors: In Vivo Binding Following Voluntary Ethanol (ETOH) Intake in Rats....Pages 372-374
Closing Remarks....Pages 375-375
Back Matter....Pages 377-378