Nonmalignant Hematology: Expert Clinical Review: Questions and Answers

Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Evaluation of Anemia in Children and Adults....Pages 3-12
Iron Homeostasis and the Pathophysiology and Management of Iron Deficiency....Pages 13-22
Porphyrias: Diagnosis and Management....Pages 23-28
Disorders of Hemoglobin Synthesis: Pathophysiology and Diagnostic Evaluation....Pages 29-37
Management of Thalassemias....Pages 39-51
Allogeneic Hematopoietic Cell Transplant in β-Thalassemia Major....Pages 53-61
Sickle Cell Disease: Prevention of Complications....Pages 63-73
Sickle Cell Disease: Management of Complications....Pages 75-87
Allogeneic Hematopoietic Cell Transplant in Sickle Cell Disease....Pages 89-96
Anemia of Inflammation....Pages 97-102
Iron Overload: Diagnosis, Complications, and Management....Pages 103-112
Megaloblastic and Nutritional Anemias....Pages 113-123
Sideroblastic Anemias: Diagnosis and Management....Pages 125-135
Primary Autoimmune Warm Antibody Hemolytic Anemias....Pages 137-152
Intrinsic Hemolytic Anemias: Pathophysiology, Diagnosis, and Management....Pages 153-167
Front Matter....Pages 169-169
Platelet Disorders: Diagnostic Tests and Their Interpretations....Pages 171-183
Inherited Platelet Disorders: Diagnosis and Management....Pages 185-197
Acquired Platelet Disorders: Diagnosis and Management....Pages 199-207
Immune-Mediated Thrombocytopenia....Pages 209-220
Coagulation Cascade and Fibrinolysis Pathway: Assessment in the Laboratory....Pages 221-233
Front Matter....Pages 169-169
Abnormalities in the Fibrinolysis Pathway and Clinical Implications....Pages 235-242
Congenital Disorders of Fibrinogen: Clinical Presentations, Diagnosis and Management....Pages 243-254
Hemophilia A and B: Diagnosis and Management....Pages 255-262
Coagulation Factor Inhibitors: Diagnosis and Management....Pages 263-272
Rare Coagulation Factor Deficiencies: Diagnosis and Management....Pages 273-283
von Willebrand Disease: Differential Diagnosis and Diagnostic Approach to Specific Subtypes....Pages 285-293
von Willebrand Disease: Prevention of Complications and Management of the Disease....Pages 295-311
Antifibrinolytics: Indications and Precautions....Pages 313-319
Gene Therapy for Bleeding Disorders....Pages 321-336
Front Matter....Pages 337-337
Disseminated Intravascular Coagulation....Pages 339-347
Coagulopathy in Critically Ill Subjects....Pages 349-359
Trauma-Associated Coagulopathy....Pages 361-367
Coagulation-Related Issues in Malignant Hematology: Diagnosis and Management....Pages 369-378
Unmet Clinical Needs of Antithrombotic Treatment in BCR/ABL-Negative Myeloproliferative Neoplasms....Pages 379-393
Bleeding and Thrombosis in a Cancer Patient....Pages 395-402
Management of the Surgical Patient with Thrombotic and Bleeding Diathesis....Pages 403-413
Front Matter....Pages 415-415
Prevention and Treatment of Arterial Thromboembolism....Pages 417-428
Prevention of Venous Thromboembolism....Pages 429-443
Diagnostic, Prognostic, and Therapeutic Challenges in Venous Thromboembolism....Pages 445-461
Complications of Venous Thromboembolic Disease....Pages 463-474
Front Matter....Pages 415-415
Hereditary Thrombophilias: Pathophysiology, Timing of Testing and Familial Testing....Pages 475-484
Antiphospholipid Antibodies and Syndrome: Complexities in Diagnosis and Management....Pages 485-494
Unidentifiable Thrombophilia....Pages 495-502
Anticoagulation Drugs: Indications, Therapeutic Monitoring, and Antidotes....Pages 503-517
Heparin-Induced Thrombocytopenia: Diagnosis and Management....Pages 519-529
Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome....Pages 531-547
Surgical Treatment of Thromboembolic Disease....Pages 549-560
Front Matter....Pages 561-561
Nonmalignant Leukocyte Disorders....Pages 563-573
Primary Immunodeficiency Disorders: Diagnosis and Management....Pages 575-584
Disorders of Phagocytic Function: Diagnosis and Treatment....Pages 585-594
Inherited Bone Marrow Failure Syndromes....Pages 595-609
Hemophagocytic Lymphohistiocytosis: Diagnosis and Management Challenges....Pages 611-617
Lysosomal Storage Disorders: Haematology Perspective....Pages 619-631
Cryoglobulins and Cryoglobulinemia....Pages 633-645
Front Matter....Pages 647-647
Reproductive Issues in Women with Bleeding and Thrombotic Disorders....Pages 649-659
Pregnancy in Subjects with Hemoglobinopathies: Precautions and Management....Pages 661-668
Neonatal Thrombosis and Coagulopathies....Pages 669-676
Bleeding and Thrombosis in the Elderly....Pages 677-684
Front Matter....Pages 685-685
Transfusion Support: Indications, Efficacy, and Complications....Pages 687-696
Human Blood Antigens and Antibodies: Diagnostic and Therapeutic Implications....Pages 697-705
Front Matter....Pages 685-685
Therapeutic Apheresis in Hematologic Disorders: When and Why?....Pages 707-718