Non-Vitamin K Antagonist Oral Anticoagulants

Contents
Chapter 1: Introduction
	1.1 Overview of the Coagulation Cascade
	1.2 Current Approaches to Anticoagulation
	1.3 The Ideal Anticoagulant
	References
Chapter 2: Direct Thrombin Inhibitors
	2.1 Historical Excursus: Ximelagatran
	2.2 Dabigatran Etexilate
		2.2.1 Venous Thromboembolism Prevention in Major Orthopedic Surgery
		2.2.2 Venous Thromboembolism Treatment
		2.2.3 Stroke Prevention in Atrial Fibrillation
		2.2.4 Other Directions
	References
Chapter 3: Factor Xa Inhibitors
	3.1 Rivaroxaban
		3.1.1 Venous Thromboembolism Prevention following Joint Surgery
		3.1.2 Treatment of Venous Thromboembolism
		3.1.3 Stroke Prevention in Atrial Fibrillation
		3.1.4 Acute Coronary Syndromes
	3.2 Apixaban
		3.2.1 Venous Thromboembolism Prevention in Major Orthopedic Surgery
		3.2.2 Stroke Prevention in Atrial Fibrillation
		3.2.3 Thromboprophylaxis in Other Clinical Settings
		3.2.4 Treatment of Venous Thrombosis
		3.2.5 Acute Coronary Syndrome
	3.3 Edoxaban
		3.3.1 Venous Thromboembolism Prevention in Major Orthopedic Surgery
		3.3.2 Stroke Prevention in Atrial Fibrillation
		3.3.3 Treatment of Venous Thromboembolism
	3.4 Emerging Factor Xa Inhibitors
		3.4.1 Betrixaban
		3.4.2 TTP889
	References
Chapter 4: Conclusions
	4.1 Future Directions
	References