Non-viral vectors for gene therapy : lipid- and polymer-based gene transfer

Content: Front Cover
 Advances inGenetics Nonviral Vectors for Gene Therapy
 Copyright
 DEDICATION
 CONTENTS
 CONTRIBUTORS
 Chapter 1 --
Nonviral Vectors: We Have Come a Long Way
 1. INTRODUCTION
 2. CHEMICAL METHODS
 3. PHYSICAL METHODS
 4. PERSPECTIVES
 ACKNOWLEDGMENTS
 REFERENCES
 Chapter 2 --
Lipid Nanoparticles for Gene Delivery
 1. INTRODUCTION
 2. RATIONAL DESIGNS TO OVERCOME EXTRACELLULAR AND INTRACELLULAR BARRIERS
 3. CURRENT LIPIDIC VECTORS FOR GENE DELIVERY
 4. GENE THERAPY APPLICATIONS
 5. PHARMACOKINETICS, BIODISTRIBUTION AND TOXICITY OF LNPS
 6. CLINICAL TRIALS
 7. CONCLUSIONS. ACKNOWLEDGMENTSREFERENCES
 Chapter 3 --
Nanotechnology for In vivo Targeted siRNA Delivery
 1. RNA POTENTLY MODIFIES GENE EXPRESSION
 2. TARGETING STRATEGIES
 3. TARGETING THE LIVER
 4. TARGETING PRIMARY TUMORS AND METASTASIS
 5. ENDOTHELIAL CELL TARGETING
 6. FUTURE PERSPECTIVES
 REFERENCES
 Chapter 4 --
Lipid Nanoparticles for Short Interfering RNA Delivery
 1. INTRODUCTION
 2. CHALLENGES AND STRATEGIES FOR DELIVERY OF SIRNA
 3. LIPID-BASED DELIVERY SYSTEMS
 4. LNP-SIRNA FORMULATIONS IN CLINICAL TRIALS
 5. FUTURE PROSPECTS
 REFERENCES
 Chapter 5 --
Composite Nanoparticles for Gene Delivery. 1. NANOMEDICINE AND GENE THERAPY2. COMPOSITE NANOPARTICLES
 3. FABRICATION METHODS OF COMPOSITE NANOPARTICLES
 4. COMPOSITE NANOPARTICLES FOR TARGETED GENE DELIVERY
 5. CONCLUSION
 ACKNOWLEDGMENTS
 REFERENCES
 Chapter 6 --
Multifunctional Enveloped Nanodevices (MENDs)
 1. INTRODUCTION
 2. R8-MEND
 3. KALA-MEND
 4. MITO-PORTER
 5. YSK-MEND
 6. SS-CLEAVABLE PROTON-ACTIVATED LIPID-LIKE MATERIAL (SSPALM)
 7. PERSPECTIVES
 ACKNOWLEDGMENTS
 REFERENCES
 Chapter 7 --
Lipid-Coated Calcium Phosphate Nanoparticles for Nonviral Gene Therapy. 1. RECENT PROGRESS OF NONVIRAL GENE THERAPY AND IN VITRO/IN VIVO DELIVERY SYSTEMS2. LCP NANOPARTICLES AS A MULTIFUNCTIONAL PLATFORM FOR GENE DELIVERY
 3. POTENTIAL THERAPEUTIC APPLICATIONS OF LCP: CANCER, CHRONIC LIVER DISEASE, AND GENE THERAPY
 4. LCP NANOPARTICLES: CONCLUSIONS
 REFERENCES
 Chapter 8 --
Polymers for Nucleic Acid Transfer-An Overview
 1. FIVE DECADES IN POLYPLEXES: CHALLENGES AND BREAKTHROUGHS
 2. OPTIMIZING THE CORE: BIODEGRADABLE AND BIOCOMPATIBLE POLYMERS
 3. OPTIMIZING THE SHELL: BIOINSPIRED SMART POLYPLEXES
 4. NEXT STEPS: MULTIFUNCTIONAL AND SEQUENCE-DEFINED POLYMERS. 5. PERSPECTIVESREFERENCES
 Chapter 9 --
Recent Developments in Nucleic Acid Delivery with Polyethylenimines
 1. INTRODUCTION
 2. MECHANISM OF PEI-MEDIATED DNA TRANSFECTION
 3. PROTON SPONGE: MYTH OR REALITY?
 4. PEI FOR GENE DELIVERY
 5. PEI DERIVATIVES FOR THE DELIVERY OF EXON SKIPPING OLIGONUCLEOTIDES
 6. PEIS FOR SIRNA DELIVERY
 7. CONCLUSION
 REFERENCES
 Chapter 10 --
Bioresponsive Polymer-Based Nucleic Acid Carriers
 1. INTRODUCTION
 2. POLYMER SELF-ASSEMBLIES FOR NUCLEIC ACID DELIVERY
 3. REDUCTIVE ENVIRONMENT-RESPONSIVE NUCLEIC ACID DELIVERY.