Non-canonical Cyclic Nucleotides

Front Matter....Pages i-viii
cCMP and cUMP Across the Tree of Life: From cCMP and cUMP Generators to cCMP- and cUMP-Regulated Cell Functions....Pages 3-23
cCMP and cUMP in Apoptosis: Concepts and Methods....Pages 25-47
Mammalian Nucleotidyl Cyclases and Their Nucleotide Binding Sites....Pages 49-66
The Pseudomonas aeruginosa Exoenzyme Y: A Promiscuous Nucleotidyl Cyclase Edema Factor and Virulence Determinant....Pages 67-85
Cyclic Nucleotide Monophosphates in Plants and Plant Signaling....Pages 87-103
cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase as Cyclic Nucleotide Effectors....Pages 105-122
Regulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides....Pages 123-133
Interaction of Epac with Non-canonical Cyclic Nucleotides....Pages 135-147
Identification of cCMP and cUMP Substrate Proteins and Cross Talk Between cNMPs....Pages 149-167
Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport....Pages 169-205
3′,5′-cIMP as Potential Second Messenger in the Vascular Wall....Pages 209-228
Discovery and Roles of 2′,3′-cAMP in Biological Systems....Pages 229-252
8-Nitro-cGMP: A Novel Protein-Reactive cNMP and Its Emerging Roles in Autophagy....Pages 253-268
Cyclic Dinucleotides in the Scope of the Mammalian Immune System....Pages 269-289
Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides....Pages 293-306
Medicinal Chemistry of the Noncanonical Cyclic Nucleotides cCMP and cUMP....Pages 307-337
Holistic Methods for the Analysis of cNMP Effects....Pages 339-357
The Chemistry of the Noncanonical Cyclic Dinucleotide 2′3′-cGAMP and Its Analogs....Pages 359-384
Back Matter....Pages 385-387