NMR in the Life Sciences

Front Matter....Pages i-viii
Special Problems of NMR in H 2 O Solution....Pages 1-10
2D NMR with Biopolymers....Pages 11-22
Proton Assignment Strategies in Nucleic Acid NMR Studies....Pages 23-36
Genetic Methods in High-Resolution NMR Studies of Proteins....Pages 37-48
Determination of Macromolecular Structure and Dynamics by NMR....Pages 49-72
NMR Studies of Protein-Ligand Interactions: Dihydrofolate Reductase....Pages 73-86
Diversity of Molecular Recognition: The Combining Sites of Monoclonal Anti Spin Label Antibodies....Pages 87-91
NMR Approaches to the Characterization of the Interaction of Metal Ions with Proteins....Pages 93-103
Volume Selection Strategies for In Vivo Biological Spectroscopy....Pages 105-117
The Use of Nuclear Magnetic Resonance Rotating Frame Experiments for One Dimensional Discrimination of Metabolites in Tissues....Pages 119-147
Proton-NMR of Nuclei, Cell and Intact Tissue in Normal and Abnormal States: Significance of Relaxation Times as Correlated with Other Non-Invasive Biophysical Probes....Pages 149-163
Towards NMR Spectroscopy In Vivo : The Use of Models....Pages 165-177
Towards NMR Spectroscopy In Vivo: II. Relationship between NMR Parameters and Histology....Pages 179-185
Theory of NMR Imaging....Pages 187-197
Some Observations on NMR Imaging Particularly in Lower Fields....Pages 199-215
Signal, Noise and R. F. Power in Magnetic Resonance Imaging....Pages 217-221
High Field NMR Imaging and Spectroscopy....Pages 223-234
Back Matter....Pages 235-237