Nitroarenes: Occurrence, Metabolism, and Biological Impact

Front Matter....Pages i-ix
Evidence from Animal Studies for the Carcinogenicity of Inhaled Diesel Exhaust....Pages 1-13
Interpretation of Carcinogenicity and Effective Dose in Chronic Exposures of Rats to High Diesel Exhaust Concentrations....Pages 15-27
Carcinogenicity of Dinitroarenes in Rat Lung....Pages 29-37
In Vivo Metabolism and Genotoxic Effects of the Air Pollutant and Marker for Nitro-Pah’s, 2-Nitrofluorene....Pages 39-59
Nitroarenes: Their Detection, Mutagenicity and Occurrence in the Environment....Pages 61-72
The Atmospheric Formation of Nitroarenes and Their Occurrence in Ambient Air....Pages 73-84
Metabolism of 1-Nitropyrene Oxides and Effect of Nitrogen Dioxide on Arene Activation....Pages 85-93
Mutagenic and Biochemical Consequences of the Reaction of Arylamines with DNA....Pages 95-103
Mutagenesis Induced by a Single Acetylaminofluorene Adduct Within the NarI Site is Position Dependent....Pages 105-112
Unusual Hydrogen Bonding Patterns in 2-Aminofluorene (AF) and 2-Acetylaminofluorene (AAF) Modified DNA....Pages 113-123
DNA Adduct Formation During Chronic Administration of an Aromatic Amine....Pages 125-133
Aerial Oxidation of Acetylaminofluorene-Derived DNA Adducts....Pages 135-147
Mutations and Homologous Recombination Induced by N -Substituted Aryl Compounds in Mammalian Cells....Pages 149-156
Comparison of the Mutagenic Potency of DNA Adducts Formed by Reactive Derivatives of Aflatoxin, Benzidine and 1-Nitropyrene in a Plasmid System....Pages 157-166
Mutations Induced in the lacI Gene of E. coli by 1-Nitroso-8-Nitropyrene and Furylfuramide: The Influence of Plasmid pKM101 and Excision Repair on the Mutational Spectrum....Pages 167-180
DNA Adduct Formation by 1-Nitropyrene 4,5- and 9,10-Oxide....Pages 181-187
Nitropolycyclic Aromatic Hydrocarbons and Diesel Exhaust: Potential Role of DNA Binding in Carcinogenicity....Pages 189-199
Validation/Application of 32 P-Postlabeling Analysis for the Detection of DNA Adducts Resulting from Complex Air Pollution Sources Containing PAHs and Nitrated PAHs....Pages 201-209
Analysis of NO 2 -PAH DNA Adducts by Mass Spectrometry....Pages 211-217
Generation of Reactive Intermediates from 2-Nitrofluorene that Bind Covalently to DNA, RNA and Protein in Vitro and in Vivo in the RAT....Pages 219-230
Activation of Carcinogenic N-Arylhydroxamic Acids by Peroxidase/H 2 O 2 /Halide Systems: Route to C-Nitroso Aromatics....Pages 231-244
Biochemical Studies on the Putative Nitroso Metabolite of Chloramphenicol: A New Model for the Cause of Aplastic Anemia....Pages 245-255
Mechanisms of Fanft/Anft Induced Bladder Cancer....Pages 257-264
Mutagenic Arylazides, Arylnitrenes, Arylnitrenium Ions....Pages 265-271
Products Obtained by in Vitro Reaction of 4, 5-Epoxy-4, 5-Dihydro-1-Nitropyrene with DNA....Pages 273-284
Oxidative Metabolism of Nitrated Polycyclic Aromatic Hydrocarbons in Mammalian Cell Fractions....Pages 285-293
Metabolic Activation of 6-Nitrochrysene and 6-Aminochrysene in Vitro and in Vivo ....Pages 295-307
The Possible Role of Nitroarenes in Human Cancer....Pages 309-316
Reaction of Glutathione with 4-Nitrosobiphenyl....Pages 317-317
Determination of Carcinogenic Arylamine N -Oxidation Phenotype in Humans by Analysis of Caffeine Urinary Metabolites....Pages 318-318
Assessing the Biological Significance of Nitracrine Analogues: The Relationship Between Microbial and Mammalian Mutagenicity....Pages 319-319
The Direct-Acting Mutagenicity of Nitrothiophenes Derivatives in Salmonella Typhimurium ....Pages 320-320
An Evaluation of the Metabolism of 1-Nitro[ 14 C]Pyrene by Rabbit Tracheal Epithelial Cells: Kinetic Analysis....Pages 321-321
Comparison of Anti-genotoxic Activities of Dibenzoylmethane, 1,3-Indandione and 2-(Methylmercapto)benzimidazole in Bacteria and Human Cells.....Pages 322-322
Differential Cytotoxicity and Genotoxicity of 1, 3- and 1, 6-Dinitropyrene in Mammilian Cell Lines Derived from Various Tissues and Species....Pages 323-323
Cooked-Meat Derived Aromatic Amine Mutagens and Their Immunoassay....Pages 324-324
Establishment of New Strains of S. Typhimurium Highly Sensitive to Nitroarenes and Aromatic Amines: TA98 and TA100 Substrains with Rich Nitroreductase or Acetyltransferase Activities....Pages 325-325
Back Matter....Pages 327-333