Nitric Oxide Research from Chemistry to Biology

Front Matter....Pages i-xx
Prologue....Pages 1-1
Introduction: The Origins of Nitric Oxide....Pages 3-13
Basic Chemistry of Nitric Oxide and Related Nitrogen Oxides....Pages 15-46
Basic EPR Methodology....Pages 47-60
EPR Characterization of Nitric Oxide Binding to Hemoglobin....Pages 61-86
Effects of Nitric Oxide on Red Blood Cells....Pages 87-97
Utilization of Nitric Oxide as a Paramagnetic Probe of the Molecular Oxygen Binding Site of Metalloenzymes....Pages 99-143
Nitric Oxide, an Intermediate in the Denitrification Process and Other Bacterial Pathways, as Detected by EPR Spectroscopy....Pages 145-173
Nitric Oxide Biosynthesis in Mammals....Pages 175-192
The Use of EPR Spectroscopy for the Identification of the Nature of Endothelium-Derived Relaxing Factor....Pages 193-204
Enzymatic Targets of Nitric Oxide as Detected by EPR Spectroscopy within Mammal Cells....Pages 205-233
Overproduction of Nitric Oxide in Physiology and Pathophysiology: EPR Detection....Pages 235-270
Palliatives to Underproduction of Nitric Oxide as Assayed by EPR Spectroscopy....Pages 271-291
Nitric Oxide-Specific Spin-Trapping EPR Methods....Pages 293-305
General Discussion: Crossregulations of Metalloenzymes Triggered by Nitric Oxide....Pages 307-328
Back Matter....Pages 329-331