Nisoldipine 1987

Front Matter....Pages I-XX
Front Matter....Pages 1-1
Experimental Pharmacology of Nisoldipine: Perspectives from Long-Term Studies....Pages 3-12
Membrane Potential and Nisoldipine Block of Calcium Channels in the Heart: Interactions with Channel Gating....Pages 13-26
Review of Nisoldipine Binding Studies....Pages 27-35
Comparison of Nifedipine and Nisoldipine on Human Arteries and Human Cardiac Tissues In Vitro....Pages 36-44
Effect of Prolonged Treatment with Nisoldipine on Cholesterol Deposition and Cardiac Noradrenaline Reserves: A Comparative Study....Pages 45-58
Pharmacokinetics of Nisoldipine....Pages 59-66
Plasma Level-Effect Relationships for some Acute Cardiovascular Effects of Nisoldipine and Other Dihydropyridine Calcium Channel Antagonists....Pages 67-75
Pharmacokinetics and Haemodynamic Effects of Nisoldipine in Patients with Liver Cirrhosis....Pages 76-79
Steady-State Pharmacokinetics of Nisoldipine in Patients with Liver Disease....Pages 80-84
Biotransformation of Nisoldipine in Man....Pages 85-88
Effect of Nisoldipine on Electrophysiological Parameters in Man....Pages 89-93
Chairman’s Analysis....Pages 94-95
Front Matter....Pages 97-97
Effect of Nisoldipine on Variant Angina....Pages 99-102
Hemodynamic Effects of Intravenous Nisoldipine....Pages 103-108
Direct Cardiac and Peripheral Vascular Effects of Intracoronary Nisoldipine....Pages 109-114
Antianginal Efficacy of Nisoldipine in Patients with Unstable Angina Pectoris: Evaluation on Holter ECG....Pages 115-122
Attenuation by Nisoldipine of the Abnormal Response to Cold Pressor Stimulation in Patients with Ischaemia and Normal Coronary Arteries....Pages 123-127
Nisoldipine for Patients Undergoing Coronary Revascularisation....Pages 128-130
Cardiovascular Profile of Nisoldipine as Compared to Nifedipine in Dogs....Pages 131-143
The Effect of Nisoldipine in Experimentally Induced Renal Failure....Pages 144-150
Front Matter....Pages 97-97
Nisoldipine Delays Progression of Chronic Renal Failure in Man Irrespective of Change in Blood Pressure....Pages 151-158
Influence of Nisoldipine on Hemodynamics and Atrial Natriuretic Polypeptides at Exercise Loading in Hypertensive Patients....Pages 159-164
Coronary Vasomotility with Different Intravenous Doses of Nisoldipine....Pages 165-170
Hemodynamic Effects of Intravenous Nisoldipine and Nitroglycerin in Patients with Coronary Heart Disease....Pages 171-176
Front Matter....Pages 177-177
Acute Hemodynamic Effects of Intravenous Nisoldipine in Patients with Left Ventricular Failure....Pages 179-182
Hemodynamic Effects of Long-Term Oral Nisoldipine Versus Placebo in Patients with Impaired Ventricular Function....Pages 183-189
A Comparison of the Acute Hemodynamic Effects of Nifedipine and Nisoldipine in Patients with Ischemic Reduced Left Ventricular Function....Pages 190-194
Nisoldipine After Acute Myocardial Infarction: Comparison with Other Calcium Channel Blocking Agents....Pages 195-200
Assessment of Long-Term Efficacy and Tolerability of Nisoldipine by the Clinical Data Pool....Pages 201-209
Chairman’s Analysis....Pages 210-210
Front Matter....Pages 211-211
Effects of Long-Term Therapy with the Association of Nisoldipine and a Beta-Blocker on Exercise Tolerance and Coronary Hemodynamics in Patients with Stable Angina: A Comparison with Monotherapy....Pages 213-222
Is There a Difference Between the Acute and Chronic Anti-Ischemic Efficacy of Nisoldipine?....Pages 223-227
Nisoldipine Versus Mononitrate in Stable Angina....Pages 228-232
Efficacy of Nisoldipine Compared with Nifedipine in Chronic Stable Angina Pectoris....Pages 233-237
Effect of Nisoldipine and Nitroglycerin on Myocardial Ischemia and Dysfunction During Coronary Angioplasty....Pages 238-243
Anti-Ischemic Effect of Nisoldipine in Patients with Stable Angina Pectoris....Pages 244-248
Efficacy of Nisoldipine in Chronic Stable Angina in Patients Taking Beta-Blockers....Pages 249-255
Assessment and Comparison of Single and Double Dose of Nisoldipine in the Prevention of Exercise-Induced Ischaemia — Match with Sublingual Nitroglycerin....Pages 256-262
Acute Hemodynamic Response to Intravenous Nisoldipine (Bay k 5552) Versus Nifedipine in Patients with Ischemic Cardiomyopathy....Pages 263-263
Chairman’s Analysis....Pages 264-264
Front Matter....Pages 265-265
The Relevance of Silent Ischaemia for the Clinician....Pages 267-270
Prognostic Significance of Ischemic Changes in Patients After Myocardial Infarction....Pages 271-275
Effect of Nisoldipine on Myocardial Ischemia: Evaluation by Holter Monitoring....Pages 276-281
Calcium Antagonists in Silent Myocardial Ischemia — Preliminary Results with Nisoldipine....Pages 282-287
Effects of Oral Nisoldipine on Transient and Exercise-Induced Ischaemia in Patients with Coronary Heart Disease....Pages 288-295
Improvement in Silent Myocardial Ischemia with Nisoldipine....Pages 296-298
Front Matter....Pages 299-299
Vasodilators in the Treatment of Chronic Heart Failure — An Overview....Pages 301-306
Hemodynamic Effects of Nisoldipine in Patients with Severe Heart Failure....Pages 307-314
Acute Effects of Intravenous Nisoldipine on Hemodynamics and Left Ventricular Function in Cardiac Failure....Pages 315-323
Effects of Nisoldipine in Heart Failure....Pages 324-328
Hemodynamic Effects of Nisoldipine in Patients with Severe Chronic Congestive Heart Failure....Pages 329-342
Influence of Chronic Nisoldipine Therapy upon Severe Congestive Heart Failure — Comparison with Nitrates....Pages 343-346
Chairman’s Analysis....Pages 347-347
Closing Remarks....Pages 348-348