Nicotinic Acetylcholine Receptor: Structure and Function

Front Matter....Pages I-XVIII
Three-Dimensional Structure of the Acetylcholine Receptor....Pages 1-6
Ultrastructural Analysis of the Native Acetylcholine Receptor....Pages 7-17
Probing Acetylcholine Receptors with Monoclonal Antibodies....Pages 19-33
Acetylcholine Receptor Conformation Probed by Subunit-Specific Monoclonal Antibodies....Pages 35-47
What Can We Learn about the Acetylcholine Receptor from Synthetic Peptides?....Pages 49-59
Topography of the Acetylcholine Receptor Revealed by Fluorescence Energy Transfer....Pages 61-74
Infrared Studies of the Acetylcholine Receptor Structure....Pages 75-82
Monoclonal Antibodies as Probes of Acetylcholine Receptor Function....Pages 83-91
Antigenic Specificity of Monoclonal Antibodies Against Torpedo and Human Acetylcholine Receptor, and Use of These Antibodies to Investigate Myasthenia Gravis....Pages 93-102
Tertiary Structure of the Nicotinic Acetylcholine Receptor Probed by Photolabeling and Protein Chemistry....Pages 103-114
A Structural Model of the Ion Channel of the Nicotinic Acetylcholine Receptor....Pages 115-127
A General Treatment of Ligand Binding to the Acetylcholine Receptor....Pages 129-146
Lipid-Protein Interactions and Acetylcholine Receptor Function in Reconstituted Membranes....Pages 147-157
Regulation of Intercellular Signal Transmission. New Approaches to Chemical Kinetic Measurements....Pages 159-176
Hysteresis and Channel Properties of the Acetylcholine Receptor of Torpedo Californica....Pages 177-196
States of the Nicotinic Acetylcholine Receptor: Enumeration, Characteristics and Structure....Pages 197-218
Function of Mammalian Nicotinic Acetylcholine Receptors....Pages 219-232
Single Channel Studies of Acetylcholine Receptors Covalently Alkylated with Acetylcholine....Pages 233-241
Effects of Allosteric Ligands on the Gating of Single Channel Currents in BC 3 H-1 Cells....Pages 243-257
On the Role of Trophic Factors VS. Muscle Activity in the Development of Acetylcholine-Receptor Ion Channels in Rat Endplates....Pages 259-262
Molecular Electrophysiology of Cloned AChR Channels expressed in Xenopus Oocytes....Pages 263-273
The Transglutaminase of Acetylcholine Receptor Rich Membranes....Pages 275-279
Association of the Postsynaptic 43K Protein with Sites of Clustered and Diffusely-Distributed Acetylcholine Receptors....Pages 281-289
cAMP-Dependent Phosphorylation of the Nicotinic Acetylcholine Receptor: Characterization of the Protein Kinase in Torpedo Electric Organ, Lack of Correlation in Myotubes between Increased Intracellular Levels of cAMP and Influx of Monovalent Ions, Block of Influx by Forskolin Independently of cAMP Levels....Pages 291-303
Common Antigenic Determinants between Acetylcholine Receptor and Protozoan Membranes....Pages 305-318
Identification and Reconstitution of a Neuronal Acetylcholinereceptor from Insects....Pages 319-332
Studies on the Nicotinic Cholinergic Receptor of Sympathetic Neurones....Pages 333-344
Radioligand Labelling of Nicotinic Receptors in Mammalian Brain....Pages 345-357
Molecular Biology of Muscle and Neural Acetylcholine Receptors....Pages 359-387
Molecular Biology of Nicotinic Acetylcholine Receptors from Chicken Muscle and Brain....Pages 389-415
Acetylcholine Receptor Related Genes Expressed in the Nervous System....Pages 417-422
Expression Cloning and Fusion Proteins as Tools to Study Receptor Structure....Pages 423-429
Establishing a System for the Stable Expression of Torpedo Acetylcholine Receptors....Pages 431-435
Characterization of the mRNA and the Gene of a Putative Neuronal Nicotinic Acetylcholine Receptor Protein from Drosophila ....Pages 437-446
Review and Revision of Structural Models for the Transmembrane Portion of the Acetylcholine Receptor Channel....Pages 447-463
A Structural and Dynamic Model for the Nicotinic Acetylcholine Receptor....Pages 465-483
Back Matter....Pages 485-491