New Trends in Genetic Risk Assessment

Content: 
Inside Front Cover, Page ii
Front Matter, Page iii
Copyright, Page iv
Contributors, Pages v-x
Participants, Pages xi-xv
Preface, Pages xvii-xviii, G. Jolles, A. Cordier
Acknowledgements, Page xix, G. Jolies, A. Cordier
1 - The Role of Genotoxicity in Drug Safety Evaluation, Pages 3-12, E. MOUSTACCHI
Introduction, Pages 15-17, A. SARASIN
2 - DNA Repair and Genetic Alterations, Pages 19-39, M. RADMAN
3 - Molecular Approaches to the Detection of Germinal Mutations in Mammalian Organisms, Including Man, Pages 41-56, H.W. MOHRENWEISER, E.W. BRANSCOMB
4 - Molecular Analysis of Genetic and Epigenetic Alterations in Human Cells, Pages 57-70, A.R. LEHMANN, C.F. ARLETT, M. GEBARA, S.A. HARCOURT, M.R. JAMES, J.R. LAMB, W.J. MURIEL, H. STEINGRIMSDOTTIR
5 - Artificial Intelligence in the Study of the Structural Relationships Amongst Mutagens and Carcinogens, Pages 71-88, H.S. ROSENKRANZ, G. KLOPMAN
Genotoxicity and Covalent Binding. An Introduction, Pages 91-95, G. DIRHEIMER
6 - Fluorimetric Analysis of DNA-strand Breakage and Repair Kinetics. Application to Radiotoxicology, Pages 97-108, O. RIGAUD, H. MAGDELENAT
7 - Detection by 32P-postlabelling of Carcinogen–DNA Adducts in Animals and Man, Pages 109-124, D.H. PHILLIPS
8 - SOS Chromotest and the Use of Bacteria for the Detection and Diagnosis of Genotoxic Agents, Pages 125-136, M. HOFNUNG, P. QUILLARDET, O. GOERLICH, E. TOUATI
Introduction, Pages 139-143, E. MOUSTACCHI
9 - Mutation at the hprt Locus in Human T-lymphocytes: In Vivo and In Vitro Studies, Pages 145-159, R.J. ALBERTINI, JA NICKLAS, J.P. O'NEILL
10 - Mutagenicity and Clastogenicity Testing with Mouse Lymphoma Cells, Pages 161-174, C.F. ARLETT, J. COLE, M.-C. DIOT, B.A. BRIDGES
11 - Measurement of Mutant Frequency to 6-Thioguanine Resistance in Circulating T-lymphocytes for Human Population Monitoring, Pages 175-203, J. COLE, C.F. ARLETT, M.H.L GREEN, S.E. JAMES, L. HENDERSON, H. COLE, M. SALA-TREPAT, R. BENZI, M.L. PRICE, B.A. BRIDGES
Introduction, Pages 207-209, C. MELCION, A. CORDIER
12 - Specific Sites of Chromosomal Radiation-induced Rearrangements, Pages 211-224, L. SABATIER, M. MULERIS, M. PRIEUR, W. AL ACHKAR, F. HOFFSCHIR, M. PROD'HOMME-RICOUL, M. GERBAULT-SEUREAU, E. VIEGAS-PEQUIGNOT, B. DUTRILLAUX
13 - Flow Cytometric Analysis and Sorting of Chromosomes, Pages 225-245, M.A. VAN DILLA, P.N. DEAN, J.C. FUSCOE, J.W. GRAY, J.N. LUCAS, D.C. PETERS, B.J. TRASK, G.J. VAN DEN ENGH
14 - Flow Cytometric Detection of Micronuclei, Pages 247-260, C. MELCION, A. CORDIER
15 - Induced Chromosome Aneuploidy: its Role in the Assessment of the Genetic Toxicology of Environmental Chemicals, Pages 261-296,296a,296b, J.M. PARRY, E.M. PARRY
16 - Assessment of Chemically-induced Aneuploidy: an Assay System Using a Mouse/Human Hybrid Cell Line, Pages 297-316, R.S. ATHWAL, R. GUDI, S.S. SANDHU
Introduction, Pages 319-322, A. LEONARD
17 - Prospective Overview on Germ Cell Mutations in Mice, Pages 323-342, U.H. EHUNG
18 - Flow Cytometric Analysis of Toxic Chemical-induced Alterations in Testicular Cell Kinetics and Sperm Chromatin Structure, Pages 343-365, D.P. EVENSON
Introduction, Pages 369-372, F.J.C. ROE
19 - Reflections on the Declining Ability of the Salmonella Assay to Detect Rodent Carcinogens as Positive, Pages 373-387, J. ASHBY
20 - Methods for Genetic Toxicology Testing Strategies, Pages 389-400, D. BRUSICK
21 - New Approaches to Battery Selection and Interpretation, Pages 401-431, H.S. ROSENKRANZ, F.K. ENNEVER
28 - Risk Assessment of Genotoxic Agents: Problems and Possible Solutions, Pages 433-448, L. EHRENBERG
23 - Genetic Risk Estimation: Experience with Ionizing Radiation and its Relevance for Mutagenic Chemicals, Pages 449-477, K. SANKARANARAYANAN
Index, Pages 479-486