New Toxicology for Old: A Critique of Accepted Requirements and Methodology

Front Matter....Pages I-X
Young Scientists Award Lecture 1981: The Identification of an Accumulation System for Diamines and Polyamines Into the Lung and Its Relevance to Paraquat Toxicity....Pages 1-14
Front Matter....Pages 15-15
Assessment of Mammalian Toxicity of Pesticides and Other Industrial Chemicals — Flexible Guidelines or Rigid Protocols?....Pages 17-28
Critical Evaluation of the Toxicological Documents Produced for the Authorization of Drugs According to the Commission of the European Communities Directives....Pages 29-32
The EEC Policy in the Hazard Assessment of New Chemicals....Pages 33-39
Protocols for Routine Toxicity Studies: A Statistician’s View....Pages 40-44
The Council of Europe Approach to Toxicity Testing and Toxicological Evaluation....Pages 45-47
Behavioural Teratology: Post-Natal Consequences of Drug Exposure in Utero....Pages 48-58
Toxicity Testing in Relation to Aging....Pages 59-63
Perinatal Toxicology: Problems and Hazards....Pages 64-66
Safety Evaluation of Cosmetic Ingredients....Pages 67-67
Can the Design of the ‘Routine’ 90 Day Rat Study be Improved?....Pages 68-68
Front Matter....Pages 69-69
Neurotoxicity of Industrial Chemicals and Contaminants: Aspects of Biochemical Mechanisms and Effects....Pages 71-83
Task Dependent Neurobehavioral Effects of Lead in Rats....Pages 84-93
Quantitative Morphological and Autoradiographical Studies of Neurotoxicological Changes....Pages 94-95
Short-Term Exposure of Human Subjects to m-Xylene and 1,1,1-Trichloroethane....Pages 96-99
Impaired Nerve Function in Rats After Prolonged Exposure to Vinyltoluene....Pages 100-102
Organic Glue Neuropathies: Epidemiology, Clinical Investigation and Therapy of 100 Cases....Pages 103-104
Toxicology of the Central Nervous System — Pathogenetical Aspects....Pages 105-106
The Toxicity of p-Benzoquinone on the Central Nervous System of the Cockroach....Pages 107-111
A Possible Site of Action of Dieldrin in the Brain....Pages 112-115
Front Matter....Pages 69-69
Mechanisms of Recovery of Brain Acetylcholinesterase in Rats During Chronic Intoxication by Isoflurophate....Pages 116-119
Neurophysiological Effects of Long-Term Exposure to Hydrocarbon Mixtures....Pages 120-124
Effect of Dithiocarbamate-Type Chemicals on the Nervous System of Rats....Pages 125-128
Pertussis Antigens—Screening Models on Toxicity....Pages 129-132
Effects of Physostigmine on Acute Toxicity of Tricyclic Antidepressants and Benzodiazepines in Mice and Rats....Pages 133-135
Effect of Cadmium and Phenobarbital on Cerebral Aldehyde Reductase....Pages 136-138
Front Matter....Pages 139-139
Newer Diagnostic Procedures in Chronic Toxicity Studies in Rats....Pages 141-151
Animal Clinical Chemistry and Haematology for the Toxicologist....Pages 152-159
In Vivo Evaluation of Hepatotoxicity by Invasive and Non-Invasive Techniques....Pages 160-161
Measurement of Urinary Metabolites of Xenobiotics as a Non-Invasive Technique in Toxicology....Pages 162-178
Heart Rate- and ECG-Recording in the Rat by Biotelemetry....Pages 179-183
Monitoring of the Oestrus Cycle in the Rat by Measurement of Vaginal Impedance....Pages 184-186
The Effect of Pregnancy on the Pharmacokinetics of Caffeine....Pages 187-192
Front Matter....Pages 193-193
Drug Toxicity in Obstetrics....Pages 195-196
The Embryotoxicity of a New Class of Antispermatogenic Agents: the 3-Indazole-Carboxylic Acids....Pages 197-201
A Case of Acute Poisoning by Methyl Demeton in a Female 5 Months Pregnant....Pages 202-204
Effects of Diet Substituted in Protein Components on the Fertility and on Postnatal Growth and Behaviour of Rats....Pages 205-208
The Anti-Implantation Action of Tamoxifen in Mice....Pages 209-213
Effects of Tranexamic Acid on the Coagulation and Fibrinolytic Systems in Pregnancy Complicated by Placental Bleeding....Pages 214-220
Toxicity of the Progestagen STS 557 Compared to Levonorgestrel in Beagles After Oral Administration for 6 Months....Pages 221-224
Front Matter....Pages 193-193
Organ/Tissue Disposition of Thallium in Pregnant Rats....Pages 225-230
The Effect of the Progesterone-Releasing Intrauterine Device on Uterine Endometrium and Fallopian Tube Epithelium....Pages 231-234
Front Matter....Pages 235-235
Statistical Analysis and Normality of Selected Hematologic and Clinical Chemistry Measurements Used in Toxicologic Studies....Pages 237-253
Statistical Simplicity in Long-Term Animal Feeding Studies of Suspect Carcinogens....Pages 254-255
Statistical Analysis of Behavioral Toxicology Data and Studies....Pages 256-266
Statistics and the LD 50 Study....Pages 267-270
Toxicology Reference Data for the Wistar Rat....Pages 271-276
Front Matter....Pages 277-277
The Ferret for Non-Rodent Toxicity Studies — A Pathologist’s View....Pages 279-282
Necrotizing Vasculitis as an Immunological Complication in Toxicity Study....Pages 283-286
Early Toxic Events in Kidney of Rat and Man Following Administration of Gentamicin at Low Doses....Pages 287-290
Ultrastructural Changes Induced by p-Benzoquinone in the Terminal Abdominal Ganglion of the Cockroach....Pages 291-294
Plasma Fibronectin in Man After a Severe Paraquat Intoxication....Pages 295-297
Choice of Rat Strain: A Comparison of the General Pathology and the Tumour Incidence in 2-year old Sprague-Dawley and Long-Evans Rats....Pages 298-303
Prediction of the Efficacy of Hemoperfusion and Hemodialysis in Severe Poisoning....Pages 304-306
Preliminary Communication Investigations on Leukaemia in the F344 Rat....Pages 307-309
Front Matter....Pages 311-311
Drug Toxicity and Motor Driving....Pages 313-316
Surgical Approach to Chemical Burn Injuries of the Upper GI-Tract....Pages 317-321
Congestive Cardiomyopathy due to Chronic Inhalation of Trichlorethylene....Pages 322-325
Inorganic Arsenic Metabolism in Man....Pages 326-327
Sequential Effects of Dioctyltin Dichloride on the Rat Thymus....Pages 328-330
Front Matter....Pages 311-311
Influence of Carbon Tetrachloride Induced Liver Injury and Bile Duct Ligation on Methotrexate Pharmacokinetics in the Rat....Pages 331-334
Inhibition by Some Flavonoids of Enhanced Spontaneous Lipid Peroxidation in Vitro Due to Glutathione Depletion in Vivo....Pages 335-338
The Estimation of Caffeine in the Urine of Dogs....Pages 339-344
Detection of Mutagenicity of Vinclozolin and Its Epoxide Intermediate....Pages 345-348
Cells for in Vitro Assessment of Chromosome Damage....Pages 349-354
Evaluation of Damage to DNA After in Vivo Exposure to Different Classes of Chemicals....Pages 355-359
Dihydrodiol Dehydrogenase: Substrate Specificity, Inducibility and Tissue Distribution....Pages 360-364
Identification and Characterization of a Novel Epoxide Hydrolase From Mouse Liver Microsomes....Pages 365-367
Drug Metabolism in Rat Liver Injured by Thioacetamide....Pages 368-371
Effects of Combined Administration of Lindane and Ethylenethiourea on Biochemical and Morphological Parameters in Rats....Pages 372-377
Two Year Toxicity in Beagle Dogs Fed a New Protein Source....Pages 378-381
Elimination of Chlorfenvinphos by Different Hemoperfusion Systems....Pages 382-385
Back Matter....Pages 387-396