New Technologies and Perinatal Medicine-Prediction and Prevention of Pregnancy Complications

List of contributors
Preface
Introduction: Why do we need Omics and Systems Biology
Joe Leigh Simpson and Moshe Hod
A Pregnancy Complications: Setting the Scene 
1. The Mother: Adaptation to Pregnancy and normal metabolism 
Irene Cetin, Francesca Parisi, Alice Zavatta, and Roberta Milazzo
2. Maternal and fetal normal and abnormal nutrition 
Sarah Louise Killeen, Eilleen C O’Brien, and Fionnuala M McAuliffe
3. The Great Obstetrical Syndromes: It`s all in the placenta
Martin Gauster and Gernot Desoye
4. Embryo-specific communication and interaction with the maternal environment: The role of PreImplantation Factor
Eytan R Barnea and Michael Stark
5. Normal and abnormal fetal growth
Javier Caradeux, Eduard Gratacos, and Francesc Figueras 
6. Pre-term labor and birth 
Vincenzo Berghella and Eduardo da Fonseca 
7. Gestational Diabetes Mellitus
Silvia Vannuccini and Federico Mecacci
8. Pre-eclampsia
Jon Hyett and Liona Poon
9. Maternal obesity
Tahir A. Mahmood and Rohan Chodankar
10. Maternal health: Immediate, short-, and long-term complications following pregnancy
Gil Gutvirtz, Omri Zamstein, and Eyal Sheiner
11. The fetus and the neonate: Immediate, short, and long term impact
Umberto Simeoni and Elie Saliba 
12. The cost of pregnancy complications related to non-communicable diseases and the cost effectiveness of interventions to address them 
Anil Kapur, Jon Hyett, and H David McIntyre 
B Towards Prediction and Prevention
13. Integrated System Biology approaches to Fetal Medicine problems
Jezid Miranda, Fátima Crispi, and Eduard Gratacós 
14. Omics and female reproduction
Galia Oron
15. The maternal genome and pregnancy outcomes 
Nagendra K. Monangi, Ge Zhang, Mikko Hallman, Kari Teramo, Bo Jacobsson, and Louis J Muglia 
16. Placental development and Omics
Sylvie Hauguel-de Mouzon, Gernot Desoye, and Silvija Cvitic
17. Placental metabolomics in obese pregnancies
Irene Cetin, Chiara Novielli, and Chiara Mandò
18. The methylome and epigenetics markers
Skevi Kyriakou, Marios Ioannides, George Koumbaris, and Philippos Patsalis
19. The microbiome and pregnancy complications
Maria Carmen Collado and Omry Koren
20. Small non-coding RNAs as biomarkers for pregnancy complications
Liron Yoffe, Meitar Grad, Avital Polsky, Moshe Hod, and Noam Shomron 
21. Urine metabolomics and proteomics in prenatal health
Daniela Duarte, Maria do Céu Almeida, Pedro Domingues, and Ana M. Gil
22. The metabolomics and perinatal complications
Flaminia Bardanzellu, Moshe Hod, and Vassilios Fanos
23. Metabolomics in normal and pathologic pregnancies
Antonio Ragusa, Alessandro Svelato, and Sara D’Avino
24. Metabolomics in amniotic fluid
Alexandra-Maria Michaelidou, Foteini Tsakoumaki, Maria Fotiou, Charikleia Kyrkou, and Apostolos P. Athanasiadis
25. Omics and coagulation disorders in pregnancy
Sara Ornaghi and Michael J Paidas
26. The omics and preeclampsia
Piya Chaemsaithong and Liona C. Poon
27. Single Nucleotide Polymorphisms and pregnancy complications
Federica Tarquini, Giuliana Coata, Elena Picchiassi, and GianCarlo Di Renzo 
28. Metabolomics and perinatal cardiology
Roberta Pintus, Angelica Dessì, and Vassilios Fanos 
29. Metabolomics and human breast milk: a unique and inimitable food for infants
Flamina Cesare Marincola, Sara Corbu, Roberta Pintus, Angelica Dessì, and Vassilios Fanos
30. Neurodevelopment and placental omics
Despina D. Briana and Ariadne Malamitsi-Puchner
31. Early life complications, placental genomics, and the risk for neurodevelopmental disorders in the offspring
Pasquale Di Carlo, Giovanna Punzi, and Gianluca Ursini
32. Metabolomics and perinatal asphyxia
Ernesto d’Aloja, Emanuela Locci, Antonio Noto, Matteo Nioi, Giovanni Bazzano, and Vassilios Fanos
33. Environment, pregnancy complications, and omics
Chen Ben David and Ido Solt
34. Sleep and pregnancy complications
Orna Sever and Riva Tauman
35. Maternal plasma cell-free DNA screening: I. Basic science and applications 
Peter Benn and Howard Cuckle
36. Maternal plasma cell-free DNA screening: II. Integration into clinical practice 
Howard Cuckle and Peter Benn 
37. Microarrays
Melissa Stosic, Jessica L. Giordano, Brynn Levy, and Ronald Wapner 
38. Whole exome and whole genome sequencing 
Mary E. Norton 
Index