New Developments in Asthma Research

NEW DEVELOPMENTS IN ASTHMA RESEARCH......Page 5
NOTICE TO THE READER......Page 6
Contents......Page 7
Preface......Page 9
ABSTRACT......Page 13
MAIN ABBREVIATIONS......Page 14
INTRODUCTION......Page 15
I. MAGNESIUM DEFICIT IN ASTHMA......Page 16
I.3. The Two Forms of Magnesium Deficits in Asthma......Page 17
I.4. Links between Magnesium Status and Chronobiology......Page 19
II.1. Hyperfunction of the Biological Clock (HBC) in Asthma......Page 20
II.2. Hypofunction of the Biological Clock in Asthma......Page 24
III.1. Conventional Pharmacological Treatment......Page 28
III.2. Indirect Asthma Therapies......Page 32
III.3. Balanced Magnesium Intake......Page 33
III.4. Chronobiological Treatments......Page 34
CONCLUSION......Page 42
REFERENCES......Page 43
ABSTRACT......Page 67
INTRODUCTION......Page 68
MECHANISMS OF ACTION......Page 69
OMEGA-3 FATTY ACIDS AS A TREATMENT MODALITY IN ASTHMA......Page 71
Epidemiological Studies......Page 73
Clinical studies......Page 74
OMEGA-3 FATTY ACIDS AS A TREATMENT MODALITY IN EXERCISE-INDUCED BRONCHOCONSTRICTION......Page 77
REFERENCES......Page 80
ABSTRACT......Page 87
MECHANISM OF ACTION OF ANTI-INFLAMMATORY DRUGS......Page 88
PROSTAGLANDIN RECEPTORS......Page 90
EICOSANOIDS IN THE PATHOGENESIS OF EXERCISE- AND ALLERGEN – INDUCED ASTHMA......Page 91
ASPIRIN – INDUCED ASTHMA......Page 92
CHRONIC INFLAMMATION OF THE AIRWAYS......Page 93
PATHOGENESIS OF ASPIRIN – INDUCED ASTHMA......Page 94
THE CYCLOOXYGENASE THEORY......Page 95
OVEREXPRESSION OF LEUKOTRIENE C4 SYNTHASE IN AIA......Page 96
OTHER HYPOTHESIS......Page 97
NASAL POLYPS......Page 98
PREVENTION AND TREATMENT......Page 99
DESENSITIZATION IN ASPIRIN – INDUCED ASTHMA......Page 102
CONCLUSION......Page 103
REFERENCES......Page 104
ABSTRACT......Page 115
1. AIRWAY INFLAMMATION IN ALLERGIC ASTHMA......Page 116
1.2. Late Phase Response......Page 117
2. AIRWAY HYPERREACTIVITY (AHR)......Page 118
3.1. Parasympathetic Neurons......Page 119
3.2. Sympathetic Neurons......Page 121
3.3. NANC Neurons......Page 122
3.4. The Axon Reflex......Page 123
3.5. Neuronal Changes in Allergic Asthma......Page 124
4.1. Neurotrophins......Page 126
4.3. Effects of Cytokines on Sensory Nerve Plasticity......Page 134
5. NEURONAL SECRETED MEDIATORS AND THEIR INFLUENCE ON IMMUNE CELLS......Page 135
REFERENCES......Page 138
ABSTRACT......Page 155
INTRODUCTION......Page 156
METHODS......Page 157
ADJUVANT EFFECT OF TOBACCO SMOKE......Page 158
Smoking and Occupational Exposures......Page 159
Smoking and Exposures to Environmental Tobacco Smoke among Adults in the General Population......Page 160
In Utero Exposure and Passive Smoking in Children......Page 163
Epidemiological Studies in Cleaners......Page 166
Indoor Dust......Page 167
Surfactants......Page 169
Quaternary Ammonium Compounds......Page 170
Ozone......Page 171
Nitrogene Oxides......Page 173
Road Traffic Pollution......Page 174
ACKNOWLEDGEMENT......Page 179
REFERENCES......Page 180
ABSTRACT......Page 189
INTERACTION BETWEEN AIR POLLUTION AND PLANT DERIVED ALLERGEN-CARRYING PARTICLES......Page 192
CLIMATIC CHANGES AND POLLEN ALLERGY......Page 193
AIR POLLUTION-INDUCED INCREASE IN AIRWAY REACTIVITY IN ALLERGIC SUBJECTS......Page 194
REFERENCES......Page 195
Index......Page 199