New Concepts in Depression

Front Matter....Pages i-xix
Neuropharmacological Adaptive Effects in the Actions of Antidepressant Drugs, ECT and Lithium....Pages 1-14
Modulation of 5-HT Autoreceptors Probably Contributes to the Antidepressant Action of 5-HT Uptake Blockers....Pages 15-24
Effects of Acute and Chronic Treatment with Imipramine on 5-Hydroxytryptamine and 5-Hydroxytryptamine Comodulators in Central 5-Hydroxytryptamine Neurons and on Glucocorticoid Receptors in Central Monoaminergic Neurons: a Morphometrical and Microdensitometrical Analysis....Pages 25-41
Molecular Interactions of Antidepressants with the Serotonergic Receptor 5-HT1D Coupled to a High-affinity Adenylate Cyclase Activity: Importance of the Site Labelled by [3H]-Minaprine....Pages 42-59
Thyrotrophin-realeasing Hormone (TRH) and 5-Hydroxytryptamine (5-HT) Interactions and Their Involvement in the Pharmacology of Antidepressants....Pages 60-68
Selective Antagonism by Serotonin Uptake Inhibitors of H 75/12-lnduced Hyperthermia in Rats....Pages 69-89
Beyond Nosology in Biological Psychiatry. 5-HT Disturbances in Mood, Aggression and Anxiety Disorders....Pages 90-95
5-HT and Depression: the Present Position....Pages 96-119
Platelet [3H]-Imipramine Binding Differentiates Major Depression from Alzheimer’s Disease in Elderly....Pages 120-136
Lithium Augmentation of Antidepressant Treatments: Evidence for the Involvement of the 5-HT System?....Pages 137-143
Is Down-regulation of β-Adrenoceptors Necessary for Antidepressant Activity?....Pages 144-160
BTS 54 524—an Approach to a Rapidly Acting Antidepressant....Pages 161-166
Central and Peripheral Effects of CH-38083: a New α2-Antagonist....Pages 167-172
Contributions from Peripheral Autonomic Pharmacology to an Understanding of Antidepressant Drug Action....Pages 173-176
Primary Cultures of Monoaminergic Neurons as a Prospective Tool in Neuropharmacology....Pages 177-189
Effects of the Membrane-active Antidepressant Drugs, Selective 5-HT or NA Uptake Inhibitors, on p-Chloroamphetamine (PCA)-induced Hyperthermia in Heat-adapted Rats....Pages 190-203
Involvement of both α1- and β-Adrenoceptors in the Antagonism of Tetrabenazine-induced Effects by Antidepressants....Pages 204-210
Pretreatment by DSP4 Fails to Reduce the Effectiveness of Desipramine in Blocking Tetrabenazine-induced Ptosis or Hypothermia....Pages 211-215
Sleep Polygraphic Recordings as a Probe for Central Dopamine Deficiency: Polygraphic and Clinical Criteria of Dopamine-dependent Depressions....Pages 216-220
Hypothalamo-hypophyseal Mechanisms Involved in the Regulation of Hormones and Behaviour....Pages 221-227
Endogenous Enkephalins, Depression and Antidepressants....Pages 228-234
Neuroendocrine Responses in Major Depression....Pages 235-246
Prediction of Treatment Response to Selective Antidepressants from Clonidine and Apomorphine Neuroendocrine Challenges....Pages 247-259
Defective Second-messenger Function in the Etiology of Endogenous Depression: Novel Therapeutic Approaches....Pages 260-268
Differential Scanning Calorimetry Studies of the Interaction of Antidepressant Drugs, Noradrenaline and Serotonin with a Membrane Model....Pages 269-276
Immunopharmacological Aspects of Mental Disorders....Pages 277-293
New Concepts in the Action of Mood Stabilisers and Antidepressants....Pages 294-305
Carbohydrate Craving, Obesity, Seasonal Depression and D-Fenfluramine....Pages 306-319
Allosteric Modulation of GABA Receptors and the Symptoms of Affective Disorders....Pages 320-333
The Benzodiazepine—GABA Receptor Complex in Experimental Stress, Anxiety and Depression....Pages 334-339
Back Matter....Pages 340-350
....Pages 351-362