New Concepts in Alzheimer’s Disease

Front Matter....Pages i-xxiii
New Concepts in the Pathophysiology of Alzheimer’s Disease....Pages 1-16
The ‘Autocannibalism’ of Choline-containing Membrane Phopholipids in the Pathogenesis of Alzheimer’s Disease....Pages 17-22
Future Prospects Offered by Positron Emission Tomography for the Study of Alzheimer’s Disease....Pages 23-34
The Neuronal Cytoskeleton and Neurofibrillary Tangles....Pages 35-52
Neurochemical and Behavioural Effects Following Lesions of the Nucleus Basalis in the Rat....Pages 53-62
In Search of Possible Markers and Models in Alzheimer’s Disease....Pages 63-72
Neurotransmitter Systems in Alzheimer’s Disease....Pages 73-88
Serotonin Neurones and Receptors in Alzheimer’s Disease....Pages 89-102
Two Drug Binding Sites on Muscarinic Receptors....Pages 103-121
Regulation and Biosynthesis of Cholinesterases in the Human Brain....Pages 122-139
An Immunohistochemical Study Comparing Selected Features of the Anatomy of Cholinergic Innervation in the Cerebral Cortex of Six Mammalian Species....Pages 140-156
Cell Biology of the Forebrain Cholinergic Neurons: Effects of NGF, Triiodothyronine and Gangliosides....Pages 157-168
Dissociated Monolayer Cultures of Human Spinal Cord....Pages 169-180
A Glycoprotein from Muscle-conditioned Medium Involved in the Differentiation of Rat Cholinergic Neurons in Culture: Partial Purification and Regulation of Neurotransmitter Metabolism Enzymes in Central-Nervous-System Cultures....Pages 181-189
Neurite-promoting Factors for Embryonic Spinal Neurons: Studies on Develpoment in the Chick and Possible Importance for the Understanding of Degenerative Disorders of the Nervous System....Pages 190-202
Molecular Biology as a Possible Approach to Human Inherited Disorders....Pages 203-215
Genetics of Alzheimer’s Disease: A Large Kindred with Apparent Mendelian Transmission: Possible Implications for a Linkage Study....Pages 216-241
DNA Markers in Familial Alzheimer’s Disease....Pages 242-256
Behavioural Recovery Following 6-OHDA Lesions of the Nucleus Accumbens and Intra-accumbens Implantation of Dopaminergic Grafts....Pages 257-264
Transplantation of 5-HT Neurons to the Adult Rat Brain....Pages 265-279
Back Matter....Pages 280-299
....Pages 300-308