New Approaches in the Treatment of Cancer (Cancer Etiology, Diagnosis and Treatments)

New Approaches In The Treatment Of Cancer......Page 4
Contents......Page 6
Abstract......Page 8
Epidemiology Of Cancer: Incidence, Mortality, Costs And Prevention......Page 9
Factors On Cancer Etiology......Page 12
Antimetabolites......Page 17
Plant Alkaloids......Page 18
Other Metals......Page 19
Photon Treatment......Page 20
Biologic Therapy......Page 21
Hormone Therapy......Page 22
IV) Immunotherapy......Page 24
Modified Tumor Cells As Cancer Vaccines......Page 25
Viral Vector Vaccines......Page 26
Allogeneic Transplant (bone Marrow & Stem Cell)......Page 27
References......Page 28
Introduction......Page 40
Inhibitors Of Tyrosine-kinases......Page 41
Effectiveness Of The Biological Therapy......Page 42
Conclusion......Page 45
References......Page 46
Abstract......Page 50
Genetic Abnormalities Guides Therapeutic Decision......Page 51
Differentiation And Apoptotic Therapy......Page 53
Immunotherapy......Page 55
Angiogenesis As Target For Treatment......Page 57
Gene Therapy......Page 59
Gene Expression Profile As “signature” Of Therapeutic Targets......Page 61
References......Page 63
Abstract......Page 78
Introduction......Page 79
Cell Membrane Glycosylation And Lectins: The Key Of Selectivity......Page 82
Lectins As Anticancer Agents......Page 85
References......Page 89
Abstract......Page 98
Bowman-birk Protease Inhibitors......Page 99
Kunitz Trypsin Inhibitors......Page 100
Bikunin......Page 101
Other Kunitz Inhibitors......Page 102
Maspin......Page 103
Pigment Epithelium-derived Factor (PEDF)......Page 105
Other Serpins......Page 106
Matrix Metalloproteinase Inhibitors......Page 107
Cisteine Protease Inhibitors......Page 108
Secretory Leukocyte Protease Inhibitor (SLPI)......Page 109
A New Approach To Obtain PI Based Cancer Treatments......Page 110
Conclusion......Page 111
References......Page 112
Abstract......Page 132
Sample Preparation......Page 133
Pas Experimental Set-up......Page 134
Thermal Lens Measurements......Page 137
TLS Experimental Set-up......Page 138
Nanoparticles Incorporated Into PPIX For Application In Pdt......Page 141
Pdt Application......Page 142
References......Page 143
Chemotherapy......Page 146
Metals And Its Compounds Used In Medicine......Page 147
Anticancer Metal Based Drugs......Page 149
Platinum Compounds......Page 150
Ruthenium......Page 152
Gold......Page 153
Titanium And Vanadium......Page 155
Tin......Page 156
Essential Metal Based Antitumor Drugs......Page 157
Copper......Page 158
Research In Casiopeinas......Page 159
Biologic Evaluation And Structure-activity Relationships......Page 160
Mode Of Action......Page 161
Toxicity......Page 164
References......Page 165
Introduction......Page 180
Definition Of Gene Therapy......Page 181
Transference Method......Page 182
Adenovirus......Page 183
Poxviruses......Page 184
Herpes Simplex Virus......Page 185
Adeno-associated Virus......Page 186
Other Vectors And The Ideal Vector......Page 187
Targeted Delivery......Page 188
Targeted Expression......Page 189
Therapeutic Genes......Page 190
Immunotherapy......Page 191
A) Vaccination With Tumor Cells Engineered To Express Immunostimulatory Molecules:......Page 192
C) Vaccination With Dendritic Cells Expressing Tumor Antigens:......Page 193
Adoptive Therapy Using Antigen-specific T Lymphocyte Transfer (tcr Gene Therapy):......Page 194
Transference Of Toxic Or Tumor Growth Suppression Genes......Page 195
Oncolytic Agents......Page 196
Clinical Use......Page 198
Safety......Page 200
Conclusion......Page 201
References......Page 202
Index......Page 210