Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology

Front Matter....Pages i-viii
Neuroteratology and Animal Modeling of Brain Disorders....Pages 1-40
Perinatal Lesioning and Lifelong Effects of the Noradrenergic Neurotoxin 6-Hydroxydopa....Pages 43-50
Selective Lifelong Destruction of Brain Monoaminergic Nerves Through Perinatal DSP-4 Treatment....Pages 51-71
Noradrenergic–Dopaminergic Interactions Due to DSP-4–MPTP Neurotoxin Treatments: Iron Connection....Pages 73-86
Perinatal Domoic Acid as a Neuroteratogen....Pages 87-110
Perinatal 192 IgG-Saporin as Neuroteratogen....Pages 111-123
NGF in Early Embryogenesis, Differentiation, and Pathology in the Nervous and Immune Systems....Pages 125-152
Disrupted Circadian Rhythm as a Common Player in Developmental Models of Neuropsychiatric Disorders....Pages 155-181
Neurobehavioral Effects from Developmental Methamphetamine Exposure....Pages 183-230
Early-Life Toxic Insults and Onset of Sporadic Neurodegenerative Diseases—an Overview of Experimental Studies....Pages 231-264
The Use of Perinatal 6-Hydroxydopamine to Produce a Rodent Model of Lesch–Nyhan Disease....Pages 265-277
Perinatal 6-Hydroxydopamine Modeling of ADHD....Pages 279-293
Attention-Deficit/Hyperactivity Disorder: Focus upon Aberrant N-Methyl-d-Aspartate Receptors Systems....Pages 295-311
Perinatal 6-Hydroxydopamine to Produce a Lifelong Model of Severe Parkinson’s Disease....Pages 313-332
Exercise and Nutritional Benefits in PD: Rodent Models and Clinical Settings....Pages 333-351
Lifelong Rodent Model of Tardive Dyskinesia—Persistence After Antipsychotic Drug Withdrawal....Pages 353-362
Perinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism....Pages 363-386
Applications of the Neonatal Quinpirole Model to Psychosis and Convergence upon the Dopamine D2 Receptor....Pages 387-402
Postnatal Phencyclidine (PCP) as a Neurodevelopmental Animal Model of Schizophrenia Pathophysiology and Symptomatology: A Review....Pages 403-428
Pathological Implications of Oxidative Stress in Patients and Animal Models with Schizophrenia: The Role of Epidermal Growth Factor Receptor Signaling....Pages 429-446