Neurotoxic Factors in Parkinson’s Disease and Related Disorders

Front Matter....Pages i-xv
Mechanisms of Selective Toxicity in Neurodegenerative Disorders....Pages 1-16
The Dopamine Transporter: Involvement in Selective Dopaminergic Neurodegeneration....Pages 17-40
Advances in our Knowledge of MPTP Action and Mechanism....Pages 41-53
Role of Microtubules in the Genesis of MPTP Neurotoxicity....Pages 55-58
Complex I Inhibition in Cultured Cells as Model for Parkinson’s Disease....Pages 59-63
Nigral Degeneration in Animal Models of Multiple System Atrophy....Pages 65-68
Isoquinoline Neurotoxins....Pages 69-76
Apoptosis by an Endogenous Neurotoxin, N -Methyl( R )Salsolinol: Relevance to Parkinson’s Disease....Pages 77-89
Isoquinolines in Parkinson’s Disease....Pages 91-100
Systematic Studies of Dopamine and Dopamine-Derived Salsolinol and Norsalsolinol levels in Various Human Brain Areas....Pages 101-104
Antidopaminergic Effects of Putative Endogenous MPTP-Like Agents: 1,2,3,4-Tetrahydroisoquinoline and 1-Methyl-6,7-Dihydroxy-l,2,3,4-Tetrahydroisoquinoline....Pages 105-110
Development of an HPLC-Method and Synthesis of 1,2,3,4-Tetrahydroisoquinolines as Reference Compounds for the Identification of Possible Neurotoxins in the Blood of Parkinson’s Disease Patients....Pages 111-114
 ß -Carboline Analogues of MPP + as Environmental Neurotoxins....Pages 115-130
 N -Methyl- ß -Carbolinium Neurotoxins in Parkinson’s Disease....Pages 131-143
‘TaClo’, A Chloral-Derived Mammalian Alkaloid with Neurotoxic Properties....Pages 145-149
Nutritional Sources of Novel Tetrahydro- ß -Carbolines....Pages 151-154
Endogenous Brain Catechol Thioethers in Dopaminergic Neurodegeneration....Pages 155-166
Catecholamine-Derived Aldehyde Neurotoxins....Pages 167-180
Potential Roles of Accelerated Dopamine Oxidation, Altered Glutathione Metabolism, 5-S-Cysteinyl-Dopamine and its Oxidative Metabolites in the Pathogenesis of Parkinson’s Disease....Pages 181-209
Neuromelanin may Mediate Neurotoxicity via its Interaction with Redox Active Iron....Pages 211-218
bcl-2 Protects SK-N-SH Cells From 6-Hydroxydopamine Induced Apoptosis by Inhibition of Cytochrome c Redistribution....Pages 219-231
Generation of Neurotoxins by New Reaction Pathways of Dopamine under Oxidative Stress Conditions: Contributing Etiopathological Factors in Parkinson’s Disease....Pages 233-236
Relationship of Organochlorine Pesticides to Parkinsonism....Pages 237-245
Paraquat is a Model Environmental Neurotoxin for Studying Parkinson’s Disease....Pages 247-257
Brain Iron and other Trace Metals in Neurodegenerative Diseases....Pages 259-276
Contribution of Intracellular Non-Haem Iron, NF- k B Activation and Inflammatory Responses to Neurodegeneration in Parkinson’s Disease: Prospects for Neuroprotection....Pages 277-288
Neurochemical Mechanisms Underlying Neuroprotective Actions of Bromocriptine, Salicylate, d - and L -Deprenyl in Neurodegeneration caused by MPTP....Pages 289-293
Attenuation of Levodopa-Induced Toxicity in Primary Dopamine Neurons by Catechol- O -Methyltransferase Inhibition....Pages 295-300
Unilateral 6-Hydroxydopamine Lesions of Nigrostriatal Dopaminergic Neurons Increased Cannabinoid CB 1 Receptor mRNA Levels in the Rat Striatum: Possible Therapeutic Implications....Pages 301-305
Front Matter....Pages 307-307
Riluzole as a Neuroprotective Therapy in Animal Models of Parkinson’s Disease....Pages 309-309
Progressive Reduction of the Rat Nigrostriatal Dopamine Metabolism Induced by Iron-III and TaClo....Pages 310-310
Brain N -Methylation of Indolic ß -Carbolines in Parkinsonism....Pages 311-311
Deleterious Effects of Highly Halogenated ß -Carbolines on Dopaminergic Cells in Culture and on Mitochondrial Respiration....Pages 312-312
Neuroprotective Role of Endogenous Adenosine in Methamphetamine-Induced Toxicity in Rat Striatum....Pages 313-314
New Taurine Analogues in Treatment Strategies for Parkinson’s Disease....Pages 315-315
The Neurotoxicity of Manganese....Pages 316-316
Organotypic Striatal Slices: Neuroprotective Effects of Vitamins....Pages 317-317
Impairment of Energy Metabolism is not Responsible for Cytotoxicity of 6-Hydroxydopamine towards Human SH-SY5Y Dopaminergic Neuroblastoma Cells....Pages 318-318
Development of a Sensitive and Selective GC/MS Method for the Determination of Tetrahydro- ß -Carbolines in Urine Samples. Occurrence of Some of these Compounds in the Urine of Parkinson’s Disease Patients....Pages 319-319
Chronic Treatment with 1,2,3,4-Tetrahydroiso-Quinoline (TIQ), an Environmental and Endogenous Substance, Induces Parkinsonian like Muscle Rigidity in Young and Old Rats....Pages 320-320
Front Matter....Pages 307-307
Propargylamines Protect Dopamine Cells from Apoptosis Induced by a Neurotoxin, N -Methyl( R ) Salsolinol....Pages 321-321
1-Methyl-4-Phenyl-l,2,3,6-Tetrahydropyridine and 1-Methyl-4-Phenylpyridinium Ions have Opposite Effects on Membrane Currents of Cultured Dorsal Root Ganglia Neurons....Pages 322-322
The Effects of Catecholic and O -Methylated Tetrahydroisoquinolines on the Production of Hydroxyl Radical....Pages 323-323
Differential Cytotoxicity of Isoquinolines in HEK-293 Cells Stably Transfected with the Dopamine Transporter Gene....Pages 324-324
HEK-293 Cells Expressing the Human Dopamine Transporter are Susceptible to Low Concentrations of 1-Methyl-4-Phenylpyridinium (MPP + ) via Impairment of Energy Metabolism....Pages 325-325
Opposite Effects of Simple Tetrahydroisoquinolines on Amphetamine and Morphine-Stimulated Locomotor Activity in Mice....Pages 326-326
Neurological Disorders — Acetylcholine Mimics and their Role as Uncompetitive Inhibitors of Esterases....Pages 327-327
Nicotinic Acetylcholine Receptor Agonist Activity of Isoquinoline Alkaloids....Pages 328-328
Effects of TaClo (1-Trichloromethyl-1,2,3,4-Tetrahydro- ß -Carboline) on Mice Neuronal Culture and Possibilities of Cellular Regeneration in Vitro after Toxin Withdrawal....Pages 329-329
Back Matter....Pages 331-340