Neuroscientific Basis of Dementia

Front Matter....Pages I-XXI
Front Matter....Pages 1-1
A tale of protein kinase C and membrane lipid signaling....Pages 3-13
Complement, neuroinflammation and neuronal degeneration in Alzheimer disease....Pages 15-20
Front Matter....Pages 21-21
Neurobiological mechanisms by which emotional arousal influences longterm memory formation....Pages 23-34
Amygdalar damage and memory impairment in Alzheimer’s disease....Pages 35-41
Neural substrate for spatial memory in the monkey hippocampus....Pages 43-48
Involvement of CaM kinase II and mitogen-activated protein kinase in hippocampal long-term potentiation....Pages 49-57
Front Matter....Pages 59-59
Transgenic mice overexpressing the shortest human tau isoform develop a progressive tauopathy....Pages 61-69
Tau and neurodegenerative disease: genetics and pathogenetic mechanisms....Pages 71-79
Tau mutations altering splicing of tau exon 10 in japanese frontotemporal dementia....Pages 81-84
Amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula of Japan (Kii ALS/PDC) may be a familial tauopathy. Epidemiological trends, clinical features, neuropathology and molecular genetics....Pages 85-93
Senile dementia of the neurofibrillary tangle type (SD-NFT): a clinical, neuropathological and molecular genetic study....Pages 95-99
The dual role of tau in cell polarisation and organelle trafficking....Pages 101-111
Rearrangement of microtubule networks by tau bearing missense mutations....Pages 113-120
Possible role of tau phosphorylation on ER membrane in Alzheimer pathology....Pages 121-128
Front Matter....Pages 129-129
Pathogenesis of dementia: updating the role of synuclein pathology in sporadic and hereditary Alzheimer’s disease....Pages 131-136
α-Synuclein/NACP and neurodegeneration....Pages 137-141
α-Synuclein fibrillogenesis as target for drug development....Pages 143-149
Front Matter....Pages 151-151
Genetics of early-onset Alzheimer disease....Pages 153-165
Lessons from presenilin domain analysis: endoproteolytic processing and enhanced Aβ42 production mediated by FAD-linked variants....Pages 167-175
Amyloid and presenilins in the pathobiology of Alzheimer’s disease....Pages 177-181
Front Matter....Pages 151-151
Role of presenilin in APP processing and Aβ production....Pages 183-191
Impairment of response to ER stress in presenilin 1 mutant....Pages 193-199
Mechanism of neuron death in Alzheimer’s disease....Pages 201-207
Notch3 gene in CADASIL syndrome: mutation frequencies in Japanese and its expression and processing....Pages 209-216
Etiological roles of A β and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease....Pages 217-224
Amyloid β–protein granules in glial cells in Alzheimer’s disease brain....Pages 225-228
Amyloid β induces phosphorylation and translocation of MARCKS through tyrosine kinase-activated PKC-δ signaling pathway in microglia....Pages 229-232
Amyloid β-protein accumulation in the human brain during aging....Pages 233-240
Molecular mechanisms underlying initiation of amyloid fibril formation....Pages 241-247
Catabolism of amyloid-β peptide in brain parenchyma....Pages 249-256
Front Matter....Pages 257-257
Lessons in familial Alzheimer’s disease....Pages 259-265
Biological markers for differential diagnosis of Alzheimer’s disease and related disorders....Pages 267-273
Dietary factors and the risk of Alzheimer’s disease: a low fish consumption and a relative deficiency of ω-3 polyunsaturated fatty acids....Pages 275-278
Risk factors for dementia....Pages 279-286
New therapeutic approaches to Alzheimer’s disease....Pages 287-294
Back Matter....Pages 295-298