Neuropsychopharmacology: 1 and 2 Proceedings of the XVIth C.I.N.P. Congress, Munich, August, 15–19, 1988

Front Matter....Pages I-XIX
Front Matter....Pages 1-1
Perspectives on Dopamine as a Regulator of Brain Function....Pages 2-10
A View of Psychopharmacology, Neuroscience, and the Major Psychoses....Pages 11-26
Lithium Is All Right, but … About Some Misconceptions and Some Recent Findings....Pages 27-34
Improvement in the Quality of Sleep: A New Goal in Psychopharmacology....Pages 35-39
The Future of Psychopharmacology and Positron Emission Tomography....Pages 40-54
Front Matter....Pages 55-55
Molecular Biological Approaches to Brain Region- and Cell-Specific Molecules....Pages 56-62
The α 1 -Adrenergic Receptor as a Paradigm of Receptors Coupled to Guanine Nucleotide Binding Proteins....Pages 63-69
The Alpha-2 Adrenoceptor Vulnerability Hypothesis of Depression: From the Clonidine Growth Hormone Stimulation Test to the Genes Encoding a Human Alpha-2 Adrenoceptor and Phenylethanolamine N -Methyltransferase....Pages 70-83
Front Matter....Pages 85-85
Genetic Linkage Analysis in Early-Onset Familial Alzheimer’s Dementia....Pages 86-91
Molecular Genetic Approach in Affective Illness....Pages 92-107
Molecular Genetic Studies in Affective Disorders....Pages 108-116
Front Matter....Pages 117-117
Long-Term Changes in Parkinson’s Disease Patients with Adrenal Medullary Autografts to the Caudate Nucleus....Pages 118-132
Front Matter....Pages 133-133
Lymphocyte Cholinergic Receptor Changes in Alzheimer’s Disease....Pages 134-141
Increased Platelet Membrane Fluidity in Alzheimer’s Disease: An Initial Assessment of Specificity....Pages 142-147
[ 3 H] Spiperone Binding to Lymphocytes in Psychiatric Disorders....Pages 148-155
Platelet Binding Sites for Serotonin Uptake Inhibitors: Is [ 3 H]Imipramine Binding Decreased in Depression?....Pages 156-162
Changes in Platelet Serotonergic and Adrenergic Function in Patients with Depression, Panic Attack, and Mania....Pages 163-171
Platelet Monoamine Receptor Binding and Tricyclic Antidepressant Treatment....Pages 172-181
Front Matter....Pages 183-183
Endogenous Opioids and Motivational Processes: Examination of the Neural Substrates Mediating Opioid-Induced Reward and Aversion....Pages 184-193
Front Matter....Pages 195-195
Sleep-Physiological Characteristics as Potential Biological Markers in Affective Disorders....Pages 196-207
Front Matter....Pages 195-195
Experimental Approaches for Testing the Cholinergic-Noradrenergic Imbalance Hypothesis of Affective Disorders....Pages 208-220
Cortisol Response to Corticotropin Releasing Hormone in Dexamethasone-Pretreated Patients with Depression....Pages 221-233
Differential Effects and Receptors of Corticosteroids in the Brain: Implications for Psychopathophysiology....Pages 234-248
Neuropeptides and Affective Disorder....Pages 249-260
Molecular Mechanisms Controlling Proopiomelanocortin Gene Expression....Pages 261-268
Front Matter....Pages 269-269
Antidepressant Drugs Given Repeatedly and α 1 -Adrenoceptors....Pages 270-276
The Effect of Phenylethanolamine- N -Methyltransferase Inhibitor on Locomotor Activity in Rats: The Role of Central α 2 -Adrenoceptor and PNMT Activity....Pages 277-285
Neuroendocrine Studies of α 2 -Adrenoceptor Function and the Mechanism of Action of Antidepressant Drugs....Pages 286-293
Levoprotiline: Clinical Therapeutic Efficacy and Tolerability....Pages 294-305
α 2 -Adrenoceptor Interaction with Opiate Receptors....Pages 306-310
Influence of Psychotropic Drugs on Pituitary Hormone Secretion with Special Reference to Norepinephrine Reuptake Inhibition....Pages 311-326
Front Matter....Pages 327-327
The TRH Test in Psychiatric Disorders....Pages 328-336
The Blunted TSH Response to TRH — What Does It Tell Us? Biological Monitoring During Psychopharmacological Treatment....Pages 337-343
Alcoholism and the Thyroid Axis....Pages 344-351
Marginal Hypothyroidism in Mental Illness: Preliminary Assessments of Prevalence and Significance....Pages 352-361
Antithyroid Antibodies: Behavioral Significance....Pages 362-370
The Simultaneous Use of Four Releasing Factors: Theoretical and Practical Issues....Pages 371-384
Front Matter....Pages 385-385
Strategies for In Vivo Quantification of Human Neuroreceptors by Positron Emission Tomography....Pages 386-399
Positron Emission Tomography with [ 18 F]Deoxyglucose and Topographic EEG in Schizophrenia....Pages 400-408
PET Imaging of D 2 Receptors in the Living Baboon and Human Brain in Normal and Pathological Conditions Using [ 76 Br]Bromolisuride....Pages 409-417
Front Matter....Pages 385-385
Dopamine Metabolism in Brain Studied with PET....Pages 418-428
Front Matter....Pages 429-429
Activation of Human Monocytes by the Neuropeptide Substance P and by Immune Interferon-γ: Evidence of Different Mechanisms....Pages 430-434
Neuroimmunomodulation: Electrophysiological Patterns in Brain During the Course of Immune Responses....Pages 435-441
Sympathetic Noradrenergic Neural Contacts with Lymphocytes and Macrophages in the Splenic White Pulp of the Rat: Site of Possible Bidirectional Communication and Local Regulation Between the Nervous and Immune Systems....Pages 442-456
Front Matter....Pages 457-457
Gene Expression of Opioid Peptides is Regulated by Electrical Activity....Pages 458-464
Biosynthesis of Opioid Peptides....Pages 465-473
Modulation of Energy Metabolism by Vasoactive Intestinal Peptide, Adenosine, and K + in the Cerebral Cortex: Focus on the Cellular Level....Pages 474-487
How Neuropeptides Alter Neuronal Excitability....Pages 488-505
Front Matter....Pages 507-507
Corticotropin Releasing Factor, the Amygdaloid Complex, and Depression: A Hypothetical Interrelationship....Pages 508-519
Clinical Aspects of Neuropeptide Research....Pages 520-528
Thyroid Axis Stimulation Tests in Psychiatry....Pages 529-539
Corticotropin-Releasing Hormone and the Proopiomelanocortin-Derived Peptides in Depression....Pages 540-548
Alterations in Neuropeptide Systems in Alzheimer’s Disease....Pages 549-562
Endocrine Response to Tricyclic Antidepressants and Peptides in Depression with Special Regard to Growth Hormone Secretion....Pages 563-577
Front Matter....Pages 579-579
Relative Toxicity of Antidepressants Using Reports Independent of Observer Bias....Pages 580-584
Assessment of Drug Utilization and Adverse Drug Reactions in the Federal Republic of Germany....Pages 585-589
Drug Surveillance in Psychiatric Patients in the Federal Republic of Germany....Pages 590-597
Surveillance of Toxicity of Antidepressants....Pages 598-607
A General Perspective of Post-Marketing Surveillance....Pages 608-616
Surveillance of Adverse Drug Reactions in the United States....Pages 617-622
Front Matter....Pages 623-623
Sleep and Sleep Deprivation Studies in Patients with Premenstrual Depression....Pages 624-635
Epidemiological Aspects of Insomnia Research....Pages 636-638
Antidepressant Medication and Total Sleep Deprivation in Depressives....Pages 639-651
Pharmacology of New Sleep-Improving Drugs....Pages 652-666
Front Matter....Pages 667-667
Neurotransmitter Function in Post-Mortem Human Brain: An Overview....Pages 668-674
Modulation of Cholinergic Activity in Alzheimer Brains by Potential Drugs....Pages 675-683
Reduced Stimulated Adenylate Cyclase Activity in Postmortem Hippocampus of Demented Patients....Pages 684-692
Molecular Neuropathology: The Study of Transmitter and Receptor Expression in Human Postmortem Materials by In Situ Hybridization and Receptor Autoradiography....Pages 693-703
Further Cytoarchitectonic and Quantitative Studies in the Entorhinal Region of Schizophrenics and Normal Controls by Means of a Modified Nissl Technique....Pages 704-713
The Dopaminergic and Glutamatergic Systems in Schizophrenia....Pages 714-720
Front Matter....Pages 721-721
Peptide Intervention in Neuronal Death Caused by the HIV External Envelope Protein: Clinical Implications....Pages 722-730
AIDS as a Neuropeptide Disorder: Does HIV Bind to a VIP Receptor?....Pages 731-736
Neuropsychiatry of AIDS: Clinical Presentation and Treatment Research....Pages 737-744
Psychiatric Symptoms and Neuropsychological Deficits in HIV Infection....Pages 745-755
Back Matter....Pages 757-825