Neuroprotection and Regeneration of the Spinal Cord

Front Matter....Pages i-x
Front Matter....Pages 1-1
The Mechanism Behind Functional Recovery After the Incomplete Spinal Cord Injury....Pages 3-10
Microenvironment Within the Injured Spinal Cord Focusing on IL-6....Pages 11-18
Autophagy in Spinal Cord Injury: Pathogenic Roles and Therapeutic Implications....Pages 19-30
The Role of the Endoplasmic Reticulum Stress Response in Neural Apoptosis of the Injured Spinal Cord....Pages 31-41
Roles of Microglia in Spinal Cord Injury....Pages 43-57
Front Matter....Pages 59-59
Biomechanics of the Spinal Cord and the Pia Mater....Pages 61-74
Biomechanical Analysis of Compressive Myelopathy: The Influence of Morthometry of the Spinal Cord....Pages 75-82
Morphologic Change and Glial Response to Unilateral Spinal Cord Compression....Pages 83-96
Morphological Changes in Anterior Horn Cells, Immunoreactivity to Neurotrophic Factors, and Neuronal Cell Death of Spinal Cord Lesions in the Spinal Hyperostotic Mouse ( twy / twy ) with Chronic Mechanical Cord Compression....Pages 97-106
In Vivo Tracing of Neural Tracts in Tiptoe-Walking Yoshimura Mice by Diffusion Tensor Tractography....Pages 107-117
Microarray Analysis of Expression of Cell Death-Associated Genes in Spinal Cord Cells with Cyclic Tensile Strain....Pages 119-127
Spinal Kyphosis Causes Demyelination and Neuronal Loss in the Spinal Cord....Pages 129-138
Front Matter....Pages 139-139
Granulocyte Colony-Stimulating Factor-Mediated Neuroprotective Therapy for Spinal Cord Injury....Pages 141-146
Recombinant Human Hepatocyte Growth Factor Promotes Functional Recovery After Spinal Cord Injury....Pages 147-167
The Proteoglycan-Degrading Enzymes Promote Functional Recovery After Spinal Cord Injury: Keratan Sulfate and Chondroitin Sulfate....Pages 169-191
Targeted Retrograde Gene Delivery into the Injured Spinal Cord Using Recombinant Adenovirus Vector Carrying Neurotrophic Factor Gene....Pages 193-201
Blockade of Interleukin-6 Effects on Cytokine Profiles and Macrophage Activation After Spinal Cord Injury in Mice....Pages 203-212
Oxidative Stress as Secondary Injury Mechanism After Mechanical Trauma in the Spinal Cord....Pages 213-226
Front Matter....Pages 227-227
Regenerative Medicine for Spinal Cord Injury Utilizing iPS Cells....Pages 229-245
Transplantation of Neural Stem Cells with Valproate for Spinal Cord Injury....Pages 247-253
Front Matter....Pages 227-227
The Effects of Mesenchymal Stem Cell-Transduced Multineurotrophin to Improve Function Following Spinal Cord Injury....Pages 255-268
Axonal Regeneration Across an Artificial Scaffold Combined with Cell Transplantation Applied to the Transected Spinal Cord....Pages 269-281
Transplantation of Mesenchymal Stem Cells Derived from Bone Marrow in the Injured Spinal Cord....Pages 283-293
Vascular Regeneration Therapies for Spinal Cord Injury....Pages 295-307
Front Matter....Pages 309-309
Stress Distribution of the Spinal Cord and Clinical Relevance in Cervical Spondylotic Myelopathy....Pages 311-321
Applications and Limitations of pNF-H, a Novel Biomarker for Spinal Cord Injury: Strategy for the Evaluation of Therapeutic Outcomes....Pages 323-331
Neuroprotective Therapy Using Granulocyte Colony-Stimulating Factor for Acute Spinal Cord Injury: A Multicenter Prospective Controlled Clinical Trial....Pages 333-344
Assessment of Injured Spinal Cord Using Diffusion Tensor Tractography....Pages 345-365
Clinical Significance of 3D-MRI/ 18 F-FDG PET Fusion Imaging of Patients with Cervical Compressive Myelopathy....Pages 367-376
Visualization of Electrophysiological Activity in the Spinal Cord Using Magnetospinography....Pages 377-385
Spinal Synaptic Plasticity in Chronic Pain....Pages 387-398
Evaluation of Pain with Functional Neuroimaging....Pages 399-412
Back Matter....Pages 413-419