Neuropathology and Genetics of Dementia

Front Matter....Pages i-xiii
Can the Physician Predict the Neuropathologist?....Pages 1-4
The Molecular Parameters of Tau Pathology....Pages 5-19
Tau Gene Mutations and Tau Pathology in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17....Pages 21-37
Argyrophilic Grain Disease....Pages 39-58
Tau Pathology in Neurons and Glial Cells of Aged Baboons....Pages 59-69
Human Tau Transgenic Mice....Pages 71-83
Regulation of Alzheimer ß-Amyloid Precursor Trafficking and Metabolism....Pages 85-100
Role of Type 10 17ß-Hydroxysteroid Dehydrogenase in the Pathogenesis of Alzheimer’s Disease....Pages 101-110
The Spectrum of Vascular Disease in Dementia....Pages 111-122
Transgenic Mouse Models of Cerebral Amyloid Angiopathy....Pages 123-128
Alpha-Synuclein....Pages 129-134
Dementia with Lewy Bodies....Pages 135-145
Mouse Models of α-Synucleinopathy and Lewy Pathology....Pages 147-167
Ubiquitin and the Molecular Pathology of Neurodegenerative Diseases....Pages 169-186
Perisomatic Granules of Hippocampal CA1 Neurons in Alzheimer’s Disease, Pre-Alzheimer Stage and Pick’s Disease: An Overlooked Pathological Entity....Pages 187-198
Pathological Mechanisms in Polyglutamine Expansion Diseases....Pages 199-210
Dementia in the Neuronal Ceroidlipofuscinoses....Pages 211-217
Neurodegeneration-Associated Proteins and Inflammation in Sporadic Inclusion-Body Myositis....Pages 219-228
Mitochondrial Dysfunction in Neurodegenerative Disorders and Ageing....Pages 229-251
Back Matter....Pages 253-255