Neuronal and Cognitive Effects of Oestrogens (Novartis Foundation Symposium 230)

NEURONAL AND COGNITIVE EFFECTS OF OESTROGENS......Page 3
Contents......Page 7
Participants......Page 9
Chairman’s introduction......Page 13
Mechanism of oestrogen signalling with particular reference to the role of ERb in the central nervous system......Page 19
Discussion......Page 27
Oestrogen receptor function at classical and alternative response elements......Page 32
Discussion......Page 39
General discussion I......Page 45
Nuclear receptor versus plasma membrane oestrogen receptor......Page 53
Discussion......Page 62
Novel sites and mechanisms of oestrogen action in the brain......Page 68
Discussion......Page 81
Oestrogen modulation of noradrenaline neurotransmission......Page 86
Discussion......Page 97
Oestrogen and the cholinergic hypothesis: implications for oestrogen replacement therapy in postmenopausal women......Page 106
Discussion......Page 119
Ovarian steroid action in the serotonin neural system of macaques......Page 124
Discussion......Page 142
Oestrogen effects on dopaminergic function in striatum......Page 146
Discussion......Page 157
General discussion II......Page 164
Oestrogen effects in olivo-cerebellar and hippocampal circuits......Page 167
Discussion......Page 180
Effects of oestradiol on hippocampal circuitry......Page 185
Discussion......Page 193
Oestrogen and cognitive function throughout the female lifespan......Page 200
Discussion......Page 208
Neuroprotective effects of phenolic A ring oestrogens......Page 214
Discussion......Page 225
The female sex hormone oestrogen as neuroprotectant: activities at various levels......Page 233
Discussion......Page 246
Neurohormonal signalling pathways and the regulation of Alzheimer b-amyloid metabolism......Page 251
Discussion......Page 263
Oestrogens and dementia......Page 266
Discussion......Page 277
Index of contributors......Page 286
Subject index......Page 288