Neurological Complications of Systemic Cancer and Antineoplastic Therapy

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
About the editors
Preface
Section I: Metastatic neurological complications
	Chapter 1: Common symptoms at presentation of nervous system metastases
		Abstract
		1: Introduction
		2: Brain metastases
		3: Leptomeningeal disease
		4: Spinal cord metastases
		5: Epidural spinal cord metastases/epidural spinal cord compression
		6: Cauda equina syndrome
		7: Neoplastic and radiation plexopathy
		8: Conclusion
		References
	Chapter 2: Neuroimaging of systemic metastatic disease
		Abstract
		Acknowledgment
		1: Technical considerations
		2: Anatomic locations
		3: Intracranial complications of systemic disease
		References
	Chapter 3: Nonimaging evaluation of patients with nervous system metastases
		Abstract
		Disclosures
		1: Introduction
		2: Electroencephalography
		3: Evoked potentials
		4: Electromyography and nerve conduction studies
		5: Nerve biopsy
		6: Cerebrospinal fluid
		7: Conclusion
		References
	Chapter 4: Biology and pathophysiology of central nervous system metastases
		Abstract
		1: Introduction
		2: Molecular biology of neoplasms
		3: Mechanisms of brain metastasis
		4: Biological mechanisms of the metastatic cascade
		5: Blood–brain barrier
		6: Genetics of metastases
		7: Conclusion
		Disclosure
		References
	Chapter 5: Intracranial metastases
		Abstract
		1: Introduction and epidemiology
		2: Pathology
		3: Clinical presentation
		4: Neuroimaging
		5: Surgical therapy
		6: Radiation therapy
		7: Chemotherapy
		References
		Further reading
	Chapter 6: Neurosurgical approaches to the treatment of intracranial metastases
		Abstract
		1: Background
		2: Initial approach
		3: Tumor resection
		4: Surgical adjuncts
		5: Other neurosurgical techniques
		6: Management of recurrence—When to repeat resection
		7: Management of CNS metastases in uncommon locations
		8: Conclusion
		Disclosures
		References
	Chapter 7: Epidural metastasis and spinal cord compression
		Abstract
		1: Introduction
		2: Epidemiology
		3: Pathophysiology
		4: Clinical presentation
		5: Diagnosis
		6: Prognosis
		7: Treatment
		8: Conclusion
		References
	Chapter 8: Leptomeningeal metastasis
		Abstract
		1: Introduction
		2: Prognosis
		3: Anatomy
		4: Pathogenesis
		5: Clinical presentation
		6: Diagnostic studies/staging
		7: Treatment
		8: Summary
		References
	Chapter 9: Cranial nerve involvement by metastatic cancer
		Abstract
		1: Introduction
		2: Clinical presentation of cranial nerve involvement
		3: Typical imaging findings of cranial nerve involvement
		4: Cancers of special interest
		5: Summary
		References
	Chapter 10: Cancer-related plexopathies
		Abstract
		1: Introduction
		2: Review of plexus anatomy
		3: Plexopathy
		4: Diagnosis of plexopathy in patients with cancer
		5: Diagnostic studies
		6: Cancers of special interest
		7: Supportive treatment of cancer-related plexopathy
		8: Summary
		References
Section II: Nonmetastatic neurological complications
	Chapter 11: Cerebrovascular complications of malignancy
		Abstract
		1: Epidemiology of cerebrovascular disease in malignancy
		2: Direct tumor effects and intracranial hemorrhage
		3: Direct tumor effects and cerebral infarction
		4: Coagulation disorders
		5: Cancer-related infectious disease and stroke: Septic cerebral infarction
		6: Infectious vasculitis
		7: Complications of cancer treatment
		8: Conclusion
		References
	Chapter 12: Metabolic and nutritional nervous system dysfunction in cancer patients
		Abstract
		1: Introduction
		2: Metabolic and toxic encephalopathy
		3: Tumor lysis syndrome
		4: Cancer anorexia-cachexia syndrome
		5: Nutritional myelopathy
		6: Peripheral neuropathy
		7: Nutritional and toxic myopathy
		8: Immunotherapy side effects
		9: CAR-T cell complications
		References
	Chapter 13: Central nervous system infections in cancer patients
		Abstract
		1: Introduction
		2: Approach to cancer patients with suspected CNS infection
		3: High-risk patient groups
		4: Management of common CNS infections
		5: Vaccine-preventable infections: The COVID-19 pandemic and cancer patients
		6: Conclusions
		References
	Chapter 14: Diagnosis and treatment of paraneoplastic neurological disorders
		Abstract
		1: Introduction
		2: Pathogenesis
		3: Clinical diagnosis
		4: Antineuronal antibodies
		5: Treatment
		6: Underlying malignancy
		7: Paraneoplastic disorders and immune checkpoint inhibitors
		8: Paraneoplastic neurological disorders
		9: Conclusion
		References
Section III: Neurological complications of specific neoplasms
	Chapter 15: Neurological complications of lung cancer
		Abstract
		1: Introduction
		2: Direct complications of lung cancer
		3: Indirect complications of lung cancer
		References
	Chapter 16: Neurological complications of breast cancer
		Abstract
		1: Introduction
		2: Metastatic complications
		3: Nonmetastatic complications
		4: Regional approach to the diagnosis of neurological symptoms
		5: Conclusion
		References
	Chapter 17: Neurological complications of melanoma
		Abstract
		1: Introduction
		2: Neurological complications of malignant melanoma
		3: Neurological complications of noncutaneous melanomas
		References
	Chapter 18: Neurological complications of lymphoma
		Abstract
		1: Introduction
		2: Intracranial metastases
		3: Spinal cord processes
		4: Peripheral nervous system disease
		5: Paraneoplastic neurological syndromes
		References
	Chapter 19: Neurologic complications of the leukemias
		Abstract
		1: Introduction
		2: Diagnostic considerations
		3: The acute leukemias
		4: The chronic leukemias
		5: Conclusion
		References
	Chapter 20: Neurological complications of systemic cancer of the head and neck
		Abstract
		1: Introduction
		2: Local and locoregional complications
		3: Distant metastases
		4: Leptomeningeal carcinomatosis
		5: Medical therapy
		6: Syncope in patients with head and neck cancer
		References
		Further reading
	Chapter 21: Neurological complications of gynecological cancers
		Abstract
		1: Introduction
		2: Local/regional spread of gynecological cancers to the lumbosacral plexus
		3: Distant CNS metastases from gynecological cancers
		4: Paraneoplastic syndromes due to gynecological cancers
		5: Neurological complications associated with treatment of gynecological cancers
		6: Conclusion
		References
	Chapter 22: Neurological complications of GI cancers
		Abstract
		Permissions summary
		1: Overview of gastrointestinal cancers
		2: Neurological complications of GI cancers
		3: Common systemic treatment regimens for GI cancers and their neurological complications
		References
	Chapter 23: Neurologic complications associated with genitourinary cancer
		Abstract
		1: Introduction
		2: Prostate cancer
		3: Uterus
		4: Ovarian cancer
		5: Renal carcinoma
		6: Germ cell testicular cancer
		7: Bladder carcinoma
		8: Conclusion
		References
	Chapter 24: Sarcoma and the nervous system
		Abstract
		1: Introduction
		2: Primary CNS sarcomas
		3: Primary sarcomas of the peripheral nervous system
		4: Extra-CNS sarcoma affecting the nervous system
		5: CNS metastases from extra-CNS sarcoma
		6: Neurologic toxicities from sarcoma treatments
		7: Conclusions
		References
	Chapter 25: Neurological complications of multiple myeloma
		Abstract
		1: Introduction
		2: Central nervous system complications
		3: Peripheral nervous system complications
		4: Conclusion
		References
	Chapter 26: Neurologic complications in the treatment of childhood malignancies
		Abstract
		1: Introduction
		2: Part I: Acute complications of cancer treatment
		3: Part II: Late effects of cancer treatment
		4: Conclusion
		References
Section IV: Neurological complications of antineoplastic therapy
	Chapter 27: Neurological complications of radiation therapy
		Abstract
		1: Introduction
		2: Pathophysiology of neurological complications from radiation
		3: Radiation-induced brain toxicity
		4: Radiation-induced complications of spinal cord
		5: Radiation-induced nerve injury
		6: Endocrinopathy after radiation therapy
		7: Cerebrovascular complications after radiation treatment
		8: Radiation-induced secondary malignancy
		9: Conclusion
		References
	Chapter 28: Neurological complications of systemic cancer and antineoplastic therapy
		Abstract
		1: Introduction
		2: Mechanisms of neurotoxicity
		3: Neurotixicity of specific agents
		4: Targeted therapies
		5: Biological agents
		6: Chemotherapy-induced cognitive impairment
		7: Conclusion
		References
	Chapter 29: Neurological complications of hematopoietic stem cell transplantation
		Abstract
		1: Introduction
		2: Neurologic complications associated with conditioning regimens
		3: Toxic-metabolic encephalopathy
		4: Cerebrovascular complications
		5: CNS infections
		6: Neurologic complications associated with chronic graft versus host disease (GVHD)
		7: Neurologic complications associated with immunosuppressive therapy
		8: Neurocognitive dysfunction
		9: Secondary malignancies
		10: Conclusion
		References
	Chapter 30: Chemotherapy-induced peripheral neuropathy
		Abstract
		1: Introduction
		2: Pathophysiology of CIPN
		3: Clinical presentation and diagnostic evaluation of CIPN
		4: Clinical management of CIPN
		References
	Chapter 31: Neurological complications of immunotherapy and monoclonal antibody therapy
		Abstract
		1: Introduction
		2: Bevacizumab
		3: Cetuximab and other anti-EGFR mAbs
		4: Trastuzumab
		5: Rituximab and other anti-CD20 mAbs
		6: Dinutuximab
		7: Brentuximab vedotin
		8: Polatuzumab vedotin
		9: Enfortumab vedotin
		10: Trastuzumab emtansine
		11: Blinatumomab
		12: Interleukin-2 (IL2)
		13: Interferon alpha
		References
	Chapter 32: Neurologic complications of immune modulatory therapy
		Abstract
		1: Introduction
		2: Epidemiology
		3: Headache
		4: Malignant cerebral edema
		5: Peripheral nervous system
		6: Central nervous system
		7: CAR T cell-mediated neurotoxicity (immune effector cell-associated neurotoxicity syndrome)
		8: Conclusion: Diverse presentation, kinetics, importance of multidisciplinary and early treatment, consideration of re-challenge
		References
	Chapter 33: Neurological complications of steroids and of supportive care
		Abstract
		Acknowledgment
		1: Introduction
		2: Corticosteroids
		3: Seizures
		4: Vascular complications
		5: Analgesics
		6: Antiemetics
		7: Depression
		8: Summary
		References
Section V: Psychiatric, pain, psychosocial, and supportive care issues
	Chapter 34: Psychiatric aspects of care in the cancer patient
		Abstract
		1: Introduction
		2: Historical background
		3: Common psychological responses to cancer
		4: Epidemiology of psychiatric disorders in cancer patients
		5: General principles of psychiatric assessment and treatment in patients with cancer
		6: Delirium
		7: Adjustment disorders
		8: Anxiety disorders
		9: Trauma and stressor-related disorders
		10: Depressive disorders
		11: Suicide assessment and management in cancer patients
		12: Psychiatric considerations in cancer-related fatigue
		13: Cancer survivors
		14: Families issues and bereavement
		15: Psychological issues for staff
		References
	Chapter 35: Chronic cancer pain syndromes and their treatment
		Abstract
		1: Bone pain
		2: Pain syndromes of the viscera and miscellaneous tumor-related syndromes
		3: Headache and facial pain
		4: Neuropathic pain involving the peripheral nervous system
		5: Paraneoplastic nociceptive pain syndromes
		6: Chronic pain syndromes associated with cancer therapy
		7: Clinical evaluation of the patients with difficult pain
		References
		Further reading
	Chapter 36: Psychosocial issues in cancer patients with neurological complications
		Abstract
		1: Introduction
		2: Neurocognitive concerns
		3: Psychological concerns
		4: Behavioral concerns
		5: Social concerns
		6: Disparity concerns
		7: End-of-life concerns
		8: Conclusion
		References
	Chapter 37: Supportive care
		Abstract
		1: Introduction
		2: Novel antiangiogenic agents
		3: Conclusion
		References
Index
Copyright
Title Page
Dedication
Contents
Chapter 1: ‘I’m thinking’ – Oh, but are you?
Chapter 2: Renegade perception
Chapter 3: The Pushbacker sting
Chapter 4: ‘Covid’: The calculated catastrophe
Chapter 5: There is no ‘virus’
Chapter 6: Sequence of deceit
Chapter 7: War on your mind
Chapter 8: ‘Reframing’ insanity
Chapter 9: We must have it? So what is it?
Chapter 10: Human 2.0
Chapter 11: Who controls the Cult?
Chapter 12: Escaping Wetiko
Postscript
Appendix: Cowan-Kaufman-Morell Statement on Virus Isolation
Bibliography
Index
Copyright
Title Page
Dedication
Contents
Chapter 1: ‘I’m thinking’ – Oh, but are you?
Chapter 2: Renegade perception
Chapter 3: The Pushbacker sting
Chapter 4: ‘Covid’: The calculated catastrophe
Chapter 5: There is no ‘virus’
Chapter 6: Sequence of deceit
Chapter 7: War on your mind
Chapter 8: ‘Reframing’ insanity
Chapter 9: We must have it? So what is it?
Chapter 10: Human 2.0
Chapter 11: Who controls the Cult?
Chapter 12: Escaping Wetiko
Postscript
Appendix: Cowan-Kaufman-Morell Statement on Virus Isolation
Bibliography
Index
Copyright
Title Page
Dedication
Contents
Chapter 1: ‘I’m thinking’ – Oh, but are you?
Chapter 2: Renegade perception
Chapter 3: The Pushbacker sting
Chapter 4: ‘Covid’: The calculated catastrophe
Chapter 5: There is no ‘virus’
Chapter 6: Sequence of deceit
Chapter 7: War on your mind
Chapter 8: ‘Reframing’ insanity
Chapter 9: We must have it? So what is it?
Chapter 10: Human 2.0
Chapter 11: Who controls the Cult?
Chapter 12: Escaping Wetiko
Postscript
Appendix: Cowan-Kaufman-Morell Statement on Virus Isolation
Bibliography
Index
Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
About the editors
Preface
Section I: Metastatic neurological complications
	Chapter 1: Common symptoms at presentation of nervous system metastases
		Abstract
		1: Introduction
		2: Brain metastases
		3: Leptomeningeal disease
		4: Spinal cord metastases
		5: Epidural spinal cord metastases/epidural spinal cord compression
		6: Cauda equina syndrome
		7: Neoplastic and radiation plexopathy
		8: Conclusion
		References
	Chapter 2: Neuroimaging of systemic metastatic disease
		Abstract
		Acknowledgment
		1: Technical considerations
		2: Anatomic locations
		3: Intracranial complications of systemic disease
		References
	Chapter 3: Nonimaging evaluation of patients with nervous system metastases
		Abstract
		Disclosures
		1: Introduction
		2: Electroencephalography
		3: Evoked potentials
		4: Electromyography and nerve conduction studies
		5: Nerve biopsy
		6: Cerebrospinal fluid
		7: Conclusion
		References
	Chapter 4: Biology and pathophysiology of central nervous system metastases
		Abstract
		1: Introduction
		2: Molecular biology of neoplasms
		3: Mechanisms of brain metastasis
		4: Biological mechanisms of the metastatic cascade
		5: Blood–brain barrier
		6: Genetics of metastases
		7: Conclusion
		Disclosure
		References
	Chapter 5: Intracranial metastases
		Abstract
		1: Introduction and epidemiology
		2: Pathology
		3: Clinical presentation
		4: Neuroimaging
		5: Surgical therapy
		6: Radiation therapy
		7: Chemotherapy
		References
		Further reading
	Chapter 6: Neurosurgical approaches to the treatment of intracranial metastases
		Abstract
		1: Background
		2: Initial approach
		3: Tumor resection
		4: Surgical adjuncts
		5: Other neurosurgical techniques
		6: Management of recurrence—When to repeat resection
		7: Management of CNS metastases in uncommon locations
		8: Conclusion
		Disclosures
		References
	Chapter 7: Epidural metastasis and spinal cord compression
		Abstract
		1: Introduction
		2: Epidemiology
		3: Pathophysiology
		4: Clinical presentation
		5: Diagnosis
		6: Prognosis
		7: Treatment
		8: Conclusion
		References
	Chapter 8: Leptomeningeal metastasis
		Abstract
		1: Introduction
		2: Prognosis
		3: Anatomy
		4: Pathogenesis
		5: Clinical presentation
		6: Diagnostic studies/staging
		7: Treatment
		8: Summary
		References
	Chapter 9: Cranial nerve involvement by metastatic cancer
		Abstract
		1: Introduction
		2: Clinical presentation of cranial nerve involvement
		3: Typical imaging findings of cranial nerve involvement
		4: Cancers of special interest
		5: Summary
		References
	Chapter 10: Cancer-related plexopathies
		Abstract
		1: Introduction
		2: Review of plexus anatomy
		3: Plexopathy
		4: Diagnosis of plexopathy in patients with cancer
		5: Diagnostic studies
		6: Cancers of special interest
		7: Supportive treatment of cancer-related plexopathy
		8: Summary
		References
Section II: Nonmetastatic neurological complications
	Chapter 11: Cerebrovascular complications of malignancy
		Abstract
		1: Epidemiology of cerebrovascular disease in malignancy
		2: Direct tumor effects and intracranial hemorrhage
		3: Direct tumor effects and cerebral infarction
		4: Coagulation disorders
		5: Cancer-related infectious disease and stroke: Septic cerebral infarction
		6: Infectious vasculitis
		7: Complications of cancer treatment
		8: Conclusion
		References
	Chapter 12: Metabolic and nutritional nervous system dysfunction in cancer patients
		Abstract
		1: Introduction
		2: Metabolic and toxic encephalopathy
		3: Tumor lysis syndrome
		4: Cancer anorexia-cachexia syndrome
		5: Nutritional myelopathy
		6: Peripheral neuropathy
		7: Nutritional and toxic myopathy
		8: Immunotherapy side effects
		9: CAR-T cell complications
		References
	Chapter 13: Central nervous system infections in cancer patients
		Abstract
		1: Introduction
		2: Approach to cancer patients with suspected CNS infection
		3: High-risk patient groups
		4: Management of common CNS infections
		5: Vaccine-preventable infections: The COVID-19 pandemic and cancer patients
		6: Conclusions
		References
	Chapter 14: Diagnosis and treatment of paraneoplastic neurological disorders
		Abstract
		1: Introduction
		2: Pathogenesis
		3: Clinical diagnosis
		4: Antineuronal antibodies
		5: Treatment
		6: Underlying malignancy
		7: Paraneoplastic disorders and immune checkpoint inhibitors
		8: Paraneoplastic neurological disorders
		9: Conclusion
		References
Section III: Neurological complications of specific neoplasms
	Chapter 15: Neurological complications of lung cancer
		Abstract
		1: Introduction
		2: Direct complications of lung cancer
		3: Indirect complications of lung cancer
		References
	Chapter 16: Neurological complications of breast cancer
		Abstract
		1: Introduction
		2: Metastatic complications
		3: Nonmetastatic complications
		4: Regional approach to the diagnosis of neurological symptoms
		5: Conclusion
		References
	Chapter 17: Neurological complications of melanoma
		Abstract
		1: Introduction
		2: Neurological complications of malignant melanoma
		3: Neurological complications of noncutaneous melanomas
		References
	Chapter 18: Neurological complications of lymphoma
		Abstract
		1: Introduction
		2: Intracranial metastases
		3: Spinal cord processes
		4: Peripheral nervous system disease
		5: Paraneoplastic neurological syndromes
		References
	Chapter 19: Neurologic complications of the leukemias
		Abstract
		1: Introduction
		2: Diagnostic considerations
		3: The acute leukemias
		4: The chronic leukemias
		5: Conclusion
		References
	Chapter 20: Neurological complications of systemic cancer of the head and neck
		Abstract
		1: Introduction
		2: Local and locoregional complications
		3: Distant metastases
		4: Leptomeningeal carcinomatosis
		5: Medical therapy
		6: Syncope in patients with head and neck cancer
		References
		Further reading
	Chapter 21: Neurological complications of gynecological cancers
		Abstract
		1: Introduction
		2: Local/regional spread of gynecological cancers to the lumbosacral plexus
		3: Distant CNS metastases from gynecological cancers
		4: Paraneoplastic syndromes due to gynecological cancers
		5: Neurological complications associated with treatment of gynecological cancers
		6: Conclusion
		References
	Chapter 22: Neurological complications of GI cancers
		Abstract
		Permissions summary
		1: Overview of gastrointestinal cancers
		2: Neurological complications of GI cancers
		3: Common systemic treatment regimens for GI cancers and their neurological complications
		References
	Chapter 23: Neurologic complications associated with genitourinary cancer
		Abstract
		1: Introduction
		2: Prostate cancer
		3: Uterus
		4: Ovarian cancer
		5: Renal carcinoma
		6: Germ cell testicular cancer
		7: Bladder carcinoma
		8: Conclusion
		References
	Chapter 24: Sarcoma and the nervous system
		Abstract
		1: Introduction
		2: Primary CNS sarcomas
		3: Primary sarcomas of the peripheral nervous system
		4: Extra-CNS sarcoma affecting the nervous system
		5: CNS metastases from extra-CNS sarcoma
		6: Neurologic toxicities from sarcoma treatments
		7: Conclusions
		References
	Chapter 25: Neurological complications of multiple myeloma
		Abstract
		1: Introduction
		2: Central nervous system complications
		3: Peripheral nervous system complications
		4: Conclusion
		References
	Chapter 26: Neurologic complications in the treatment of childhood malignancies
		Abstract
		1: Introduction
		2: Part I: Acute complications of cancer treatment
		3: Part II: Late effects of cancer treatment
		4: Conclusion
		References
Section IV: Neurological complications of antineoplastic therapy
	Chapter 27: Neurological complications of radiation therapy
		Abstract
		1: Introduction
		2: Pathophysiology of neurological complications from radiation
		3: Radiation-induced brain toxicity
		4: Radiation-induced complications of spinal cord
		5: Radiation-induced nerve injury
		6: Endocrinopathy after radiation therapy
		7: Cerebrovascular complications after radiation treatment
		8: Radiation-induced secondary malignancy
		9: Conclusion
		References
	Chapter 28: Neurological complications of systemic cancer and antineoplastic therapy
		Abstract
		1: Introduction
		2: Mechanisms of neurotoxicity
		3: Neurotixicity of specific agents
		4: Targeted therapies
		5: Biological agents
		6: Chemotherapy-induced cognitive impairment
		7: Conclusion
		References
	Chapter 29: Neurological complications of hematopoietic stem cell transplantation
		Abstract
		1: Introduction
		2: Neurologic complications associated with conditioning regimens
		3: Toxic-metabolic encephalopathy
		4: Cerebrovascular complications
		5: CNS infections
		6: Neurologic complications associated with chronic graft versus host disease (GVHD)
		7: Neurologic complications associated with immunosuppressive therapy
		8: Neurocognitive dysfunction
		9: Secondary malignancies
		10: Conclusion
		References
	Chapter 30: Chemotherapy-induced peripheral neuropathy
		Abstract
		1: Introduction
		2: Pathophysiology of CIPN
		3: Clinical presentation and diagnostic evaluation of CIPN
		4: Clinical management of CIPN
		References
	Chapter 31: Neurological complications of immunotherapy and monoclonal antibody therapy
		Abstract
		1: Introduction
		2: Bevacizumab
		3: Cetuximab and other anti-EGFR mAbs
		4: Trastuzumab
		5: Rituximab and other anti-CD20 mAbs
		6: Dinutuximab
		7: Brentuximab vedotin
		8: Polatuzumab vedotin
		9: Enfortumab vedotin
		10: Trastuzumab emtansine
		11: Blinatumomab
		12: Interleukin-2 (IL2)
		13: Interferon alpha
		References
	Chapter 32: Neurologic complications of immune modulatory therapy
		Abstract
		1: Introduction
		2: Epidemiology
		3: Headache
		4: Malignant cerebral edema
		5: Peripheral nervous system
		6: Central nervous system
		7: CAR T cell-mediated neurotoxicity (immune effector cell-associated neurotoxicity syndrome)
		8: Conclusion: Diverse presentation, kinetics, importance of multidisciplinary and early treatment, consideration of re-challenge
		References
	Chapter 33: Neurological complications of steroids and of supportive care
		Abstract
		Acknowledgment
		1: Introduction
		2: Corticosteroids
		3: Seizures
		4: Vascular complications
		5: Analgesics
		6: Antiemetics
		7: Depression
		8: Summary
		References
Section V: Psychiatric, pain, psychosocial, and supportive care issues
	Chapter 34: Psychiatric aspects of care in the cancer patient
		Abstract
		1: Introduction
		2: Historical background
		3: Common psychological responses to cancer
		4: Epidemiology of psychiatric disorders in cancer patients
		5: General principles of psychiatric assessment and treatment in patients with cancer
		6: Delirium
		7: Adjustment disorders
		8: Anxiety disorders
		9: Trauma and stressor-related disorders
		10: Depressive disorders
		11: Suicide assessment and management in cancer patients
		12: Psychiatric considerations in cancer-related fatigue
		13: Cancer survivors
		14: Families issues and bereavement
		15: Psychological issues for staff
		References
	Chapter 35: Chronic cancer pain syndromes and their treatment
		Abstract
		1: Bone pain
		2: Pain syndromes of the viscera and miscellaneous tumor-related syndromes
		3: Headache and facial pain
		4: Neuropathic pain involving the peripheral nervous system
		5: Paraneoplastic nociceptive pain syndromes
		6: Chronic pain syndromes associated with cancer therapy
		7: Clinical evaluation of the patients with difficult pain
		References
		Further reading
	Chapter 36: Psychosocial issues in cancer patients with neurological complications
		Abstract
		1: Introduction
		2: Neurocognitive concerns
		3: Psychological concerns
		4: Behavioral concerns
		5: Social concerns
		6: Disparity concerns
		7: End-of-life concerns
		8: Conclusion
		References
	Chapter 37: Supportive care
		Abstract
		1: Introduction
		2: Novel antiangiogenic agents
		3: Conclusion
		References
Index