Neuroinflammation: Mechanisms and Management

Front Matter....Pages i-x
Front Matter....Pages 1-1
A Historical Perspective on the Clinical Diagnostic Laboratory....Pages 3-13
An Overview of Nucleic Acid Chemistry, Structure, and Function....Pages 15-33
Basic Nucleic Acid Procedures....Pages 35-60
Front Matter....Pages 61-61
Nucleic Acid Blotting Techniques....Pages 63-87
DNA Amplification Techniques....Pages 89-101
RT-PCR....Pages 103-121
PCR-Based Methods for Mutation Detection....Pages 123-162
Nucleic Acid Hybridization and Amplification In Situ ....Pages 163-191
Gene Therapy....Pages 193-214
Front Matter....Pages 215-215
An Overview of Molecular Genetics....Pages 217-228
Genetic Basis of Neurologic and Neuromuscular Diseases....Pages 229-248
Molecular Mechanisms of Endocrine Disorders....Pages 249-269
Molecular Pathogenesis of Cardiovascular Disease....Pages 271-291
Molecular Mutations in Human Neoplastic Disease....Pages 293-316
Molecular Genetics and the Diagnosis of Hematological Malignancies....Pages 317-339
Molecular Techniques in Laboratory Diagnosis of Infectious Diseases....Pages 341-360
Front Matter....Pages 361-361
Quality Control Issues for the Clinical Molecular Pathologist....Pages 363-371
Prospects for the Future Role of the Clinical Laboratory....Pages 373-378
Back Matter....Pages 379-390