Neuroendocrine Molecular Biology

Front Matter....Pages i-xii
Structure, Function and Expression of the Human Calcitonin/α-CGRP Gene....Pages 1-16
Neuronal Specific Gene Expression in the Murine Hippocampus....Pages 17-31
Hybridization Histochemistry — Locating Gene Expression....Pages 33-39
The Identification and Function of Differentiation Antigens on Primary Sensory Neurons....Pages 41-45
The Physiological Actions of LHRH — Evidence from the Hypogonadal (hpg) Mouse....Pages 47-56
The Biosynthetic Precursor of Gonadotropin-Releasing Hormone: A Multifunctional Prohormone....Pages 57-65
Gonadotropin-Releasing Hormone: Differentiation of Structure and Function During Evolution....Pages 67-83
The Biosynthesis of LHRH....Pages 85-90
Evidence for Sex Differences in GnRH Receptors and Mechanism of Action....Pages 91-100
The Role of Brain Peptides in the Control of Anterior Pituitary Hormone Secretion....Pages 101-111
Phospholipid Turnover, Ca 2+ Mobilization and Protein Kinase C Activation in GnRH Action on Pituitary Gonadotrophs....Pages 113-123
Hormonal Regulation of Pituitary Gonadotropin Gene Expression....Pages 125-134
The Mammalian Tachykinins and Their Receptors: Structure-Activity Relationship of the Mammalian Tachykinins....Pages 135-145
Biosynthesis of the Tachykinins and Somatostatin....Pages 147-158
Biosynthesis of Somatostatin, Vasoactive Intestinal Polypeptide, and Thyrotropin Releasing Hormone....Pages 159-173
Enzymes Processing Somatostatin-Precursors, The Somatostatin-28 Convertase of Rat Brain, A System Converting Somatostatin-28 to Both Somatostatins-14 and -28(1–12)....Pages 175-184
Oxytocin and Vasopressin Secretion: New Perspectives....Pages 185-209
Organization and Expression of the Vasopressin and Oxytocin Genes....Pages 211-218
Measurement of Expression of the Vasopressin and Oxytocin Genes in Single Neurons by In Situ Hybridization....Pages 219-229
Neurohypophysial Peptides in the Gonads....Pages 231-237
Molecular Biology of Ovarian Oxytocin....Pages 239-247
Characterization, Regulation and Functional Activity of Specific Vasopressin Receptors in the Anterior Pituitary Gland....Pages 249-260
The Regulation of Proopiomelanocortin Gene Expression by Estrogen in the Rat Hypothalamus....Pages 261-270
Differential Regulation of ACTH and β-Endorphin by Controlled Processing....Pages 271-280
Strategies in the Regulation of Secretory Signals from Proopiomelanocortin-Producing Cells....Pages 281-294
Expression of Preprosomatostatin Genes in Heterologous Cells....Pages 295-307
Degradation of Luteinizing Hormone-Releasing Hormone (LHRH) by Pituitary Plasma Membrane and by Pituitary Cells in Culture....Pages 309-323
Analysis of Hormone Secretion from Individual Pituitary Cells....Pages 325-340
LHRH Priming in Gonadotrophs: A Model System for the Analysis of Neuroendocrine Mechanisms at the Cellular Level....Pages 341-352
Membrane Traffic in Relation with Release Mechanisms in Neuroendocrine Cells in Culture....Pages 353-365
Neuro-Steroids: 3β-Hydroxy-Δ5-Derivatives in the Rat Brain....Pages 367-377
Ion Channels and the Control of Secretion in Normal Anterior Pituitary Cells....Pages 379-392
Biochemical and Functional Characterization of GnRH Receptors....Pages 393-404
Hormonal Receptor Plasticity in the Brain as Shown by In Vitro Quantitative Autoradiography....Pages 405-416
Cytosolic Factors Modulating Prolactin Binding....Pages 417-427
Pituitary GnRH Receptors — Recent Studies and Their Functional Significance....Pages 429-440
Effects of an LHRH Antagonist on Luteal Function in the Macaque....Pages 441-450
Comparison of Protein and Ribonucleic Acid Composition of Post Mortem Brain Tissue Between Controls and Cases of Alzheimer Type Dementia....Pages 451-455
Neuroendocrine Changes in Alzheimer’s Disease: Raised Plasma Concentrations of Growth Hormone and Thyroid Stimulating Hormone and Reduced Concentrations of Oestrogen-Stimulated Neurophysin....Pages 457-464
The use of an LHRH Agonist in the Treatment and Investigation of the Premenstrual Syndrome....Pages 465-473
Direct Effects of LHRH and Agonists on Human Breast Cancer Cells....Pages 475-488
Back Matter....Pages 489-498