Neurodegenerative Diseases: Pathology, Mechanisms, and Potential Therapeutic Targets

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Alzheimer’s Disease: Insights from Genetic Mouse Models and Current Advances in Human IPSC-Derived Neurons....Pages 3-29
Clinical Aspects of Alzheimer’s Disease....Pages 31-53
Parkinson’s Disease: Basic Pathomechanisms and a Clinical Overview....Pages 55-92
Huntington’s Disease: Pathogenic Mechanisms and Therapeutic Targets....Pages 93-128
The Complexity of Clinical Huntington’s Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers....Pages 129-161
Motoneuron Disease: Basic Science....Pages 163-190
Motoneuron Disease: Clinical....Pages 191-210
Multiple Sclerosis: Basic and Clinical....Pages 211-252
Front Matter....Pages 253-253
Schizophrenia: Basic and Clinical....Pages 255-280
Stroke: Basic and Clinical....Pages 281-293
Epileptic Encephalopathies as Neurodegenerative Disorders....Pages 295-315
Neurodegeneration and Pathology in Epilepsy: Clinical and Basic Perspectives....Pages 317-334
Prion Diseases....Pages 335-364
Leukodystrophy: Basic and Clinical....Pages 365-382
Traumatic Brain Injury as a Trigger of Neurodegeneration....Pages 383-400
Front Matter....Pages 401-401
Cell Death Mechanisms of Neurodegeneration....Pages 403-425
Neuroglia: Functional Paralysis and Reactivity in Alzheimer’s Disease and Other Neurodegenerative Pathologies....Pages 427-449
Advances in Neuroimaging for Neurodegenerative Disease....Pages 451-478
Gene Linkage and Systems Biology....Pages 479-489
Biomarkers in Neurodegenerative Diseases....Pages 491-528
Back Matter....Pages 529-542