Neurodegeneration and Prion Disease

Preliminaries......Page 1
Contents......Page 6
1. Introduction......Page 13
2. Neuropathology of transmissible spongiform encephalopathies (prion diseases)......Page 25
3. Central pathogenesis of prion diseases......Page 61
4. Hereditary prion protein Amyloidoses......Page 95
5. Mouse behavioural studies and what they can teach us about prion diseases......Page 123
6. Electrophysiological approaches to the study of prion diseases......Page 151
7. Prion protein, prion protein-like protein, and neurodegeneration......Page 179
8. Oxidative stress and mitochondrial dysfunction in......Page 207
9. Mechanisms of prion toxicity and their relationship to prion infectivity......Page 229
10. A stone guest on the brain: Death as a prion......Page 253
11. Molecular mechanisms mediating neuronal cell death in 11. Molecular mechanisms mediating neuronal cell death in......Page 285
12. Processing and mis-processing of the prion protein......Page 311
13. Signaling pathways controling prion neurotoxicity......Page 331
14. Cell culture models to unravel prion protein function and aberrancies in TSE......Page 357
15. Insights into the cellular trafficking of prion proteins......Page 391
16. The molecular basis of prion protein-mediated neuronal damage......Page 419
17. Conclusion: Intervention, the final frontier......Page 463
Index......Page 469