Neurochemistry: Cellular, Molecular, and Clinical Aspects

Front Matter....Pages i-xxvi
Front Matter....Pages 1-1
A Brief History of the European Society for Neurochemistry....Pages 1-7
Development of Neurochemical Research in the Ukraine....Pages 9-12
Front Matter....Pages 13-13
Neuroinflammation and Alzheimer’s Disease....Pages 15-19
Neurochemical Derangements and Cognitive Deficits in Apolipoprotein E Deficient Mice Following Closed Head Injury....Pages 21-26
The Role of Cytokines in Alzheimer’s Disease....Pages 27-32
Profiles of Brain Phospholipids and Fatty Acids in Alzheimer’s Disease Brain....Pages 33-38
Synaptic Pathology in Alzheimer’s Disease....Pages 39-46
5-HT 1A Partial Agonists as Anxiolytics and Antidepressants....Pages 47-53
Effects of Repeated Administration of Dizocilpine on 5HT 1A Receptor Binding in the Rat Brain....Pages 55-57
A Pharmacological Characterization Of Hippocampal 5-HT 1D Receptors In The Guinea Pig....Pages 59-62
Antidepressant Drug Actions on Hypothalamic-Pituitary-Adrenal Axis in Olfactory Bulbectomized Male Rats....Pages 63-67
Antagonist Affinity Estimates from Radioligand Binding and Functional Studies Vary at the Cloned Human 5-HT 2C Receptor....Pages 69-72
Glia and the Development of Brain Damage....Pages 73-78
L-Deprenyl Reduces Brain Damage in the Caudate Putamen by a Mao-Dependent Effect....Pages 79-82
Homeostatic Effects of Adenosine on Potentially Neurotoxic Glial Cell Activation....Pages 83-90
Protective Effects of Mild Hypothermia on the Brain and Endothelium in Acute Embolic Stroke....Pages 91-95
Prevention of Cerebral Thermo-Pooling, Free Radical Reactions, and Protection of A10 Nervous System by Control of Brain Tissue Temperature in Severely Brain Injured Patients....Pages 97-103
Experimental Allergic Encephalomyelitis....Pages 105-111
Autoreactive T Lymphocytes in Multiple Sclerosis....Pages 113-119
Cytokines And Multiple Sclerosis....Pages 121-124
Front Matter....Pages 13-13
Oligodendrocytes and Schwann Cells Respond Differently to a Transgene Induced Reduction of Axon Caliber....Pages 227-232
Major Myelin Specific Genes Expression in pt PLP Gene Mutant Rabbit....Pages 233-237
Growth Regulation and Myelin Protein Expression in a Newly Established Permanent Glial Cell Line....Pages 239-242
N-3 Polyunsaturated Fatty Acids....Pages 125-136
Suppression of Experimental Autoimmune Encephalomyelitis in the Rat by Oral Administration of Spinal Cord Protein Hydrolysate....Pages 137-140
Selective Blood Brain Barrier Dysfunction After Intravenous Injections of RTNFα in the Rat....Pages 141-146
Hypoxia, Ca 2+ Homeostasis, and Development and Aging of the Brain....Pages 147-152
Glutamatergic Function in Alzheimer’s Disease....Pages 153-159
Morphochemical Changes in the Brain of Rats Under the Conditions of Dopamine System Dysfunction....Pages 161-164
Neuroprotective Signal Transduction Pathways of sAPP and TNF....Pages 165-172
Combined Fructose 1,6-Diphosphate-Dimethyl Sulfoxide Treatment Reverses Chronic Memory Deficits in Brain Ischemic Rats....Pages 173-176
Carnosine Protective Effect on Ischemic Brain in Vivo Study Using Proton Magnetic Resonance Spectroscopy....Pages 177-182
A Magnetic Resonance Imaging Study of the Brain and the Spinal Cord During Ischemia....Pages 183-186
The Role of 5-Hydroxytryptamine in Depression....Pages 187-191
The Role of Noradrenaline in Depression and its Therapy....Pages 193-196
Monoaminergic and Glutamatergic Mechanisms in a Realistic Animal Model of Depression....Pages 197-200
Effects of Ammonia and L-Tryptophan Loading on Brain Extracellular 5-HT and 5-HIAA Levels in Chronic Experimental Hepatic Encephalopathy....Pages 201-207
Dopamine Metabolism Trafficking in Genetically Defined Anxiety and Neuropathology....Pages 209-213
Differential Effects of 2-(Ethylthio)Apomorphine Enantiomers on Striatal Dopamine Overflow in Vivo ....Pages 215-219
Neurosynaptic Nets and the Induction of Consciousness....Pages 221-225
Front Matter....Pages 13-13
The Role of Glutathione in the Pathogenesis of Parkinson’s Disease....Pages 243-248
Sources of Cells for Transplantation and Gene Therapy in Parkinson’s Disease....Pages 249-257
Characterization of a Signalling Pathway Underlying Neuronal Cell Death After Trophic Support Withdrawal Or TNFα Treatment....Pages 259-263
Autoantibodies Against Human Brain AMPA/Quisqualate Receptor Capable of Determining Persons with Brain Paroxysmal Activity and Epilepsy....Pages 265-274
GABA-Dependent Modulation of [ 3 H]TBOB Binding to the GABA A Receptor Complex....Pages 275-279
Increased Incidence of CNS- and Phospholipid Antibodies in Epileptic Syndromes of Childhood....Pages 281-286
Effect of Some Neuropeptides on MAO Activity Under Experimental Epilepsy....Pages 287-289
The Dynamics of Neurophysins, Exogenous Ferritin, Albumin in Pituitary (Neurohypophysis), and Blood Serum of Rats at Oxygen Epilepsia....Pages 291-293
The Anticonvulsive Drug Valproic Acid Affects Cell Morphology and Cytoskeletal Organization....Pages 295-298
Possible Mechanisms of Neuroprotection in Response to Diverse Insults....Pages 299-302
The Role of the Metabolism of (−)-Deprenyl in Neuroprotection....Pages 303-308
The Iron Chelator Desferrioxamine Protects Against MPP + Neurotoxicity....Pages 309-313
Production of Metabolites of L-Deprenyl and pFluoro-L-Deprenyl in Rat Brain After Central Administration....Pages 315-322
The Possible Involvement of Death-Related Genes in Methamphetamine-Induced Apoptosis....Pages 323-325
Methamphetamine Administration and Associated Neurotoxicity....Pages 327-330
Long-Term Safety and Efficacy of Selegiline in the Treatment of Parkinson’s Disease....Pages 331-337
The Protective Effect of Delta-Sleep Inducing Peptide Under Hypokinetic Conditions....Pages 339-343
Amiridine Delays Functional Degradation of Isolated Crayfish Neuron Occurring Spontaneously or Under Energy Metabolism Inhibition....Pages 345-349
Combined Therapy with 8-OH-DPAT and Nimodipine Against in Vivo NMDA-Induced Cell Death in Rat Nucleus Basalis....Pages 351-355
Biological Effects of P 2 Purinoceptor Modulators in Cultured Primary Cerebellar Granule Neurons....Pages 357-360
Front Matter....Pages 13-13
Generation of Ca 2+ Signal in NMDA Receptors of Rat and Rabbit Hippocampus in Vivo ....Pages 361-367
Transient Increase of Calcium/Calmodulin-Dependent Kinase II (CaM KII) in its Autonomous State Under Brain Ischemia....Pages 369-373
Ischemia-Reperfusion Decreases Protein Levels of InsP 3 Receptor and PMCA but not Organellar Ca 2+ Pump and Calreticulin in Gerbil Forebrain....Pages 375-382
Immunological and Functional Identification of Intracellular Ca 2+ Store from Gerbil Forebrain....Pages 383-388
Type I Inositol (1,4,5) Trisphosphate Receptor and Phosphate-Activated Glutaminase are Highly Enriched in Neurons as Compared to Glial Cells in Rat Neostriatum....Pages 389-394
Quantification of Extracellular Calcium in Fish Brain after Optic Nerve Cut....Pages 395-399
Neuroprotective Approaches in Vivo Against Ca 2+ -Induced Neurodegeneration in Rat Nucleus Basalis....Pages 401-406
On the Mechanism of Calpain Activation Under Ischemia....Pages 407-414
Proteolytic Activity is Increased in Lymphocytes from Patients with Alzheimer’s Disease....Pages 415-418
The Role of Delta-Sleep Inducing Peptide in Calpain Activity Regulation Under Hypoxia....Pages 419-422
CSF Flow....Pages 423-432
Quality Assurance and Sample Handling in CSF Investigation....Pages 433-441
Glutamine Synthetase in Cerebrospinal Fluid is Brain-Derived and Elevated in Neurodegenerative Diseases....Pages 443-449
Glial Cell Pathobiology in Multiple Sclerosis Detected by CSF Markers....Pages 451-455
BB-Isoform of Creatine Kinase in Amniotic Fluid as a Marker of Brain Development Disorders....Pages 457-460
Excitation-Contraction Coupling of Extensor Digitorum Longus Muscle of Dystrophic MDX Mouse....Pages 461-464
Graded Postischemic Reoxygenation, Phospholipids and Neuronal Damage in Rabbits after Ischemia....Pages 465-468
Do Prostaglandins E 2 , F 2Alfa , and D 2 Have a Role in the Development of Idiopathic Trigeminal Neuralgia?....Pages 469-474
Leg Movements are Transiently Present in Fetuses and Infants with Spina Bifida Aperta....Pages 475-478
Histamine-Induced Vasogenic Brain Oedema Formation in Newborn Pigs....Pages 479-483
Front Matter....Pages 13-13
Progressive Motor Neuron Impairment in an Animal Model of Familial Amyotrophic Lateral Sclerosis....Pages 485-490
The Influence of Hypokinesia on Synapsoarchitectonical Features of Rat’s Lymbic and Extrapyramidal Structures....Pages 491-494
Front Matter....Pages 495-495
Role of Neuron-Glia Interactions in Coupling Neuronal Activity to Energy Metabolism....Pages 555-560
The Source of Metabolic Substrates for Neuronal Energy Metabolism....Pages 561-569
Regulation of Glial Lipid Metabolism During Osmotic Stress Studied by 13 C-NMR Spectroscopy....Pages 571-575
Determination of Brain Extracellular Glucose in Vivo with an Implanted Biosensor....Pages 577-581
Time Course of Trophic Responses of Astrocytes in Rat Hippocampus Induced by Trimethyltin Intoxication: an Immunocytochemical Study....Pages 497-500
Interleukin-1 β Receptor Mediated NGF Synthesis and Secretion from Rat Cortical Astrocytes....Pages 501-506
Changes in Hippocampal PKCγ, mAChR- and trkB-Immunoreactivity after a Spatial Learning Paradigm....Pages 507-511
Devascularizing Injury of the Rat Brain Neocortex Causes Different Neurotrophic Responses in Denervated Nucleus Basalis Magnocellularis and Thalamic Nuclei....Pages 513-518
Analysis of Perfusates Collected from Surviving Rat Brain Olfactory Cortex Slices....Pages 519-521
Pharmacology of Melatonin as a Neural Antioxid Ant....Pages 599-603
A Cellular Model for the Study of Estrogen Activity in Cells of Neural Origin....Pages 523-528
The Disturbances of the Hypothalamic Circadian Rhythm Regulation in Female Rats Under the Influence of Xenobiotics....Pages 529-533
Regulation of Parathyroid Secretion by Chromogranin a Amino Terminal Peptides....Pages 583-588
Pancreastatin Signaling in the Liver....Pages 589-593
The Functional Role of Bovine Adrenal Medullary New Cardioactive Peptides....Pages 595-598
Molecular Determinants of Microglial Activation Stages....Pages 535-539
Is Regulation of Cyclooxygenase-2 Important for the Neuroprotective and Neurotoxic Roles of Microglia?....Pages 541-547
The Response of Microglia to Axon Injury....Pages 549-554
Front Matter....Pages 495-495
Gene Expression in Axons and Nerve Endings....Pages 637-641
Protein Synthesis in Brain Presynaptic Endings....Pages 643-646
Long Term Survival of Isolated Axonal Segments as Revealed by in Vitro Studies....Pages 647-653
Direct Evidence for De Novo Protein Synthesis in Isolated Axons of Identified Lymnaea Neurons....Pages 655-660
Ribosomes in Peripheral and Presynaptic Domains of Axons....Pages 661-665
Periaxoplasmic Plaques as Discrete Putative Translational Domains in Mauthner Axons....Pages 667-673
The Major Protein of a Large Ribonucleoprotein Particle (Vault) is Localized in Nerve Terminals....Pages 675-681
Molecular Identification of Proteins Involved in Transport of Branched-Chain Amino Acids in Glial Cells....Pages 619-623
Role of Arginine Transport in the Production of Nitric Oxide in Cultured Neural Cells....Pages 625-629
Metabolic Trafficking in the Fetal Brain Under Normal and Diabetic Maternal Conditions, by 13 C NMR Isotopomer Analysis....Pages 631-635
New Insights Into the Structure and Function of the Endopeptidase-24.11 Family of Ectoenzymes....Pages 683-689
Inactivation of Thyrotropin-Releasing Hormone (TRH) by the TRH-Degrading Ectoenzyme....Pages 691-694
Ecto-Nucleotidases....Pages 695-700
Functional Role of Ecto-5′-Nucleotidase in the Nervous System....Pages 701-706
NCAM and Ecto-ATpases of Rat Synaptosomes....Pages 707-711
Melatonin Biosynthesis in the Retina....Pages 605-609
Melatonin Protects Against Ischaemic-Like Insults to Retinal Cells, in Vitro ....Pages 611-618
Quantal Transmitter Release at Botulinum-Treated Vertebrate Neuromuscular Junctions....Pages 713-717
Identification of Proteins Involved in Regulated Exocytosis....Pages 719-727
Catecholamines Levels in the Rat Brain and Plasma during Cardiac Arrest and after Resuscitation....Pages 729-732
Front Matter....Pages 495-495
Effect of Glutathione on [ 3 H]Dopamine Release from the Mouse Striatum Evoked by Glutamate Receptor Agonists....Pages 733-736
Compartmentation of Acetyl-CoA and Acetylcholine Metabolism in Pyrithiamine Encephalopathy....Pages 737-741
Enhancement of Hippocampal Acetylcholine Release by Local Ethanol Infusion....Pages 743-749
Effects of Inhibitors of the Mitochondrial Electron Transport Chain on Fatty Acid Beta-Oxidation in Rat Brain Cultured Astrocytes....Pages 751-755
Brain Metabolic Adaptation to Hypoxia Stress....Pages 757-760
Changes in Contents of Phospholipids in Rat Brain Under the Action of Noise....Pages 761-764
Postnatal Development of Malic Enzyme Isoforms in Rat Brain....Pages 765-769
Front Matter....Pages 771-771
Towards Overexpression of the Serotonin Transporter....Pages 773-780
Scorpion Toxins....Pages 783-789
A Novel Strategy of Effect-Directed Ligand Design for G-Protein Coupled Receptors....Pages 791-796
Role of Some Biochemical Correlates in Mechanisms of LTP in Olfactory Cortex Slices....Pages 797-800
Presynaptic Nicotinic Receptors in the CNS....Pages 801-805
Muscarinic Receptors....Pages 807-811
Presence of Acetylcholine in the Blood and its Production by Choline Acetyltransferase in Lymphocytes....Pages 813-819
Metabolism of Acetyl-CoA and Cholinergic Neuropathies....Pages 821-827
Targeted Immunolesion of Cholinergic Neurons by 192 IgG-Saporin....Pages 829-835
The Relationships Between Two Choline Uptake Components within Wide Range of pH....Pages 837-842
Influence of Nicotinic Stimulation on [Ca 2+ ] i in Processes of Chick Sympathetic Neurons in Culture....Pages 843-846
Cholinergic Mechanisms in Inherited and Acquired Tolerance to Ethanol....Pages 847-851
The State of M-Cholino- and Beta- Adrenoreception of Autonomic Ganglia in Spontaneously Hypertensive Rats....Pages 853-856
Front Matter....Pages 771-771
Structure and Function of the Neural Cell Adhesion Molecule Ncam....Pages 857-862
Polysialic Acid (PSA) Associated with the Neural Cell Adhesion Molecule (N-CAM) May Play a Role in Spatial Learning and LTP in Rats....Pages 863-868
Regulated Expression of the CNS-Specific Cell Adhesion Molecule Ependymin After Acquisition of an Active Avoidance Behaviour Provides a Possible Mechanism for Memory Consolidation....Pages 869-876
Time-Limited Roles for Cell Adhesion Molecule-Mediated Neuroplastic Events in the Commitment of Memory to Long Term Storage....Pages 877-883
Expression of α-2,8-Polysialyltransferase During Retinoic Acid Induced Differentiation of a Neuroblastoma Cell Line....Pages 885-889
Functional Characterization of the First Immunoglobulin-Like Domain of The Neural Cell Adhesion Molecule....Pages 891-895
Expression of a Transmembrane Isoform of the Neural Cell Adhesion Molecule (NCAM) in Rat Glioma BT4Cn Cells Increases Their Motility....Pages 897-900
Brevican, a Conditional Proteoglycan from Rat Brain....Pages 901-904
Enhancement of Hippocampal Long-Term Potentiation in Vitro by Fucosyl-Carbohydrates....Pages 905-908
Glycoconjugates and Nuclear Membrane Lectin from Rat Brain Cell Nuclei....Pages 909-912
Glycosyltransferase Activities in 15 Human Meningiomas....Pages 913-917
Administration of Gangliosides Changes the Properties of Adenylate Cyclase System in the Sensorimotor and Limbic Structures of Rat Brain....Pages 919-923
Organ-Specific Expression of Membrane Lipids, Especially of Gangliosides, Depending on the State of Thermal Adaptation....Pages 925-928
N-Linked Oligosaccharide Expression in Whole Tissue and Specific Glycoproteins of Rodent CNS....Pages 929-932
Anti-Ganglioside Antibodies and Molecular Mechanism of Development of Guillain-Barre Syndrome....Pages 933-937
Neuroprotective Actions of Taurine....Pages 939-942
The Volume Responses of Brain Cells During Osmotic Stress....Pages 943-948
Kainic Acid-Stimulated Release of Taurine from the Rat Substantia Nigra in Vivo ....Pages 949-953
Kainic Acid-Stimulated Release of Taurine and Gaba from the Rat Globus Pallidus and Substantia Nigra in Vivo ....Pages 955-958
Different Specificities for Taurine Analogues and their Target Sites in Brain....Pages 959-962
Front Matter....Pages 771-771
Nitric Oxide in the Central Nervous System of Rats Suffering from Rabies Virus Infection or Experimental Allergic Encephalomyelitis....Pages 967-972
The Effect of Glutamate, Antioxid Ants, and Gangliosides on Na + ,K + -Atpase Activity in Rat Brain Cortex Synaptosomes....Pages 973-976
Nitric Oxide Level Dramatically Increases in the Rat Brain during Epileptiform Seizures....Pages 977-981
Resistivity of Leech Retzius Nerve Cells to Long-Lasting Oxidant....Pages 983-986
Effects of Nitric Oxide on the Catecholamine Release from cultured Bovine Adrenal Chromaffin Cells....Pages 987-992
Modification by Nitric Oxide of Acetyl-CoA and Acetylcholine Metabolism in Nerve Terminals....Pages 993-997
The Effect of Taurine and Saline on Neuroactive Amino Acid Levels in the Mouse Brain....Pages 963-965
Age-Dependent Changes of the in Situ Protein Phosphorylation in Hippocampal Slices After Stimulation of Glutamate Receptors....Pages 1071-1075
Role of the Phosphatidylinositol Transfer Protein in Intracellular Membrane Traffic....Pages 999-1004
Lipid Metabolism in Human Neuroblastoma SK-N-BE Differentiated with Retinoic Acid....Pages 1005-1010
The Role of Ca 2+ and Protein Kinase C in Regulation of Phosphatidylserine Synthesis in Glioma C6 Cells....Pages 1011-1018
The Possible Mechanisms Involved in New Opioid Agonist Fenaridin and its Antagonist....Pages 1019-1023
Lipid Metabolism Markers in Multi-Infarct Dementia....Pages 1025-1028
CMP-Dependent Degradation of Platelet-Activating Factor (PAF) by Rat Brain Microsomes....Pages 1029-1034
The Effect of Antidepressants on Phospholipase A2 Activity in the Brain of Rats....Pages 1035-1038
A Brief History of Carnitine and its Presence in the CNS....Pages 1039-1045
Carnitine and the Maintenance of Cell Function....Pages 1047-1051
The Carnitine System and Acyl Trafficking in CNS....Pages 1053-1057
Carnitine Transport and Physiological Function in Neurones....Pages 1059-1064
Cerebral Metabolic Compartmentation as Revealed by 13 C NMR Analysis of [1- 13 C....Pages 1065-1070
Front Matter....Pages 771-771
Suppression of Immediate Early Gene Expression By Intracerebrally Applied Antisense Oligonucleotides Impairs Mechanisms of Learning and Memory....Pages 1117-1121
β-Alanine Behaves as γ-Aminobutyric Acid at Xenopus Oocytes Expressing γ-Aminobutyric Acid Receptors....Pages 1123-1129
Regulation of Activity of Brain Phosphate Activated Glutaminase Isoforms....Pages 1077-1081
Effect of Gaba-Ergic Substances on Cerebral Blood Flow and Intracellular Ca 2+ in Hypokinesia....Pages 1083-1088
Dopamine Release in N. accumbens in a Conditioned Reward Paradigm....Pages 1157-1160
Neuronal Activation Visualized by Fos-Expression after Intracerebral Microdialysis of Drugs....Pages 1161-1166
A Role of the Phosphoproteins Dynamin and Rabphilin-3A in Neurotransmitter Release from Synaptic Vesicles....Pages 1095-1099
Synaptic Vesicle Proteins are Rapidly Transported in the Optic Nerve....Pages 1101-1105
Overexpression of B-50/GAP-43 Induces Formation of Filopodia in PC12 Cells....Pages 1107-1110
Salt-Soluble Myelin Basic Protein is Degraded by Myelin-Adsorbed Proteinases....Pages 1111-1115
Neuroreceptor Mapping In Vivo ....Pages 1139-1144
Pet Imaging of Neurotransmission Systems in Neurology....Pages 1145-1148
Measurement of the Cerebral Uptake and Metabolism of L-6-[ 18 F] Fluoro-3,4-Dihydroxy-Phenylalanine in Newborn Piglets....Pages 1149-1155
Functional Evaluation of the Benzodiazepine Cholecystokinin Type-B Receptor Antagonists L-365,260, L-740,093, and YM022....Pages 1089-1094
Patch Clamp Detection of Neuroreceptor Modulators in Capillary Electrophoresis....Pages 1131-1138
Back Matter....Pages 1167-1219