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دانلود کتاب NETosis: Immunity, Pathogenesis and Therapeutic Drug Development
دانلود کتاب NETosis: ایمنی، پاتوژنز و توسعه دارویی
مشخصات کتاب
NETosis: Immunity, Pathogenesis and Therapeutic Drug Development
ویرایش: 1
نویسندگان: Geeta Rai Dr.
سری:
ISBN (شابک) : 0128161477, 9780128161470
ناشر: Academic Press
سال نشر: 2019
تعداد صفحات: 191
زبان: English
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود)
حجم فایل: 8 مگابایت
قیمت کتاب (تومان) : 42,000
در صورت تبدیل فایل کتاب NETosis: Immunity, Pathogenesis and Therapeutic Drug Development به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب NETosis: ایمنی، پاتوژنز و توسعه دارویی نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
توضیحاتی در مورد کتاب NETosis: ایمنی، پاتوژنز و توسعه دارویی
NETosis: ایمنی، پاتوژنز و درمان رویکردی متمرکز به جنبه‌های بالینی NETosis و توسعه دارو دارد و یافته‌های مهمی را به همراه دارد. فصل‌ها NETosis را معرفی می‌کنند، مکانیسم‌ها و استراتژی‌های ضد میکروبی را در نظر می‌گیرند که NETosis را تنظیم می‌کنند، NETosis را در نوزادان بررسی می‌کنند، نقش NETosis در خودایمنی را بررسی می‌کنند، به NETosis و سایر بیماری‌ها می‌پردازند، و رویکردهای درمانی برای NETosis بی‌نظم ارائه می‌دهند. از آنجایی که برینکام و همکارانش در سال 2004 یک مکانیسم ضد میکروبی نوتروفیلی ناشناخته را کشف کردند که مسئول کشتن خارج سلولی پاتوژن های مهاجم است، فرآیند جدیدی که در آن کروماتین هسته ای متراکم می شود و DNA به محیط خارج سلولی پرتاب می شود و پاتوژن های بافت را به دام می اندازد و غیرفعال می کند. به سرعت تکامل یافته است.
توضیحاتی درمورد کتاب به خارجی
NETosis: Immunity, Pathogenesis and Therapeutics takes a focused approach to the clinical aspects of NETosis and drug development, bringing critical findings. Chapters introduce NETosis, consider mechanisms and antimicrobial strategies regulating NETosis, examine NETosis in neonates, explore the role of NETosis in autoimmunity, delve into NETosis and other diseases, and present therapeutic approaches for dysregulated NETosis. Since Brinkamm, et al, discovered an unrecognized neutrophil anti-microbial mechanism responsible for the extracellular killing of invading pathogens in 2004, the novel process in which nuclear chromatin de-condenses and DNA is ejected into the extra cellular environment, trapping and inactivating tissue pathogens has rapidly evolved.
فهرست مطالب
Cover NETosis: Immunity, Pathogenesis, and Therapeutics Copyright Dedication Foreword Preface 1 Neutrophil extracellular trap formation: an introduction Two distinct forms of NETosis Suicidal NETosis Vital NETosis Differences between suicidal and vital NETosis NETosis: sequence of events NET formation from reactive oxygen species to chromatin decondensation Histone modification in NETosis Mechanism of clearance of NETotic debris Regulation of NETosis Other cells involved in NETosis Basophils Eosinophils Mast cells Monocytes and macrophages References Further reading 2 NETosis: mechanisms and antimicrobial strategies Role of DNA and histones in neutrophil extracellular trap release DNA in NETosis Microbicidal activity of DNA in neutrophil extracellular traps Major proteins involved in NETosis Histones in neutrophil extracellular trap Histones as damage-associated molecular patterns Reactive oxygen species as key factor in NETosis Cell-cycle kinases in reactive oxygen species–dependent NETosis Reactive oxygen species–independent NETosis Signaling pathways involved in NETosis Rac2 signaling pathway Raf/MEK/ERK signaling pathway PI3K/AKT/mTOR pathway Other kinases involved in neutrophil extracellular trap signaling Antimicrobial strategies of neutrophil extracellular traps Bacteria Staphylococcus aureus Streptococcus pneumoniae Escherichia coli Clostridium difficile Shigella flexneri Salmonella typhimurium Yersinia enterocolitica Mycobacterium tuberculosis Vibrio cholerae Lactobacillus rhamnosus Viruses Influenza Dengue virus (DENV) Human immunodeficiency virus 1 Respiratory syncytial virus Fungi Candida albicans Aspergillus fumigatus Cryptococcus spp. Parasites Plasmodium falciparum Toxoplasma gondii NETosis and cytokines References Further reading 3 Factors regulating NETosis Autophagy in NETosis Various autophagic stimulants induce NETosis Antineutrophil cytoplasmic antibodies Phorbol myristate acetate Bacteria-derived formyl-methionyl-leucyl-phenylalanine Lipopolysaccharide Autophagy-related molecules in NETosis PMA-induced chromatin decondensation requires NOX2 activity in NETosis Effect of autophagy inhibition on NETosis Role of Toll-like receptors in autophagy Involvement of autophagy in neutrophil extracellular trap formation during fungal infection Apoptosis in NETosis ApoNETosis Molecules at the interface of apoptosis and NETosis Phagocytotic uptake: Apotosis versus NETosis Necrosis in NETosis Response to necrosis Morphology of necrotic neutrophils Various stimuli for neutrophil extracellular trap induction Microcrystals Monosodium urate crystals Calcium pyrophosphate dihydrate crystals (CPPD) Alum Cholesterol crystals Silica crystals Nanoparticles NET formation under hypoxic condition Cellular effects of hypoxia Hypoxia increases NETosis Role of pH in neutrophil extracellular trap induction References Further reading 4 NETosis in neonates Neutrophil activity during pregnancy and in newborns Impaired and delayed NETosis in newborns Distinct neutrophil extracellular trap regulation exists in newborns Calprotectin is associated with neutrophil extracellular trap in newborns Inhibitors of neutrophil extracellular trap activity in newborns Reactive oxygen species-independent pathway in newborns Differential regulation of neutrophil extracellular traps components in newborns References 5 NETosis in Autoimmunity NETosis in rheumatoid arthritis Rheumatoid arthritis pathogenesis NETosis as a source of autoantigens in rheumatoid arthritis Citrullination of histones in neutrophils in rheumatoid arthritis Citrullinated histones as autoantigens in rheumatoid arthritis Ectopic lymphoid structures as a source of antineutrophil extracellular trap antibodies in rheumatoid arthritis Role of NETosis generated cell-free DNA in rheumatoid arthritis Therapeutics based on modulating NETosis in rheumatoid arthritis NETosis in systemic lupus erythematosus Neutrophil extracellular trap components in systemic lupus erythematosus Role of DNase I Neutrophil extracellular traps drive plasmacytoid dendritic cells to produce type I interferon in systemic lupus erythematosus Low-density granulocytes have heightened capacity to make neutrophil extracellular traps Neutrophil extracellular traps mediate enhanced inflammasome activation in systemic lupus erythematosus Impaired neutrophil extracellular trap degradation in systemic lupus erythematosus Neutrophil extracellular trap has protective role in drug-induced systemic lupus erythematosus Role of mitochondrial DNA in neutrophil extracellular trap in systemic lupus erythematosus Neutrophil extracellular trap–based therapeutics in neutrophil extracellular traps Effect of inhibition of JAK on NETosis and systemic lupus erythematosus Effect of B cells–inhibiting drugs in NETosis Neutrophil extracellular traps in multiple sclerosis Higher circulating levels of neutrophil extracellular traps in sera from relapsing-remitting multiple sclerosis patients Neutrophil extracellular trap exhibits gender-specific difference in pathogenesis of multiple sclerosis References 6 NETosis in other diseases and therapeutic approaches NETosis in cystic fibrosis Antimicrobial role of neutrophil extracellular trap in cystic fibrosis Pathophysiological role of neutrophil extracellular trap in cystic fibrosis Alternative fates of neutrophils in the cystic fibrosis lung Neutrophil extracellular trap–based therapeutic options in cystic fibrosis NETosis in diabetes mellitus NETosis severely impairs wound healing in diabetes mellitus Antineutrophil extracellular trap therapy in diabetes mellitus NETosis in cardiometabolic disease Increased peptidylarginine deiminase 4 and neutrophil extracellular trap activation in atherosclerosis NETosis-based therapy NETosis in cancer Consequences of neutrophil extracellular trap in cancer Therapeutic targeting of neutrophil extracellular trap in individuals with cancer Neutrophil extracellular trap in Alzheimer’s disease Two types of NETosis in Alzheimer’s disease: intravascular and intraparenchymal NET Intravascular NETosis Intraparenchymal NETosis Neutrophil extracellular trap–based therapeutic approaches in Alzheimer’s disease NETosis in gout Immunology of the acute inflammatory response in gout MSU crystals induce neutrophil extracellular trap via a distinct molecular pathway Pseudogout and necroptosis induction Neutrophil extracellular trap–based therapeutic targets in gout NETosis in pancreatitis Neutrophil extracellular trap–based therapeutic options in pancreatitis NETosis in infectious diseases Bacterial diseases Fungal diseases Parasitic diseases Viral diseases In Vitro neutrophil extracellular trap formation: measurement techniques References Further reading Nomenclature list Index Back Cover
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