Nephrotoxicity: In Vitro to In Vivo Animals to Man

Front Matter....Pages i-xx
Species Differences in Renal Structure and Function — Applications to Nephrotoxicity in Man....Pages 1-10
Lead Induced Nephrotoxicity: Kidney Calcium as an Indicator of Tubular Injury....Pages 11-20
Predicting the Kidney Burden of Toxic Metals....Pages 21-31
A Prospective Study of Proteinuria in Cadmium Workers....Pages 33-36
Red Blood Cell Negative Charges as an Index of the Glomerular Polyanion in Chronic Cadmium Poisoning....Pages 37-41
Some Considerations on Critical Concentration of Cadmium for Renal Toxicity in Rats....Pages 43-49
Historical Perspective on Cadmium-Induced Nephrotoxicity....Pages 51-57
Cadmium May Predispose Mice to Immune Complex-Mediated Renal Injury: Another Possible Mechanism for Cadmium-Induced Nephrotoxicity....Pages 59-63
Nephrotoxicity of Cadmium in Chickens....Pages 65-70
Differential Effects of Cadmium and Mercury on Lysosomal Enzymes in the Kidney of Myxine Glutinosa....Pages 71-74
The Effects of Cadmium and Adriamycin on the Isolated Perfused Glomerulus of Myxine Glutinosa (Cyclostomata)....Pages 75-79
Protective Effect of Low Concentrations of Mercury Against HgCl 2 -Induced Nephrotoxicity....Pages 81-83
Induction of Antinuclear Antibodies by Mercuric Chloride in Mice....Pages 85-91
Analysis of Unscheduled Dna Synthesis and S-Phase Synthesis in F344 Rat Kidney After in Vivo Treatment with Mercuric Chloride....Pages 93-97
In Vitro and in Vivo HgCl 2 -Induced Nephrotoxicity Assessed by Tubular Enzymes Release....Pages 99-102
Prevention and Reversal of Mercuric Chloride-Induced Increases in Renal Vascular Resistance by Captopril....Pages 103-106
Regioselective Acute Tubular Necrosis in Renal Cortical Slices Following HgCl 2 and K 2 Cr 2 O 7 : Localization and Transport Studies....Pages 107-112
In-Vivo Bone Lead Measurements and Renal Effects....Pages 113-118
Early Indicators of Lead Nephropathy....Pages 119-126
Nephrotoxicity of Uranyl Fluoride and Reversibility of Renal Injury in the Rat....Pages 127-132
Low Molecular Weight Proteins in the Kidney of Copper-Loaded Rats....Pages 133-137
Gold Nephropathy — Effect of Gold on Immune Response to Renal Tubular Basement Membrane (TBM) Antigen in Mice....Pages 139-145
Drug Induced Renal Effects of Cyclosporine, Aminoglycoside Antibiotics and Lithium: Extrapolation of Animal Data to Man....Pages 147-170
Lithium-Induced Distal Nephron Dilatation in Young Rabbits With Associated Encephalitazoan Cuniculi Related Interstitial Fibrosis....Pages 171-175
Urinary Phospholipids Patterns After Treatment With Aminoglycoside Antibiotics and Cis-Platinum....Pages 177-181
Comparative Uptake and Lysosomal Phospholipidosis Induced by Gentamicin Components C1, C1a, and C2....Pages 183-187
Uptake and Subcellular Distribution of Poly-L-Aspartic Acid, a Protectant Against Aminoglycoside-Induced Nephrotoxicity, in Rat Kidney Cortex....Pages 189-192
Aminoglycoside Antibiotics Inhibit the Phosphatidylinositol Cascade in Renal Proximal Tubular Cells: Possible Role in Toxicity....Pages 193-200
Silymarin Ameliorates Gentamicin Nephrotoxicity....Pages 201-206
Possible Role of the Renin-Angiotensin System in the Development of Gentamicin Nephrotoxicity in the Rat....Pages 207-216
Effect of Furosemide and Verapamil on Gentamicin Nephrotoxicity....Pages 217-220
Renal Phospholipidosis in Rats after Gentamicin and Pefloxacin Coadministration at Low Doses....Pages 221-223
Morphological and Functional Impairment of the Developing Rat Kidney Exposed to Gentamicin in Utero....Pages 225-231
Morphological and Functional Effects in Rat Neonates of Aminoglycosides Given to the Mother During Gestation....Pages 233-239
Gentamicin-Stimulated Increase in Para-Aminohippurate Uptake in Renal Cortical Slices and Isolated Proximal Tubular Cells....Pages 241-246
Investigation of Gentamicin Nephrotoxicity Using Renal Brush Border Membrane Vesicles....Pages 247-252
Time Dependent Nephrotoxicity of Amikacin....Pages 253-256
Effect of Latamoxef [Moxalactam] on Tobramycin Binding to Kidney Brush Border Membranes in Rats.....Pages 257-262
Amphotericin-B Nephrotoxicity is Decreased by Intravenous Flucytosine in the Rat....Pages 263-267
Apparent Amoxapine Nephrotoxicity: Dependence on Rhabdomyolysis and Acidosis....Pages 269-275
Mechanisms of Cyclosporin a Nephrotoxicity — Rat to Man....Pages 277-283
The Effects of Cyclosporin a on the Urine Excretion of Specific Proteins in Humans....Pages 285-290
Renal Tubular Function in Experimental and Clinical Cyclosporin (CsA) Nephrotoxicity....Pages 291-296
The Effect of Biliary Cannulation or Ligation on Cyclosporin A (CsA) Nephrotoxicity in The Rat....Pages 297-302
Cyclosporine A-induced Lipid Peroxidation in Rat Renal Microsomes and Effect on Glucose Uptake by Renal Brush Border Membrane Vesicles....Pages 303-308
Chronic Renal Tubular Damage Caused by Cyclosporin A....Pages 309-314
Effects of Acute and Chronic Cyclosporine Administration on Glomerular Haemodynamics in Rats....Pages 315-323
Intracellular Localization of Cyclosporin A in the Rat Kidney....Pages 325-330
Distribution of Platinum Amongst the Subcellular Organelles of the Rat Kidney After Oral Administration of Cisplatin....Pages 331-336
Alpha-Methylglucose Uptake by Isolated rat Kidney Proximal Tubular Cells as a Parameter for Cell Integrity in Vitro....Pages 337-342
Lipid Peroxidation as a Mechanism of Cisplatin-Induced Nephrotoxicity....Pages 343-347
Renal Toxicity of Cis-Dichlorodiammine Platinum in Rats....Pages 349-351
Uptake of Cisplatin ( 195m Pt) Into LLCPK 1 Cells in the Presence of Diethyldithiocarbamate (DDTC) , Mercaptoethanesulphate (MESNA) and Amiloride....Pages 353-356
The Effect of Amiloride on Cisplatin Induced Nephrotoxicity and the Renal Uptake of ( 195m Pt) Cisplatin in Male Wistar Rats....Pages 357-359
The Response of the Pig Kidney to a Combination of Cisplatin and Irradiation....Pages 361-366
The Effect of Acetazolamide and Furosemide on Lithium Clearance and Cisplatin Nephrotoxicity in the Rat....Pages 367-370
Sensitivity of in Vitro Ion Accumulation, Gluconeogenesis and other Parameters as Indicators of Cisplatin-Induced Renal Toxicity....Pages 371-375
Assessment of Nephrotoxicity by Analysis of a Randomized Multi-Centre Comparative Study Regarding the Previous Extend of Kidney Damage....Pages 377-382
Drug Pharmacokinetics in Renal Failure — Influence of Disease Type....Pages 383-388
Analgesic Related renal Injury in Man....Pages 389-396
Progression of Renal Failure in Analgesic Associated Nephropathy....Pages 397-400
The Renal Response of a Nonhuman Primate (Baboon) to Certain Nonsteroidal Anti-Inflammatory Drugs....Pages 401-406
Morphological Changes in the Pig Kidney Associated with an Acutely Induced Renal Papillary Necrosis....Pages 407-410
Upper Urothelial Carcinoma, Using N-Butyl-N-(4-Hydroxybutyl)-Nitrosamine and an Acute Papillary Necrosis....Pages 411-414
High Resolution Microscopic Changes in an Acutely Induced Renal Papillary Necrosis: Morphology and Enzyme Histochemistry....Pages 415-421
Cannulation of the Bile Duct Protects Against Para-Aminophenol-Induced Nephrotoxicity in the Fischer 344 Rat....Pages 423-432
Effects of Antidotes on the Hepato- and Nephrotoxicity of Paracetamol in the Rat....Pages 433-438
Celiptium Induced Lipid Peroxidation and Toxicity in Rat Renal Cortex....Pages 439-445
Nephrotoxicity of Ifosfamide in Combination Chemotherapy....Pages 447-450
Risk Evaluation of Muzolimine and Furosemide in Experimental Models of Nephrotoxicity....Pages 451-456
The Role of Oxidative Stress in Cephaloridine Nephrotoxicity....Pages 457-461
Studies on the Mechanism of Radiological Contrast Media Induced Renal Failure....Pages 463-468
Radiocontrast Nephrotoxicity in Diabetes: Clinical Considerations and Studies in the Diabetic Rat....Pages 469-478
Renal Microcirculation During Urographic Contrast Media Administration....Pages 479-484
Hypertonic Radiocontrast Medium and the Kidney: Effects on Renal Functions in the Euvolaemic and in the Dehydrated Dogs....Pages 485-489
Renal Effects of Ionic and Nonionic Contrast Media: Comparison between Diatrizoate Meglumine and Iopamidol....Pages 491-496
Renal Proton Nuclear Magnetic Resonance in Gentamicin, Cyclosporin a and Cisplatinum Acute Renal Failure in Rats....Pages 497-502
 31 Phosphorus NMR Studies of Mercuric Chloride Nephrotoxicity in the in Vitro Perfused Rat Kidney....Pages 503-507
Application of 1 H NMR Urinalysis to the Examination of Nephrotoxic Lesions Induced by Mercuric Chloride, Hexachloro-1, 3-Butadiene, and Propyleneimine....Pages 509-517
Pathogenesis of Protein Droplet Nephropathy and Its Relationship to Renal Carcinogenesis in the Male Rat....Pages 519-526
Light Hydrocarbon-Induced Nephrotoxicity: the Interaction of 2,2,4-Trimethylpentane with Alpha-2U-Globulin in the Male Rat Kidney....Pages 527-534
Male Rat Specific Alpha 2u Globulin Nephropathy and Renal Tumourigenesis....Pages 535-541
Nephrotoxicity and Studies on the Reabsorption and Disposal of Alpha 2U-Globulin....Pages 543-549
Induction of Hyaline Droplet Accumulation in Renal Cortex of Male Rats by Aromatic Compounds....Pages 551-556
1,4-Dichlorobenzene-Induced Nephrotoxicity: Similarity with Unleaded Gasoline (UG)-Induced Renal Effects....Pages 557-562
Comparison of the Subacute Nephrotoxicity of Industrial Solvents in the Rat....Pages 563-567
Nephrotoxic Responses to Multiple Chemical Exposure....Pages 569-576
Dichlorovinyl Cysteine Accumulation and β-Lyase Activity in the Developing Mouse Kidney....Pages 577-581
Regioselective Toxicity by Dichlorovinylcysteine in Rabbit Renal Cortical Slices....Pages 583-589
Use of LLC-PK 1 Monolayers as an In Vitro Model for Nephrotoxicity....Pages 591-594
Bioactivation Mechanism and Cytotoxicity of S (2-Chloro-1,1,2-Trifluoroethyl)-L-Cysteine....Pages 595-600
Role of Biotransformation in Acute N-(3,5-Dichlorophenyl)Succinimide-Induced Nephrotoxicity....Pages 601-605
Chloroform Nephrotoxicity and Renal Uptake of Calcium....Pages 607-609
Renal Pathology of Orally Administered L-Triiodothyronine (T3) in the Rat....Pages 611-615
Lipid Peroxidation as a Possible Cause of Ochratoxin a Toxicity....Pages 617-622
Silicon in Uraemic Rats....Pages 623-625
Nephrotoxicity of Experimental Endotoxaemia in Rats....Pages 627-632
Studies on a Physiological Model for the Hunman Renal Fanconi Syndrome....Pages 633-638
Chronic Ureter Cannula in Pig....Pages 639-644
Effects of Glycerol-Induced Acute Renal Failure on Renal Phosphorus Handling....Pages 645-649
Renal Haemodynamics and Renin Response During Acute Hypercapnea in Dogs....Pages 651-657
The Isolated Perfused Rat Kidney: Filtering and Non-Filtering Models in the Assessment of Altered Renal Vascular Resistance in Nephrotoxicity....Pages 659-662
Endotoxin-Haemoglobin Induced Nephropathy and Haptoglobin Administration....Pages 663-671
Partially Purified Bovine Atrial Fraction on Animal Kidney, Smooth Muscle and Sodium Transport in Toad Skin....Pages 673-679
Investigations on the Nephrotoxic Potential Of Recombinant Human Tumour Necrosis Factor....Pages 681-684
Characterisation of Human Renal Embryonic Antigens by Monoclonal Antibodies....Pages 685-691
Species Differences in the Immunocytochemical Distribution of Tamm-Horsfall Glycoprotein....Pages 693-698
Immunocytochemical Localization of Glutathione Peroxidase in Uremic Rat Kidney....Pages 699-704
Urine Glutathione-S-Transferase Associated with Nephrotoxic Drugs....Pages 705-710
Age-Related Changes in Renal Brush Borders and Brush Border Enzymes....Pages 711-718
Characterization of Isolated Renal Proximal Tubules for Nephrotoxicity Studies....Pages 719-723
Isolated Rat Renal Proximal Tubular Cells: A Model to Investigate Drug Induced Nephrotoxicity....Pages 725-730
Ion Deregulation in Injured Proximal Tubule Epithelial Cells....Pages 731-741
Lipophilic Cations as Membrane Probes in Cultured Renal (LLC-PK 1 ) and Muscle Cells (L6)....Pages 743-748
Characterization of an Unscheduled DNA Synthesis Assay with a Cultured Line of Porcine Kidney Cells (LLC-PK1)....Pages 749-754
Micropuncture Studies on Mechanisms of Proteinuria in Early Adriamycin-Nephrosis in MWF-RATS....Pages 755-760
Back Matter....Pages 761-765