Nephrology: Volume I

Front Matter....Pages I-XXXII
Front Matter....Pages 1-1
Pathogenesis of Glomerulonephritis — 1990....Pages 3-17
Functional Morphology of the Nephron....Pages 19-38
Function of Thin Segments of Henle’s Loop....Pages 39-60
IgA Nephropathy: Recent Views on Pathogenesis and Treatment....Pages 61-76
Pathophysiology of Obstructive Nephropathy....Pages 77-93
Very Long Term Dialysis....Pages 95-97
Biology of Acid-Base Transport in Distal Urinary Epithelia....Pages 99-115
Osmolytes and Cell Osmoregulation in the Kidney....Pages 117-133
The Pathogenesis of Tubulointerstitial Nephritis....Pages 135-149
Lipids and the Pathogenesis of Kidney Disease....Pages 151-163
Front Matter....Pages 165-177
Glomerular Injury Induced by the C5b-9 Membrane Attack Complex of Complement....Pages 179-179
Platelets in Immune Mediated Glomerular Disease....Pages 182-190
The Role of Eicosanoids in Glomerular Immune Injury....Pages 191-200
Mechanisms of Glomerular Fibrin Deposition in Glomerulonephritis....Pages 201-208
Hapten-Specific Cellular Immune Response Producing Glomerular Injury....Pages 209-221
Acid-Base Implications of the K-NH 4 Interactions....Pages 222-226
Reabsorption of Bicarbonate Along the Nephron: Importance of Potassium....Pages 228-233
Role of Acid-Base Disturbance on Potassium Transport Along the Nephron....Pages 234-241
Mechanisms of Transcellular Potassium Shifts in Acid-Base Disorders....Pages 242-251
Front Matter....Pages 252-261
Cell Volume Regulation and Transport Characteristics of Macula Densa Cells....Pages 179-179
Intracellular and Membrane Events in the Activation of Afferent Arteriolar and Granular Cells....Pages 314-322
Macula Densa Control of Renin Secretion....Pages 323-337
Macula Densa Control of Renin Secretion and Proximal Tubular Pressure....Pages 338-347
The Afferent Arteriole in Tubuloglomerular Feedback and Autoregulation....Pages 348-355
Neutrophil Function in Uremia: Inhibition by Endogenous Plasma Inhibitor(s)....Pages 356-365
The Impact of Anemia in the Pathogenesis of Endocrine Abnormalities in Chronic Renal Failure....Pages 368-372
Growth Hormone Treatment for Patients with Renal Failure....Pages 373-378
Myocardial Function in Hemodialysis Patients....Pages 379-388
Electrophysiological and Biofunctional Abnormalities in Uremic Neuropathy....Pages 389-398
Localization of Transport ATPases in the Mammalian Nephron....Pages 399-408
Regulation of Tubular Na-K-ATPase....Pages 410-418
Properties and Function of the Kidney Vacuolar H + ATPase: a Versatile Proton Pump Responsible for Urinary Acidification....Pages 419-434
Role of Ca 2+ ATPase and Plasma Membrane Ca 2+ Pump in Ca 2+ Transport by the Mammalian Kidney....Pages 435-443
Hypokalemia in Metabolic Alkalosis: A New Look at an Old Controversy....Pages 444-447
Vitamin D 3 and Uremic Bone Disease....Pages 262-269
The Renin Angiotensin System, the Kidney, and the Pathogenesis of Hypertension....Pages 450-454
Renal Microcirculation in Essential Hypertension....Pages 272-279
The Pathogenesis of Salt-Sensitive Hypertension....Pages 280-290
Ion Transport Abnormalities in the Development of Hypertension....Pages 291-302
Front Matter....Pages 303-311
Highlights of Major Differences Between Children and Adults with HIV-Associated Nephropathy....Pages 179-179
Human Immunodeficiency Virus Associated Nephropathy (HIVAN)....Pages 472-477
The Epidemiology of Human Immunodeficiency Virus Associated Nephropathy....Pages 478-483
Pathology of Human Immunodeficiency Virus (HIV) Associated Nephropathy in Adults and Children....Pages 484-492
HIV-Associated Nephropathy in Children in Spain....Pages 493-502
Considerations of Pathogenesis of HIV-Associated Nephropathy....Pages 503-511
Evidence of Renal Cell Injury in Acute Renal Failure....Pages 512-519
Cellular Mechanisms of Cyclosporin Nephrotoxicity....Pages 642-647
Glomerular Hemodynamic Effects of Cyclosporine....Pages 522-533
Mechanisms and Mediators of Cyclosporine-Induced Renal Vascular Changes....Pages 534-542
Animal Models of Cyclosporine Nephrotoxicity....Pages 543-554
Clinical Aspects of Cyclosporine Nephrotoxicity....Pages 555-563
Evolution of Cyclosporin Nephrotoxicity....Pages 564-575
Water Permeability, Reflection Coefficients, and Cell Volume Regulation....Pages 576-588
Fluid Transport by Leaky Epithelia and Cell Volume Regulation....Pages 590-597
Organic Compounds in Renal Volume Regulation....Pages 598-610
Volume Regulation in the Collecting Duct and Related Epithelia....Pages 611-619
Rapid Cell Volume Regulation by the Mouse Medullary Thick Ascending Limb of Henle....Pages 620-629
The Therapeutic Role of 24,25 Dihydroxycholecalciferol in Dialysis Patients with Secondary Hyperparathyroidism....Pages 630-640
The Future of New Vitamin D Analogs in Uremic Bone Disease....Pages 455-462
Front Matter....Pages 463-469
Pathogenetic Role of Calcium in Renal Cell Injury....Pages 179-179
Cyclosporine Nephrotoxicity in the 1990s....Pages 648-659
Heterogeneity of Nephron Energy Metabolism: Implications for Response to Hypoxic Insult....Pages 660-664
Ischemia-Induced Loss of Epithelial Polarity....Pages 665-672
Acquired Resistance to Rechallenge Injury to Acute Renal Failure....Pages 673-681
Hormonal Control of Medullary Blood Flow....Pages 682-687
On the Intrinsic Control of Capillary Permeability....Pages 690-695
Regulation of Renal Vascular Resistance: Studies Using Pharmacological Probes....Pages 696-708
Role of Intracellular Calcium in the Regulation of Renal Hemodynamics....Pages 709-717
The Role of Angiotensin in the Control of Renal Vascular Resistance....Pages 718-730
Effects of Lipid Manipulations in Chronic Renal Failure....Pages 731-739
Which Diet and When to Start It, in Patients with Chronic Renal Disease....Pages 742-748
Low Protein Diet and Progression of Chronic Renal Failure: Results of Controlled Clinical Trials....Pages 749-756
Dietary Protein Restriction Retards Progressive Renal Failure in Type I Diabetes....Pages 757-764
Proposed Mechanisms for Changes in Progression by Dietary Manipulation....Pages 765-774
Hepatitis B Virus Infection and Primary Glomerular Disease....Pages 775-782
Snake Bite Induced Renal Disease....Pages 784-793
Acute Renal Failure in Asia....Pages 794-803
Renal Stone Disease in the Middle East....Pages 804-814
Environmental Studies in Man in the Dead Sea Region....Pages 815-822
Front Matter....Pages 823-827
Progression and Chronicity of Acute Post-Streptococcal Glomerulonephritis (APSGN)....Pages 179-179
High Resolution Ultrastructure of the Basement Membrane....Pages 828-839
Glomerular Basement Membrane: Molecular Structure of Type IV Collagen and Its Involvement in Diseases....Pages 842-851
Relevance of Proteoglycans in Glomerular Matrix Pathology....Pages 852-863
Pathobiology of Tubular Basement Membranes in Renal Cystic Disease....Pages 864-875
Front Matter....Pages 876-884
The Terminal Complement Complex C5b-9: A Possible Mediator of Acute and Chronic Glomerulonephritis....Pages 885-885
The Biosynthesis and Action of Tumor Necrosis Factor α in the Kidney....Pages 888-897
The Renal Biology of Endothelins....Pages 898-907
Effect of Insulin-Like Growth Factor-I on Glomerular Cells in Vitro....Pages 908-914
Brain Natriuretic Peptide is a Novel Cardiac Hormone Secreted from the Ventricle in Humans....Pages 915-922
Structural and Functional Relationships of Atrial Peptide Receptor Subtypes....Pages 924-931
Functional Properties and Cell Biology of Renal and Vascular Receptors of Atrial Natriuretic Factor....Pages 932-938
Comparison Between Apical and Basolateral Transporters in Tubular Epithelia: A Dual Location of Na + /H + -Exchange with Different Properties....Pages 939-948
Electrophysiological Localization of Transporters in the Distal Nephron Segments....Pages 950-955
Vesicle Trafficking and Membrane Polarity in Epithelial Cells: Relationship to Intercalated Cell Function in Kidney Collecting Ducts....Pages 956-964
Sorting of Surface Proteins and Lipids in Epithelial Cells....Pages 965-976
Matazo Masugi and Nephrotoxic Nephritis....Pages 977-983
In Situ Immune Complex Nephritis....Pages 986-989
Pathogenesis of IgA Immune Complex-Mediated Glomerulonephritis....Pages 990-995
Anti-Thymocyte Antibody Induced Mesangiolytic Nephritis....Pages 996-1003
Front Matter....Pages 1004-1013
Experimental Nephritis—Other Models and Future Directions....Pages 885-885
Proximal Renal Tubular Acidosis (RTA): Normal Proximal Tubule Function and Evidence of Cellular Defects....Pages 1014-1025
Cellular Mechanisms of Type 2 Renal Tubular Acidosis/Fanconi Syndrome....Pages 1164-1171
Mechanism of Distal Acidification: Relevance to Distal RTA....Pages 1172-1183
Pathophysiological Basis of Distal Renal Tubular Acidosis: Lessons from Animal Models....Pages 1184-1188
Ultrastructure of the Mesangial Matrix....Pages 1189-1195
The Proteoglycans of Glomerular Mesangial Cells....Pages 1138-1143
Cell and Matrix in Monoclonal Antibody-Induced Mesangiolysis....Pages 1144-1152
Regulation of Collagen IV Expression....Pages 1153-1155
The Mode of Action of Diuretics....Pages 1156-1162
Biochemical Action of Loop Diuretics....Pages 1072-1081
Molecular Properties of the Na-K-Cl-Cotransporter....Pages 1082-1094
The Cellular Receptor for Thiazide-Type Diuretics....Pages 1095-1102
Application of the Amiloride Series in the Study of Ion Transport....Pages 1103-1112
Target Cell Metabolism of Corticosteroids Mediating Antisteroid Effects....Pages 1113-1121
Idiopathic Hypercalciuria: Proposal for a New Cascade....Pages 1122-1135
Extracorporeal Shock Wave Lithotripsy (ESWL): Past, Present, and Future....Pages 1028-1042
Extracorporeal Shock Wave Lithotripsy (ESWL): Late Consequences....Pages 1043-1051
Nephrolithiasis — Extracorporeal Shock Wave Lithotripsy (ESWL): Current Status in Japan....Pages 1052-1056
New Drugs to Prevent Recurrence of Renal Stone Disease....Pages 1057-1062
Front Matter....Pages 1063-1070
Classification and Characterization of Types of Distal Acidification Defects in Humans....Pages 885-885
The Specificity of the Autoimmune Response in Vasculitis....Pages 1196-1208
New Perspectives on Systemic Vasculitis: Implications for Diagnosis and Treatment....Pages 1270-1275
Therapeutic Trials in Lupus Nephritis....Pages 1276-1282
Current Strategy of Management for Lupus Nephritis and Renal Vasculitis....Pages 1283-1288
Endothelin in Renal Diseases....Pages 1289-1296
The Cell Biology of Endothelin Peptides: Insights From Studies of Glomerular Mesangial Cells....Pages 1210-1217
Endothelin Action and Production in Renal Tubular Cells....Pages 1218-1228
A Novel Immunosuppressive Agent, Deoxyspergualin....Pages 1229-1237
Therapeutic Use of Monoclonal Antibodies in Renal Transplantation....Pages 1240-1250
Long-Term Follow-Up of Renal Transplantation—Chronic Rejection and Recurrence of Nephritis....Pages 1251-1262
Expression of Growth-Related Genes in Human Fetal Kidney....Pages 1263-1268
Growth Hormone, Insulin-Like Growth Factor I, and Kidney....Pages 1298-1303
Epidermal Growth Factor and the Kidney....Pages 1304-1310
Determinants of Autocrine and Paracrine Growth Factor Release by Kidney Epithelial Cells....Pages 1311-1321
Transport of Organic Molecules....Pages 1322-1332
Renal Hypertrophy and Hyperfunction in Experimental Diabetes....Pages 1372-1375
Renal Pathology in Insulin Dependent (IDDM) and Noninsulin Dependent Diabetes Mellitus (NIDDM)....Pages 1334-1341
The Proteinuric Phase of Diabetic Nephrology....Pages 1342-1350
Management of Advanced Nephrotic Disease in Diabetics: Short-term and Long-term Effects of Angiotensin Converting Enzyme (ACE)-Inhibitors and a New Trial Using Camostat Mesilate....Pages 1351-1361
Front Matter....Pages 1362-1369
Control of Renal Cyst Formation and Enlargement....Pages 885-885
Inflammatory Mediators in the Progression of Renal Cystic Disease....Pages 1524-1529
Towards Structural Identification of the Na + /P i -Cotransport System....Pages 1530-1536
Insulin-Like Growth Factor I (IGF-I), Possible Mediator of the Stimulatory Effects of Growth Hormone on Renal Phosphate Transport and 1,25-Dihydroxyvitamin D3 Production....Pages 1488-1493
Parathyroid Hormone Receptor Coupling to Phospholipase C is an Alternate Pathway of Signal Transduction in the Bone and Kidney....Pages 1494-1498
The Effects of Parathyroid Hormone (PTH) on Ca Transport....Pages 1499-1508
The Biology of Vitamin D-Dependent Calcium Binding Proteins....Pages 1509-1516
Steroids and Cytotoxic Drugs in the Treatment of Minimal Change Nephrotic Syndrome....Pages 1517-1521
New Therapies for the Treatment of Idiopathic Nephrotic Syndrome....Pages 1458-1467
Nephrotic Syndrome in Japan and Other Asian Countries — Epidemiology and Treatment....Pages 1468-1473
Treatment of Childhood Steroid-Resistant Focal Segmental Glomerulosclerosis with Pulse Methylprednisolone and Alkylating Agents....Pages 1474-1479
Optical Approaches for Studying Intracellular pH in Epithelial Cells....Pages 1480-1485
Cell pH Regulation in Collecting Tubules....Pages 1418-1428
Ultramicro-Analysis of Tubular Fluid by Continuous-Flow Methodology....Pages 1429-1437
Optical Methods for Quantifying Cell Volume Changes in Isolated Nephron Segments....Pages 1438-1444
Strategies for Evaluating the Molecular Structure of Membrane Transport Systems....Pages 1445-1456
 p -Aminohippurate Uptake Across the Basolateral Membrane of Rat Proximal Tubule Cells: Specificity and Mode of Energetization....Pages 1376-1379
Organic Cation Transport in the Renal Brush-Border and Basolateral Membranes....Pages 1380-1390
Urate Transport in Mammalian Nephron....Pages 1391-1398
Pump, Leak and Metabolism: Postproximal Handling of Amino Acids in the Kidney....Pages 1399-1407
Front Matter....Pages 1408-1416
Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease....Pages 885-885
Malignancy and Cystic Disease....Pages 1537-1543
Overview of Continuous Ambulatory Peritoneal Dialysis —1990....Pages 1544-1554
Understanding the Kinetics of Peritoneal Transport....Pages 1556-1562
Comparing the Adequacy of Continuous Ambulatory Peritoneal Dialysis (CAPD) and Hemodialysis....Pages 1563-1572
Pharmacological Alteration of Ultrafiltration....Pages 1573-1580
The Impact of the Y-System and Low Peritonitis Rate on CAPD Results....Pages 1581-1591
Calcium, Phosphorus, Aluminum, and Bone Disease in Continuous Ambulatory Peritoneal Dialysis (CAPD) Patients....Pages 1592-1601
Oxidant Mechanisms in Glomerulonephritis....Pages 1602-1608
Mechanisms of the Biological Effects of Eicosanoids in the Glomerulus....Pages 1610-1617
The Functional Significance of Lipoxygenase Products of Arachidonic Acid in the Glomerular Microcirculation....Pages 1618-1627
Activation by Adenosine of Cultured Mesangial Cells: Receptors Involved and Intracellular Mechanisms....Pages 1628-1633
Interactions Between Glomerular Autacoids....Pages 1634-1642
Ion Channels in the Mammalian Nephron....Pages 1643-1653
Single Sodium Channels in the Apical Membrane of Proximal Tubule Cells in Culture....Pages 1656-1668
Regulation of K + Channels in Proximal Tubules: Studies in Opossum Kidney Cells....Pages 1669-1676
Regulation of K + Channels in the Thick Ascending Limb....Pages 1677-1684
Ion Channels in the Distal Convoluted Tubule in Primary Culture....Pages 1685-1697
Back Matter....Pages 1698-1712
....Pages 1713-1748